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21C Museum Hotel St Louis

4.5 star property

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Photo gallery for 21C Museum Hotel St Louis

Restaurant
Bar (on property)
Exterior
Exterior
Massages

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Pet friendly
  • Free WiFi
  • Air conditioning

Explore the area

View in a map
1528 Locust street, St. Louis, MO, 63103
  • Place, City Museum
    ‪5 min walk‬
  • Place, St. Louis Union Station
    ‪8 min walk‬
  • Place, Enterprise Center
    ‪8 min walk‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪19 min drive‬

Room options

View all photos for Deluxe Room, 1 King Bed

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, 1 King Bed

9.0 out of 10
Wonderful
(92 reviews)
  • 309 sq ft
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout drapes

Luxury Double Room, 2 Queen Beds

9.4 out of 10
Exceptional
(29 reviews)
  • 423 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room (Bunk Bed)

Room (Bunk Bed) | In-room safe, desk, laptop workspace, blackout drapes

Room (Bunk Bed)

8.0 out of 10
Very good
(6 reviews)
  • 237 sq ft
  • Sleeps 2
  • 1 Twin Bunk Bed

View all photos for Loft, 2 Queen Beds

Loft, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout drapes

Loft, 2 Queen Beds

8.0 out of 10
Very good
(1 review)
  • 431 sq ft
  • Sleeps 4
  • 2 Queen Beds

View all photos for Deluxe Room, Accessible (Accessible)

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, Accessible (Accessible)

  • 269 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed (21C)

  • 1119 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed (Library)

  • City view
  • 732 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed | In-room safe, desk, laptop workspace, blackout drapes

Luxury Suite, 1 King Bed

10.0 out of 10
Exceptional
(1 review)
  • 549 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible | In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, 1 Double Bed, Accessible

  • 388 sq ft
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Suite, 1 Double Bed, Accessible

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Suite, 1 Double Bed, Accessible

  • 517 sq ft
  • Sleeps 2
  • 1 Double Bed

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About the neighborhood

St. Louis

Located in Downtown West, 21C Museum Hotel St Louis is within a 10-minute walk of popular sights such as Enterprise Center and St. Louis Union Station. This 4.5-star hotel welcomes guests with 104 rooms and conveniences like an indoor pool, free in-room WiFi, and a gym.

What's nearby

  • Washington Avenue Historic District - 2 min walk - 0.1 miles
  • City Museum - 5 min walk - 0.3 miles
  • St. Louis Union Station - 8 min walk - 0.4 miles
  • Enterprise Center - 8 min walk - 0.5 miles
  • St. Louis Aquarium at Union Station - 11 min walk - 0.6 miles

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • St. Louis Lambert Intl. Airport (STL) - 24 min drive

Restaurants

  • ‪Imo's Pizza Headquarters & Retail Store - ‬7 min walk
  • ‪Budweiser Kiel Club - ‬6 min walk
  • ‪Rosalita's Cantina - ‬6 min walk
  • ‪White Knight Diner - ‬4 min walk
  • ‪Blood & Sand - ‬2 min walk

About this property

21C Museum Hotel St Louis

Guests of 21C Museum Hotel St Louis have access to an indoor pool, a gym, and a steam room. Valet parking is offered for USD 50 per day. The front desk is staffed 24/7 to help with concierge services, dry cleaning/laundry, and luggage storage. Other amenities at this luxury hotel include free WiFi in public areas, meeting rooms, and a business center.
Guests can expect free WiFi and flat-screen TVs with cable channels. Bathrooms offer hair dryers, free toiletries, and bathrobes. Espresso makers, safes, and phones are also available. Change of towels is available on request.
Recreational amenities at the hotel include an indoor pool, a steam room, and a fitness center.
Guests can pamper themselves by indulging in the onsite spa services. Services include massages.

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Apr 2 - Apr 3
Total with taxes and fees
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Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business center
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • This property welcomes pets for USD 100 per accommodation, per stay
  • Dogs only
  • Service animals exempt from fees

Property payment types

Important information

Fees

  • Service fee: USD 5 per accommodation, per stay

These are all of the charges provided to us by the property.

Optional extras

These fees and deposits will be charged at check-in, check-out, or the time of service.

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

This list may not be comprehensive. Fees and deposits might not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a fire extinguisher, a smoke detector, and outdoor lighting
  • Check-in: 4:00 PM—-11:00 AM
  • Check-out: 11:00 AM
  • Minimum check-in age: 21
The front desk is open 24 hours a day. Driving? This property offers valet parking (fees apply).

We should mention

Details about charges, deposits, or other important information:

  • This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
  • Charges for extra guests may apply and vary depending on the property's policy.
  • A cash deposit, credit card, or debit card for incidental charges, as well as a government-issued photo ID, may be required at check-in.
  • Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
  • This property accepts credit cards. Cash is not accepted. 
  • Onsite safety features include a fire extinguisher, a smoke detector, and outdoor lighting.

Additional information about polices, regulations, and more:

  • Reservations need to be made in advance for massage services. Contact the hotel at the phone number listed on your booking confirmation.
  • No cribs or infant beds are available.
  • No rollaway or extra beds are available.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

Frequently asked questions

Is free cancellation available at 21C Museum Hotel St Louis ?

21C Museum Hotel St Louis offers free cancellation on select room rates. If you'd like to learn more, look at the cancellation policy on Orbitz.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of Mar 21, 2026, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on Apr 5, 2026 start from $162, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

What's there to do close to 21C Museum Hotel St Louis ?

This hotel is situated in Downtown West, just steps from City Museum, and within a 10-minute walk of Enterprise Center and St. Louis Union Station. You'll also find Busch Stadium and Dome at America’s Center less than a mile away.

Will I be able to park at 21C Museum Hotel St Louis ?

Yes, valet parking is offered for USD 50 per day with in/out privileges.

Is there a spa available at 21C Museum Hotel St Louis ?

Spa services at the hotel include massages.

Does 21C Museum Hotel St Louis have luxury amenities?

Yes, guests can indulge in luxuries such as an indoor pool, a restaurant, and massages at this hotel.

Does 21C Museum Hotel St Louis include a casino at the property?

No, 21C Museum Hotel St Louis doesn't have a casino.

Will I find an indoor pool at 21C Museum Hotel St Louis ?

Yes, this hotel has an indoor pool.

What amenities will couples enjoy at 21C Museum Hotel St Louis ?

There are plenty of amenities for couples at this hotel, including a restaurant, an indoor pool, and a bar/lounge.

Are there hot tubs at 21C Museum Hotel St Louis ?

No, but guests can enjoy a steam room at this hotel.

Does 21C Museum Hotel St Louis have a restaurant with a breakfast menu?

Yes, 21C Museum Hotel St Louis serves a cooked-to-order breakfast each morning for a surcharge from its restaurant.

Will 21C Museum Hotel St Louis allow pets to stay for free?

Although they can't stay for free, dogs are welcome at 21C Museum Hotel St Louis for a fee of USD 100 per accommodation, per stay.

Are there connecting rooms at 21C Museum Hotel St Louis ?

No, there aren't connecting guestrooms at this hotel.

What is the closest airport to 21C Museum Hotel St Louis ?

The closest major airport to 21C Museum Hotel St Louis is St. Louis Lambert Intl. Airport (STL), which is 18.4 mi away (24 minutes by car). Another top airport is St. Louis, MO (SUS-Spirit of St. Louis), which is located 25.8 mi away (32-minute drive).

Can I book a room with a balcony at 21C Museum Hotel St Louis ?

No, you won't find guestrooms with balconies at 21C Museum Hotel St Louis .

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 1195 out of 1680 reviews
Rating 8 - Good. 258 out of 1680 reviews
Rating 6 - Okay. 116 out of 1680 reviews
Rating 4 - Poor. 51 out of 1680 reviews
Rating 2 - Terrible. 60 out of 1680 reviews

9.2/10

Cleanliness

9.0/10

Staff & service

9.2/10

Amenities

9.4/10

Property conditions & facilities

Reviews

10/10 Excellent

Richard

Stayed 1 night in Feb 2026

10/10 Excellent

LR

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The cafe that sold breakfast ran out of healthy options each morning (yogurt parfait cup/ overnight oats & quinoa $8 each) They had other plates, egg with meat, etc that looked nice fwiw. Cute gift shop in the cafe. Fashionable hotel with no real 'front desk' just a checkin counter, but volunteers were staffing a St. Louis info table in the lobby while we were there- very friendly. The bar/tapas restaurant across the lobby was fun, $$, and kitchen closed at 10 or so when our events got out so I didn't get to try it. LOVED the historic building, originally a YMCA, the handsome billiards room and the terrific tiled pool with vaulted ceiling- they don't make them like that anymore. Steam room, sauna, showers were great- bring a room towel in case the spa runs short! Open til 10:30p or 11p fyi. Art Museum on the 2nd floor is free to visitors, and had some challenging, gorgeous, funny, and thought-provoking art. Historic Campbell Mansion next door was a neat contrast and a quick peek into the high Victorian era. Glad I went, would stay again
Stayed 3 nights in Jan 2026

10/10 Excellent

Andrea, Clayton

Stayed 1 night in Dec 2025

10/10 Excellent

Hazley

Stayed 2 nights in Dec 2025

10/10 Excellent

AVA

Stayed 1 night in Dec 2025

10/10 Excellent

Rebecca

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Dec 2025

10/10 Excellent

Jennifer

Liked: Cleanliness, staff & service, amenities
Clean room, nice linens, great view!
Stayed 1 night in Dec 2025

10/10 Excellent

Robbey

Stayed 2 nights in Nov 2025

10/10 Excellent

Unique

Stayed 2 nights in Dec 2025

8/10 Good

Jayden

Stayed 2 nights in Dec 2025

10/10 Excellent

Audrey

Liked: Cleanliness, staff & service, amenities
Room was awesome
Stayed 1 night in Nov 2025

10/10 Excellent

Brandon

Great
Stayed 1 night in Dec 2025

10/10 Excellent

Abraham

Stayed 1 night in Dec 2025

10/10 Excellent

Sharon

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Hotel was comfortable, clean and unique. All staff was wonderful
Stayed 3 nights in Dec 2025

6/10 Okay

Sarah, Louisville

Stayed 2 nights in Nov 2025

6/10 Okay

Brianna

Stayed 2 nights in Dec 2025

10/10 Excellent

Michael

Stayed 1 night in Dec 2025

8/10 Good

Josiah

Liked: Cleanliness, property conditions & facilities, room comfort
Hotel was very cool, certainly niche. Service was not the best. There was a language barrier between us and the receptionist. Definitely scour the area before arrival to find parking, otherwise you'll have to pay to park. the restaurants inside are really great, food and drinks are highly recommended. Atmosphere is a 10/10. DEFINITELY RECOMMEND STAYING HERE. We will be back.
Stayed 1 night in Nov 2025

10/10 Excellent

JACK, Mount Pleasant

Stayed 3 nights in Dec 2025

8/10 Good

scott

Liked: Cleanliness, amenities, property conditions & facilities
Yes allwas good
Stayed 3 nights in Nov 2025

10/10 Excellent

Kyle

Stayed 1 night in Dec 2025

8/10 Good

Daniel

Liked: Cleanliness
Room
Stayed 3 nights in Dec 2025

10/10 Excellent

Kevin, Leawood

Traveled with partner, Traveled with pets
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
If you have ever wanted to step inside a Wes Anderson film—complete with the perfect symmetry, whimsical color palettes, and that distinct feeling of curated reality—the 21c Museum Hotel in St. Louis is it. The rooms are the true showstopper. Opening the door felt less like entering a hotel room and more like being transported to a high-end, 1960s Mad Men-inspired apartment. The attention to detail is staggering. The aesthetic is a masterclass in mid-century modern design, featuring rich wood paneling, deep jewel tones, and opulent finishings that scream Don Draper excellence. The furniture feels substantial and curated, not mass-produced, with tactile fabrics and silhouettes that anchor the space in that golden era of design. And then, there is the bathroom. I can say, without hyperbole, that this is the best bathroom of any hotel we’ve ever stayed at. It is an absolute sanctuary. The design continues that opulent, retro-modern theme with stunning tiling and heavy, brushed brass fixtures that feel incredible to use. It’s spacious and bright, featuring a vanity area that actually allows you to spread out. The shower pressure was perfect, and the high-end amenities (Malin+Goetz) were the cherry on top. It’s the kind of bathroom that makes you want to renovate your own home the second you leave. The 21c St. Louis manages to thread the needle between a serious art gallery and a cozy, nostalgic retreat.
Stayed 1 night in Nov 2025

10/10 Excellent

Ashton

Traveled with group, Business traveler, Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
The hotel is beautiful! It was a great pick for so much to do on the property. From the pool area with hot tub and saunas . To the art gallery, and the stubbing bar! Grab some fantastic cocktails! Ask for Sunday, she was wonderful bartending! Perfect stay.
Stayed 2 nights in Nov 2025

10/10 Excellent

Mark

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
We stay every year for Dirt in December at the Dome. And we enjoy are stay every year.
Stayed 3 nights in Dec 2025