$85 Cheap flight deals from Mayagüez (SJU) to Santo Domingo (SDQ)

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This Weekend's Flight Deals from Mayagüez to Santo Domingo

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Sep 19 - Tue, Sep 22
SJU
Luis Munoz Marin Intl.
SDQ
Las Americas Intl.
$370 Roundtrip, found 8 hours ago
$370
Roundtrip
found 8 hours ago
Select Arajet flight, departing Sat, Sep 19 from Luis Munoz Marin Intl. to Las Americas Intl., returning Tue, Sep 22, priced at $370 found 8 hours ago

Airfares from $85 One Way, $203 Round Trip from Mayagüez to Santo Domingo

Prices starting at $203 for return flights and $85 for one-way flights to Santo Domingo were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Jan 24 - Sun, Jan 31
SJU
San Juan
SDQ
Santo Domingo
$203 Roundtrip, found 1 day ago
$203
Roundtrip
found 1 day ago
Select Arajet flight, departing Sun, Jan 24 from San Juan to Santo Domingo, returning Sun, Jan 31, priced at $203 found 1 day ago
Sat, Oct 10 - Sun, Dec 6
SJU
San Juan
SDQ
Santo Domingo
$206 Roundtrip, found 4 days ago
$206
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Sat, Oct 10 from San Juan to Santo Domingo, returning Sun, Dec 6, priced at $206 found 4 days ago
Mon, Nov 2 - Mon, Nov 9
SJU
San Juan
SDQ
Santo Domingo
$208 Roundtrip, found 1 day ago
$208
Roundtrip
found 1 day ago
Select Arajet flight, departing Mon, Nov 2 from San Juan to Santo Domingo, returning Mon, Nov 9, priced at $208 found 1 day ago
Sat, Dec 5 - Mon, Dec 7
SJU
San Juan
SDQ
Santo Domingo
$209 Roundtrip, found 7 hours ago
$209
Roundtrip
found 7 hours ago
Select Arajet flight, departing Sat, Dec 5 from San Juan to Santo Domingo, returning Mon, Dec 7, priced at $209 found 7 hours ago
Sat, Oct 17 - Sat, Oct 24
SJU
San Juan
SDQ
Santo Domingo
$210 Roundtrip, found 1 day ago
$210
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sat, Oct 17 from San Juan to Santo Domingo, returning Sat, Oct 24, priced at $210 found 1 day ago

Santo Domingo economy flight packages

Price found within the past 48 hours. Click for updated prices.
Coral Costa Caribe Beach Resort - All Inclusive
4.0-star property

Coral Costa Caribe Beach Resort - All Inclusive

8/10 Very Good! (2,690 reviews)

Oct 16 - Oct 18

2 night stay

San Juan (SJU) to Santo Domingo (SDQ)

Frontier Airlines • Roundtrip • Coach
Save 100% on your flight
Price was $819, price is now $427 per person
$427
per person
found 1 day ago

HERITAGE RESIDENCES STYLE
3.0-star property

HERITAGE RESIDENCES STYLE

7.4/10 Good! (17 reviews)

Oct 31 - Nov 8

8 night stay

San Juan (SJU) to Santo Domingo (SDQ)

Sterling Blue • Roundtrip • Coach
Save 100% on your flight
Price was $4,157, price is now $2,364 per person
$2,364
per person
found 1 day ago
It’s a bait and switch the address is not where the location is and the rooms shown are not available. It’s still under construction and has regular black outs. Next to a cemetery. Do not stay here pictures not as shown. AGAIN DO NOT STAY HERE BAIT AND SWITCH NOT AS ADVERTISE. And Expedia nor the hotel will compensate.

Reviewed on Nov 12, 2025

Eurostars Grand Cayacoa
4.5-star property

Eurostars Grand Cayacoa

8.2/10 Very Good! (656 reviews)

Nov 2 - Nov 7

5 night stay

San Juan (SJU) to Santo Domingo (SDQ)

Frontier Airlines • Roundtrip • Coach
Save 100% on your flight
Price was $1,071, price is now $668 per person
$668
per person
found 1 day ago

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Santo Domingo packages with premium economy flights

Price found within the past 48 hours. Click for updated prices.
Cataleya Hotel
3.0-star property

Cataleya Hotel

8.6/10 Excellent! (424 reviews)

Nov 9 - Nov 14

5 night stay

San Juan (SJU) to Santo Domingo (SDQ)

JetBlue Airways • Roundtrip • PremiumEconomy
Price was $814, price is now $614 per person
$614
per person
found 10 hours ago
No comment the hotels is good

Reviewed on Sep 15, 2026

Bahia Principe Escape Bouganville - Hyatt Inclusive Collection - Adults Only - All Inclusive
4.5-star property

Bahia Principe Escape Bouganville - Hyatt Inclusive Collection - Adults Only - All Inclusive

8.8/10 Excellent! (2,616 reviews)

Oct 29 - Nov 1

3 night stay

San Juan (SJU) to Santo Domingo (SDQ)

JetBlue Airways • Roundtrip • PremiumEconomy
Price was $1,302, price is now $942 per person
$942
per person
found 1 day ago

Bahia Principe Explore La Romana - Hyatt Inclusive Collection - All Inclusive
4.5-star property

Bahia Principe Explore La Romana - Hyatt Inclusive Collection - All Inclusive

8.4/10 Very Good! (2,633 reviews)

Oct 29 - Nov 1

3 night stay

San Juan (SJU) to Santo Domingo (SDQ)

JetBlue Airways • Roundtrip • PremiumEconomy
Price was $1,170, price is now $879 per person
$879
per person
found 1 day ago
The resort was very nice. The ambiance was great. All the staff were very friendly and knowledgeable. The rooms were clean and the beds were very comfortable. The swim up bar was great the while crew were very attentive. Kids had a lot of activities my grandkids really enjoyed it. The food was great at buffet and restaurants. It was 14 of us the whole family had a great time. Thanks

Reviewed on Sep 15, 2026

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More About Flying To Santo Domingo from Mayagüez

Route Information for Flights from Mayagüez to Santo Domingo

Origin Airport IATA Code
SJU
Destination Airport IATA Code
SDQ
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Mayagüez to Santo Domingo

Orbitz gives you great deals on your flights from Mayagüez to Santo Domingo. If you also need a discount car rental or a cheap hotel room after you arrived at your destination, Orbitz has you covered.

We Offer Great Travel Deals and Discounts

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Enjoy Savings on Last-Minute Flights

If you are looking for a discount price on last-minute flights from Mayagüez to Santo Domingo, chances are that Orbitz can offer you a deal that will save you lots of money. Whether you just want to get away for the weekend or go on a vacation lasting weeks, Orbitz can help you find the best deals on Mayagüez to Santo Domingo flights that fit your budget and your itinerary for the perfect trip.

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Frequently asked questions

Are there non-stop flights from Mayaguez to Santo Domingo?
Yes, JetBlue flies straight from Mayaguez to Santo Domingo, so you'll be embarking on your unforgettable adventure before you know it.
What is the shortest flight from Mayaguez to Santo Domingo?
If conditions are good and there are no delays, you could be coming in to land at Santo Domingo (SDQ-Las Americas Intl.) from Luis Munoz Marin Intl. Airport (SJU) in only 2 hours and 10 minutes. With such a fast flight time, contemplate traveling with just carry-on luggage.
What airlines fly from Mayaguez to Santo Domingo most frequently?
If you're looking for the carrier with the most frequent flights from Isla Verde Intl. Airport to Santo Domingo (SDQ-Las Americas Intl.), buckle up and take off with JetBlue. This airline offers 91 flights every month along this route.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.