$296 Cheap flight deals from Des Moines (DSM) to Mazatlán (MZT)

Airfares from $296 One Way, $642 Round Trip from Des Moines to Mazatlán

Prices starting at $642 for return flights and $296 for one-way flights to Mazatlán were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Feb 23 - Tue, Mar 2
DSM
Des Moines
MZT
Mazatlán
$642 Roundtrip, found 1 day ago
$642
Roundtrip
found 1 day ago
Select Aeromexico flight, departing Tue, Feb 23 from Des Moines to Mazatlán, returning Tue, Mar 2, priced at $642 found 1 day ago
Sun, Nov 15 - Tue, Nov 24
DSM
Des Moines
MZT
Mazatlán
$652 Roundtrip, found 3 days ago
$652
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sun, Nov 15 from Des Moines to Mazatlán, returning Tue, Nov 24, priced at $652 found 3 days ago
Sat, Nov 14 - Fri, Dec 18
DSM
Des Moines
MZT
Mazatlán
$659 Roundtrip, found 3 days ago
$659
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, Nov 14 from Des Moines to Mazatlán, returning Fri, Dec 18, priced at $659 found 3 days ago
Sat, Nov 14 - Fri, Dec 18
DSM
Des Moines
MZT
Mazatlán
$661 Roundtrip, found 3 days ago
$661
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, Nov 14 from Des Moines to Mazatlán, returning Fri, Dec 18, priced at $661 found 3 days ago
Sun, Nov 15 - Tue, Nov 24
DSM
Des Moines
MZT
Mazatlán
$663 Roundtrip, found 3 days ago
$663
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sun, Nov 15 from Des Moines to Mazatlán, returning Tue, Nov 24, priced at $663 found 3 days ago

Mazatlán economy flight packages

Price found within the past 48 hours. Click for updated prices.
Hotel Playa Mazatlan
3.0-star property

Hotel Playa Mazatlan

8.4/10 Very Good! (1,003 reviews)

Nov 15 - Nov 21

6 night stay

Des Moines (DSM) to Mazatlan (MZT)

American Airlines • Non-stop roundtrip • Coach
Price was $1,635, price is now $1,043 per person
$1,043
per person
found 13 hours ago
Property is infested the room has all size roaches in the bathroom in the bed ants and bedbugs. I have been itching all over my body, Horrible experience.

Reviewed on Sep 25, 2026

Pueblo Bonito Mazatlan - All Inclusive
4.0-star property

Pueblo Bonito Mazatlan - All Inclusive

9/10 Wonderful! (1,001 reviews)

Nov 15 - Nov 21

6 night stay

Des Moines (DSM) to Mazatlan (MZT)

American Airlines • Non-stop roundtrip • Coach
Save 100% on your flight
Price was $2,417, price is now $1,425 per person
$1,425
per person
found 13 hours ago

Pueblo Bonito Vantage Centro Histórico Mazatlán
4.5-star property

Pueblo Bonito Vantage Centro Histórico Mazatlán

9.6/10 Exceptional! (94 reviews)

Nov 15 - Nov 21

6 night stay

Des Moines (DSM) to Mazatlan (MZT)

American Airlines • Non-stop roundtrip • Coach
Save 100% on your flight
Price was $2,028, price is now $1,229 per person
$1,229
per person
found 13 hours ago

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More About Flying To Mazatlán from Des Moines

Frequently asked questions

What is the shortest flight from Des Moines to Mazatlan?
The fastest flight time from Des Moines Intl. Airport to General Rafael Buelna Intl. Airport (MZT) is 4 hours and 31 minutes, which gives you plenty of time to enjoy a drink or get carried away with a good book.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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