Hotels in Sikeston

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Dec 30 - Dec 31
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Dec 31 - Jan 1
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Top Rated Sikeston Hotels

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Free Cancellation
Reserve now, pay when you stay
3.13 mi from city center
$90 nightly
The price is $103 total per night
$103 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Drury Inn & Suites Sikeston, MO features an indoor pool, an outdoor pool, and a gym. If you drive, put free parking to good use. The front desk is staffed 24/7 to help with luggage storage, securing valuables, and dry cleaning/laundry. Additional amenities include free WiFi in public areas, meeting rooms, and a business center.
Pool
Breakfast included
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
Free Cancellation
Reserve now, pay when you stay
1.46 mi from city center
$103 nightly
The price is $116 total per night
$116 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
At Hampton Inn Sikeston, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The front desk is staffed 24 hours a day to help with securing valuables and luggage storage. Additional amenities include meeting rooms, conference space, and a 24-hour business center.
Pool
Breakfast included
Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 out of 5
120 S Interstate Drive Sikeston MO
Free Cancellation
Reserve now, pay when you stay
3.35 mi from city center
$80 nightly
The price is $91 total per night
$91 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Guests of Best Western Plus Sikeston have access to an indoor pool, a gym, and free WiFi in public areas. If you plan to drive, free parking is available. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a 24-hour business center, a computer station, and express check-out.
Pool
Breakfast included
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

2.5 out of 5
2602 E Malone Avenue Sikeston MO
Free Cancellation
Reserve now, pay when you stay
3.06 mi from city center
$75 nightly
The price is $86 total per night
$86 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Pear Tree Inn Sikeston features an indoor pool, an outdoor pool, and a gym. The front desk is staffed 24 hours a day to help with securing valuables and dry cleaning/laundry. Additional amenities include free WiFi in public areas, a hot tub, and a business center.
Pool
Hot Tub
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 out of 5
100 Matthews Lane Sikeston MO
Free Cancellation
Reserve now, pay when you stay
3.07 mi from city center
$55 nightly
The price is $63 total per night
$63 total
Dec 31 - Jan 1, 2026
Total with taxes and fees
Guests of Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) enjoy free WiFi in public areas, coffee in a common area, and a vending machine. If you drive, take advantage of free parking. The 24-hour front desk has staff always at the ready.
Breakfast included
Pet friendly
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Free Cancellation
Reserve now, pay when you stay
3.34 mi from city center
$63 nightly
The price is $72 total per night
$72 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Renovated in 2023, Days Inn and Suites by Wyndham Sikeston offers a gym, free WiFi in public areas, and meeting rooms. Free parking is included with your stay. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a library, laundry facilities, and a vending machine.
Breakfast included
Pet friendly
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2 out of 5
2609 E Malone Ave Sikeston MO
Free Cancellation
Reserve now, pay when you stay
2.87 mi from city center
$59 nightly
The price is $68 total per night
$68 total
Dec 31 - Jan 1, 2026
Total with taxes and fees
Guests staying at Super 8 by Wyndham Sikeston/Miner Area enjoy free WiFi in public areas, a library, and a vending machine. If you drive, take advantage of free parking. Front-desk staff are standing by 24/7 to assist with any requests.
Breakfast included
Pet friendly
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

2.5 out of 5
1239 Commerce Drive Sikeston MO
Free Cancellation
Reserve now, pay when you stay
1.56 mi from city center
$105 nightly
The price is $119 total per night
$119 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
Guests of Fairfield Inn & Suites by Marriott Sikeston enjoy an indoor pool, free WiFi in public areas, and coffee in a common area. You can take advantage of free parking if you drive. The 24-hour front desk has staff standing by to help with luggage storage, dry cleaning/laundry, and securing valuables. This hotel also has laundry facilities.
Pool
Breakfast included
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 out of 5
115 Hospitality Dr Sikeston MO
Free Cancellation
1.41 mi from city center
$93 nightly
The price is $105 total per night
$105 total
Jan 25 - Jan 26, 2026
Total with taxes and fees
Guests staying at Holiday Inn Express & Suites Sikeston Southwest by IHG enjoy an indoor pool, a gym, and free WiFi in public areas. A stay here includes free parking. The 24-hour front desk has staff standing by to help with securing valuables and luggage storage. Additional amenities include a business center, coffee/tea in a common area, and a meeting room.
Pool
Breakfast included
TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston

3 out of 5
1239 Commerce Drive Sikeston MO
Free Cancellation
Reserve now, pay when you stay
1.56 mi from city center
$127 nightly
The price is $144 total per night
$144 total
Jan 8 - Jan 9, 2026
Total with taxes and fees
At TownePlace Suites by Marriott Sikeston, guests have access to an indoor pool, free WiFi in public areas, and coffee in a common area. Free parking is included with your stay. The 24-hour front desk has multilingual staff ready to assist with securing valuables and concierge services. Additional amenities include a computer station, laundry facilities, and local meal delivery service.
Pool
Breakfast included
Country Yard Inn and Suite

Country Yard Inn and Suite

2 out of 5
110 South Interstate Drive Sikeston MO
Free Cancellation
Reserve now, pay when you stay
3.42 mi from city center
$56 nightly
The price is $64 total per night
$64 total
Dec 31 - Jan 1, 2026
Total with taxes and fees
At Country Yard Inn and Suite, guests have access to free WiFi in public areas. If you drive, put free parking to good use. The 24-hour front desk has staff always at the ready.
Pet friendly
Parking included
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
29.57 mi from city center
$90 nightly
The price is $102 total per night
$102 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
At Drury Plaza Hotel Cape Girardeau Conference Center, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include a hot tub, meeting rooms, and a conference center.
Pool
Hot Tub
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap Sikeston hotels options

    Pear Tree Inn Sikeston

    Pear Tree Inn Sikeston

    2602 E Malone Avenue Sikeston MO
    $75 nightly
    The price is $86 total per night from Jan 4 to Jan 5
    $86 total
    Jan 4 - Jan 5, 2026
    Total with taxes and fees
    9.2/10 Wonderful! (1,004 reviews)
    Pear Tree Inn Cape Girardeau West

    Pear Tree Inn Cape Girardeau West

    103 Cape West Pkwy Cape Girardeau MO
    $70 nightly
    The price is $79 total per night from Jan 4 to Jan 5
    $79 total
    Jan 4 - Jan 5, 2026
    Total with taxes and fees
    9/10 Wonderful! (1,000 reviews)
    Days Inn and Suites by Wyndham Sikeston

    Days Inn and Suites by Wyndham Sikeston

    220 S Interstate Dr Sikeston MO
    $63 nightly
    The price is $72 total per night from Jan 4 to Jan 5
    $72 total
    Jan 4 - Jan 5, 2026
    Total with taxes and fees
    7.2/10 Good! (1,003 reviews)
    Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

    Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

    3253 William Street Cape Girardeau MO
    $91 nightly
    The price is $103 total per night from Jan 11 to Jan 12
    $103 total
    Jan 11 - Jan 12, 2026
    Total with taxes and fees
    9.4/10 Exceptional! (1,000 reviews)
    Eagle Inn Charleston

    Eagle Inn Charleston

    2811 East Marshall Street Charleston MO
    $60 nightly
    The price is $67 total per night from Dec 31 to Jan 1
    $67 total
    Dec 31 - Jan 1, 2026
    Total with taxes and fees
    6.6/10 (105 reviews)
    Super 8 by Wyndham Charleston/Sikeston East MO

    Super 8 by Wyndham Charleston/Sikeston East MO

    310 S Story St Charleston MO
    $62 nightly
    The price is $69 total per night from Dec 31 to Jan 1
    $69 total
    Dec 31 - Jan 1, 2026
    Total with taxes and fees
    6.6/10 (613 reviews)

Where is a good place to stay in Sikeston?

What are the best hotels to stay with the kids in Sikeston?

Check out these hotels for you and the kids in Sikeston. Drury Inn & Suites Sikeston, MO is a hotel offering an outdoor pool, free parking, and free breakfast. You and your family can also consider Pear Tree Inn Sikeston, a hotel offering an outdoor pool, free breakfast, and laundry facilities.

What are some of the best hotels in central Sikeston?

These are some of our travelers' favorite hotels in central Sikeston:

You'll love Sikeston for its array of shops and popular restaurants.

What are some favorite hotels close to Isle Casino Cape Girardeau?

Try your luck at this well-known casino, 3.6 mi from central Cape Girardeau. You'll find 9 hotels within a mile of Isle Casino Cape Girardeau and here are some of the top choices in the area:

Sikeston hotels essential information

Accommodation
281 hotels
Lowest Price
$63
Highest Price
$144
Popular hotels
Drury Inn & Suites Sikeston, MO, Hampton Inn Sikeston, Best Western Plus Sikeston, Pear Tree Inn Sikeston, Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67), Days Inn and Suites by Wyndham Sikeston, Super 8 by Wyndham Sikeston/Miner Area, Fairfield Inn & Suites by Marriott Sikeston, Holiday Inn Express & Suites Sikeston Southwest by IHG, TownePlace Suites by Marriott Sikeston, Country Yard Inn and Suite, Drury Plaza Hotel Cape Girardeau Conference Center

Recent Reviews

Hampton Inn Sikeston

Hampton Inn Sikeston

5/5 Excellent
"Very clean and super friendly staff!"
A verified traveler stayed at Hampton Inn Sikeston
Posted 2 days ago
Hampton Inn Sikeston

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