$327 Cheap flight deals from Panama City (PTY) to Santo Domingo (SDQ)

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This Weekend's Flight Deals from Panama City to Santo Domingo

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Aug 15 - Thu, Oct 15
PTY
Tocumen Intl.
SDQ
Las Americas Intl.
$622 Roundtrip, found 3 days ago
$622
Roundtrip
found 3 days ago
Select avianca flight, departing Sat, Aug 15 from Tocumen Intl. to Las Americas Intl., returning Thu, Oct 15, priced at $622 found 3 days ago

Airfares from $327 One Way, $571 Round Trip from Panama City to Santo Domingo

Prices starting at $571 for return flights and $327 for one-way flights to Santo Domingo were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Sep 9 - Sat, Sep 12
PTY
Panama City
SDQ
Santo Domingo
$571 Roundtrip, found 1 day ago
$571
Roundtrip
found 1 day ago
Select Copa flight, departing Wed, Sep 9 from Panama City to Santo Domingo, returning Sat, Sep 12, priced at $571 found 1 day ago
Fri, Aug 28 - Mon, Aug 31
PTY
Panama City
SDQ
Santo Domingo
$582 Roundtrip, found 2 days ago
$582
Roundtrip
found 2 days ago
Select Copa flight, departing Fri, Aug 28 from Panama City to Santo Domingo, returning Mon, Aug 31, priced at $582 found 2 days ago
Fri, Aug 28 - Mon, Aug 31
PTY
Panama City
SDQ
Santo Domingo
$592 Roundtrip, found 2 days ago
$592
Roundtrip
found 2 days ago
Select Copa flight, departing Fri, Aug 28 from Panama City to Santo Domingo, returning Mon, Aug 31, priced at $592 found 2 days ago
Sat, Feb 13 - Tue, Mar 9
PTY
Panama City
SDQ
Santo Domingo
$622 Roundtrip, just found
$622
Roundtrip
just found
Select avianca flight, departing Sat, Feb 13 from Panama City to Santo Domingo, returning Tue, Mar 9, priced at $622 just found
Thu, Aug 27 - Sun, Aug 30
PTY
Panama City
SDQ
Santo Domingo
$625 Roundtrip, found 17 hours ago
$625
Roundtrip
found 17 hours ago
Select avianca flight, departing Thu, Aug 27 from Panama City to Santo Domingo, returning Sun, Aug 30, priced at $625 found 17 hours ago

Santo Domingo economy flight packages

Price found within the past 48 hours. Click for updated prices.
Coral Costa Caribe Beach Resort - All Inclusive
4.0-star property

Coral Costa Caribe Beach Resort - All Inclusive

8/10 Very Good! (2,643 reviews)

Oct 1 - Oct 9

8 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Price was $2,472, price is now $1,075 per person
$1,075
per person
found 16 hours ago

Bahia Principe Escape Bouganville - Hyatt Inclusive Collection - Adults Only - All Inclusive
4.5-star property

Bahia Principe Escape Bouganville - Hyatt Inclusive Collection - Adults Only - All Inclusive

8.8/10 Excellent! (2,643 reviews)

Oct 1 - Oct 9

8 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Save 100% on your flight
Price was $2,450, price is now $1,495 per person
$1,495
per person
found 16 hours ago
Muy ordenado y bonito

Reviewed on Aug 10, 2026

Bahia Principe Explore La Romana - Hyatt Inclusive Collection - All Inclusive
4.5-star property

Bahia Principe Explore La Romana - Hyatt Inclusive Collection - All Inclusive

8.4/10 Very Good! (2,680 reviews)

Oct 1 - Oct 9

8 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Save 100% on your flight
Price was $2,074, price is now $1,333 per person
$1,333
per person
found 16 hours ago

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More About Flying To Santo Domingo from Panama City

Route Information for Flights from Panama City to Santo Domingo

Origin Airport IATA Code
PTY
Destination Airport IATA Code
SDQ
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Panama City to Santo Domingo

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Frequently asked questions

Are there non-stop flights from Panama City to Santo Domingo?
Copa Airlines will fly you straight from PTY to Santo Domingo (SDQ-Las Americas Intl.), which means you won't have to stress about swapping planes or missing your connecting flight on this route.
What is the shortest flight from Panama City to Santo Domingo?
From Panama City, the eclectic sights and sounds of Santo Domingo are at least 4 hours and 15 minutes away. Book your favorite seat, or maybe even one with a bit more legroom, and get to your destination in comfort.
What airlines fly from Panama City to Santo Domingo most frequently?
Copa Airlines is the most frequent airline servicing the Panama City to Santo Domingo route. Choose from 73 flights every month with this carrier.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.