$72 Cheap flight deals from Mayagüez (SJU) to Santo Domingo (SDQ)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

This Weekend's Flight Deals from Mayagüez to Santo Domingo

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Apr 25 - Mon, Apr 27
SJU
Luis Munoz Marin Intl.
SDQ
Las Americas Intl.
$313 Roundtrip, found 2 hours ago
$313
Roundtrip
found 2 hours ago
Select Arajet flight, departing Sat, Apr 25 from Luis Munoz Marin Intl. to Las Americas Intl., returning Mon, Apr 27, priced at $313 found 2 hours ago
Sun, Apr 26 - Mon, Apr 27
BQN
Rafael Hernandez
SDQ
Las Americas Intl.
$1,048 Roundtrip, just found
$1,048
Roundtrip
just found
Select JetBlue Airways flight, departing Sun, Apr 26 from Rafael Hernandez to Las Americas Intl., returning Mon, Apr 27, priced at $1,048 just found
Sun, Apr 26 - Mon, Apr 27
PSE
Mercedita
SDQ
Las Americas Intl.
$1,694 Roundtrip, just found
$1,694
Roundtrip
just found
Select JetBlue Airways flight, departing Sun, Apr 26 from Mercedita to Las Americas Intl., returning Mon, Apr 27, priced at $1,694 just found

Airfares from $72 One Way, $161 Round Trip from Mayagüez to Santo Domingo

Prices starting at $161 for return flights and $72 for one-way flights to Santo Domingo were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, May 9 - Mon, May 18
SJU
San Juan
SDQ
Santo Domingo
$161 Roundtrip, found 5 days ago
$161
Roundtrip
found 5 days ago
Select Arajet flight, departing Sat, May 9 from San Juan to Santo Domingo, returning Mon, May 18, priced at $161 found 5 days ago
Sat, Jun 27 - Sat, Jul 4
SJU
San Juan
SDQ
Santo Domingo
$163 Roundtrip, found 2 days ago
$163
Roundtrip
found 2 days ago
Select Arajet flight, departing Sat, Jun 27 from San Juan to Santo Domingo, returning Sat, Jul 4, priced at $163 found 2 days ago
Sun, May 3 - Sat, May 16
SJU
San Juan
SDQ
Santo Domingo
$163 Roundtrip, found 1 hour ago
$163
Roundtrip
found 1 hour ago
Select Arajet flight, departing Sun, May 3 from San Juan to Santo Domingo, returning Sat, May 16, priced at $163 found 1 hour ago
Fri, May 15 - Mon, May 18
SJU
San Juan
SDQ
Santo Domingo
$251 Roundtrip, just found
$251
Roundtrip
just found
Select JetBlue Airways flight, departing Fri, May 15 from San Juan to Santo Domingo, returning Mon, May 18, priced at $251 just found
Tue, Jun 2 - Tue, Jun 16
SJU
San Juan
SDQ
Santo Domingo
$322 Roundtrip, just found
$322
Roundtrip
just found
Select Copa flight, departing Tue, Jun 2 from San Juan to Santo Domingo, returning Tue, Jun 16, priced at $322 just found

Santo Domingo economy flight packages

Price found within the past 48 hours. Click for updated prices.
Bahia Principe Explore La Romana - All Inclusive
4.5-star property

Bahia Principe Explore La Romana - All Inclusive

8.4/10 Very Good! (2,650 reviews)

May 24 - May 28

4 night stay

San Juan (SJU) to Santo Domingo (SDQ)

Frontier Airlines • Roundtrip • Coach
Save 100% on your flight
Price was $967, price is now $538 per person
$538
per person
found 1 day ago
Room and property was very clean. Good service! The down fall was the food and the beach. Food was not that great and beach was lake/river water. No blue turquoise water

Reviewed on Apr 21, 2026

Coral Costa Caribe Beach Resort - All Inclusive
4.0-star property

Coral Costa Caribe Beach Resort - All Inclusive

7.8/10 Good! (2,566 reviews)

Jun 14 - Jun 19

5 night stay

San Juan (SJU) to Santo Domingo (SDQ)

Sterling Blue • Coach

Santo Domingo (SDQ) to San Juan (SJU)

JetBlue Airways • Coach
Price was $1,575, price is now $668 per person
$668
per person
found 1 day ago
Place and staff was awesome would def be bk Food was great

Reviewed on Oct 14, 2025

Viva V Samana by Wyndham, A Trademark Adults All Inclusive
4.5-star property

Viva V Samana by Wyndham, A Trademark Adults All Inclusive

7.8/10 Good! (1,005 reviews)

Jun 2 - Jun 6

4 night stay

San Juan (SJU) to Santo Domingo (SDQ)

JetBlue Airways • Coach

Santo Domingo (SDQ) to San Juan (SJU)

Sterling Blue • Coach
Save 100% on your flight
Price was $1,029, price is now $577 per person
$577
per person
found 1 day ago
The hotel and the beach location are quite nice, the employees at the restaurants and the bars are very dedicated and friendly and the drinks at the bars are quite good. There are three theme restaurants, we tried a variety of dishes but based on the quality of the food and service, I would only recommend the Fusion restaurant at the the lobby. There is plenty of food options at the buffet, although most of the dishes are average....pizza quality is very good. However, per comparison to similar resorts in DR the night entertainment offering is quite limited, especially at night. The entertainment team does their best, but it is very noticeable that they operate with very limited resources to be able to provide watch-worthy night entertainment for guests. That is quite important as there are not other sources for nightlife or entertainment for miles around the hotel. Even a the night club, musical rhythms are mainly local not catering to their diverse international customer base.

Reviewed on Aug 12, 2025

Don't see what you're looking for?
See all available trips from Mayagüez to Santo Domingo
View all trips

Santo Domingo packages with premium economy flights

Price found within the past 48 hours. Click for updated prices.
Hotel Silvestre
3.0-star property

Hotel Silvestre

6.8/10 (143 reviews)

May 24 - May 31

7 night stay

San Juan (SJU) to Santo Domingo (SDQ)

Frontier Airlines • Roundtrip • PremiumEconomy
Price was $851, price is now $851 per person
$851
per person
found 3 hours ago
Not as advertised! The room and hotel amenities were overpriced

Reviewed on May 14, 2021

Playa Nueva Romana
3.5-star property

Playa Nueva Romana

8.8/10 Excellent! (39 reviews)

May 24 - May 31

7 night stay

San Juan (SJU) to Santo Domingo (SDQ)

Frontier Airlines • Roundtrip • PremiumEconomy
Price was $983, price is now $897 per person
$897
per person
found 3 hours ago
Don't see what you're looking for?
See all available trips from Mayagüez to Santo Domingo
View all trips

More About Flying To Santo Domingo from Mayagüez

Route Information for Flights from Mayagüez to Santo Domingo

Origin Airport IATA Code
SJU
Destination Airport IATA Code
SDQ
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Mayagüez to Santo Domingo

Rack up your savings with low-cost flights from Mayagüez to Santo Domingo with Orbitz On-the-Go. Orbitz On-the-Go offers mobile-only deals and cutting edge mobile tools to help you find bargain flights from Mayagüez to Santo Domingo.

Mobile-Only Deals on Mayagüez to Santo Domingo flights

Find guaranteed low prices on Mayagüez to Santo Domingo flights using Orbitz On-the-Go. You can book discount domestic flights from Mayagüez to Santo Domingo, and international tickets on Mayagüez to Santo Domingo flights using our mobile site and apps.

Free Alerts Are No Surprise

Not only will you find cheap tickets on flights from Mayagüez to Santo Domingo, but Orbitz free alerts will keep you up to speed on flight status, plus gate and baggage claim details. Receive instant updates via your choice of email, voice or text. Orbitz keeps you easily on task and on budget.

Share Itineraries on Flights from Mayagüez to Santo Domingo

Are you traveling for business, pleasure or a combination of both? Keep family, friends and business contacts posted on flight and gate info. Just use MyTrips for iPhone, Android and web phones like Blackberry and Windows.

Add Smiles to Your Miles with Sales and Deals on Mayagüez to Santo Domingo Flights

Travel planning is easy when you store your frequent flyer and loyalty program information on your Orbitz account. Then snag a low-fare air ticket on Mayagüez to Santo Domingo flights, and you’re done. No muss, no fuss. Your miles will fly by with Orbitz On-the-Go cutting edge mobile tools and guaranteed low prices.

Frequently asked questions

Are there non-stop flights from Mayaguez to Santo Domingo?
Yes, JetBlue flies straight from Mayaguez to Santo Domingo, so you'll be embarking on your unforgettable adventure before you know it.
What is the shortest flight from Mayaguez to Santo Domingo?
If conditions are good and there are no delays, you could be coming in to land at Santo Domingo (SDQ-Las Americas Intl.) from Luis Munoz Marin Intl. Airport (SJU) in only 2 hours and 10 minutes. With such a fast flight time, contemplate traveling with just carry-on luggage.
What airlines fly from Mayaguez to Santo Domingo most frequently?
If you're looking for the carrier with the most frequent flights from Isla Verde Intl. Airport to Santo Domingo (SDQ-Las Americas Intl.), buckle up and take off with JetBlue. This airline offers 91 flights every month along this route.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.