$159 Cheap flight deals from Quad Cities (MLI) to San Francisco (SJC)

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This Weekend's Flight Deals from Quad Cities to San Francisco

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Jun 28 - Sun, Jul 6
MLI
Quad City Intl.
SFO
San Francisco Intl.
$459 Roundtrip, found 4 days ago
$459
Roundtrip
found 4 days ago
Select United flight, departing Sat, Jun 28 from Quad City Intl. to San Francisco Intl., returning Sun, Jul 6, priced at $459 found 4 days ago

Airfares from $159 One Way, $289 Round Trip from Quad Cities to San Francisco

Prices starting at $289 for return flights and $159 for one-way flights to San Francisco were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Sep 24 - Sun, Sep 28
MLI
Moline
SFO
San Francisco
$289 Roundtrip, found 5 days ago
$289
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Sep 24 from Moline to San Francisco, returning Sun, Sep 28, priced at $289 found 5 days ago
Wed, Sep 24 - Sun, Sep 28
MLI
Moline
SFO
San Francisco
$289 Roundtrip, found 5 days ago
$289
Roundtrip
found 5 days ago
Select United flight, departing Wed, Sep 24 from Moline to San Francisco, returning Sun, Sep 28, priced at $289 found 5 days ago
Sat, Aug 16 - Mon, Sep 1
MLI
Moline
SFO
San Francisco
$294 Roundtrip, found 1 day ago
$294
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Aug 16 from Moline to San Francisco, returning Mon, Sep 1, priced at $294 found 1 day ago
Tue, Sep 23 - Sun, Sep 28
MLI
Moline
SFO
San Francisco
$309 Roundtrip, found 5 days ago
$309
Roundtrip
found 5 days ago
Select United flight, departing Tue, Sep 23 from Moline to San Francisco, returning Sun, Sep 28, priced at $309 found 5 days ago
Tue, Aug 19 - Sat, Aug 30
MLI
Moline
SFO
San Francisco
$317 Roundtrip, found 1 day ago
$317
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Aug 19 from Moline to San Francisco, returning Sat, Aug 30, priced at $317 found 1 day ago

San Francisco economy flight packages

Price found within the past 48 hours. Click for updated prices.
The Grove Inn
3.0-star property

The Grove Inn

9.2/10 Wonderful! (641 reviews)

Aug 19 - Aug 23

4 night stay

Moline (MLI) to San Francisco (SFO)

American Airlines • Non-stop roundtrip • Coach
Save 100% on your flight
per person
found 4 hours ago
Very quaint property with very personal contact info and desk - would stay again for sure; room small but comfortable and shower fantastic… very walkable to restaurants and the Gilmore

Reviewed on Jan 6, 2025

@ Marbella Lane - Vibrant 5BR Home in Daly City
3.0-star property

@ Marbella Lane - Vibrant 5BR Home in Daly City

No reviews

Aug 19 - Aug 23

4 night stay

Moline (MLI) to San Francisco (SFO)

American Airlines • Non-stop roundtrip • Coach
Save 100% on your flight
per person
found 4 hours ago
Avatar Hotel Santa Clara, Tapestry Collection by Hilton
3.5-star property

Avatar Hotel Santa Clara, Tapestry Collection by Hilton

8.6/10 Excellent! (153 reviews)

Aug 10 - Aug 16

6 night stay

Moline (MLI) to San Jose (SJC)

American Airlines • Non-stop roundtrip • Coach
per person
found 3 hours ago
This hotel was a nice surprise. First off they had a full gym and separate cardio room. It was great and convenient. The room was super nice. Huge tv, large shower with glass sliding doors and tons of luxurious touches. A great Indian restaurant is next door and it also has a Starbucks attached.

Reviewed on Jun 13, 2025

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More About Flying To San Francisco from Quad Cities

Route Information for Flights from Quad Cities to San Francisco

Origin Airport IATA Code
MLI
Destination Airport IATA Code
SJC
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Frequently asked questions

What is the shortest flight from Quad Cities to San Francisco?
Jetting from Quad City Intl. Airport (MLI) to San Francisco, CA (SFO-San Francisco Intl.) will take you at least 5 hours and 9 minutes. Enjoy a tipple and watch a movie or two --- here's your chance to chill out.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.