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Comfort Inn & Suites Sikeston I-55

2.5 star property

Choose dates to view prices

Photo gallery for Comfort Inn & Suites Sikeston I-55

Exterior
Desk, free WiFi, bed sheets, alarm clocks
Desk, free WiFi, bed sheets, alarm clocks
Indoor pool
Lobby

Reviews

8.4 out of 10
Very good

Popular amenities

  • Pet friendly
  • Parking included
  • Free WiFi
  • Air conditioning
  • Gym

Explore the area

View in a map
109 Matthews Ln, Sikeston, MO, 63801
  • Place, City of Miner Convention Center
    ‪5 min walk‬
  • Place, Sikeston Depot Museum
    ‪5 min drive‬
  • Place, Century Casino & Hotel Cape Girardeau
    ‪31 min drive‬
  • Airport, Cape Girardeau, MO (CGI-Cape Girardeau Municipal)
    ‪22 min drive‬

Room options

View all photos for 1 King Bed, Suite, Nonsmoking

Desk, free WiFi, bed sheets, alarm clocks

1 King Bed, Suite, Nonsmoking

  • Sleeps 2
  • Free WiFi

View all photos for 2 Queen Beds, Nonsmoking, Accessible

Desk, free WiFi, bed sheets, alarm clocks

2 Queen Beds, Nonsmoking, Accessible

  • Sleeps 4
  • Free WiFi

View all photos for 1 King Bed, Nonsmoking, Accessible

Desk, free WiFi, bed sheets, alarm clocks

1 King Bed, Nonsmoking, Accessible

  • Sleeps 2
  • Free WiFi

View all photos for Standard Room, 2 Queen Beds, Non Smoking

Standard Room, 2 Queen Beds, Non Smoking | Desk, free WiFi, bed sheets, alarm clocks

Standard Room, 2 Queen Beds, Non Smoking

8.0 out of 10
Very good
(13 reviews)
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds
  • Free WiFi

View all photos for Suite, 1 King Bed with Sofa bed, Non Smoking

Suite, 1 King Bed with Sofa bed, Non Smoking | Desk, free WiFi, bed sheets, alarm clocks

Suite, 1 King Bed with Sofa bed, Non Smoking

  • 1 bedroom
  • Sleeps 4
  • 1 King Bed and 1 Double Sofa Bed
  • Free WiFi

View all photos for Room, 1 King Bed, Accessible, Non Smoking

Room, 1 King Bed, Accessible, Non Smoking | Desk, free WiFi, bed sheets, alarm clocks

Room, 1 King Bed, Accessible, Non Smoking

8.6 out of 10
Excellent
(4 reviews)
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Room, 2 Queen Beds, Accessible, Non Smoking

Room, 2 Queen Beds, Accessible, Non Smoking | Desk, free WiFi, bed sheets, alarm clocks

Room, 2 Queen Beds, Accessible, Non Smoking

10.0 out of 10
Exceptional
(4 reviews)
  • Sleeps 4
  • 2 Queen Beds
  • Free WiFi

View all photos for Standard Room, 1 King Bed, Non Smoking

Standard Room, 1 King Bed, Non Smoking | Desk, free WiFi, bed sheets, alarm clocks

Standard Room, 1 King Bed, Non Smoking

8.0 out of 10
Very good
(15 reviews)
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

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Jun 14 - Jun 15
Total with taxes and fees
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About the neighborhood

Sikeston

Located within a leisurely stroll of City of Miner Convention Center, Comfort Inn & Suites Sikeston I-55 is within a 10-minute drive of Sikeston Depot Museum. This 64-room hotel welcomes guests with conveniences like an indoor pool, free in-room WiFi, and free self parking.

What's nearby

  • City of Miner Convention Center - 5 min walk - 0.3 miles
  • Central Park - 4 min drive - 3.7 miles
  • Sikeston Depot Museum - 5 min drive - 3.7 miles
  • Southeast Missouri State University - 31 min drive - 38.7 miles
  • Century Casino & Hotel Cape Girardeau - 31 min drive - 38.2 miles

Getting around

  • Cape Girardeau, MO (CGI-Cape Girardeau Municipal) - 29 min drive

Restaurants

  • ‪Lambert's Cafe - ‬17 min walk
  • ‪Buffalo Wild Wings - ‬5 min drive
  • ‪Burger King - ‬4 min drive
  • ‪Imo's Pizza - ‬6 min drive
  • ‪Starbucks - ‬6 min drive

About this property

Comfort Inn & Suites Sikeston I-55

At Comfort Inn & Suites Sikeston I-55, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. A stay here includes free parking. The front desk is staffed 24/7 to help secure valuables, and answer any questions about the accommodations. Additional amenities include a business center and laundry facilities.
Guests can expect to find free WiFi. Other amenities include coffee makers, phones, and desks.
Recreational amenities at the hotel include an indoor pool and a fitness center.

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Best Western Plus Sikeston I-55
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  • Pet friendly
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The price is $104
Jun 14 - Jun 15
Total with taxes and fees
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Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Free self parking on site
  • Wheelchair-accessible parking available

Things to do

  • Gym
  • Indoor pool

Family friendly

  • Indoor pool
  • Laundry facilities

Conveniences

  • 24-hour front desk
  • Laundry facilities
  • Safe at front desk

Business services

  • Business center

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Elevator
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible parking
  • Wheelchair-accessible registration desk

More

  • 3 floors
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided

Bathroom

  • Bathtub or shower
  • Private bathroom
  • Towels provided

Entertainment

  • Cable/satellite channels

Food and drink

  • Coffee/tea maker

More

  • Air conditioning
  • Desk
  • Phone

Policies

Check-in

Check-in start time: 2:00 PM; Check-in end time: anytime
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • This property welcomes pets for USD 20 per pet, per night
  • Dogs and cats only
  • 2 total (20 lbs is the maximum weight per pet)
  • Certain rooms only
  • Guests can request a pet-friendly room by contacting the property at the number on the booking confirmation
  • Service animals exempt from fees

Property payment types

Important information

Optional extras

These fees and deposits will be charged at check-in, check-out, or the time of service.

  • Pet fee: USD 20 per pet, per night
  • Service animals are exempt from fees

This list may not be comprehensive. Fees and deposits might not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
This property affirms that it follows the cleaning and disinfection practices of Commitment to Clean (Choice)
  • Check-in: 2:00 PM
  • Check-out: 11:00 AM
  • Minimum check-in age: 21
The front desk is open 24 hours a day. Driving? This property offers free parking.

We should mention

Details about charges, deposits, or other important information:

  • This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
  • Charges for extra guests may apply and vary depending on the property's policy.
  • A cash deposit, credit card, or debit card for incidental charges, as well as a government-issued photo ID, may be required at check-in.
  • Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
  • This property accepts credit cards. Cash is not accepted. 
  • This property affirms that it follows the cleaning and disinfection practices of Commitment to Clean (Choice).

Additional information about polices, regulations, and more:

  • No cribs or infant beds are available.
  • No rollaway or extra beds are available.

Property is also known as

Comfort Inn Sikeston Hotel
Comfort Inn Sikeston

Frequently asked questions

Is free cancellation available at Comfort Inn & Suites Sikeston I-55?

Comfort Inn & Suites Sikeston I-55 provides free cancellation on some room rates. For additional details, look at the cancellation policy on our site.

How much does it cost to stay at Comfort Inn & Suites Sikeston I-55?

As of Jun 4, 2026, prices found for a 1-night stay for 2 adults at Comfort Inn & Suites Sikeston I-55 on Jun 12, 2026 start from $115, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

What's there to do close to Comfort Inn & Suites Sikeston I-55?

This hotel is located in Sikeston, close to Sikeston Depot Museum and Central Park.

Is there parking available at Comfort Inn & Suites Sikeston I-55?

Yes, self parking is offered for free at the hotel. Wheelchair-accessible parking is also available for guests.

Does Comfort Inn & Suites Sikeston I-55 have a casino?

No, Comfort Inn & Suites Sikeston I-55 doesn't have a casino.

Is there an indoor pool at Comfort Inn & Suites Sikeston I-55?

Yes, this hotel has an indoor pool.

Is Comfort Inn & Suites Sikeston I-55 good for couples?

Couples will appreciate amenities like an indoor pool, a gym, and a 24-hour front desk at this hotel.

Are there hot tubs at Comfort Inn & Suites Sikeston I-55?

No, this hotel doesn't have a spa tub.

Does Comfort Inn & Suites Sikeston I-55 have a restaurant that serves breakfast?

No, Comfort Inn & Suites Sikeston I-55 doesn't have a restaurant that serves breakfast.

Does Comfort Inn & Suites Sikeston I-55 allow pets to stay for free?

Although they can't stay for free, cats and dogs are welcome at Comfort Inn & Suites Sikeston I-55 for a fee of USD 20 per pet, per night.

Are there connecting rooms at Comfort Inn & Suites Sikeston I-55?

No, this hotel doesn't feature connecting guestrooms.

How far is the airport from Comfort Inn & Suites Sikeston I-55?

The closest major airport to Comfort Inn & Suites Sikeston I-55 is Cairo, IL (CIR-Cairo Regional), which is 28.1 mi away (29 minutes by car). Another top airport is Cape Girardeau, MO (CGI-Cape Girardeau Municipal), which is located 26.7 mi away (29-minute drive).

Are there rooms with balconies at Comfort Inn & Suites Sikeston I-55?

No, there aren't any guestrooms at Comfort Inn & Suites Sikeston I-55 that offer a balcony.

Comfort Inn & Suites Sikeston I-55 Reviews

Reviews

8.4

Very Good

Rating 10 - Excellent. 141 out of 293 reviews
Rating 8 - Good. 94 out of 293 reviews
Rating 6 - Okay. 29 out of 293 reviews
Rating 4 - Poor. 19 out of 293 reviews
Rating 2 - Terrible. 10 out of 293 reviews

8.4/10

Cleanliness

8.8/10

Staff & service

8.2/10

Amenities

8.2/10

Property conditions & facilities

Reviews

Verified

10/10 Excellent

aileen

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The hotel was very clean, beds were comfortable, and staff was friendly and helpful.
Stayed 1 night in Dec 2025
Verified

10/10 Excellent

Dorothy

facility was very clean. night staff was a pleasure and most helpful. very nice room with lots of space. great stay! good breakfast as well.
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Soo

Liked: Cleanliness, staff & service, amenities
Very nice staff & clean room
Stayed 1 night in Dec 2025
Verified

10/10 Excellent

JESSICA

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Connie

Liked: Cleanliness, property conditions & facilities
Room was clean, breakfast was very good.
Stayed 1 night in Nov 2025
Verified

10/10 Excellent

Lisa

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
It was a very nice stay. The pool was clean and enjoying!
Stayed 1 night in Jul 2025
Verified

10/10 Excellent

Jamaal

Liked: Cleanliness, staff & service, amenities
Awesome no complaints
Stayed 2 nights in Nov 2025
Verified

10/10 Excellent

jacqueline

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
It was quiet and peaceful. It was by everything we wanted to go.
Stayed 2 nights in Oct 2025
Verified

10/10 Excellent

Shonta'

Liked: Cleanliness, staff & service, property conditions & facilities
Love Everything
Stayed 4 nights in Oct 2025
Verified

8/10 Good

Amanda

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Nice hotel with great staff. Room was fine, breakfast could be better but overall a good stay for this area.
Verified

10/10 Excellent

Sasha

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We were happy with our stay
Stayed 1 night in Oct 2024
Verified

10/10 Excellent

Kimberly

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We were in town for a pit-stop to sleep and the staff was very nice. Comfy beds and nice location
Stayed 1 night in Mar 2025
Verified

10/10 Excellent

Shonta'

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The Jacuzzi was the Best!!! 👏
Stayed 6 nights in Oct 2025
Verified

8/10 Good

Walter

Liked: Cleanliness, staff & service, property conditions & facilities
Good place to spend a night
Stayed 1 night in Mar 2025
Verified

10/10 Excellent

Peggy

Liked: Cleanliness, staff & service, property conditions & facilities
The facility was very nice.
Stayed 2 nights in May 2025
Verified

10/10 Excellent

Tammi

Liked: Cleanliness, staff & service, property conditions & facilities
Very clean, nice staff and good breakfast
Stayed 1 night in Aug 2023
Verified

8/10 Good

Denise

hotel was fine clean and convient
Stayed 1 night in Feb 2025
Verified

10/10 Excellent

John

Liked: Cleanliness, staff & service, property conditions & facilities
Great for overnights, staff friendly and attentive
Stayed 1 night in Apr 2024
Verified

10/10 Excellent

Mike

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean, and available rooms when we needed it most due to storms
Stayed 1 night in Feb 2025
Verified

10/10 Excellent

Cindy

Place was great
Stayed 1 night in May 2024
Verified

8/10 Good

John

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Good stay

It was decent…slept well The room was clean
Stayed 1 night in May 2025
Verified

8/10 Good

Dylan

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Right off the main drag, huge complimentary breakfast area
Stayed 1 night in May 2024
Verified

8/10 Good

Alan

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The room was chilly. Didn't seem to warm up to our satisfaction.
Stayed 1 night in Nov 2025
Verified

10/10 Excellent

Michael

Liked: Cleanliness, staff & service, property conditions & facilities
Conveniant to I55, clean, and comfortable,
Stayed 1 night in Dec 2024
Verified

8/10 Good

Willie

Stay was okay but they wouldn't give me a receipt. What's up with that?
Stayed 1 night in Nov 2025

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