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Sat, Apr 4 - Sun, Apr 12
PTY
Tocumen Intl.
MDE
José María Córdova Intl.
$321 Roundtrip, found 4 days ago
$321
Roundtrip
found 4 days ago
Select Copa flight, departing Sat, Apr 4 from Tocumen Intl. to José María Córdova Intl., returning Sun, Apr 12, priced at $321 found 4 days ago
Mon, Apr 13 - Thu, Apr 16
PTY
Panama City
MDE
Medellin
$317 Roundtrip, found 5 days ago
$317
Roundtrip
found 5 days ago
Select avianca flight, departing Mon, Apr 13 from Panama City to Medellin, returning Thu, Apr 16, priced at $317 found 5 days ago
Thu, May 28 - Sun, May 31
PTY
Panama City
MDE
Medellin
$319 Roundtrip, found 6 days ago
$319
Roundtrip
found 6 days ago
Select avianca flight, departing Thu, May 28 from Panama City to Medellin, returning Sun, May 31, priced at $319 found 6 days ago
Sun, May 3 - Sun, May 31
PTY
Panama City
MDE
Medellin
$332 Roundtrip, found 2 days ago
$332
Roundtrip
found 2 days ago
Select Copa flight, departing Sun, May 3 from Panama City to Medellin, returning Sun, May 31, priced at $332 found 2 days ago
Thu, Jun 18 - Mon, Jun 22
PTY
Panama City
MDE
Medellin
$334 Roundtrip, found 2 days ago
$334
Roundtrip
found 2 days ago
Select Copa flight, departing Thu, Jun 18 from Panama City to Medellin, returning Mon, Jun 22, priced at $334 found 2 days ago
Thu, May 28 - Sun, May 31
PTY
Panama City
MDE
Medellin
$336 Roundtrip, found 6 days ago
$336
Roundtrip
found 6 days ago
Select avianca flight, departing Thu, May 28 from Panama City to Medellin, returning Sun, May 31, priced at $336 found 6 days ago
Price found within the past 48 hours. Click for updated prices.
La Martina Campestre
3.0-star property

La Martina Campestre

8/10 Very Good! (8 reviews)

May 21 - May 28

7 night stay

Panama City (PTY) to Medellín (MDE)

Copa • Roundtrip • Coach
Price was $748, price is now $482 per person
$482
per person
found 1 day ago
Aparta Suites Torre Poblado
3.0-star property

Aparta Suites Torre Poblado

8.8/10 Excellent! (888 reviews)

May 6 - May 10

4 night stay

Panama City (PAC) to Medellín (MDE)

Copa • Roundtrip • Coach
Price was $868, price is now $568 per person
$568
per person
found 2 days ago
Central location. Close to food and entertainment

Reviewed on Jun 12, 2023

Autenthico Sajonia Hotel Aeropuerto
2.0-star property

Autenthico Sajonia Hotel Aeropuerto

9.2/10 Wonderful! (75 reviews)

May 21 - May 28

7 night stay

Panama City (PTY) to Medellín (MDE)

Copa • Roundtrip • Coach
Price was $746, price is now $496 per person
$496
per person
found 1 day ago
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Price found within the past 48 hours. Click for updated prices.
York Medellin, Curio Collection by Hilton
4.0-star property

York Medellin, Curio Collection by Hilton

9.6/10 Exceptional! (1,490 reviews)

May 6 - May 10

4 night stay

Panama City (PTY) to Medellín (MDE)

Copa • Roundtrip • BusinessClass
Price was $1,082, price is now $1,056 per person
$1,056
per person
found 1 day ago
El hotel super limpio y muy bien decorado. La atención del staff fue muy buena. Uno llamaba para servicio al cuarto o por información y resolvían inmediatamente. Me vuelvo a hospedar todas las veces que pueda.

Reviewed on Nov 24, 2025

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Frequently asked questions

Are there non-stop flights from Panama City to Medellin?
Get your passport ready, because Copa Airlines will take you straight from Panama City to Medellin. Book your fare now and enjoy a stress-free, nonstop flight.
What is the shortest flight from Panama City to Medellin?
If conditions are good and everything goes to plan, you could be landing at MDE from Panama Airport in just 1 hour and 12 minutes. With such a speedy flight time, think about taking hand luggage only.
What airlines fly from Panama City to Medellin most frequently?
If you're looking for the airline that offers the most flights from Panama City to Medellin, Copa Airlines is your best bet. This respected airline operates 152 flights along this route every month.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.