
$109 Cheap flight deals from St. Louis (STL) to Middlesboro (TYS)
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This Weekend's Flight Deals from St. Louis to Middlesboro
This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Airfares from $109 One Way, $220 Round Trip from St. Louis to Middlesboro
Prices starting at $220 for return flights and $109 for one-way flights to Middlesboro were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Middlesboro economy flight packages

The Oliver Hotel
Dec 27 - Jan 1
St. Louis (STL) to Knoxville (TYS)
Reviewed on Jun 17, 2025

River Terrace Resort & Convention Center
Dec 29 - Jan 2
St. Louis (STL) to Knoxville (TYS)
Knoxville (TYS) to St. Louis (STL)
Reviewed on Jun 20, 2025

River Edge Inn
Dec 29 - Jan 2
St. Louis (STL) to Knoxville (TYS)
Knoxville (TYS) to St. Louis (STL)
Reviewed on Nov 9, 2025
More About Flying To Middlesboro from St. Louis
Route Information for Flights from St. Louis to Middlesboro
Origin Airport IATA Code | STL |
|---|---|
Destination Airport IATA Code | TYS |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
St. Louis to Middlesboro
If you are looking to get guaranteed low prices for St. Louis to Middlesboro flights then Orbitz is the place to go. We use cutting edge mobile tools to find the best deals on air tickets and to keep you updated on delays and changes.
Get Package Savings by Booking Flights and Hotels at the Same Time
Using the Orbitz Matrix display, you can see how much you will save on flights from St. Louis to Middlesboro if the discount fare is combined with a hotel. You can also look at hotel reviews, photos and maps of the area, so it will be convenient to make your budget travel plans.
Orbitz for Business Helps Corporations save Money
Orbitz can assist all businesses from the small to major corporations with discounts on flights from St. Louis to Middlesboro. We fine- tune your needs for St. Louis to Middlesboro flights and optimize your plans by assessing your business and coming up with ways for you to save on air tickets.
Using Online Check-In Makes Flying Simple
You can use the Orbitz website to check-in for your flights from St. Louis to Middlesboro. You can also make changes to your schedule or even cancel a flight.
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Middlesboro Airports
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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.



