$464 Cheap flight deals from Panama City (PTY) to Santo Domingo (SDQ)

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This Weekend's Flight Deals from Panama City to Santo Domingo

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Oct 16 - Mon, Oct 19
PTY
Tocumen Intl.
SDQ
Las Americas Intl.
$622 Roundtrip, found 4 days ago
$622
Roundtrip
found 4 days ago
Select avianca flight, departing Fri, Oct 16 from Tocumen Intl. to Las Americas Intl., returning Mon, Oct 19, priced at $622 found 4 days ago

Airfares from $464 One Way, $492 Round Trip from Panama City to Santo Domingo

Prices starting at $492 for return flights and $464 for one-way flights to Santo Domingo were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Dec 21 - Mon, Dec 28
PTY
Panama City
SDQ
Santo Domingo
$492 Roundtrip, found 4 hours ago
$492
Roundtrip
found 4 hours ago
Select Copa flight, departing Mon, Dec 21 from Panama City to Santo Domingo, returning Mon, Dec 28, priced at $492 found 4 hours ago
Thu, Oct 22 - Sun, Oct 25
PTY
Panama City
SDQ
Santo Domingo
$502 Roundtrip, found 4 hours ago
$502
Roundtrip
found 4 hours ago
Select Copa flight, departing Thu, Oct 22 from Panama City to Santo Domingo, returning Sun, Oct 25, priced at $502 found 4 hours ago
Fri, Oct 23 - Mon, Oct 26
PTY
Panama City
SDQ
Santo Domingo
$513 Roundtrip, found 3 days ago
$513
Roundtrip
found 3 days ago
Select Copa flight, departing Fri, Oct 23 from Panama City to Santo Domingo, returning Mon, Oct 26, priced at $513 found 3 days ago
Thu, Nov 26 - Mon, Nov 30
PTY
Panama City
SDQ
Santo Domingo
$542 Roundtrip, found 1 day ago
$542
Roundtrip
found 1 day ago
Select Copa flight, departing Thu, Nov 26 from Panama City to Santo Domingo, returning Mon, Nov 30, priced at $542 found 1 day ago
Mon, Aug 23 - Mon, Aug 30
PTY
Panama City
SDQ
Santo Domingo
$571 Roundtrip, found 2 days ago
$571
Roundtrip
found 2 days ago
Select Copa flight, departing Mon, Aug 23 from Panama City to Santo Domingo, returning Mon, Aug 30, priced at $571 found 2 days ago

Santo Domingo economy flight packages

Price found within the past 48 hours. Click for updated prices.
Coral Costa Caribe Beach Resort - All Inclusive
4.0-star property

Coral Costa Caribe Beach Resort - All Inclusive

8/10 Very Good! (2,708 reviews)

Dec 4 - Dec 10

6 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Price was $2,126, price is now $946 per person
$946
per person
found 1 day ago
We (3 person aircrew) stayed here 2 weekends in a row. The buffet food is good. The Dominican Saturday Night theme and food is a bonus. Beach is great. Rooms are generally good..always clean. Sometimes there is no hot water for awhile. Drinks are always plentiful..be careful! The Sports Bar is a nice airconditioned place to hang out. There's a "happening" night club on the weekends..I guess (didn't go, but could hear it from my room!) Nice little gym. Nothing else (shops, resto's) around but you can walk the area for exercise, safely. The biggest problem is Check-In..expect to wait for your room..and I mean WAIT. Hours..as long as 8 or 9 PM ! For some reason people don't seem to check out on time, causing the cleaning staff to be well behind in getting rooms ready for new guests. It should be an easy issue to solve (enforce Check Out Times / Don't allow extensions when you know you are fully booked for incoming guests!) Also..you might reserve a nice King Bed Room Ocean View and end up getting a Double Garden View..with no explantion why and no attempt to resolve the issue. And don't expect to get the published Uber rate heading back to the airport..the drivers will show up and demand double the rate. Expect $40 USD back to airport. Its a scam. All said, however..its a decent place to spend a weekend.

Reviewed on Oct 13, 2026

Bahia Principe Explore La Romana - Hyatt Inclusive Collection - All Inclusive
4.5-star property

Bahia Principe Explore La Romana - Hyatt Inclusive Collection - All Inclusive

8.6/10 Excellent! (2,628 reviews)

Dec 4 - Dec 10

6 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Save 100% on your flight
Price was $1,819, price is now $1,083 per person
$1,083
per person
found 1 day ago

Bahia Principe Escape Bouganville - Hyatt Inclusive Collection - Adults Only - All Inclusive
4.5-star property

Bahia Principe Escape Bouganville - Hyatt Inclusive Collection - Adults Only - All Inclusive

8.8/10 Excellent! (2,571 reviews)

Dec 4 - Dec 10

6 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Save 100% on your flight
Price was $2,177, price is now $1,299 per person
$1,299
per person
found 1 day ago
So welcoming and great staff. Entertainment team was AMAZING

Reviewed on Oct 10, 2026

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More About Flying To Santo Domingo from Panama City

Route Information for Flights from Panama City to Santo Domingo

Origin Airport IATA Code
PTY
Destination Airport IATA Code
SDQ
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Panama City to Santo Domingo

Orbitz gives you great deals on your flights from Panama City to Santo Domingo. If you also need a discount car rental or a cheap hotel room after you arrived at your destination, Orbitz has you covered.

We Offer Great Travel Deals and Discounts

When you book flights from Panama City to Santo Domingo with Orbitz for, you can be assured that you are getting the lowest price possible. Orbitz works constantly with our airline partners to ensure guaranteed low prices on Panama City to Santo Domingo flights for your trip—whether you are traveling for business or for fun with your family.

Enjoy Savings on Last-Minute Flights

If you are looking for a discount price on last-minute flights from Panama City to Santo Domingo, chances are that Orbitz can offer you a deal that will save you lots of money. Whether you just want to get away for the weekend or go on a vacation lasting weeks, Orbitz can help you find the best deals on Panama City to Santo Domingo flights that fit your budget and your itinerary for the perfect trip.

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Need more mobility when it comes to travel planning? Orbitz has easy-to-use mobile apps for iPhone, iPad, and Android, to help the traveler on the go. Not only can use the apps to find huge savings on Panama City to Santo Domingo flights wherever you are, but you can also check out and book discount hotel rooms too. The apps will also keep you up-to-date when it’s time to fly. Get easy access to your itinerary for flights from Panama City to Santo Domingo and review gate and baggage claim details too.

Frequently asked questions

Are there non-stop flights from Panama City to Santo Domingo?
Copa Airlines will fly you straight from PTY to Santo Domingo (SDQ-Las Americas Intl.), which means you won't have to stress about swapping planes or missing your connecting flight on this route.
What is the shortest flight from Panama City to Santo Domingo?
From Panama City, the eclectic sights and sounds of Santo Domingo are at least 4 hours and 15 minutes away. Book your favorite seat, or maybe even one with a bit more legroom, and get to your destination in comfort.
What airlines fly from Panama City to Santo Domingo most frequently?
Copa Airlines is the most frequent airline servicing the Panama City to Santo Domingo route. Choose from 73 flights every month with this carrier.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.