Two words: Bed bugs.
Now, to be clear: the desk workers were very pleasant. No complaints. Check in was easy, and other than a bizarre charge for using the safe, unremarkable. (That said, the solution for getting that charge taken off was clearly explained).
The property itself looked really nice. Bedding was comfortable. Hallways were quiet.
But I woke up in the middle of the night clawing at my skin. When I looked in the mirror this morning, I had welts on my upper arms, legs, and feet.
I went back and stripped the bed (at least the part where I slept); not knowing what to look for, I can't say I saw anything definitive. There were tiny black specks on the sheets and the mattress cover. Nothing my phone (which is really old) could pick up well.
I told the desk person. I knew she couldn't do anything about it because I paid Expedia for the room, not the hotel directly.
But I'm leaving this review so other travellers will know.