$77 Cheap flight deals from Panama City (PNS) to St. Louis (STL)

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This Weekend's Flight Deals from Panama City to St. Louis

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Jul 4 - Fri, Jul 11
PNS
Pensacola Intl.
STL
Lambert-St. Louis Intl.
$355 Roundtrip, found 1 day ago
$355
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Fri, Jul 4 from Pensacola Intl. to Lambert-St. Louis Intl., returning Fri, Jul 11, priced at $355 found 1 day ago

Airfares from $77 One Way, $175 Round Trip from Panama City to St. Louis

Prices starting at $175 for return flights and $77 for one-way flights to St. Louis were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Nov 15 - Tue, Nov 18
VPS
Fort Walton Beach
STL
St. Louis
$175 Roundtrip, found 4 days ago
$175
Roundtrip
found 4 days ago
Select Delta flight, departing Sat, Nov 15 from Fort Walton Beach to St. Louis, returning Tue, Nov 18, priced at $175 found 4 days ago
Wed, Jul 23 - Sun, Jul 27
PNS
Pensacola
STL
St. Louis
$204 Roundtrip, found 5 days ago
$204
Roundtrip
found 5 days ago
Select Spirit Airlines flight, departing Wed, Jul 23 from Pensacola to St. Louis, returning Sun, Jul 27, priced at $204 found 5 days ago
Tue, Oct 21 - Wed, Oct 22
PNS
Pensacola
STL
St. Louis
$207 Roundtrip, found 2 days ago
$207
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Oct 21 from Pensacola to St. Louis, returning Wed, Oct 22, priced at $207 found 2 days ago
Tue, Aug 19 - Tue, Sep 2
PNS
Pensacola
STL
St. Louis
$210 Roundtrip, found 5 days ago
$210
Roundtrip
found 5 days ago
Select Delta flight, departing Tue, Aug 19 from Pensacola to St. Louis, returning Tue, Sep 2, priced at $210 found 5 days ago
Mon, Oct 20 - Thu, Oct 23
PNS
Pensacola
STL
St. Louis
$254 Roundtrip, found 2 days ago
$254
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, Oct 20 from Pensacola to St. Louis, returning Thu, Oct 23, priced at $254 found 2 days ago

St. Louis economy flight packages

Price found within the past 48 hours. Click for updated prices.
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
3.0-star property

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

7.2/10 Good! (1,015 reviews)

Jul 31 - Aug 3

3 night stay

Panama City (ECP) to St. Louis (STL)

Delta • Non-stop • Coach

St. Louis (STL) to Panama City (ECP)

Southwest Airlines • Non-stop • Coach
per person
found 21 hours ago
Check in took too long, had to wait. Given an unclean room first, then after we got our room, another couple showed up because they’d given our room to someone else

Reviewed on Jun 23, 2025

The Wildwood Hotel
3.5-star property

The Wildwood Hotel

9/10 Wonderful! (1,547 reviews)

Jul 31 - Aug 3

3 night stay

Panama City (ECP) to St. Louis (STL)

Delta • Non-stop • Coach

St. Louis (STL) to Panama City (ECP)

Southwest Airlines • Non-stop • Coach
Save 100% on your flight
per person
found 21 hours ago
Attentive front desk

Reviewed on May 15, 2025

Hilton Garden Inn Chesterfield
3.0-star property

Hilton Garden Inn Chesterfield

8.2/10 Very Good! (754 reviews)

Jul 31 - Aug 3

3 night stay

Panama City (ECP) to St. Louis (STL)

Delta • Non-stop • Coach

St. Louis (STL) to Panama City (ECP)

Southwest Airlines • Non-stop • Coach
per person
found 21 hours ago
Great stay great service

Reviewed on Apr 8, 2025

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More About Flying To St. Louis from Panama City

Route Information for Flights from Panama City to St. Louis

Origin Airport IATA Code
PNS
Destination Airport IATA Code
STL
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Panama City to St. Louis

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Frequently asked questions

Are there non-stop flights from Panama City to St. Louis?
There sure is. You can fly directly from Panama City to St. Louis with Southwest Airlines. It's the only carrier with nonstop services from Northwest Florida Beaches Intl. Airport (ECP) to Lambert Field.
What is the shortest flight from Panama City to St. Louis?
The trip from Panama City to St. Louis can be as fast as 2 hours and 30 minutes. With a leisurely flight time like this, why not book a spontaneous getaway?
What airlines fly from Panama City to St. Louis most frequently?
If you're looking for the airline that offers the most flights from Panama City to St. Louis, Southwest Airlines is your best bet. This well-known airline operates 39 flights along this route every month.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.