$328 Cheap flight deals from Quito (UIO) to Santiago (SCL)

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This Weekend's Flight Deals from Quito to Santiago

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Oct 2 - Fri, Oct 9
UIO
Mariscal Sucre Intl.
SCL
Arturo Merino Benitez
$633 Roundtrip, found 1 day ago
$633
Roundtrip
found 1 day ago
Select avianca flight, departing Fri, Oct 2 from Mariscal Sucre Intl. to Arturo Merino Benitez, returning Fri, Oct 9, priced at $633 found 1 day ago

Airfares from $328 One Way, $575 Round Trip from Quito to Santiago

Prices starting at $575 for return flights and $328 for one-way flights to Santiago were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Mar 17 - Sat, Mar 20
UIO
Quito
SCL
Santiago
$575 Roundtrip, found 3 hours ago
$575
Roundtrip
found 3 hours ago
Select LATAM Airlines Group flight, departing Wed, Mar 17 from Quito to Santiago, returning Sat, Mar 20, priced at $575 found 3 hours ago
Sat, Nov 7 - Wed, Nov 18
UIO
Quito
SCL
Santiago
$578 Roundtrip, found 6 days ago
$578
Roundtrip
found 6 days ago
Select Copa flight, departing Sat, Nov 7 from Quito to Santiago, returning Wed, Nov 18, priced at $578 found 6 days ago
Tue, Feb 23 - Tue, Mar 2
UIO
Quito
SCL
Santiago
$579 Roundtrip, found 13 hours ago
$579
Roundtrip
found 13 hours ago
Select LATAM Airlines Group flight, departing Tue, Feb 23 from Quito to Santiago, returning Tue, Mar 2, priced at $579 found 13 hours ago
Tue, Feb 23 - Tue, Mar 2
UIO
Quito
SCL
Santiago
$585 Roundtrip, found 13 hours ago
$585
Roundtrip
found 13 hours ago
Select LATAM Airlines Group flight, departing Tue, Feb 23 from Quito to Santiago, returning Tue, Mar 2, priced at $585 found 13 hours ago
Thu, Oct 22 - Mon, Oct 26
UIO
Quito
SCL
Santiago
$585 Roundtrip, found 2 days ago
$585
Roundtrip
found 2 days ago
Select LATAM Airlines Group flight, departing Thu, Oct 22 from Quito to Santiago, returning Mon, Oct 26, priced at $585 found 2 days ago

Santiago economy flight packages

Price found within the past 48 hours. Click for updated prices.
LOFT Hotel by Sommelier Hoteles
3.0-star property

LOFT Hotel by Sommelier Hoteles

9/10 Wonderful! (269 reviews)

Nov 19 - Nov 22

3 night stay

Quito (UIO) to Santiago (SCL)

Avianca • Non-stop roundtrip • Coach
Price was $828, price is now $699 per person
$699
per person
found 21 hours ago

Mandarin Oriental, Santiago
5.0-star property

Mandarin Oriental, Santiago

9.4/10 Exceptional! (1,002 reviews)

Nov 19 - Nov 22

3 night stay

Quito (UIO) to Santiago (SCL)

Avianca • Non-stop roundtrip • Coach
Price was $1,282, price is now $1,038 per person
$1,038
per person
found 21 hours ago
It’s the Mandarin Oriental and that’s says a lot. The staff here is very nice and helpful they accommodated us with any needs even with some simple meds from the pharmacy. They offered us suggestions as well as making us feel at home. Thank you to Fabian to give us a crash course on Pisco, Javiera to make us feel great every single morning with her smile and service, Augustina with her joyful self and by giving us suggestions in the city etc. Thank you to the entire staff at the Front Desk to accommodate for a late check out since our flight was late at night and the concierge for taking care of all our needs, and least but not last the housekeeping staff who takes care of our rooms to have it perfectly organized and clean every day. Great Job Guys! Thank you from the bottom of our hearts.

Reviewed on Sep 26, 2026

Hotel Sommelier Agustinas
3.0-star property

Hotel Sommelier Agustinas

8.6/10 Excellent! (260 reviews)

Nov 2 - Nov 6

4 night stay

Quito (UIO) to Santiago (SCL)

LATAM Airlines Group • Non-stop roundtrip • Coach
Price was $869, price is now $728 per person
$728
per person
found 4 hours ago

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More About Flying To Santiago from Quito

Route Information for Flights from Quito to Santiago

Origin Airport IATA Code
UIO
Destination Airport IATA Code
SCL
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Quito to Santiago

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Easy Flight Cancellation

In most cases, you can cancel flights from Quito to Santiago online with the same ease as you booked them.

Frequently asked questions

What is the shortest flight from Quito to Santiago?
With the flight from Quito to Santiago taking a minimum of 3 hours and 9 minutes, there's plenty of time to kick back and enjoy the ride. Order a glass of red and get comfortable in your seat with an engrossing movie or novel.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.