$61 Cheap flight deals from Mayagüez (SJU) to Santo Domingo (SDQ)

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This Weekend's Flight Deals from Mayagüez to Santo Domingo

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Feb 6 - Sun, Feb 8
SJU
Luis Munoz Marin Intl.
SDQ
Las Americas Intl.
$144 Roundtrip, found 2 hours ago
$144
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Fri, Feb 6 from Luis Munoz Marin Intl. to Las Americas Intl., returning Sun, Feb 8, priced at $144 found 2 hours ago
Fri, Feb 6 - Sun, Feb 8
PSE
Mercedita
SDQ
Las Americas Intl.
$681 Roundtrip, found 4 days ago
$681
Roundtrip
found 4 days ago
Select JetBlue Airways flight, departing Fri, Feb 6 from Mercedita to Las Americas Intl., returning Sun, Feb 8, priced at $681 found 4 days ago

Airfares from $61 One Way, $139 Round Trip from Mayagüez to Santo Domingo

Prices starting at $139 for return flights and $61 for one-way flights to Santo Domingo were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Mar 8 - Mon, Mar 16
SJU
San Juan
SDQ
Santo Domingo
$139 Roundtrip, found 1 hour ago
$139
Roundtrip
found 1 hour ago
Select Arajet flight, departing Sun, Mar 8 from San Juan to Santo Domingo, returning Mon, Mar 16, priced at $139 found 1 hour ago
Sat, Mar 28 - Mon, Apr 6
SJU
San Juan
SDQ
Santo Domingo
$143 Roundtrip, found 1 day ago
$143
Roundtrip
found 1 day ago
Select Arajet flight, departing Sat, Mar 28 from San Juan to Santo Domingo, returning Mon, Apr 6, priced at $143 found 1 day ago
Mon, Feb 23 - Sun, Mar 1
SJU
San Juan
SDQ
Santo Domingo
$143 Roundtrip, found 1 day ago
$143
Roundtrip
found 1 day ago
Select Arajet flight, departing Mon, Feb 23 from San Juan to Santo Domingo, returning Sun, Mar 1, priced at $143 found 1 day ago
Fri, Feb 6 - Sun, Feb 8
SJU
San Juan
SDQ
Santo Domingo
$144 Roundtrip, found 2 hours ago
$144
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Fri, Feb 6 from San Juan to Santo Domingo, returning Sun, Feb 8, priced at $144 found 2 hours ago
Sat, Feb 14 - Mon, Feb 16
SJU
San Juan
SDQ
Santo Domingo
$198 Roundtrip, just found
$198
Roundtrip
just found
Select JetBlue Airways flight, departing Sat, Feb 14 from San Juan to Santo Domingo, returning Mon, Feb 16, priced at $198 just found

Santo Domingo economy flight packages

Price found within the past 48 hours. Click for updated prices.
Bahia Principe Grand Samana - Adults Only
4.5-star property

Bahia Principe Grand Samana - Adults Only

8.8/10 Excellent! (624 reviews)

Mar 8 - Mar 10

2 night stay

San Juan (SJU) to Santo Domingo (SDQ)

Frontier Airlines • Coach

Santo Domingo (SDQ) to San Juan (SJU)

Sterling Blue • Coach
Price was $763, price is now $441 per person
$441
per person
found 1 day ago
Beautiful hotel, friendly staff, Room had an amazing view of the ocean. The food was far better then expected and alcohol selection was also good. My overall stay was amazing, got the rest i needed. I would definitely recommend the resort to anyone.

Reviewed on Dec 18, 2018

Coral Costa Caribe Beach Resort - All Inclusive
4.0-star property

Coral Costa Caribe Beach Resort - All Inclusive

7.8/10 Good! (2,518 reviews)

Mar 28 - Apr 2

5 night stay

San Juan (SJU) to Santo Domingo (SDQ)

Sterling Blue • Coach

Santo Domingo (SDQ) to San Juan (SJU)

Frontier Airlines • Coach
Price was $1,432, price is now $649 per person
$649
per person
found 10 hours ago
Place and staff was awesome would def be bk Food was great

Reviewed on Oct 14, 2025

Bahia Principe Luxury Bouganville - Adults Only - All Inclusive
4.5-star property

Bahia Principe Luxury Bouganville - Adults Only - All Inclusive

8.8/10 Excellent! (2,770 reviews)

Mar 13 - Mar 16

3 night stay

San Juan (SJU) to Santo Domingo (SDQ)

Sterling Blue • Coach

Santo Domingo (SDQ) to San Juan (SJU)

Frontier Airlines • Coach
Price was $1,156, price is now $629 per person
$629
per person
found 1 day ago
Luxury is definitely a good way to describe. Was more than expected when considering the price! Excellent deal. Staff went above and beyond and food exquisite. Maria and Enervira are two on a long list that created fantastico memories ... The landscape plants and statues such a beautiful place

Reviewed on Oct 20, 2025

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More About Flying To Santo Domingo from Mayagüez

Route Information for Flights from Mayagüez to Santo Domingo

Origin Airport IATA Code
SJU
Destination Airport IATA Code
SDQ
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Mayagüez to Santo Domingo

For guaranteed low prices on flights from Mayagüez to Santo Domingo, search no further than Orbitz. Planning the perfect trip is simple with Orbitz; our range of bargain holiday packages and cutting edge mobile tools makes it quick and easy.

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Frequently asked questions

Are there non-stop flights from Mayaguez to Santo Domingo?
Yes, JetBlue flies straight from Mayaguez to Santo Domingo, so you'll be embarking on your unforgettable adventure before you know it.
What is the shortest flight from Mayaguez to Santo Domingo?
If conditions are good and there are no delays, you could be coming in to land at Santo Domingo (SDQ-Las Americas Intl.) from Luis Munoz Marin Intl. Airport (SJU) in only 2 hours and 10 minutes. With such a fast flight time, contemplate traveling with just carry-on luggage.
What airlines fly from Mayaguez to Santo Domingo most frequently?
If you're looking for the carrier with the most frequent flights from Isla Verde Intl. Airport to Santo Domingo (SDQ-Las Americas Intl.), buckle up and take off with JetBlue. This airline offers 91 flights every month along this route.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.