$74 Cheap flight deals from Mayagüez (SJU) to Santo Domingo (SDQ)

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This Weekend's Flight Deals from Mayagüez to Santo Domingo

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Apr 25 - Sun, Apr 26
SJU
Luis Munoz Marin Intl.
SDQ
Las Americas Intl.
$245 Roundtrip, found 16 hours ago
$245
Roundtrip
found 16 hours ago
Select Arajet flight, departing Sat, Apr 25 from Luis Munoz Marin Intl. to Las Americas Intl., returning Sun, Apr 26, priced at $245 found 16 hours ago
Fri, Apr 24 - Sun, Apr 26
BQN
Rafael Hernandez
SDQ
Las Americas Intl.
$717 Roundtrip, found 6 days ago
$717
Roundtrip
found 6 days ago
Select JetBlue Airways flight, departing Fri, Apr 24 from Rafael Hernandez to Las Americas Intl., returning Sun, Apr 26, priced at $717 found 6 days ago

Airfares from $74 One Way, $161 Round Trip from Mayagüez to Santo Domingo

Prices starting at $161 for return flights and $74 for one-way flights to Santo Domingo were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, May 9 - Mon, May 18
SJU
San Juan
SDQ
Santo Domingo
$161 Roundtrip, found 4 days ago
$161
Roundtrip
found 4 days ago
Select Arajet flight, departing Sat, May 9 from San Juan to Santo Domingo, returning Mon, May 18, priced at $161 found 4 days ago
Sat, Jun 27 - Sat, Jul 4
SJU
San Juan
SDQ
Santo Domingo
$163 Roundtrip, found 1 day ago
$163
Roundtrip
found 1 day ago
Select Arajet flight, departing Sat, Jun 27 from San Juan to Santo Domingo, returning Sat, Jul 4, priced at $163 found 1 day ago
Sat, Sep 12 - Sat, Sep 19
SJU
San Juan
SDQ
Santo Domingo
$165 Roundtrip, found 3 hours ago
$165
Roundtrip
found 3 hours ago
Select Arajet flight, departing Sat, Sep 12 from San Juan to Santo Domingo, returning Sat, Sep 19, priced at $165 found 3 hours ago
Mon, May 11 - Thu, May 14
SJU
San Juan
SDQ
Santo Domingo
$251 Roundtrip, just found
$251
Roundtrip
just found
Select JetBlue Airways flight, departing Mon, May 11 from San Juan to Santo Domingo, returning Thu, May 14, priced at $251 just found
Wed, May 13 - Sun, May 17
SJU
San Juan
SDQ
Santo Domingo
$322 Roundtrip, found 2 hours ago
$322
Roundtrip
found 2 hours ago
Select Copa flight, departing Wed, May 13 from San Juan to Santo Domingo, returning Sun, May 17, priced at $322 found 2 hours ago

Santo Domingo economy flight packages

Price found within the past 48 hours. Click for updated prices.
Bahia Principe Explore La Romana - All Inclusive
4.5-star property

Bahia Principe Explore La Romana - All Inclusive

8.4/10 Very Good! (2,650 reviews)

Jun 6 - Jun 10

4 night stay

San Juan (SJU) to Santo Domingo (SDQ)

Frontier Airlines • Roundtrip • Coach
Save 100% on your flight
Price was $885, price is now $499 per person
$499
per person
found 1 day ago
Room and property was very clean. Good service! The down fall was the food and the beach. Food was not that great and beach was lake/river water. No blue turquoise water

Reviewed on Apr 21, 2026

Bahia Principe Escape Samaná - Adults Only
4.5-star property

Bahia Principe Escape Samaná - Adults Only

8.8/10 Excellent! (667 reviews)

Jun 6 - Jun 10

4 night stay

San Juan (SJU) to Santo Domingo (SDQ)

Frontier Airlines • Roundtrip • Coach
Save 100% on your flight
Price was $956, price is now $540 per person
$540
per person
found 1 day ago
Beautiful hotel, friendly staff, Room had an amazing view of the ocean. The food was far better then expected and alcohol selection was also good. My overall stay was amazing, got the rest i needed. I would definitely recommend the resort to anyone.

Reviewed on Dec 18, 2018

Coral Costa Caribe Beach Resort - All Inclusive
4.0-star property

Coral Costa Caribe Beach Resort - All Inclusive

7.8/10 Good! (2,566 reviews)

Jun 15 - Jun 19

4 night stay

Aguadilla (BQN) to Santo Domingo (SDQ)

JetBlue Airways • Non-stop roundtrip • Coach
Price was $1,842, price is now $1,111 per person
$1,111
per person
found 1 day ago
Place and staff was awesome would def be bk Food was great

Reviewed on Oct 14, 2025

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More About Flying To Santo Domingo from Mayagüez

Route Information for Flights from Mayagüez to Santo Domingo

Origin Airport IATA Code
SJU
Destination Airport IATA Code
SDQ
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Mayagüez to Santo Domingo

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Frequently asked questions

Are there non-stop flights from Mayaguez to Santo Domingo?
Yes, JetBlue flies straight from Mayaguez to Santo Domingo, so you'll be embarking on your unforgettable adventure before you know it.
What is the shortest flight from Mayaguez to Santo Domingo?
If conditions are good and there are no delays, you could be coming in to land at Santo Domingo (SDQ-Las Americas Intl.) from Luis Munoz Marin Intl. Airport (SJU) in only 2 hours and 10 minutes. With such a fast flight time, contemplate traveling with just carry-on luggage.
What airlines fly from Mayaguez to Santo Domingo most frequently?
If you're looking for the carrier with the most frequent flights from Isla Verde Intl. Airport to Santo Domingo (SDQ-Las Americas Intl.), buckle up and take off with JetBlue. This airline offers 91 flights every month along this route.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.