$72 Cheap flight deals from Mayagüez (SJU) to Santo Domingo (SDQ)
Earn rewards on top of your airline miles with Orbitz Rewards
Many airlines offer flexible change policies
Sign up to receive text alerts about your trip
This Weekend's Flight Deals from Mayagüez to Santo Domingo
This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Airfares from $72 One Way, $165 Round Trip from Mayagüez to Santo Domingo
Prices starting at $165 for return flights and $72 for one-way flights to Santo Domingo were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Santo Domingo economy flight packages
Xeliter Balcones del Atlantico
Jul 5 - Jul 9
San Juan (SJU) to Santo Domingo (SDQ)
Santo Domingo (SDQ) to San Juan (SJU)
Reviewed on Feb 24, 2025
Viva V Samana by Wyndham, A Trademark Adults All Inclusive
Jul 8 - Jul 13
San Juan (SJU) to Santo Domingo (SDQ)
Reviewed on May 3, 2026
Bahia Principe Escape Samaná - Adults Only
Jul 8 - Jul 13
San Juan (SJU) to Santo Domingo (SDQ)
Reviewed on Dec 18, 2018
Santo Domingo packages with premium economy flights
Bahia Principe Escape Bouganville - Adults Only - All Inclusive
Jul 23 - Jul 26
San Juan (SJU) to Santo Domingo (SDQ)
Reviewed on May 19, 2026
Luca Hotel by Heritage Residences Signature Collection
Jul 27 - Jul 31
San Juan (SJU) to Santo Domingo (SDQ)
Reviewed on Oct 12, 2025
More About Flying To Santo Domingo from Mayagüez
Route Information for Flights from Mayagüez to Santo Domingo
Origin Airport IATA Code | SJU |
|---|---|
Destination Airport IATA Code | SDQ |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
Mayagüez to Santo Domingo
Whether you want to book cheap flights from Mayagüez to Santo Domingo or are looking for the perfect package holiday, Orbitz is your one-stop source. Taking the stress and expense out of travel, Orbitz helps you find the best fares for Mayagüez to Santo Domingo flights.
Make the Most of Your Vacation
Not only does Orbitz have cheap deals for Mayagüez to Santo Domingo flights, we can also help you plan your vacation in advance. Why wait in lengthy lines for tickets to shows, amusement parks, and other attractions when you could be making the most of your holiday? Add activities to your flight booking for fewer hassles once you arrive in Santo Domingo.
Planning on the Go
Book your flights from Mayagüez to Santo Domingo wherever you are with the Orbitz app for Android and iPhone. Or simply use m.orbitz.com on your mobile browser to search and book the Mayagüez to Santo Domingo flights that you want. And if you’re running late, you check your flight status and baggage claim information on your mobile device too too.
Craft Your Perfect Vacation
Orbitz takes the stress out of vacation planning with great deals on flights from Mayagüez to Santo Domingo, hotels, car rentals, cruises, and more. Mix and match results for your perfect trip, or book a complete vacation package.
Keep Informed With Orbitz
With Orbitz’s free alerts service, you will stay informed of flight or services disruptions to your Mayagüez to Santo Domingo flights. The alerts can be sent straight to your mobile phone or email.
Frequently asked questions
- Flights to Santo Domingo
- Flights from Mayagüez
- Mayagüez Airports
- Santo Domingo Airports
- Airlines Operating
Flights to Santo Domingo
- New York to Santo Domingo
- Fort Lauderdale to Santo Domingo
- Toronto to Santo Domingo
- Orlando to Santo Domingo
- Chicago to Santo Domingo
- Houston to Santo Domingo
- Detroit to Santo Domingo
- New Orleans to Santo Domingo
- Washington to Santo Domingo
- San Francisco to Santo Domingo
- Buenos Aires to Santo Domingo
- Paris to Santo Domingo
- São Paulo to Santo Domingo
- San José to Santo Domingo
- Bucaramanga to Santo Domingo
Santo Domingo Airports
More Destinations
- All Inclusive Resorts & in Santo Domingo
- Romantic Getaways & Hotels in Santo Domingo
- Waterpark Hotels & Resorts in Santo Domingo
- Santo Domingo Hotels
- Hotels near Assembly Hall of Jehovah's Witnesses
- Villa Mella Hotels
- Hotels near Plaza de la Bandera
- Residencial Santo Domingo Hotels
- Hotels near Megacentro Mall
- Hotels near Caucedo Port
- Apartments in Santo Domingo Oeste
- Condo Rentals in Santo Domingo Oeste
- Hostels in Santo Domingo Oeste
- Santo Domingo Oeste Hotels
- Villas in Santo Domingo Oeste
- Hotels near La Caleta Park
- Hotels near Hipódromo V Centenario
- Los Frailes Hotels
- Hotels near Boca Chica Beach
- Ensanche Isabelita Hotels
- Hotels near Dream Casino Be Live Hamaca
- Apartments in Santo Domingo Este
- Extended Stay Hotels in Santo Domingo Este
- Hotels with Kitchenettes in Santo Domingo Este
- Romantic Getaways & Hotels in Santo Domingo Este
- Hotels with a Wedding Venue in Santo Domingo Este
- Santo Domingo Este Hotels
- Villas in Santo Domingo Este
- Hotels near Agua Splash Caribe Parque Acuatico
- Hotels near Zona Franca de San Isidro Industrial Area
- Hotels near Las Americas Intl.
- Extended Stay Hotels in Boca Chica
- All Inclusive Resorts & in Boca Chica
- Beach Resorts & in Boca Chica
- Casino Resorts & in Boca Chica
- Golf Resorts & in Boca Chica
- Hotels with Bar in Boca Chica
- Hotels with Hot Tubs in Boca Chica
- Hotels with Waterslides in Boca Chica
- Luxury Hotels in Boca Chica
- Waterpark Hotels & Resorts in Boca Chica
- Hotels with a Wedding Venue in Boca Chica
- Boca Chica Hotels
- Guest Houses in Mama Tingo Station
- Flights to Santo Domingo
- Flights from Santo Domingo
- Flights from Las Americas Intl.
- Flights from Newark Liberty Intl. Airport (EWR) to Santo Domingo (SDQ)
- Flights from New York (JFK) to Santo Domingo (SDQ)
- Flights from Kingston (KIN) to Santo Domingo (SDQ)
- Flights from Miami (MIA) to Santo Domingo (SDQ)
- Flights from Port-au-Prince (PAP) to Santo Domingo (SDQ)
- Flights from San Juan (SJU) to Santo Domingo (SDQ)
- Flights from La Isabela Intl.
- Flights to Boca Chica
- Flights from Boca Chica
Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.