$61 Cheap flight deals from Mayagüez (SJU) to Santo Domingo (SDQ)
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This Weekend's Flight Deals from Mayagüez to Santo Domingo
This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Airfares from $61 One Way, $139 Round Trip from Mayagüez to Santo Domingo
Prices starting at $139 for return flights and $61 for one-way flights to Santo Domingo were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Santo Domingo economy flight packages
Hacienda Samana Bay Hotel & Residence
Mar 7 - Mar 10
San Juan (SJU) to Santo Domingo (SDQ)
Reviewed on Jan 1, 2023
Coral Costa Caribe Beach Resort - All Inclusive
Mar 19 - Mar 23
San Juan (SJU) to Santo Domingo (SDQ)
Reviewed on Oct 14, 2025
Santo Domingo packages with premium economy flights
Cataleya Hotel
Mar 12 - Mar 16
San Juan (SJU) to Santo Domingo (SDQ)
Reviewed on Aug 29, 2022
More About Flying To Santo Domingo from Mayagüez
Route Information for Flights from Mayagüez to Santo Domingo
Origin Airport IATA Code | SJU |
|---|---|
Destination Airport IATA Code | SDQ |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
Mayagüez to Santo Domingo
If it is not enough that we have guaranteed low prices for Mayagüez to Santo Domingo flights, Orbitz can also integrate your hotel and car rental needs into the package. This ensures your trip goes smoothly and you get the best possible bargain.
Save Big On Hotels With Our Summer Hotel Sale When Booking Mayagüez to Santo Domingo Flights
We will get you bargain air tickets for Mayagüez to Santo Domingo flights and can save you even more with our Summer Hotel sale. You can get a discount of up to 40% when you book a hotel along with your bargain flight from Orbitz.
If You Are Going To The Beach We Can Save You Even More
When you are arranging budget flights from Mayagüez to Santo Domingo, you can save even more by staying near a beach. Orbitz Beach Hotel Deals will allow you to get as much as half off the price of an already cheap hotel. Saving money has never been this fun.
Plan A Spontaneous Trip Using Our Top Hotel and Flight Destinations
Want to know where other people are staying after flights from Mayagüez to Santo Domingo? We not only recommend top destinations, but will tell you the most popular places to stay after {origin.name} to Santo Domingo flights.
Use Orbitz.com For Up To The Minute Hot Deals
Budget deals on flights from Mayagüez to Santo Domingo are constantly changing. You can get up-to-the-minute updates on the hottest deals on discount tickets and hotels on our website.
Frequently asked questions
- Flights to Santo Domingo
- Flights from Mayagüez
- Mayagüez Airports
- Santo Domingo Airports
- Airlines Operating
Flights to Santo Domingo
- New York to Santo Domingo
- Orlando to Santo Domingo
- Fort Lauderdale to Santo Domingo
- Toronto to Santo Domingo
- Chicago to Santo Domingo
- Detroit to Santo Domingo
- Houston to Santo Domingo
- New Orleans to Santo Domingo
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Santo Domingo Airports
More Destinations
- All Inclusive Resorts & in Santo Domingo
- Romantic Getaways & Hotels in Santo Domingo
- Waterpark Hotels & Resorts in Santo Domingo
- Santo Domingo Hotels
- Hotels near Assembly Hall of Jehovah's Witnesses
- Villa Mella Hotels
- Hotels near Plaza de la Bandera
- Residencial Santo Domingo Hotels
- Hotels near Megacentro Mall
- Hotels near Caucedo Port
- Apartments in Santo Domingo Oeste
- Condo Rentals in Santo Domingo Oeste
- Hostels in Santo Domingo Oeste
- Santo Domingo Oeste Hotels
- Villas in Santo Domingo Oeste
- Hotels near La Caleta Park
- Hotels near Hipódromo V Centenario
- Los Frailes Hotels
- Hotels near Boca Chica Beach
- Ensanche Isabelita Hotels
- Hotels near Dream Casino Be Live Hamaca
- Apartments in Santo Domingo Este
- Extended Stay Hotels in Santo Domingo Este
- Hotels with Kitchenettes in Santo Domingo Este
- Romantic Getaways & Hotels in Santo Domingo Este
- Hotels with a Wedding Venue in Santo Domingo Este
- Santo Domingo Este Hotels
- Villas in Santo Domingo Este
- Hotels near Agua Splash Caribe Parque Acuatico
- Hotels near Zona Franca de San Isidro Industrial Area
- Hotels near Las Americas Intl.
- Extended Stay Hotels in Boca Chica
- All Inclusive Resorts & in Boca Chica
- Beach Resorts & in Boca Chica
- Casino Resorts & in Boca Chica
- Golf Resorts & in Boca Chica
- Hotels with Bar in Boca Chica
- Hotels with Hot Tubs in Boca Chica
- Hotels with Waterslides in Boca Chica
- Luxury Hotels in Boca Chica
- Waterpark Hotels & Resorts in Boca Chica
- Hotels with a Wedding Venue in Boca Chica
- Boca Chica Hotels
- Guest Houses in Mama Tingo Station
- Flights to Santo Domingo
- Flights from Santo Domingo
- Flights from Las Americas Intl.
- Flights from Newark Liberty Intl. Airport (EWR) to Santo Domingo (SDQ)
- Flights from New York (JFK) to Santo Domingo (SDQ)
- Flights from Kingston (KIN) to Santo Domingo (SDQ)
- Flights from Miami (MIA) to Santo Domingo (SDQ)
- Flights from Port-au-Prince (PAP) to Santo Domingo (SDQ)
- Flights from San Juan (SJU) to Santo Domingo (SDQ)
- Flights from La Isabela Intl.
- Flights to Boca Chica
- Flights from Boca Chica
Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.