Hotels in Sikeston

Name: La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Price range: $91 total

Search over 285 hotels from $63

Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels

Save 10% or more on select hotels with Insider Prices

Book on the app to instantly earn 5% on 350,000+ hotels

Dec 14 - Dec 15

Tonight

Dec 15 - Dec 16

Tomorrow night

Top Rated Sikeston Hotels

Free Cancellation

Reserve now, pay when you stay

1.46 mi from city center

$95 nightly

$108 total

Dec 21 - Dec 22

Total with taxes and fees

At Hampton Inn Sikeston, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The front desk is staffed 24 hours a day to help with securing valuables and luggage storage. Additional amenities include meeting rooms, conference space, and a 24-hour business center.

Free Cancellation

Reserve now, pay when you stay

3.13 mi from city center

$90 nightly

$103 total

Dec 18 - Dec 19

Total with taxes and fees

Drury Inn & Suites Sikeston, MO features an indoor pool, an outdoor pool, and a gym. If you drive, put free parking to good use. The front desk is staffed 24/7 to help with luggage storage, securing valuables, and dry cleaning/laundry. Additional amenities include free WiFi in public areas, meeting rooms, and a business center.

Free Cancellation

Reserve now, pay when you stay

3.35 mi from city center

$71 nightly

$81 total

Dec 21 - Dec 22

Total with taxes and fees

Guests of Best Western Plus Sikeston have access to an indoor pool, a gym, and free WiFi in public areas. If you plan to drive, free parking is available. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a 24-hour business center, a computer station, and express check-out.

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Free Cancellation

Reserve now, pay when you stay

3.07 mi from city center

$55 nightly

$63 total

Dec 15 - Dec 16

Total with taxes and fees

Guests of Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) enjoy free WiFi in public areas, coffee in a common area, and a vending machine. If you drive, take advantage of free parking. The 24-hour front desk has staff always at the ready.

Free Cancellation

Reserve now, pay when you stay

3.06 mi from city center

$75 nightly

$86 total

Dec 21 - Dec 22

Total with taxes and fees

Pear Tree Inn Sikeston features an indoor pool, an outdoor pool, and a gym. The front desk is staffed 24 hours a day to help with securing valuables and dry cleaning/laundry. Additional amenities include free WiFi in public areas, a hot tub, and a business center.

Free Cancellation

Reserve now, pay when you stay

3.34 mi from city center

$63 nightly

$72 total

Dec 21 - Dec 22

Total with taxes and fees

Renovated in 2023, Days Inn and Suites by Wyndham Sikeston offers a gym, free WiFi in public areas, and meeting rooms. Free parking is included with your stay. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a library, laundry facilities, and a vending machine.

Fairfield Inn & Suites by Marriott Sikeston

Free Cancellation

Reserve now, pay when you stay

1.56 mi from city center

$101 nightly

$114 total

Dec 21 - Dec 22

Total with taxes and fees

Guests of Fairfield Inn & Suites by Marriott Sikeston enjoy an indoor pool, free WiFi in public areas, and coffee in a common area. You can take advantage of free parking if you drive. The 24-hour front desk has staff standing by to help with luggage storage, dry cleaning/laundry, and securing valuables. This hotel also has laundry facilities.

Free Cancellation

Reserve now, pay when you stay

2.87 mi from city center

$59 nightly

$68 total

Dec 15 - Dec 16

Total with taxes and fees

Guests staying at Super 8 by Wyndham Sikeston/Miner Area enjoy free WiFi in public areas, a library, and a vending machine. If you drive, take advantage of free parking. Front-desk staff are standing by 24/7 to assist with any requests.

Holiday Inn Express & Suites Sikeston Southwest by IHG

Free Cancellation

1.41 mi from city center

$93 nightly

$105 total

Dec 21 - Dec 22

Total with taxes and fees

Guests staying at Holiday Inn Express & Suites Sikeston Southwest by IHG enjoy an indoor pool, a gym, and free WiFi in public areas. A stay here includes free parking. The 24-hour front desk has staff standing by to help with securing valuables and luggage storage. Additional amenities include a business center, coffee/tea in a common area, and a meeting room.

Drury Plaza Hotel Cape Girardeau Conference Center

Free Cancellation

Reserve now, pay when you stay

29.57 mi from city center

$90 nightly

$102 total

Dec 21 - Dec 22

Total with taxes and fees

At Drury Plaza Hotel Cape Girardeau Conference Center, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include a hot tub, meeting rooms, and a conference center.

Free Cancellation

Reserve now, pay when you stay

30.33 mi from city center

$96 nightly

$109 total

Dec 15 - Dec 16

Total with taxes and fees

Guests of The Riverview enjoy features like a casino, free WiFi in public areas, and meeting rooms. If you decide to drive, there's free parking. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a conference center, a microwave in a common area, and wedding services.

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Free Cancellation

Reserve now, pay when you stay

32.93 mi from city center

$84 nightly

$91 total

Jan 7 - Jan 8, 2026

Total with taxes and fees

At La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. There's free parking if you drive. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a 24-hour business center, laundry facilities, and a vending machine.

Don't see what you're looking for?

See all available properties in Sikeston

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

How much is a Sikeston hotel?

Check Sikeston hotel room prices by star rating

Cheap Sikeston hotels options

Pear Tree Inn Sikeston

2602 E Malone Avenue Sikeston MO

$75 nightly

$86 total

Dec 21 - Dec 22

Total with taxes and fees

9.2/10 Wonderful! (1,000 reviews)

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

$70 nightly

$79 total

Dec 18 - Dec 19

Total with taxes and fees

9/10 Wonderful! (1,000 reviews)

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

$63 nightly

$72 total

Dec 21 - Dec 22

Total with taxes and fees

7.2/10 Good! (1,000 reviews)

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO

$95 nightly

$107 total

Dec 22 - Dec 23

Total with taxes and fees

9.4/10 Exceptional! (1,000 reviews)

Eagle Inn Charleston

2811 East Marshall Street Charleston MO

$60 nightly

$67 total

Dec 15 - Dec 16

Total with taxes and fees

6.6/10 (103 reviews)

Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St Charleston MO

$62 nightly

$69 total

Dec 15 - Dec 16

Total with taxes and fees

6.6/10 (611 reviews)

Where is a good place to stay in Sikeston?

What are the best hotels to stay with the kids in Sikeston?

Check out these hotels for you and the kids in Sikeston. Drury Inn & Suites Sikeston, MO is a hotel offering an outdoor pool, free parking, and free breakfast. You and your family can also consider Pear Tree Inn Sikeston, a hotel offering an outdoor pool, free breakfast, and laundry facilities.

What are some of the best hotels in central Sikeston?

These are some of our travelers' favorite hotels in central Sikeston:

Hampton Inn Sikeston is a hotel offering free breakfast, free WiFi, and free parking.
Drury Inn & Suites Sikeston, MO is a hotel offering free breakfast, free WiFi, and free parking.
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) is a hotel offering free breakfast, free WiFi, and free parking.

You'll love Sikeston for its array of shops and popular restaurants.

What are some favorite hotels close to Isle Casino Cape Girardeau?

Try your luck at this well-known casino, 3.6 mi from central Cape Girardeau. You'll find 9 hotels within a mile of Isle Casino Cape Girardeau and here are some of the top choices in the area:

Courtyard by Marriott Cape Girardeau Downtown: Located 0.4 mi away, this 3-star condo features a restaurant, free WiFi, and free parking.
Hampton Inn Cape Girardeau I 55 East: Located 3.2 mi away, this hotel has free breakfast, an indoor pool, and free WiFi.
Auburn Place Hotel And Suites: Located 3.3 mi away, this hotel has free breakfast, an indoor pool, and free WiFi.

Sikeston hotels essential information

Accommodation	285 hotels
Lowest Price	$63
Highest Price	$114
Popular hotels	Hampton Inn Sikeston, Drury Inn & Suites Sikeston, MO, Best Western Plus Sikeston, Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67), Pear Tree Inn Sikeston, Days Inn and Suites by Wyndham Sikeston, Fairfield Inn & Suites by Marriott Sikeston, Super 8 by Wyndham Sikeston/Miner Area, Holiday Inn Express & Suites Sikeston Southwest by IHG, Drury Plaza Hotel Cape Girardeau Conference Center, The Riverview, La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau