$149 Cheap flight deals from Houston (HOU) to Santee (CAE)

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Airfares from $149 One Way, $249 Round Trip from Houston to Santee

Prices starting at $249 for return flights and $149 for one-way flights to Santee were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Nov 27 - Tue, Dec 2
IAH
Houston
CAE
Columbia
$249 Roundtrip, found 2 days ago
$249
Roundtrip
found 2 days ago
Select Delta flight, departing Thu, Nov 27 from Houston to Columbia, returning Tue, Dec 2, priced at $249 found 2 days ago
Tue, Nov 25 - Tue, Dec 2
IAH
Houston
CAE
Columbia
$274 Roundtrip, found 2 days ago
$274
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Nov 25 from Houston to Columbia, returning Tue, Dec 2, priced at $274 found 2 days ago
Thu, Nov 20 - Sun, Nov 23
IAH
Houston
CAE
Columbia
$293 Roundtrip, found 6 days ago
$293
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Nov 20 from Houston to Columbia, returning Sun, Nov 23, priced at $293 found 6 days ago
Sat, Dec 27 - Wed, Dec 31
IAH
Houston
CAE
Columbia
$294 Roundtrip, found 2 days ago
$294
Roundtrip
found 2 days ago
Select Delta flight, departing Sat, Dec 27 from Houston to Columbia, returning Wed, Dec 31, priced at $294 found 2 days ago
Sun, Nov 23 - Mon, Nov 24
IAH
Houston
CAE
Columbia
$304 Roundtrip, found 6 days ago
$304
Roundtrip
found 6 days ago
Select Delta flight, departing Sun, Nov 23 from Houston to Columbia, returning Mon, Nov 24, priced at $304 found 6 days ago

Santee economy flight packages

Price found within the past 48 hours. Click for updated prices.
Sleep Inn Columbia
2.5-star property

Sleep Inn Columbia

8.2/10 Very Good! (1,013 reviews)

Dec 16 - Dec 18

2 night stay

Houston (IAH) to Columbia (CAE)

Delta • Non-stop roundtrip • Coach
Price was $431, price is now $399 per person
$399
per person
found 6 hours ago
This property is definitely showing its age. The rooms feel dark and old, but they are definitely taken care of. The area itself is pretty rundown and for the price I was paying, I felt like it should have been a little more updated. One of the main reasons I chose the hotel was because of the continental breakfast and it really should be listed more as a grab and go option as the only thing that was Fresh was the waffle. Everything else is prepackaged items, which was disappointing.

Reviewed on Oct 14, 2025

Graduate by Hilton Columbia SC
4.0-star property

Graduate by Hilton Columbia SC

9.4/10 Exceptional! (1,019 reviews)

Dec 16 - Dec 18

2 night stay

Houston (IAH) to Columbia (CAE)

Delta • Non-stop roundtrip • Coach
Price was $514, price is now $470 per person
$470
per person
found 6 hours ago
The Graduate Columbia is quaint, our GPS took us to the front of the building but the checkin desk is in the back so we thought we were walking into someone’s house! Obviously the entrance says Graduate so we knew we were in the right place. So the ground floor area is cute and cozy. The themed gamecock areas/rooms are fun and the convenience to USC is great, easy walk across the street. However, the rooms are pretty small and tight, the bathrooms even more so and the shower door is rusting, also the room/bathroom was not very clean. I had turned down housekeeping upon checkin, two nights, thought we would be in and out so much it would be easier and wouldn’t really need it. I wonder if the infrequent cleaning these days and then a rushed cleaning on room turnover is contributing to a less than thorough clean? Also the coffee in the room is instant? The latte from the bar downstairs was undrinkable, I threw it away. There is a cute coffee shop nearby on Gervais in an old funeral home that we got on our way out of town, highly recommend-knowledge coffee, also good breakfast sandwich. Overall it served its purpose for our college tour but if we came back I would look for somewhere else to stay.

Reviewed on Jul 29, 2025

Spark by Hilton Orangeburg
2.5-star property

Spark by Hilton Orangeburg

7.8/10 Good! (1,008 reviews)

Dec 16 - Dec 18

2 night stay

Houston (IAH) to Columbia (CAE)

Delta • Non-stop roundtrip • Coach
Price was $449, price is now $419 per person
$419
per person
found 6 hours ago
We stayed one night as a layover. Staff was friendly.

Reviewed on Jan 2, 2025

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More About Flying To Santee from Houston

Route Information for Flights from Houston to Santee

Origin Airport IATA Code
HOU
Destination Airport IATA Code
CAE
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Houston to Santee

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.