$263 Cheap flight deals from Panama City (PTY) to Santo Domingo (SDQ)

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This Weekend's Flight Deals from Panama City to Santo Domingo

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Oct 5 - Wed, Oct 22
PTY
Tocumen Intl.
SDQ
Las Americas Intl.
$512 Roundtrip, found 5 days ago
$512
Roundtrip
found 5 days ago
Select Copa flight, departing Sun, Oct 5 from Tocumen Intl. to Las Americas Intl., returning Wed, Oct 22, priced at $512 found 5 days ago

Airfares from $263 One Way, $450 Round Trip from Panama City to Santo Domingo

Prices starting at $450 for return flights and $263 for one-way flights to Santo Domingo were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Oct 18 - Mon, Oct 27
PTY
Panama City
SDQ
Santo Domingo
$450 Roundtrip, found 7 hours ago
$450
Roundtrip
found 7 hours ago
Select Copa flight, departing Sat, Oct 18 from Panama City to Santo Domingo, returning Mon, Oct 27, priced at $450 found 7 hours ago
Thu, Oct 23 - Wed, Nov 12
PTY
Panama City
SDQ
Santo Domingo
$451 Roundtrip, found 2 days ago
$451
Roundtrip
found 2 days ago
Select Copa flight, departing Thu, Oct 23 from Panama City to Santo Domingo, returning Wed, Nov 12, priced at $451 found 2 days ago
Sat, Nov 15 - Thu, Nov 20
PTY
Panama City
SDQ
Santo Domingo
$453 Roundtrip, found 1 day ago
$453
Roundtrip
found 1 day ago
Select Copa flight, departing Sat, Nov 15 from Panama City to Santo Domingo, returning Thu, Nov 20, priced at $453 found 1 day ago
Sat, Oct 18 - Mon, Oct 27
PTY
Panama City
SDQ
Santo Domingo
$461 Roundtrip, found 7 hours ago
$461
Roundtrip
found 7 hours ago
Select Copa flight, departing Sat, Oct 18 from Panama City to Santo Domingo, returning Mon, Oct 27, priced at $461 found 7 hours ago
Thu, Oct 23 - Wed, Nov 12
PTY
Panama City
SDQ
Santo Domingo
$462 Roundtrip, found 2 days ago
$462
Roundtrip
found 2 days ago
Select Copa flight, departing Thu, Oct 23 from Panama City to Santo Domingo, returning Wed, Nov 12, priced at $462 found 2 days ago

Santo Domingo economy flight packages

Price found within the past 48 hours. Click for updated prices.
Bahia Principe Grand Samana - Adults Only
4.5-star property

Bahia Principe Grand Samana - Adults Only

8.8/10 Excellent! (592 reviews)

Oct 31 - Nov 3

3 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Price was $850, price is now $613 per person
$613
per person
found 1 day ago
Beautiful hotel, friendly staff, Room had an amazing view of the ocean. The food was far better then expected and alcohol selection was also good. My overall stay was amazing, got the rest i needed. I would definitely recommend the resort to anyone.

Reviewed on Dec 18, 2018

Bahia Principe Luxury Bouganville - Adults Only - All Inclusive
4.5-star property

Bahia Principe Luxury Bouganville - Adults Only - All Inclusive

8.8/10 Excellent! (2,811 reviews)

Oct 31 - Nov 3

3 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Price was $1,070, price is now $718 per person
$718
per person
found 1 day ago
Absolutely amazing. Maria from entertainment was so sweet and amazing!!! Would absolutely recommend!!

Reviewed on Jun 22, 2025

Bahia Principe Grand La Romana - All Inclusive
4.5-star property

Bahia Principe Grand La Romana - All Inclusive

8.4/10 Very Good! (2,604 reviews)

Oct 31 - Nov 3

3 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Price was $958, price is now $665 per person
$665
per person
found 1 day ago
The property is beautiful and very well kept. Easy to maneuver around from start to finish. The check in process was fast and everyone at the counter was super nice and helpful. The carts that help with luggage, moved efficiently and quickly getting everyone settled. Rooms were clean, stocked, and the temperature was nice and cool. The food was great and had a big variety. The staff at the main food area was always so nice and went above and beyond no matter how busy they were. Lala was amazing and always had a smile on her face. From what I saw, she was like that with everyone. Whatever she gets paid, its not enough on how that woman is always on the go. There was always something to do at the resort. The animation group was amazing in keeping everyone entertained. You can tell that they truly love their jobs because they gave it their all...EVERYDAY. We scheduled a tour and that was extremely fun. The man that schedules you was friendly and helpful as well. I went this time with no kids and saw how much the kids there had fun. I would absolutely love to repeat my visit with my children here.

Reviewed on Aug 13, 2025

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More About Flying To Santo Domingo from Panama City

Route Information for Flights from Panama City to Santo Domingo

Origin Airport IATA Code
PTY
Destination Airport IATA Code
SDQ
Distance
917 mi
Direct Flight Airlines
KLM, Air France, Copa Airlines
Earliest Flight Arrival
3:56PM UTC
Latest Flight Arrival
3:25AM UTC

Panama City to Santo Domingo

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You can always find affordable flights from Panama City to Santo Domingo on Orbitz. Use different airlines to book arrival and departure flights, take advantage of vacation package deals, and secure exclusive rewards.

Frequently asked questions

Are there non-stop flights from Panama City to Santo Domingo?
Copa Airlines will fly you straight from PTY to Santo Domingo (SDQ-Las Americas Intl.), which means you won't have to stress about swapping planes or missing your connecting flight on this route.
What is the shortest flight from Panama City to Santo Domingo?
From Panama City, the eclectic sights and sounds of Santo Domingo are at least 4 hours and 15 minutes away. Book your favorite seat, or maybe even one with a bit more legroom, and get to your destination in comfort.
What airlines fly from Panama City to Santo Domingo most frequently?
Copa Airlines is the most frequent airline servicing the Panama City to Santo Domingo route. Choose from 73 flights every month with this carrier.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.