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Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
Hotel in Cape Girardeau with a full-service spa and free breakfast

Choose dates to view prices

Photo gallery for Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Exterior
Indoor pool, open 8 AM to 11 PM, sun loungers
Free breakfast
Exterior
Premium bedding, down comforters, pillowtop beds, in-room safe

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Laundry
  • Housekeeping

Explore the area

View in a map
3253 William Street, Cape Girardeau, MO, 63701
  • Place, Saint Francis Medical Center
    ‪6 min walk‬
  • Place, Southeast Missouri State University
    ‪6 min drive‬
  • Place, Isle Casino Cape Girardeau
    ‪8 min drive‬
  • Airport, Cape Girardeau, MO (CGI-Cape Girardeau Municipal)
    ‪5 min drive‬

Room options

View all photos for Suite, 2 Queen Beds, Accessible (Roll-In Shower)

Suite, 2 Queen Beds, Accessible (Roll-In Shower) | Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 2 Queen Beds, Accessible (Roll-In Shower)

8.0 out of 10
Very good
(5 reviews)
  • 400 sq ft
  • Sleeps 6
  • 2 Queen Beds

View all photos for Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 1 King Bed, Accessible (Roll-In Shower)

9.4 out of 10
Exceptional
(6 reviews)
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 1 King Bed

9.6 out of 10
Exceptional
(32 reviews)
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 2 Queen Beds

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 2 Queen Beds

9.6 out of 10
Exceptional
(53 reviews)
  • Sleeps 6
  • 2 Queen Beds

View all photos for Suite, 2 Queen Beds, Accessible (Mobility)

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 2 Queen Beds, Accessible (Mobility)

9.4 out of 10
Exceptional
(14 reviews)
  • 400 sq ft
  • Sleeps 6
  • 2 Queen Beds

View all photos for Standard Room, 1 Queen Bed

Premium bedding, down comforters, pillowtop beds, in-room safe

Standard Room, 1 Queen Bed

9.2 out of 10
Wonderful
(5 reviews)
  • 400 sq ft
  • Sleeps 2
  • 1 Queen Bed

View all photos for Standard Room

Premium bedding, down comforters, pillowtop beds, in-room safe

Standard Room

8.4 out of 10
Very good
(5 reviews)
  • 400 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 Bedroom (Feature)

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 1 Bedroom (Feature)

10.0 out of 10
Exceptional
(1 review)
  • Sleeps 2
  • 1 Queen Bed

View all photos for Suite, 1 King Bed, Accessible (Mobility)

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 1 King Bed, Accessible (Mobility)

10.0 out of 10
Exceptional
(2 reviews)
  • Sleeps 2
  • 1 King Bed

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About the neighborhood

Cape Girardeau

Located within a leisurely stroll of Saint Francis Medical Center, Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is within a few miles (5 km) of Saint Francis Healthcare System. This hotel has 102 rooms and welcomes guests with conveniences like free breakfast, a full-service spa, and an indoor pool.

What's nearby

  • Saint Francis Medical Center - 6 min walk - 0.4 miles
  • Southeast Missouri State University - 6 min drive - 3.9 miles
  • Riverfront Park - 6 min drive - 4.8 miles
  • Isle Casino Cape Girardeau - 8 min drive - 5.7 miles
  • Show Me Center - 9 min drive - 5.7 miles

Getting around

  • Cape Girardeau, MO (CGI-Cape Girardeau Municipal) - 10 min drive

Restaurants

  • ‪Chick-fil-A - ‬7 min walk
  • ‪Rhodes - ‬20 min walk
  • ‪White Castle - ‬10 min walk
  • ‪McDonald's - ‬10 min walk
  • ‪Chili's Grill & Bar - ‬4 min walk

About this property

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Hotel in Cape Girardeau with a full-service spa and free breakfast
At Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG, guests enjoy a full-service spa, an indoor pool, and a gym. If you plan to drive, free parking is available. The front desk is staffed 24/7 to help with luggage storage, dry cleaning/laundry, and securing valuables. Other amenities at this spa hotel include free WiFi in public areas, conference space, and a business center.
52-inch flat-screen TVs come with cable channels, and guests can stay connected with free WiFi and wired Internet. Bathrooms offer hair dryers and free toiletries, and pillowtop beds with premium bedding and pillow menus ensure a restful night. Other amenities include sitting areas, microwaves, and coffee makers.
Recreational amenities at the hotel include an indoor pool and a fitness center.
Guests can indulge in a pampering treatment at the hotel's full-service spa.

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Property amenities

Internet

  • Available in all rooms: Free WiFi and wired internet
  • Available in some public areas: Free WiFi and wired internet

Parking and transportation

  • Free self parking on site
  • Wheelchair-accessible parking available

Food and drink

  • Free breakfast available

Things to do

  • Full-service spa
  • Gym
  • Indoor pool

Family friendly

  • In-room microwave
  • Indoor pool
  • Laundry facilities
  • Mini-fridge

Conveniences

  • 24-hour front desk
  • Free newspapers in lobby
  • Laundry facilities
  • Luggage storage
  • Safe at front desk
  • Vending machine

Guest services

  • Dry cleaning/laundry service
  • Housekeeping (daily)
  • Porter/bellhop

Business services

  • 118 square feet of conference space
  • Business center
  • Meeting room

Outdoors

  • Pool loungers

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Assistive listening devices
  • Braille/raised signage
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible path to elevator

More

  • 1 building
  • 4 floors
  • Banquet hall
  • Smoking not allowed

Room amenities

Bedroom

  • Down comforter
  • Pillow menu
  • Pillowtop mattress
  • Premium bedding

Bathroom

  • Free toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Entertainment

  • 52-inch flat-screen TV with premium cable channels

Food and drink

  • Coffee/tea maker
  • Microwave
  • Mini-fridge

More

  • Air conditioning (climate-controlled)
  • Connecting rooms available
  • Desk
  • Free local calls
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Separate sitting area

Policies

Check-in

Check-in start time: 3:00 PM; Check-in end time: anytime
Contactless check-in available
Minimum check-in age: 21

Check-out

Check-out before 11 AM
Contactless check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Access methods

Staffed front desk

Pets

  • This property doesn't allow pets

Property payment types

Important information

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Cashless transactions are available
Safety features at this property include a smoke detector
This property affirms that it follows the cleaning and disinfection practices of Clean Promise (IHG)
  • Check-in: 3:00 PM—-anytime
  • Check-out: 11 AM
  • Minimum check-in age: 21
The front desk is open 24 hours a day. Driving? This property offers free parking.

We should mention

Details about charges, deposits, or other important information:

  • This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
  • Charges for extra guests may apply and vary depending on the property's policy.
  • A cash deposit, credit card, or debit card for incidental charges, as well as a government-issued photo ID, may be required at check-in.
  • Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
  • This property accepts credit cards. Cash is not accepted. 
  • Onsite safety features include a smoke detector.
  • Cashless payment methods are available for all transactions.
  • This property affirms that it follows the cleaning and disinfection practices of Clean Promise (IHG).

Additional information about polices, regulations, and more:

  • Pool access available from 8 AM to 11 PM.
  • Connecting or adjoining rooms can be requested, but all rooms are subject to availability. Contact the property using the phone number on your booking confirmation.
  • No cribs or infant beds are available.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

Holiday Inn Express Cape Girardeau I-55
Holiday Inn Express Hotel Cape Girardeau I-55
Holiday Inn Hotel I-55
Holiday Inn Express Hotel Suites Cape Girardeau I 55
Inn Express Cape Girarau I55
Holiday Inn Express Hotel Suites Cape Girardeau I 55
Holiday Inn Express Hotel Suites Cape Girardeau I 55 by IHG

Frequently asked questions

Is a free cancellation option available at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG provides free cancellation on some room rates. For more details, review the cancellation policy on our site.

How much does it cost to stay at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

As of Nov 25, 2025, prices found for a 1-night stay for 2 adults at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG on Nov 27, 2025 start from $95.2, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

What's there to see close to Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

This hotel is located in Cape Girardeau, close to Show Me Center, Riverfront Park, and Isle Casino Cape Girardeau. You'll also find Shawnee National Forest and Mississippi River within a short drive.

Will I be able to park at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

Yes, self parking is offered for free at the hotel. Accessible parking is also available for guests.

Is there a spa available at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

There is a full-service spa at this available for guests to enjoy at this hotel.

Does Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG include a casino at the property?

No, Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG doesn't have a casino.

Will I find an indoor pool at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

Yes, this hotel has an indoor pool. Guests have pool access between 8 AM and 11 PM.

Is Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG good for couples?

Couples staying at this hotel will appreciate amenities like a pillowtop mattress and free Internet access as well as an indoor pool.

Does Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG have a hot tub?

No, there isn't a spa tub at this hotel.

Does Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG have a restaurant that serves breakfast?

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG offers free breakfast though there is no restaurant.

Will Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG allow pets to stay for free?

No, pets aren't allowed at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG.

Are there connecting rooms at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

Yes, this hotel has connecting guestrooms you can book for your group event or vacation.

How close is the airport from Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

The closest major airport to Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is Cape Girardeau, MO (CGI-Cape Girardeau Municipal), which is 6.1 mi away (10 minutes by car). Another top airport is Cairo, IL (CIR-Cairo Regional), which is around 25.5 mi away.

Are there rooms with balconies that I can book at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

No, you won't find guestrooms with balconies at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG.

Reviews

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG Reviews

9.4

Exceptional

9.6/10

Cleanliness

9.6/10

Staff & service

9.2/10

Amenities

9.6/10

Property conditions & facilities

9.4/10

Eco-friendliness
Rating 10 - Excellent. 781 out of 1002 reviews
Rating 8 - Good. 150 out of 1002 reviews
Rating 6 - Okay. 38 out of 1002 reviews
Rating 4 - Poor. 16 out of 1002 reviews
Rating 2 - Terrible. 17 out of 1002 reviews

Reviews

6/10 Okay

Denise

Business traveler, Traveled with partner
Liked: Cleanliness, amenities, property conditions & facilities
Disliked: Staff & service
When I checked in for some reason I had two rooms booked. While talking to the front desk lady she started yelling at me and was very rude. She needs a new job.
Stayed 1 night in Oct 2025

10/10 Excellent

Gay

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Felt like I was in a mansion.
Stayed 1 night in Aug 2025

6/10 Okay

Jessica

Stayed 1 night in Aug 2025

8/10 Good

stephanie

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Aug 2025

10/10 Excellent

Amy Lynn

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
It was great had a wonderful time with my in-laws.
Stayed 2 nights in Aug 2025

10/10 Excellent

COYT

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Aug 2025

10/10 Excellent

Nashon

Stayed 3 nights in Jul 2025

10/10 Excellent

Jessica

Traveled with family
Liked: Amenities
The hotel was very nice and the staff were super helpful. I would stay here again!
Stayed 1 night in Aug 2025

10/10 Excellent

Dalton

Liked: Cleanliness
Stayed 1 night in Aug 2025

10/10 Excellent

Alicia

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Jul 2025

10/10 Excellent

Robert

Traveled with family
Liked: Amenities
Great room and breakfast
Stayed 1 night in Aug 2025

10/10 Excellent

Robert

Liked: Property conditions & facilities
Stayed 1 night in Aug 2025

10/10 Excellent

Evelyn

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Jul 2025

10/10 Excellent

Jill

Traveled with partner, Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Rooms are very nice and spacious. Liked the welcome cookies. Breakfast buffet had lots of options!
Stayed 1 night in Aug 2025

8/10 Good

Stephanie

Stayed 1 night in Aug 2025

6/10 Okay

Erica

Traveled with family and small children
Liked: Staff & service, amenities, property conditions & facilities
We thought there was going to be a hot tub! Also found hairs around in the bathroom floor and tub
Stayed 1 night in Aug 2025

8/10 Good

Bernadette

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
staff was very friendly. room clean
Stayed 2 nights in Jul 2025

4/10 Poor

Morag

Liked: Cleanliness
Disliked: Staff & service
My first experience upon walking in the door was Katy - GM who definitely let it be known that she hated her job without saying "I hate my job". Critical, rude, and talking down to me is NOT a way to give me a great first impression. She barked commands at me and ridiculed me infront of other customers for not knowing my license plate. News flash - my state changed their plates and assigned it to me 3 weeks ago. I'm more than sure there were no other vehicles from my state in your Missouri parking lot. Being told I needed to walk outside in the 103° heat index was ridiculous. The room was 78° when we entered - horribly stuffy. I did not feel like I could call the front desk for anything after being treated so badly when I checked in. Breakfast was lukewarm - not up to temp. Just kind of blah...
Stayed 1 night in Jul 2025

8/10 Good

Shivani

Liked: Cleanliness, staff & service, property conditions & facilities
Awesome. Comfortable and clean rooms. Very convenient location.
Stayed 1 night in Jul 2025

6/10 Okay

Raymond

Traveled with family and small children
Liked: Cleanliness, staff & service
It was about average. Breakfast not as expansive as some other reviews have mentioned. Pancake maker wasn't working so kiddos were disappointed. Not many allergen friendly options. Service was good and it was clean. Not our least favorite stay, not our most favorite.
Stayed 2 nights in Jul 2025

10/10 Excellent

Kathleen

Traveled with group
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Breakfast
Stayed 2 nights in Jul 2025

10/10 Excellent

Dawn

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Jul 2025

4/10 Poor

Brandy

Traveled with family
Liked: Staff & service
Disliked: Cleanliness, property conditions & facilities, room comfort

Avoid if possible

Bathroom door wouldnt close, room smelled like dirty dog's and there were blood stains on the bottom sheet.
Stayed 1 night in Jul 2025

8/10 Good

Judith

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Get a lot of hallway and noise from room above. Didn’t care for the bathroom. McLean but counter was limited. Shower stall was limited in size with stool and two shower heads.
Stayed 1 night in Jul 2025

10/10 Excellent

Crystal

Liked: Cleanliness, staff & service, property conditions & facilities
Pool is nice! Place is perfect
Stayed 1 night in Jul 2025

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