Hotels in Santa Ana

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Dec 26 - Dec 27
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Featured Hotels in Santa Ana

Porta Hotel Antigua

Porta Hotel Antigua

4.5 out of 5
8va Calle Poniente No1 Antigua Guatemala Sacatepequez
Free Cancellation
Reserve now, pay when you stay
0.7 mi from Santa Ana
$185 nightly
The price is $226 total per night
$226 total
Jan 7 - Jan 8, 2026
Total with taxes and fees
Porta Hotel Antigua features a full-service spa, an outdoor pool, and a children's pool. You can take advantage of free parking, along with an airport shuttle (available 24 hours) for USD 60 per room one-way. Multilingual staff at the 24-hour front desk can assist with securing valuables, tours or tickets, and dry cleaning/laundry. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Other amenities at this luxury hotel include a gym, free WiFi in public areas, and meeting rooms.
Pool
Spa
Hotel Camino Real Antigua

Hotel Camino Real Antigua

4 out of 5
7a Calle Poniente 33B Antigua Guatemala Sacatepequez
Free Cancellation
Reserve now, pay when you stay
0.89 mi from Santa Ana
$221 nightly
The price is $270 total per night
$270 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Guests staying at Hotel Camino Real Antigua enjoy access to a full-service spa, a gym, and a sauna. If you decide to drive, there's free parking. The 24-hour front desk has staff standing by to help with concierge services, securing valuables, and luggage storage. Other amenities at this spa hotel include free WiFi in public areas, a hot tub, and meeting rooms.
Hot Tub
Spa
Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo

4.5 out of 5
3a Calle Oriente No 28 A Antigua Guatemala Sacatepequez
Free Cancellation
Reserve now, pay when you stay
0.69 mi from Santa Ana
$248 nightly
The price is $303 total per night
$303 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Hotel Museo Spa Casa Santo Domingo features a full-service spa, an outdoor pool, and a gym. There's free parking, and an airport shuttle (available 24 hours) for USD 60 per person one-way. The front desk is staffed 24/7 to help with securing valuables, luggage storage, and dry cleaning/laundry. Other amenities at this luxury hotel include a sauna, free WiFi in public areas, and meeting rooms.
Pool
Spa
Tikal Futura Hotel & Convention Center

Tikal Futura Hotel & Convention Center

4.5 out of 5
Calzada Roosevelt 22-43 Guatemala City Guatemala
Free Cancellation
Reserve now, pay when you stay
12.53 mi from Santa Ana
$107 nightly
The price is $131 total per night
$131 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Tikal Futura Hotel & Convention Center features a full-service spa, an indoor pool, and a children's pool. You can take advantage of free parking, along with an airport shuttle (available on request) for GTQ 132 per person one-way. The front desk has multilingual staff on hand 24/7 to help with securing valuables, luggage storage, and dry cleaning/laundry. Other amenities at this spa hotel include a gym, a sauna, and free WiFi in public areas.
Pool
Hot Tub
Adriatika Hotel & Residence

Adriatika Hotel & Residence

4.5 out of 5
4 av 20-44 Zona 14 Guatemala City Guatemala
Free Cancellation
Reserve now, pay when you stay
13.58 mi from Santa Ana
$100 nightly
The price is $122 total per night
$122 total
Dec 27 - Dec 28
Total with taxes and fees
At Adriatika Hotel & Residence, guests enjoy an outdoor pool, a gym, and a sauna. You can take advantage of free parking, along with an airport shuttle (available 24 hours) for USD 45 per vehicle roundtrip. Front-desk staff can answer questions 24/7, and assist with tours or tickets, dry cleaning/laundry, and luggage storage. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Other amenities at this luxury hotel include free WiFi in public areas, a hot tub, and a business center.
Pool
Hot Tub
Hotel Las Americas

Hotel Las Americas

4 out of 5
Avenida Las Americas 9-08, Zona 13 Guatemala City Guatemala
Free Cancellation
Reserve now, pay when you stay
13.88 mi from Santa Ana
At Hotel Las Americas, guests enjoy an outdoor pool, a 24-hour gym, and a sauna. There's free parking, and an airport shuttle (available on request) for USD 5 per person one-way. The 24-hour front desk has staff standing by to help with tours or tickets, and answer any questions about the accommodations. Additional amenities include free WiFi in public areas, a business center, and laundry facilities.
Pool
Spa
Barceló Guatemala City

Barceló Guatemala City

4.5 out of 5
7 Avenida 15-45, Zona 9 Guatemala City Guatemala
Free Cancellation
Reserve now, pay when you stay
14.07 mi from Santa Ana
$82 nightly
The price is $100 total per night
$100 total
Jan 25 - Jan 26, 2026
Total with taxes and fees
At Barceló Guatemala City, guests enjoy a full-service spa, an outdoor pool, and a 24-hour gym. There's free parking, as well as a free airport shuttle at scheduled times. The front desk has multilingual staff on hand 24/7 to help with concierge services, luggage storage, and securing valuables. Other amenities at this luxury hotel include a sauna, free WiFi in public areas, and a hot tub.
Pool
Hot Tub
Wyndham Garden Guatemala City

Wyndham Garden Guatemala City

4 out of 5
1a Avenida 12-46 Zona 10 Guatemala City Guatemala
Free Cancellation
Reserve now, pay when you stay
14.38 mi from Santa Ana
$97 nightly
The price is $119 total per night
$119 total
Dec 31 - Jan 1, 2026
Total with taxes and fees
At Wyndham Garden Guatemala City, guests have access to a gym, free WiFi in public areas, and a hot tub. You can take advantage of free offsite parking, along with an airport shuttle (available 24 hours) for GTQ 125 per vehicle one-way. The front desk has multilingual staff on hand 24/7 to help with luggage storage, securing valuables, and tours or tickets. Additional amenities include meeting rooms, conference space, and a business center.
Hot Tub
Breakfast included
Clarion Suites Guatemala City

Clarion Suites Guatemala City

4 out of 5
14 Street 3-08 Zona 10 Guatemala City Guatemala
Free Cancellation
14.45 mi from Santa Ana
$101 nightly
The price is $124 total per night
$124 total
Jan 2 - Jan 3, 2026
Total with taxes and fees
At Clarion Suites Guatemala City, guests enjoy features like an outdoor pool, a gym, and free WiFi in public areas. Free parking is available if you drive. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. Additional amenities include meeting rooms, a conference center, and laundry facilities.
Pool
Spa
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Santa Ana Hotels

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Great selection of hotels in Santa Ana

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On Orbitz, Santa Ana hotel deals mean flexibility. If you need to change your Santa Ana hotel reservations, or cancel your stay, Orbitz doesn't charge cancel or change fees. Orbitz also offers great selection on airline tickets, vacation packages, and car rental deals to so you can plan your trip to Santa Ana all in one place.

 

Santa Ana hotels essential information

Accommodation
1,186 hotels
Lowest Price
$100
Highest Price
$303
Popular hotels
Barceló Guatemala City, Tikal Futura Hotel & Convention Center, Wyndham Garden Guatemala City, Hotel Museo Spa Casa Santo Domingo, Porta Hotel Antigua, Adriatika Hotel & Residence, Hotel Las Americas, Clarion Suites Guatemala City, Hotel Camino Real Antigua

Popular places to visit

Vue du volcan de Fuego

Antigua Guatemala Cathedral

After visiting Antigua Guatemala Cathedral, make a plan to see the other sights and activities in Antigua Guatemala. Discover the area's volcano viewpoints, or seek out its local tours.

See properties in Antigua Guatemala Cathedral
Antigua Guatemala Cathedral
Ruins of Old Mayan Monastery destroyed during earthquake in 15th century !

Casa Santo Domingo Museum

You can browse the exhibits at Casa Santo Domingo Museum, a museum with a story of its own, during your travels to Antigua Guatemala. Discover the volcano viewpoints and shops in this romantic area.

See properties in Casa Santo Domingo Museum
Casa Santo Domingo Museum
You can get amzaing views, culture and more in the colonial city: La Antigua Guatemala #LifeAtExpedia #reflections #visitantigua #visitguatemala #volcano

Santa Catalina Arch

Find out about the history of Antigua Guatemala when you spend time at Santa Catalina Arch. Discover the volcano viewpoints and shops in this romantic area.

See properties in Santa Catalina Arch
Santa Catalina Arch

Recent Reviews

Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo

5/5 Excellent
"The hotel graciously upgraded us to "
A verified traveler stayed at Hotel Museo Spa Casa Santo Domingo
Posted 4 days ago
Hotel Museo Spa Casa Santo Domingo