$162 Cheap flight deals from Guayaquil (GYE) to Medellin (MDE)

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This Weekend's Flight Deals from Guayaquil to Medellin

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Jan 2 - Wed, Jan 7
GYE
Jose Joaquin de Olmedo Intl.
MDE
José María Córdova Intl.
$424 Roundtrip, just found
$424
Roundtrip
just found
Select LATAM Airlines Group flight, departing Fri, Jan 2 from Jose Joaquin de Olmedo Intl. to José María Córdova Intl., returning Wed, Jan 7, priced at $424 just found

Airfares from $162 One Way, $348 Round Trip from Guayaquil to Medellin

Prices starting at $348 for return flights and $162 for one-way flights to Medellin were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Dec 28 - Mon, Dec 29
GYE
Guayaquil
MDE
Medellin
$348 Roundtrip, found 1 day ago
$348
Roundtrip
found 1 day ago
Select Copa flight, departing Sun, Dec 28 from Guayaquil to Medellin, returning Mon, Dec 29, priced at $348 found 1 day ago
Tue, Jan 13 - Wed, Jan 14
GYE
Guayaquil
MDE
Medellin
$357 Roundtrip, found 9 hours ago
$357
Roundtrip
found 9 hours ago
Select Copa flight, departing Tue, Jan 13 from Guayaquil to Medellin, returning Wed, Jan 14, priced at $357 found 9 hours ago
Tue, Jan 13 - Sat, Jan 17
GYE
Guayaquil
MDE
Medellin
$369 Roundtrip, found 9 hours ago
$369
Roundtrip
found 9 hours ago
Select Copa flight, departing Tue, Jan 13 from Guayaquil to Medellin, returning Sat, Jan 17, priced at $369 found 9 hours ago
Sat, Jan 24 - Wed, Jan 28
GYE
Guayaquil
MDE
Medellin
$369 Roundtrip, found 18 hours ago
$369
Roundtrip
found 18 hours ago
Select Copa flight, departing Sat, Jan 24 from Guayaquil to Medellin, returning Wed, Jan 28, priced at $369 found 18 hours ago
Tue, Jan 27 - Thu, Jan 29
GYE
Guayaquil
MDE
Medellin
$370 Roundtrip, found 1 day ago
$370
Roundtrip
found 1 day ago
Select Copa flight, departing Tue, Jan 27 from Guayaquil to Medellin, returning Thu, Jan 29, priced at $370 found 1 day ago

Medellin economy flight packages

Price found within the past 48 hours. Click for updated prices.
The Morgana Poblado Suites Hotel
3.5-star property

The Morgana Poblado Suites Hotel

8.8/10 Excellent! (855 reviews)

Jan 27 - Jan 31

4 night stay

Guayaquil (GYE) to Medellín (MDE)

Copa • Non-stop roundtrip • Coach
Price was $684, price is now $514 per person
$514
per person
found 14 hours ago
An Excellent Experience From the moment we arrived, the staff was incredibly kind and attentive. They were always ready to help with anything we needed, making our stay even more enjoyable. The place itself is very peaceful, perfect for relaxing and disconnecting. There’s a calm atmosphere that truly allows you to enjoy the surroundings. Without a doubt, it’s a place I would return to and highly recommend.

Reviewed on Oct 13, 2025

Hotel Estadio Real
3.0-star property

Hotel Estadio Real

5.8/10 (30 reviews)

Jan 27 - Jan 31

4 night stay

Guayaquil (GYE) to Medellín (MDE)

Copa • Non-stop roundtrip • Coach
Price was $726, price is now $534 per person
$534
per person
found 14 hours ago
The Charlee Hotel
5.0-star property

The Charlee Hotel

8.8/10 Excellent! (1,002 reviews)

Feb 1 - Feb 4

3 night stay

Guayaquil (GYE) to Medellín (MDE)

Copa • Non-stop roundtrip • Coach
Price was $746, price is now $565 per person
$565
per person
found 1 day ago
The staff was amazing and made me feel as if I were regular and it was my 1st stay at this specific hotel

Reviewed on Nov 3, 2025

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More About Flying To Medellin from Guayaquil

Route Information for Flights from Guayaquil to Medellin

Origin Airport IATA Code
GYE
Destination Airport IATA Code
MDE
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Guayaquil to Medellin

Whether you want to book cheap flights from Guayaquil to Medellin or are looking for the perfect package holiday, Orbitz is your one-stop source. Taking the stress and expense out of travel, Orbitz helps you find the best fares for Guayaquil to Medellin flights.

Make the Most of Your Vacation

Not only does Orbitz have cheap deals for Guayaquil to Medellin flights, we can also help you plan your vacation in advance. Why wait in lengthy lines for tickets to shows, amusement parks, and other attractions when you could be making the most of your holiday? Add activities to your flight booking for fewer hassles once you arrive in Medellin.

Planning on the Go

Book your flights from Guayaquil to Medellin wherever you are with the Orbitz app for Android and iPhone. Or simply use m.orbitz.com on your mobile browser to search and book the Guayaquil to Medellin flights that you want. And if you’re running late, you check your flight status and baggage claim information on your mobile device too too.

Craft Your Perfect Vacation

Orbitz takes the stress out of vacation planning with great deals on flights from Guayaquil to Medellin, hotels, car rentals, cruises, and more. Mix and match results for your perfect trip, or book a complete vacation package.

Keep Informed With Orbitz

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Frequently asked questions

What is the shortest flight from Guayaquil to Medellin?
The journey from Guayaquil to Medellin can be as quick as 2 hours and 51 minutes. With an easy flight time like this, why not take off on a spontaneous getaway?
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.