Book 5 Star Hotels in South San Francisco
Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels
Save 10% or more on select hotels with Insider Prices
Book on the app to instantly earn 5% on 350,000+ hotels
Featured South San Francisco 5 Stars Hotels
Travelodge by Wyndham San Francisco Airport North
326 S Airport Blvd South San Francisco CA
Free Cancellation
Reserve now, pay when you stay
0.67 mi from city center
$62 nightly
The price is $74 total per night
$74 total
Jan 25 - Jan 26, 2026
Total with taxes and fees
Travelodge by Wyndham San Francisco Airport North features an outdoor pool, free WiFi in public areas, and conference space. If you drive, self parking is USD 5.00 per day, or you can take advantage of the free airport shuttle at scheduled times. The 24-hour front desk has multilingual staff ready to assist with luggage storage and concierge services. Additional amenities include laundry facilities, a vending machine, and an ATM.
Pool
Free airport shuttle
Best Western Plus Grosvenor Airport Hotel
380 S Airport Boulevard South San Francisco CA
Free Cancellation
Reserve now, pay when you stay
0.8 mi from city center
$95 nightly
The price is $112 total per night
$112 total
Dec 31 - Jan 1, 2026
Total with taxes and fees
At Best Western Plus Grosvenor Airport Hotel, guests have access to a gym, free WiFi in public areas, and conference space. If you drive, self parking is USD 10.00 per night, or you can take advantage of the free airport shuttle at scheduled times. Multilingual staff at the front desk are standing by 24/7 to help with concierge services, luggage storage, and dry cleaning/laundry. Additional amenities include a business center, a library, and express check-in.
Breakfast included
Free airport shuttle
Sonesta Select San Francisco Airport Oyster Point Waterfront
1300 Veterans Blvd South San Francisco CA
Free Cancellation
Reserve now, pay when you stay
1.05 mi from city center
$101 nightly
The price is $121 total per night
$121 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Renovated in 2023, Sonesta Select San Francisco Airport Oyster Point Waterfront offers a 24-hour gym, free WiFi in public areas, and meeting rooms. If you drive, self parking is USD 15 per night, or you can take advantage of the free airport shuttle at scheduled times. The 24-hour front desk has staff standing by to help with securing valuables and luggage storage. Additional amenities include conference space, coffee/tea in a common area, and express check-out.
Free airport shuttle
Pet friendly
DoubleTree by Hilton San Francisco South Airport Blvd
275 S Airport Blvd South San Francisco CA
Free Cancellation
Reserve now, pay when you stay
0.56 mi from city center
$115 nightly
The price is $135 total per night
$135 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
DoubleTree by Hilton San Francisco South Airport Blvd features a gym, free WiFi in public areas, and a conference center. If you drive, self parking is USD 19.00 per night, or you can take advantage of the free airport shuttle at scheduled times. Multilingual staff at the front desk are standing by 24/7 to help with dry cleaning/laundry, luggage storage, and securing valuables. Additional amenities include a business center, a microwave in a common area, and express check-in.
Free airport shuttle
Pet friendly
Hotel Focus SFO
111 Mitchell Ave South San Francisco CA
Free Cancellation
Reserve now, pay when you stay
0.37 mi from city center
$86 nightly
The price is $101 total per night
$101 total
Jan 23 - Jan 24, 2026
Total with taxes and fees
Guests of Hotel Focus SFO enjoy access to free WiFi in public areas, a business center, and coffee in a common area. If you drive, self parking is USD 15.96 per night, or you can take advantage of the free airport shuttle (available on request). The front desk has multilingual staff standing by 24 hours a day to assist with luggage storage and dry cleaning/laundry. Additional amenities include a computer station, laundry facilities, and a vending machine.
Breakfast included
Free airport shuttle
Embassy Suites by Hilton San Francisco Airport Oyster Point
250 Gateway Blvd South San Francisco CA
Free Cancellation
Reserve now, pay when you stay
0.34 mi from city center
$147 nightly
The price is $172 total per night
$172 total
Jan 6 - Jan 7, 2026
Total with taxes and fees
At Embassy Suites by Hilton San Francisco Airport Oyster Point, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. If you drive, self parking is USD 45.00 per day, or you can take advantage of the airport shuttle at scheduled times for USD 10.00 per person one-way. The 24-hour front desk has multilingual staff ready to assist with concierge services, securing valuables, and luggage storage. Additional amenities include meeting rooms, a business center, and express check-out.
Pool
Breakfast included
Fairmont San Francisco
950 Mason Street Atop Nob Hill San Francisco CA
Free Cancellation
Reserve now, pay when you stay
9.51 mi from city center
$265 nightly
The price is $312 total per night
$312 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Guests staying at Fairmont San Francisco enjoy access to a full-service spa, a gym, and a sauna. Valet parking is available for USD 108.00 per night. The 24-hour front desk has multilingual staff ready to assist with tours or tickets, securing valuables, and luggage storage. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Other amenities at this luxury hotel include conference space, a 24-hour business center, and free use of bicycles.
Spa
Pet friendly
Hilton San Francisco Financial District
750 Kearny St San Francisco CA
Free Cancellation
Reserve now, pay when you stay
9.7 mi from city center
$89 nightly
The price is $105 total per night
$105 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
At Hilton San Francisco Financial District, guests have access to a gym, WiFi in public areas, and meeting rooms. If you drive, self parking is USD 74.10 per night, and there's also limo/town car service. Multilingual staff at the front desk are standing by 24/7 to help with luggage storage, securing valuables, and concierge services. Additional amenities include conference space, a 24-hour business center, and a microwave in a common area.
Pet friendly
Restaurant
Hotel Riu Plaza Fisherman's Wharf
2500 Mason St San Francisco CA
Free Cancellation
Reserve now, pay when you stay
10.51 mi from city center
$135 nightly
The price is $159 total per night
$159 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
Guests of Hotel Riu Plaza Fisherman's Wharf have access to an outdoor pool, a 24-hour gym, and free WiFi in public areas. Self parking is offered for USD 60.42 per night. The 24-hour front desk has multilingual staff ready to assist with concierge services and luggage storage. Additional amenities include meeting rooms, a business center, and coffee/tea in a common area.
Pool
Breakfast included
Don't see what you're looking for?
See all available properties in South San Francisco
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Best 5 star hotels in South San Francisco
Guarantee yourself a relaxing time when you book the best of the best: 5 star hotels in South San Francisco. After all, treating yourself to the finer things is what vacations are about.
What are the criteria for a 5 star hotel?
5 star hotel requirements include distinctive services and amenities that surpass all others. These South San Francisco hotels bring an incomparable degree of quality and attention to detail, with guest satisfaction being top priority. Your 5 star hotel should be dressed to impress, with design details like marble surfaces and hi-tech fixtures.
What amenities can I expect at a 5 star hotel?
South San Francisco 5 star hotels and resorts typically offer luxury amenities such as:
- Gourmet restaurant
- Full-service fitness center with pool
- Luxury spa
- Welcome gifts upon arrival
- Top-of-the-line beds and linens
- Designer personal care products
- Premium cable, free Wi-Fi and device docking stations
How do I find an amazing 5 star hotel?
Finding 5 star hotel deals in South San Francisco with Orbitz is as easy as your stay will be. For the top-shelf vacation you deserve, we’ll help you choose the right hotel in the right place:
- Search hotels by price, ranging from $74 to $312
- Find the best-loved hotels through word-of-mouth advice when you check out over reviews by Orbitz travelers
- Choose from 5,154 5 star hotels in South San Francisco!
South San Francisco hotels essential information
Accommodation | 5,154 hotels |
|---|---|
Lowest Price | $74 |
Highest Price | $312 |
Popular hotels | Travelodge by Wyndham San Francisco Airport North, Best Western Plus Grosvenor Airport Hotel, Sonesta Select San Francisco Airport Oyster Point Waterfront, DoubleTree by Hilton San Francisco South Airport Blvd, Hotel Focus SFO, Embassy Suites by Hilton San Francisco Airport Oyster Point, Hotel Riu Plaza Fisherman's Wharf, Hilton San Francisco Financial District, Fairmont San Francisco |
Recent Reviews
Embassy Suites by Hilton San Francisco Airport Oyster Point
5/5 Excellent
"Room was very nice especially the bed which was very comfortable. Enjoyed the breakfast too."
A verified traveler stayed at Embassy Suites by Hilton San Francisco Airport Oyster Point
Posted 4 days ago
