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Top Rated Sikeston Hotels

Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau West
2.5 out of 5.0 103 Cape West Pkwy, Cape Girardeau, MO
Free Cancellation
$63
3.8/5 (12 reviews)

Rooms were excellent. Newly renovated and extremely clean.

Reviewed on Nov 29, 2019
Pear Tree Inn Cape Girardeau West features a fitness center, free WiFi in public areas, and a 24-hour business center. A stay here includes free parking. The ...
Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 out of 5.0 3248 William St, Cape Girardeau, MO
Free Cancellation
$63
3.9/5 (53 reviews)

The bathroom was very tiny, although 6 foot and 250 pounds Somethings seem small, but your front desk lady was absolutely amazing

Reviewed on Dec 1, 2019
Pear Tree Inn Cape Girardeau Near the Medical Center features an outdoor pool, free WiFi in public areas, and coffee in a common area. There's free parking if ...
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
3.0 out of 5.0 3351 Percy Drive, Cape Girardeau, MO
Free Cancellation
$99
5.0/5 (6 reviews)

Everything was perfect from the moment I walked through the door, no complaints.

Reviewed on Sep 11, 2018
At Drury Plaza Hotel Cape Girardeau Conference Center, guests enjoy an indoor pool, a 24-hour fitness center, and a spa tub. If you drive, take advantage of ...
Holiday Inn Express Hotel & Suites Cape Girardeau I-55
Holiday Inn Express Hotel & Suites Cape Girardeau I-55
2.5 out of 5.0 3253 William Street, Cape Girardeau, MO
Free Cancellation
$95
4.7/5 (28 reviews)

The room was beautiful and clean as were all the grounds.

Reviewed on May 21, 2019
Guests staying at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 enjoy an indoor pool, a fitness center, and free WiFi in public areas. Free parking ...
Auburn Place Hotel And Suites
Auburn Place Hotel And Suites
2.5 out of 5.0 3265 William St, Cape Girardeau, MO
Free Cancellation
$79
4.5/5 (48 reviews)

Good stay for the price, clean, nice staff, breakfast was a little cold but all the usual amenities were present.

Reviewed on Nov 10, 2019
At Auburn Place Hotel And Suites, guests enjoy features like an indoor pool, a fitness center, and a spa tub. You can put free parking to good use if you drive. ...
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
3.0 out of 5.0 2608 East Malone Ave, Sikeston, MO
Free Cancellation
$85
4.5/5 (25 reviews)

Clean and comfortable. The evening meal and drink service kept us from having to go out again to find a restaurant after a long drive. The breakfast was good with a number of choices. The staff were very friendly and helpful.

Reviewed on Oct 1, 2019
Drury Inn & Suites Sikeston, MO features an indoor pool, an outdoor pool, and a fitness center. If you drive, put free parking to good use. The 24-hour front ...
Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape Girardeau
3.0 out of 5.0 3303 Campster Drive, Cape Girardeau, MO
Free Cancellation
$85
4.7/5 (20 reviews)

Very nice large suites!Excellent “snacks” in the evening.We were able to skip dinner and just had their tacos and salad.

Reviewed on Oct 26, 2019
Guests staying at Drury Inn & Suites Cape Girardeau enjoy an indoor pool, a fitness center, and a spa tub. Free parking is included with your stay. The front ...
Courtyard by Marriott Cape Girardeau Downtown
Courtyard by Marriott Cape Girardeau Downtown
3.0 out of 5.0 400 Broadway St., Cape Girardeau, MO
Free Cancellation
$93
5.0/5 (6 reviews)

I loved the feeling of the historical sites. The rooms were so cool and the building was amazing with the history and architectural beauty. It was quiet and so comfortable. I would definitely stay there again.

Reviewed on Oct 12, 2019
At Courtyard by Marriott Cape Girardeau Downtown, guests have access to a 24-hour fitness center, free WiFi in public areas, and a 24-hour business center. If ...
Pear Tree Inn - Sikeston
Pear Tree Inn - Sikeston
2.5 out of 5.0 2602 E Malone Avenue, Sikeston, MO
Free Cancellation
$72
4.4/5 (19 reviews)

Nice and friendly staff. Beautiful in the inside of the hotel

Reviewed on Apr 1, 2019
Pear Tree Inn - Sikeston features an indoor pool, an outdoor pool, and a fitness center. You can put free parking to good use if you drive. The front desk is ...

Luxury Hotels in Sikeston

See all 93 Properties in Sikeston

Pet Friendly Sikeston Hotels

See all 93 Properties in Sikeston

Finding a Hotel in Sikeston


So you're pondering a trip to Sikeston? If you want a place to hang your hat that's located near some well-known Sikeston attractions such as Isle Casino Cape Girardeau, just go to Orbitz, choose your travel dates, and voilà! Look through the list of hotels and other accommodations to identify those that are near what you want to see.


Whether you want a guesthouse or a budget-friendly motel, Sikeston has 39 places you can stay including:

  • 22 hotels
  • 3 apartments
  • 8 motels

We make it easy to find a convenient flight into Cairo, IL (CIR-Cairo Regional), which is 23.8 mi (38.3 km) from the heart of the city. Find the perfect flight in nothing flat by using the filters on our site to narrow down your search.


Accommodations in Sikeston


To get lodging that has all the extras you want in a hotel, use Orbitz to get your must-have amenities whether that's a swimming pool, free parking, or a kitchen.

If you want a quick meal before hitting the trail to explore your surroundings, think about one of these Sikeston properties, recommended by guests for their great free breakfast:

  • Pear Tree Inn Cape Girardeau West
  • Super 8 by Wyndham Sikeston/Miner Area
  • Quality Inn Charleston

Go swimming when you stay at one of these Sikeston properties, popular for their pools.

  • Comfort Inn & Suites Sikeston
  • Drury Inn & Suites Sikeston, MO
  • Drury Inn & Suites Cape Girardeau

What's the Weather Like in Sikeston?


If you need to know whether to pack an umbrella or your shades for your trip to Sikeston, the below weather information may be helpful. Sikeston is typically warmest in July and August, while it’s usually the chilliest in January and December. The rainiest months are May and April, while the driest months are normally August and September. Here's an overview of rain and seasonal temperatures so you'll be fully prepared for everything Mother Nature can deliver:


  • January to March: average temp during the day is 65°F and 27°F at night
  • April to June: average temp during the day is 91°F and 44°F at night
  • July to September: average temp during the day is 92°F and 54°F at night
  • October to December: average temp during the day is 78°F and 28°F at night
  • Annual average rainfall: 49.33 inches

Things to See and Do in Sikeston


When you're on your way to enjoy local activities like shopping, you may want to grab a quick bite at one of the restaurants in family-friendly Sikeston. Stop in at these interesting places during your trip:

  • Isle Casino Cape Girardeau
  • Sikeston Depot Museum
  • Central Park
  • Boot Heel Golf Club
  • Dexter Welcome Center Depot and Museum
  • The Heritage House

Recent Reviews

*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.