$142 Cheap flight deals from Knoxville (TYS) to Buffalo (MSP)
Earn rewards on top of your airline miles with Orbitz Rewards
Many airlines offer flexible change policies
Sign up to receive text alerts about your trip
This Weekend's Flight Deals from Knoxville to Buffalo
This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Airfares from $142 One Way, $171 Round Trip from Knoxville to Buffalo
Prices starting at $171 for return flights and $142 for one-way flights to Buffalo were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
More About Flying To Buffalo from Knoxville
Route Information for Flights from Knoxville to Buffalo
Origin Airport IATA Code | TYS |
|---|---|
Destination Airport IATA Code | MSP |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
Knoxville to Buffalo
Looking for guaranteed low prices on Knoxville to Buffalo flights? Orbitz is your source and much more. From cutting-edge mobile tools to great deals, Orbitz makes it easy to book your dream vacation.
Frequent Flyers Earn Miles
Earn frequent flyer miles or points on Orbitz flights from Knoxville to Buffalo. When booking your Knoxville to Buffalo flights, have your frequent flyer number on hand and add it where prompted. Your Orbitz account can store your number for future use, meaning you never miss out on your rewards.
Book Orbitz on the Go
With the Orbitz mobile apps for Android and iPhone, you no longer have to be sitting at your desk to book Knoxville to Buffalo flights. With a few easy clicks, you can book your flights, research hotel rooms, and check your flight status and other important flight information.
Easily Plan Your Vacation
Not only does Orbitz offer great prices on flights from Knoxville to Buffalo, but you will also find fantastic deals on hotels, cruises, and vacation activities. Never miss out on that dream trip or waste hours waiting in long lines—you can buy tickets to attraction in advance with Orbitz to guarantee admission to your favorite places.
Best Deals At Your Fingertips
Orbitz combines low prices on Knoxville to Buffalo flights with discounts on quality hotels. Using Orbitz’s Display Matrix, you can see all your options and savings easily. With our low price guarantee, you know you have the best deals at your fingertips.
Flights from Knoxville
- Knoxville to Orlando
- Knoxville to New York
- Knoxville to Dallas
- Knoxville to Chicago
- Knoxville to Houston
- Knoxville to Los Angeles
- Knoxville to Washington
- Knoxville to Detroit
- Knoxville to New Orleans
- Knoxville to Toronto
- Knoxville to London
- Knoxville to Kansas City
- Knoxville to Sacramento
- Knoxville to San Francisco
- Knoxville to Hartford
- Knoxville to Rome
- Knoxville to Anchorage
- Knoxville to Paris
- Knoxville to Killeen
- Knoxville to Beijing
Knoxville Airports
More Destinations
More Destinations
- Flights from Chicago to St. Louis Park
- Flights from Denver to St. Louis Park
- Flights from New York to St. Louis Park
- Flights from Tunis to St. Louis Park
- Flights from Montgomery to St. Louis Park
- Flights from Tampa to St. Louis Park
- Flights from Dallas to Albertville
- Flights from Nashville to Albertville
- Flights from New York to Albertville
- Flights from Orlando to Albertville
- Flights from Philadelphia to Albertville
- Flights from Sacramento to Albertville
- Flights from Richmond to Albertville
- Flights from Tampa to Albertville
- Flights from Bismarck to Albertville
- Flights from Calgary to Rogers
- Flights from Dallas to Rogers
- Flights from Phoenix to Rogers
- Flights from Asheville to Rogers
- Flights from Rapid City to Rogers
- Flights from Dakar to Minneapolis
- Flights from Fairbanks to Minneapolis
- Flights from Whitefish to Minneapolis
- Flights from Heraklion to Minneapolis
- Flights from Portage to Minneapolis
- Flights from SeaTac to Minneapolis
- Flights from Killeen to Minneapolis
- Flights from El Centro to Minneapolis
- Flights from Arusha to Minneapolis
- Flights from Atlanta to Minneapolis
- Flights from Boston to Minneapolis
- Flights from Detroit to Minneapolis
- Flights from Jakarta to Minneapolis
- Flights from Las Vegas to Minneapolis
- Flights from Lima to Minneapolis
- Flights from New York to Minneapolis
- Flights from Orlando to Minneapolis
- Flights from Portland to Minneapolis
- Flights from St. Louis to Minneapolis
- Flights from Washington to Minneapolis
- Flights from Christchurch to Minneapolis
- Flights from Puerto Vallarta to Minneapolis
- Flights from St. John's to Minneapolis
- Flights from Antananarivo to Minneapolis
- Flights from Amarillo to Minneapolis
- Flights from Deer Lake to Minneapolis
- Flights from Morelos to Minneapolis
- Flights from Milwaukee to Minneapolis
- Flights from Reno to Minneapolis
- Flights from Dayton to Minneapolis
- Flights from Montgomery to Minneapolis
- Flights from Pueblo to Minneapolis
- Flights from Boise to Minneapolis
- Flights from Porto to Minneapolis
- Flights from Liverpool to Minneapolis
- Flights from Innsbruck to Minneapolis
- Flights from Charleston to Minneapolis
- Flights from Kingston to Minneapolis
- Flights from Kingsville to Minneapolis
- Flights from St. Barthelemy to Minneapolis
- Flights from Strasbourg to Minneapolis
- Flights from West Columbia to Minneapolis
- Flights from North Charleston to Minneapolis
- Flights from Scottsdale to Minneapolis
- Flights from Decatur to Minneapolis
- Flights from Anchorage to Minnetonka
- Flights from Denver to Minnetonka
- Flights from Memphis to Minnetonka
- Flights from Orlando to Minnetonka
- Flights from Phoenix to Minnetonka
- Flights from Washington to Minnetonka
- Flights from Tucson to Minnetonka
- Flights from Tampa to Minnetonka
- Flights from Grand Rapids to Minnetonka
- Flights from Bozeman to Minnetonka
- Flights from Dayton to Clearwater
- Flights from Montgomery to Clearwater
- Flights from Nairobi to Otsego
- Flights from Nashville to Otsego
- Flights from Buffalo to Otsego
- Flights from Tampa to Otsego
- Flights from Calgary to Big Lake
- Flights from Chicago to Big Lake
- Flights from Miami to Big Lake
- Flights from Orlando to Big Lake
- Flights from Phoenix to Big Lake
- Flights from Grand Rapids to Big Lake
- Flights from Anjar to Eden Prairie
- Flights from Quibdó to Eden Prairie
- Flights from Tucson to Eden Prairie
- Flights from Tampico to Eden Prairie
- Flights from Gaular to Eden Prairie
- Flights from Debrecen to Eden Prairie
- Flights from Corozal to Eden Prairie
- Flights from Dallas to Annandale
- Flights from Houston to Annandale
- Flights from Memphis to Annandale
- Flights from Phoenix to Annandale
- Flights from Tampa to Annandale
- Flights from Covington to Annandale
Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.