$75 Cheap flight deals from Des Moines (DSM) to Lafayette (DEN)

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This Weekend's Flight Deals from Des Moines to Lafayette

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Sep 11 - Sun, Sep 13
DSM
Des Moines Intl.
DEN
Denver Intl.
$391 Roundtrip, found 20 hours ago
$391
Roundtrip
found 20 hours ago
Select Frontier Airlines flight, departing Fri, Sep 11 from Des Moines Intl. to Denver Intl., returning Sun, Sep 13, priced at $391 found 20 hours ago

Airfares from $75 One Way, $151 Round Trip from Des Moines to Lafayette

Prices starting at $151 for return flights and $75 for one-way flights to Lafayette were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Oct 5 - Mon, Oct 12
DSM
Des Moines
DEN
Denver
$151 Roundtrip, found 17 hours ago
$151
Roundtrip
found 17 hours ago
Select Frontier Airlines flight, departing Mon, Oct 5 from Des Moines to Denver, returning Mon, Oct 12, priced at $151 found 17 hours ago
Fri, Oct 9 - Mon, Oct 12
DSM
Des Moines
DEN
Denver
$156 Roundtrip, found 2 days ago
$156
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Fri, Oct 9 from Des Moines to Denver, returning Mon, Oct 12, priced at $156 found 2 days ago
Fri, Nov 6 - Mon, Nov 9
DSM
Des Moines
DEN
Denver
$158 Roundtrip, found 1 day ago
$158
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Fri, Nov 6 from Des Moines to Denver, returning Mon, Nov 9, priced at $158 found 1 day ago
Fri, Oct 23 - Mon, Oct 26
DSM
Des Moines
DEN
Denver
$161 Roundtrip, found 12 hours ago
$161
Roundtrip
found 12 hours ago
Select Frontier Airlines flight, departing Fri, Oct 23 from Des Moines to Denver, returning Mon, Oct 26, priced at $161 found 12 hours ago
Fri, Oct 9 - Mon, Oct 12
DSM
Des Moines
DEN
Denver
$166 Roundtrip, found 3 days ago
$166
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Fri, Oct 9 from Des Moines to Denver, returning Mon, Oct 12, priced at $166 found 3 days ago

Lafayette economy flight packages

Price found within the past 48 hours. Click for updated prices.
Cambria Hotel Denver Downtown RiNo
4.0-star property

Cambria Hotel Denver Downtown RiNo

9.2/10 Wonderful! (800 reviews)

Oct 8 - Oct 12

4 night stay

Des Moines (DSM) to Denver (DEN)

Southwest Airlines • Coach

Denver (DEN) to Des Moines (DSM)

Frontier Airlines • Coach
Price was $704, price is now $547 per person
$547
per person
found 23 hours ago

Patterson Inn
3.5-star property

Patterson Inn

9.6/10 Exceptional! (815 reviews)

Oct 8 - Oct 12

4 night stay

Des Moines (DSM) to Denver (DEN)

Southwest Airlines • Coach

Denver (DEN) to Des Moines (DSM)

Frontier Airlines • Coach
Save 100% on your flight
Price was $951, price is now $704 per person
$704
per person
found 23 hours ago
Jill-of-all-trades (breakfast chef, server; finder and bringer of irons; provider of ice) was outstanding! Cleaning staff person very kindly offered to carry my bag downstairs. A better lesson on operating that pocket door would have been helpful as we checked in. *Very heavy*. Those without decent upper body strength may not be able to operate. Room seemed oddly tired (drapery coming off ring; nearly broken through chair seat). A lot of floor space yet no comfortable place to sit (chair would not have been comfortable even if we didn't think seat about to go). So odd to have giant dresser blocking the doorway when it could have just been moved away from door. Ditch the little table holding ice bucket, put that tray on the dresser. Move chair and dresser away from the door! Cut myself on pocket door lock grabber trying to squeeze through :( Also weird that tv not opposite bed. And no mirror in bedroom; no notepad nor pen in desk. Iron was missing. Bed was comfortable, shower was great. But room just seemed to have so many "off" things for that price point.

Reviewed on Sep 2, 2026

The Brown Palace Hotel and Spa, Autograph Collection
4.5-star property

The Brown Palace Hotel and Spa, Autograph Collection

8.4/10 Very Good! (1,000 reviews)

Oct 8 - Oct 12

4 night stay

Des Moines (DSM) to Denver (DEN)

Southwest Airlines • Coach

Denver (DEN) to Des Moines (DSM)

Frontier Airlines • Coach
Price was $839, price is now $645 per person
$645
per person
found 23 hours ago

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More About Flying To Lafayette from Des Moines

Route Information for Flights from Des Moines to Lafayette

Origin Airport IATA Code
DSM
Destination Airport IATA Code
DEN
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Des Moines to Lafayette

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.