$235 Cheap flight deals from Quito (UIO) to Santiago (SCL)
Earn rewards on top of your airline miles with Orbitz Rewards
Many airlines offer flexible change policies
Sign up to receive text alerts about your trip
This Weekend's Flight Deals from Quito to Santiago
This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Airfares from $235 One Way, $422 Round Trip from Quito to Santiago
Prices starting at $422 for return flights and $235 for one-way flights to Santiago were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Santiago economy flight packages
LOFT Hotel by Sommelier Hoteles
Sep 18 - Sep 25
Quito (UIO) to Santiago (SCL)
Reviewed on Jun 12, 2026
Aubrey Hotel Boutique
Sep 18 - Sep 25
Quito (UIO) to Santiago (SCL)
Reviewed on Feb 18, 2026
Hotel Capital Bellet
Sep 18 - Sep 25
Quito (UIO) to Santiago (SCL)
Reviewed on Aug 13, 2026
More About Flying To Santiago from Quito
Route Information for Flights from Quito to Santiago
Origin Airport IATA Code | UIO |
|---|---|
Destination Airport IATA Code | SCL |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
Quito to Santiago
Orbitz is the number one travel site for finding guaranteed low prices on Quito to Santiago flights. Not only do we have discount tickets on domestic and international tickets but our cutting-edge mobile tools keep you informed on the go.
Find Low Prices in One Place
Booking a trip from Quito to Santiago has never been easier. Not only will you find great deals on flights, we offer bargains on cruises, car rentals, top-notch hotels, and more. You can also research and add local activities in Santiago to your flight or hotel reservation to keep the kids happy and active.
Flight Booking, Alerts, and More on Your Mobile Device
Use our mobile app for your iPhone, iPad, or Android phone—or our mobile website m.orbitz.com—to find bargains on flights from Quito to Santiago wherever you are. Book your cheap Quito to Santiago flights and a hotel room too—even at the last minute. Orbitz also makes your life easier with free alerts that are sent to your mobile phone or email about delays to your upcoming flights from Quito to Santiago.
Don’t Miss out on Miles
Accumulate frequent flyer miles or points on your Quito to Santiago flights. It’s as simple as entering your frequent flyer number when you’re making your flight reservation on Orbitz to rack up miles on qualified flights from Quito to Santiago. You can save your frequent flyer numbers in your Orbitz account to save time during your next flight booking.
Frequently asked questions
Flights to Santiago
- Toronto to Santiago
- Miami to Santiago
- New York to Santiago
- Chicago to Santiago
- Orlando to Santiago
- Houston to Santiago
- Buenos Aires to Santiago
- Detroit to Santiago
- San Francisco to Santiago
- Rio de Janeiro to Santiago
- Paris to Santiago
- São Paulo to Santiago
- Puerto Madryn to Santiago
- Santa Cruz to Santiago
Quito Airports
Santiago Airports
More Destinations
- El Bosque Hotels
- Las Condes Hotels
- Isla de Maipo Hotels
- Colina Hotels
- Lo Prado Hotels
- Hotels near Arturo Merino Benitez
- La Pintana Hotels
- San Alfonso Hotels
- Padre Hurtado Hotels
- Hotels near Plaza de Armas
- Ñuñoa Hotels
- Talagante Hotels
- Lodges in Buin
- Hotels near Chilean National Zoo
- Barrio Italia Hotels
- Bellavista Hotels
- Apartments in Valle Nevado
- Extended Stay Hotels in Valle Nevado
- Valle Nevado Hotels
- Barrancas Hotels
- Apartments in Chicureo
- La Parva Hotels
- Peñalolén Hotels
- San Ramón Hotels
- Hostels in Pirque
- Pirque Hotels
- Curacaví Hotels
- La Granja Hotels
- San José de Maipo Hotels
- Extended Stay Hotels in Quinta Normal Station
- Hotels near Movistar Arena
- Refugio lo Valdés Hotels
- Melipilla Hotels
- Lastarria Hotels
- Pet Friendly Hotels in Maipo Valley
- Maipo Valley Hotels
- Peñaflor Hotels
- Santa Eduviges Hotels
- Bellas Artes Hotels
- Hotels near Costanera Center
- Chada Hotels
- Hotels near Clínica Indisa
- Hotels near Fantasilandia
- Providencia Hotels
- Luxury Hotels in Santiago Metropolitan Region
- Santiago Metropolitan Region Hotels
- Lo Barnechea Hotels
- Pomaire Hotels
- San Miguel Hotels
- Hotels near Parque Arauco Mall
- Alto Jahuel Hotels
- La Cisterna Hotels
- Flights from Colina
- Flights from Arturo Merino Benitez
- Flights from Washington (DCA) to Santiago (SCL)
- Flights from Buenos Aires (EZE) to Santiago (SCL)
- Flights from New York (JFK) to Santiago (SCL)
- Flights from Los Angeles (LAX) to Santiago (SCL)
- Flights from Miami (MIA) to Santiago (SCL)
- Flights from Chicago (ORD) to Santiago (SCL)
- Flights from San Francisco (SFO) to Santiago (SCL)
- Flights to San Alfonso
- Flights to Valle Nevado
- Flights from Valle Nevado
- Flights from Raleigh to Maipo Valley
- Flights from Salt Lake City to Maipo Valley
- Flights from San José to Maipo Valley
Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.