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Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property

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Photo gallery for Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Exterior
Indoor pool, open 8 AM to 11 PM, sun loungers
Exterior
Suite, 1 Bedroom (Feature) | Premium bedding, down comforters, pillowtop beds, in-room safe
Free breakfast

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Parking included
  • Free WiFi
  • Air conditioning

Explore the area

View in a map
3253 William Street, Cape Girardeau, MO, 63701
  • Place, Saint Francis Medical Center
    ‪6 min walk‬
  • Place, Southeast Missouri State University
    ‪6 min drive‬
  • Place, Isle Casino Cape Girardeau
    ‪8 min drive‬
  • Airport, Cape Girardeau, MO (CGI-Cape Girardeau Municipal)
    ‪5 min drive‬

Room options

View all photos for Suite, 2 Queen Beds, Accessible (Roll-In Shower)

Suite, 2 Queen Beds, Accessible (Roll-In Shower) | Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 2 Queen Beds, Accessible (Roll-In Shower)

8.0 out of 10
Very good
(6 reviews)
  • 400 sq ft
  • Sleeps 6
  • 2 Queen Beds

View all photos for Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 1 King Bed, Accessible (Roll-In Shower)

9.4 out of 10
Exceptional
(6 reviews)
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 1 King Bed

9.6 out of 10
Exceptional
(32 reviews)
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 2 Queen Beds

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 2 Queen Beds

9.6 out of 10
Exceptional
(55 reviews)
  • 1 bedroom
  • Sleeps 6
  • 2 Queen Beds

View all photos for Suite, 2 Queen Beds, Accessible (Mobility)

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 2 Queen Beds, Accessible (Mobility)

9.4 out of 10
Exceptional
(14 reviews)
  • 400 sq ft
  • 1 bedroom
  • Sleeps 6
  • 2 Queen Beds

View all photos for Standard Room, 1 Queen Bed

Premium bedding, down comforters, pillowtop beds, in-room safe

Standard Room, 1 Queen Bed

9.2 out of 10
Wonderful
(5 reviews)
  • 400 sq ft
  • 1 bedroom
  • Sleeps 2
  • 1 Queen Bed

View all photos for Standard Room

Premium bedding, down comforters, pillowtop beds, in-room safe

Standard Room

8.4 out of 10
Very good
(5 reviews)
  • 400 sq ft
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 Bedroom (Feature)

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 1 Bedroom (Feature)

10.0 out of 10
Exceptional
(1 review)
  • 1 bedroom
  • Sleeps 2
  • 1 Queen Bed

View all photos for Suite, 1 King Bed, Accessible (Mobility)

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 1 King Bed, Accessible (Mobility)

10.0 out of 10
Exceptional
(2 reviews)
  • Sleeps 2
  • 1 King Bed

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  • Parking included
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About the neighborhood

Cape Girardeau

Located within a leisurely stroll of Saint Francis Medical Center, Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is within a few miles (5 km) of Saint Francis Healthcare System. This hotel has 102 rooms and welcomes guests with conveniences like free breakfast, a full-service spa, and an indoor pool.

What's nearby

  • Saint Francis Medical Center - 6 min walk - 0.4 miles
  • Riverfront Bridge Park - 6 min drive - 4.4 miles
  • Southeast Missouri State University - 6 min drive - 3.9 miles
  • Isle Casino Cape Girardeau - 8 min drive - 5.7 miles
  • Show Me Center - 9 min drive - 5.7 miles

Getting around

  • Cape Girardeau, MO (CGI-Cape Girardeau Municipal) - 10 min drive

Restaurants

  • ‪Chick-fil-A - ‬7 min walk
  • ‪Rhodes - ‬20 min walk
  • ‪McDonald's - ‬10 min walk
  • ‪White Castle - ‬10 min walk
  • ‪Wings Etc. - ‬9 min walk

About this property

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

At Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG, guests enjoy a full-service spa, an indoor pool, and a gym. If you plan to drive, free parking is available. The front desk is staffed 24/7 to help with securing valuables, luggage storage, and dry cleaning/laundry. Other amenities at this spa hotel include free WiFi in public areas, conference space, and a business center.
52-inch flat-screen TVs come with cable channels, and guests can stay connected with free WiFi and wired Internet. Bathrooms offer hair dryers and free toiletries, and pillowtop beds with premium bedding and pillow menus ensure a restful night. Other amenities include sitting areas, microwaves, and coffee makers.
Recreational amenities at the hotel include an indoor pool and a fitness center.
Guests can indulge in a pampering treatment at the hotel's full-service spa.

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Property amenities

Internet

  • Available in all rooms: Free WiFi and wired internet
  • Available in some public areas: Free WiFi and wired internet

Parking and transportation

  • Free self parking on site
  • Wheelchair-accessible parking available

Food and drink

  • Free breakfast available

Things to do

  • Full-service spa
  • Gym
  • Indoor pool

Family friendly

  • In-room microwave
  • Indoor pool
  • Laundry facilities
  • Mini-fridge

Conveniences

  • 24-hour front desk
  • Free newspapers in lobby
  • Laundry facilities
  • Luggage storage
  • Safe at front desk
  • Vending machine

Guest services

  • Dry cleaning/laundry service
  • Housekeeping (daily)
  • Porter/bellhop

Business services

  • 118 square feet of conference space
  • Business center
  • Meeting room

Outdoors

  • Pool loungers

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Assistive listening devices
  • Braille/raised signage
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible path to elevator

More

  • 1 building
  • 4 floors
  • Banquet hall
  • Smoking not allowed

Room amenities

Bedroom

  • Down comforter
  • Pillow menu
  • Pillowtop mattress
  • Premium bedding

Bathroom

  • Free toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Entertainment

  • 52-inch flat-screen TV with premium cable channels

Food and drink

  • Coffee/tea maker
  • Microwave
  • Mini-fridge

More

  • Air conditioning (climate-controlled)
  • Connecting rooms available
  • Desk
  • Free local calls
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Separate sitting area

Policies

Check-in

Check-in start time: 3:00 PM; Check-in end time: anytime
Contactless check-in available
Minimum check-in age: 21

Check-out

Check-out before 11 AM
Contactless check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • This property doesn't allow pets

Property payment types

Important information

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Cashless transactions are available
Safety features at this property include a smoke detector
This property affirms that it follows the cleaning and disinfection practices of Clean Promise (IHG)
  • Check-in: 3:00 PM—-anytime
  • Check-out: 11 AM
  • Minimum check-in age: 21
The front desk is open 24 hours a day. Driving? This property offers free parking.

We should mention

Details about charges, deposits, or other important information:

  • This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
  • Charges for extra guests may apply and vary depending on the property's policy.
  • A cash deposit, credit card, or debit card for incidental charges, as well as a government-issued photo ID, may be required at check-in.
  • Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
  • This property accepts credit cards. Cash is not accepted. 
  • Onsite safety features include a smoke detector.
  • Cashless payment methods are available for all transactions.
  • This property affirms that it follows the cleaning and disinfection practices of Clean Promise (IHG).

Additional information about polices, regulations, and more:

  • Pool access available from 8 AM to 11 PM.
  • Connecting or adjoining rooms can be requested, but all rooms are subject to availability. Contact the property using the phone number on your booking confirmation.
  • No cribs or infant beds are available.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

Holiday Inn Express Cape Girardeau I-55
Holiday Inn Express Hotel Cape Girardeau I-55
Holiday Inn Hotel I-55
Holiday Inn Express Hotel Suites Cape Girardeau I 55
Inn Express Cape Girarau I55
Holiday Inn Express Hotel Suites Cape Girardeau I 55
Holiday Inn Express Hotel Suites Cape Girardeau I 55 by IHG

Frequently asked questions

Is a free cancellation option available at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG provides free cancellation on some room rates. For more details, review the cancellation policy on our site.

How much does it cost to stay at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

As of Feb 25, 2026, prices found for a 1-night stay for 2 adults at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG on Mar 6, 2026 start from 135.2, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

What's there to see close to Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

This hotel is located in Cape Girardeau, close to Show Me Center, Riverfront Bridge Park, and Riverfront Park. You'll also find Shawnee National Forest and Mississippi River within a short drive.

Is there parking available at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

Yes, self parking is offered for free at the hotel. Accessible parking is also available for guests.

Is there a spa available at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

There is a full-service spa at this available for guests to enjoy at this hotel.

Does Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG include a casino at the property?

No, Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG doesn't have a casino.

Will I find an indoor pool at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

Yes, this hotel has an indoor pool. Guests have pool access between 8 AM and 11 PM.

What do couples enjoy most about Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

Couples staying at this hotel will appreciate amenities like a pillowtop mattress and free Internet access as well as an indoor pool.

Are there hot tubs at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

No, there isn't a spa tub at this hotel.

Does Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG have a restaurant that serves breakfast?

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG offers free breakfast though there is no restaurant.

Will Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG allow pets to stay for free?

No, pets aren't allowed at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG.

Are there connecting rooms at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

Yes, this hotel has connecting guestrooms you can book for your group event or vacation.

How close is the airport from Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

The closest major airport to Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is Cape Girardeau, MO (CGI-Cape Girardeau Municipal), which is 6.1 mi away (10 minutes by car). Another top airport is Cairo, IL (CIR-Cairo Regional), which is around 25.5 mi away.

Are there rooms with balconies at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

No, at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG, there aren't any guestrooms that list a balcony.

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG Reviews

Reviews

9.4

Exceptional

Rating 10 - Excellent. 777 out of 1000 reviews
Rating 8 - Good. 151 out of 1000 reviews
Rating 6 - Okay. 39 out of 1000 reviews
Rating 4 - Poor. 16 out of 1000 reviews
Rating 2 - Terrible. 17 out of 1000 reviews

9.6/10

Cleanliness

9.6/10

Staff & service

9.2/10

Amenities

9.6/10

Property conditions & facilities

Reviews

10/10 Excellent

John

Liked: Amenities
Room was prestine and the buffet was excellent!!
Stayed 1 night in Nov 2025

6/10 Okay

Scott

Liked: Cleanliness, staff & service, amenities
The room was nice and clean but located near an ice machine that clunked all night long. I would suggest asking about the location of your room and the ice machine. Nice place but less than ideal stay
Stayed 1 night in Nov 2025

10/10 Excellent

Ainsley

Liked: Cleanliness, amenities
Upon entering this luxurious property, it’s as if one has accidentally teleported and stumbled into the Lobby of an upscale Hotel in a metropolitan city! Very modern, beautiful and a clean line type of architecture. The bed was fabulously comfortable! Way to go to Staff and Manager!! You guys are doing a great job! Thank you for providing a spectacular space to allow me and my college bestie to create more priceless memories!!
Stayed 1 night in Nov 2025

10/10 Excellent

Scott

Liked: Cleanliness, staff & service, amenities
Great staff and clean
Stayed 1 night in Nov 2025

10/10 Excellent

Christina

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Fast, very friendly desk service. We were allowed to check in a little early, a big plus since we arrived at 2 for a wedding at 3!! We got down for breakfast 30 minutes before the end of closing and it was evident. But the pancakes were great! Thanks for everyone's service!
Stayed 1 night in Nov 2025

10/10 Excellent

Brandon

Stayed 1 night in Nov 2025

10/10 Excellent

Marianne

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Very nice with comfy bed. It’s a lovely area. We went to a brewery in town and had pizza, salad and a beer.
Stayed 1 night in Nov 2025

10/10 Excellent

Hollie

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Great
Stayed 1 night in Oct 2025

10/10 Excellent

Connie

Traveled with family
Liked: Cleanliness, staff & service, amenities
Spacious room, clean, & comfy with everything we needed.
Stayed 1 night in Nov 2025

10/10 Excellent

Bryan

Traveled with family and small children, Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Excellent place to stay.
Stayed 1 night in Nov 2025

6/10 Okay

Denise

Business traveler, Traveled with partner
Liked: Cleanliness, amenities, property conditions & facilities
Disliked: Staff & service
When I checked in for some reason I had two rooms booked. While talking to the front desk lady she started yelling at me and was very rude. She needs a new job.
Stayed 1 night in Oct 2025

2/10 Terrible

rick

Stayed 2 nights in Oct 2025

10/10 Excellent

Connie

Stayed 1 night in Oct 2025

6/10 Okay

Gene

Business traveler
Liked: Cleanliness, property conditions & facilities, room comfort
Didnt appreciate finding out upon checking in that the elevators were out of order and all they had was second floor. Couldnt they be upfront about this when booking? So questionable at this price range.
Stayed 1 night in Oct 2025

10/10 Excellent

Gerald

Traveled with group, Traveled with family
Liked: Cleanliness, property conditions & facilities, room comfort
We had a great overnight stay to see SEMO play TSU! The hotel was great! No issues whatsoever.
Stayed 1 night in Oct 2025

10/10 Excellent

Kim

Stayed 1 night in Oct 2025

10/10 Excellent

Vicki

Stayed 1 night in Oct 2025

10/10 Excellent

Sandy

Stayed 2 nights in Sep 2025

10/10 Excellent

Gretchen

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
One of the best hotel stays….. The staff was so friendly. They served warm cookies from 8-9 pm and a very nice breakfast until 10 am. Quiet and safe
Stayed 1 night in Oct 2025

10/10 Excellent

Malinda

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 2 nights in Oct 2025

10/10 Excellent

Jane

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Hotel staff at checkin very friendly & helpful. Many dining options within walking distance of hotel. Beds comfy and room clean
Stayed 1 night in Oct 2025

4/10 Poor

James E. Askew

Disliked: Cleanliness, property conditions & facilities
The room was dirty and old
Stayed 1 night in Sep 2025

10/10 Excellent

Jerry

Stayed 2 nights in Sep 2025

10/10 Excellent

John Charles

Business traveler
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Excellent
Stayed 2 nights in Sep 2025

10/10 Excellent

David

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Great staff and clean rooms.
Stayed 1 night in Sep 2025

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