
$81 Cheap flight deals from Knoxville (TYS) to Buffalo (MSP)
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This Weekend's Flight Deals from Knoxville to Buffalo
This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Airfares from $81 One Way, $174 Round Trip from Knoxville to Buffalo
Prices starting at $174 for return flights and $81 for one-way flights to Buffalo were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Buffalo economy flight packages

Hyatt House Mall Of America Msp Airport
Feb 13 - Feb 15
Knoxville (TYS) to Minneapolis (MSP)
Reviewed on Jan 7, 2026


Graduate by Hilton Minneapolis
Feb 13 - Feb 15
Knoxville (TYS) to Minneapolis (MSP)
Reviewed on Oct 24, 2025
More About Flying To Buffalo from Knoxville
Route Information for Flights from Knoxville to Buffalo
Origin Airport IATA Code | TYS |
|---|---|
Destination Airport IATA Code | MSP |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
Knoxville to Buffalo
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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.
