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21C Museum Hotel St Louis

4.5 star property
Luxury hotel with a fitness center and a steam room

Choose dates to view prices

Photo gallery for 21C Museum Hotel St Louis

Classic architecture with a grand entrance and evenly spaced windows.
Experience the grandeur of our multi-level atrium, featuring a basketball court and balcony with a railing.
Relax in a classic room with a large pool table, elegant curtains, and a chandelier.
Relax by the pool surrounded by a comfortable seating area and natural light.
Enjoy a luxurious bar experience with a curved countertop, comfortable seating, and a vibrant mural.

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Bar

Explore the area

Map
1528 Locust street, St. Louis, MO, 63103
  • St. Louis Union Station
    ‪6 min walk‬
  • Enterprise Center
    ‪6 min walk‬
  • Busch Stadium
    ‪14 min walk‬
  • St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪21 min drive‬

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Room options

Loft, 2 Queen Beds

  • 431 sq ft
  • Sleeps 4
  • 2 Queen Beds

Luxury Suite, 1 King Bed

  • 549 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Room (Bunk Bed)

Cozy retreat with a bunk bed, round table, and vibrant artwork.

Room (Bunk Bed)

8.0 out of 10
Very good
(6 reviews)
  • 237 sq ft
  • 1 bedroom
  • Sleeps 2
  • 1 Twin Bunk Bed

Deluxe Room, Accessible (Accessible)

  • 269 sq ft
  • Sleeps 2
  • 1 King Bed

Suite, 1 King Bed (Library)

  • 732 sq ft
  • City view
  • Sleeps 2
  • 1 King Bed

Suite, 1 King Bed (21C)

  • 1119 sq ft
  • Sleeps 2
  • 1 King Bed

Deluxe Room, 1 Double Bed, Accessible

  • 388 sq ft
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Room, 1 King Bed

Relax in a stylish space with a comfortable bed, armchair, and desk, surrounded by natural light and decorative touches.

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(67 reviews)
  • 309 sq ft
  • Sleeps 2
  • 1 King Bed

Deluxe Suite, 1 Double Bed, Accessible

  • 517 sq ft
  • Sleeps 2
  • 1 Double Bed

View all photos for Deluxe Double Room, 2 Queen Beds

Two spacious beds with white linens and multiple pillows, a modern headboard, and a stylish table with a lamp and flowers.

Deluxe Double Room, 2 Queen Beds

8.4 out of 10
Very good
(18 reviews)
  • 369 sq ft
  • Sleeps 4
  • 2 Queen Beds

Deluxe Room, 1 Double Bed, Accessible

  • 388 sq ft
  • Sleeps 4
  • 1 Double Bed

View all photos for Room, 1 King Bed, Corner

Relax in a stylish room with a tufted headboard, green sofa, and brown armchair.

Room, 1 King Bed, Corner

8.8 out of 10
Excellent
(23 reviews)
  • 326 sq ft
  • City view
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed

Cozy retreat with a neatly made bed, bedside table, and potted plant.

Suite, 1 King Bed

  • 517 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Suite, 1 King Bed

Cozy retreat with a neatly made bed, bedside table, and potted plant.

Deluxe Suite, 1 King Bed

9.2 out of 10
Wonderful
(5 reviews)
  • 517 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

Two spacious beds with white linens and multiple pillows, a modern headboard, and a stylish table with a lamp and flowers.

Luxury Double Room, 2 Queen Beds

9.0 out of 10
Wonderful
(20 reviews)
  • 423 sq ft
  • Sleeps 4
  • 2 Queen Beds

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About the neighborhood

St. Louis

Located in Downtown West, 21C Museum Hotel St Louis is within a 10-minute walk of popular sights such as City Museum and Enterprise Center. This 4.5-star hotel welcomes guests with 104 rooms and conveniences like an indoor pool, free in-room WiFi, and a gym.

What's nearby

  • St. Louis Union Station - 6 min walk - 0.4 miles
  • Enterprise Center - 6 min walk - 0.4 miles
  • City Museum - 6 min walk - 0.4 miles
  • Busch Stadium - 14 min walk - 0.8 miles
  • Gateway Arch - 2 min drive - 1.1 miles

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • St. Louis Lambert Intl. Airport (STL) - 26 min drive

Restaurants

  • ‪Rosalita's Cantina - ‬6 min walk
  • ‪Grand Hall Lounge Union Station - ‬11 min walk
  • ‪Hair of the Dog - ‬7 min walk
  • ‪Peabody Lounge - ‬6 min walk
  • ‪Medina Mediterranean Grill - ‬5 min walk

About this property

21C Museum Hotel St Louis

Luxury hotel with a fitness center and a steam room
Guests of 21C Museum Hotel St Louis have access to an indoor pool, a gym, and a steam room. Valet parking is offered for USD 50 per day. The front desk is staffed 24/7 to help with luggage storage, concierge services, and dry cleaning/laundry. Other amenities at this luxury hotel include free WiFi in public areas, meeting rooms, and a business center.
Guests can expect free WiFi and flat-screen TVs with cable channels. Bathrooms offer hair dryers, free toiletries, and bathrobes. Espresso makers, safes, and phones are also available. Change of towels is available on request.
Recreational amenities at the hotel include an indoor pool, a steam room, and a fitness center.
Guests can pamper themselves by indulging in the onsite spa services. Services include massages.

Languages

English

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Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business center
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Access methods

Staffed front desk

Pets

  • This property welcomes pets for USD 100 per accommodation, per stay
  • Dogs only
  • Service animals exempt from fees

Property payment types

Important information

Fees

  • Service fee: USD 5 per accommodation, per stay

These are all of the charges provided to us by the property.

Optional extras

These fees and deposits will be charged at check-in, check-out, or the time of service.

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

This list may not be comprehensive. Fees and deposits might not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a smoke detector and outdoor lighting
  • Check-in: 4:00 PM—-11:00 AM
  • Check-out: 11:00 AM
  • Minimum check-in age: 21
The front desk is open 24 hours a day. Driving? This property offers valet parking (fees apply).

We should mention

Details about charges, deposits, or other important information:

  • This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
  • Charges for extra guests may apply and vary depending on the property's policy.
  • A cash deposit, credit card, or debit card for incidental charges, as well as a government-issued photo ID, may be required at check-in.
  • Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
  • This property accepts credit cards. Cash is not accepted. 
  • Onsite safety features include a smoke detector and outdoor lighting.

Additional information about polices, regulations, and more:

  • Reservations need to be made in advance for massage services. Contact the hotel at the phone number listed on your booking confirmation.
  • No cribs or infant beds are available.
  • No rollaway or extra beds are available.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

Frequently asked questions

Is free cancellation available at 21C Museum Hotel St Louis ?

21C Museum Hotel St Louis offers free cancellation on select room rates. If you'd like to learn more, look at the cancellation policy on Orbitz.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of Aug 5, 2025, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on Sep 5, 2025 start from $323.1, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

What's there to do close to 21C Museum Hotel St Louis ?

This hotel is situated in Downtown West within a 10-minute walk of City Museum and Enterprise Center. You'll also find St. Louis Union Station and Busch Stadium less than a mile away.

Is there parking available at 21C Museum Hotel St Louis ?

Yes, valet parking is offered for USD 50 per day with in/out privileges.

Is there a spa available at 21C Museum Hotel St Louis ?

Spa services at the hotel include massages.

Does 21C Museum Hotel St Louis include a casino at the property?

No, 21C Museum Hotel St Louis doesn't have a casino.

Will I find an indoor pool at 21C Museum Hotel St Louis ?

Yes, this hotel has an indoor pool.

Is 21C Museum Hotel St Louis good for couples?

There are plenty of amenities for couples at this hotel, including an indoor pool, a bar, and a restaurant.

Are there hot tubs at 21C Museum Hotel St Louis ?

No, but this hotel does have a steam room.

Does 21C Museum Hotel St Louis have a restaurant with a breakfast menu?

Yes, 21C Museum Hotel St Louis serves a cooked-to-order breakfast each morning for a surcharge from its restaurant.

Will 21C Museum Hotel St Louis allow pets to stay for free?

Although they can't stay for free, dogs are welcome at 21C Museum Hotel St Louis for a fee of USD 100 per accommodation, per stay.

Are there connecting rooms at 21C Museum Hotel St Louis ?

No, there aren't connecting guestrooms at this hotel.

What is the closest airport to 21C Museum Hotel St Louis ?

The closest major airport to 21C Museum Hotel St Louis is St. Louis Lambert Intl. Airport (STL), which is 18.4 mi away (26 minutes by car). Another top airport is St. Louis, MO (SUS-Spirit of St. Louis), which is located 25.8 mi away (32-minute drive).

Are there rooms with balconies at 21C Museum Hotel St Louis ?

No, there aren't any guestrooms with balconies at 21C Museum Hotel St Louis .

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 929 out of 1286 reviews
Rating 8 - Good. 191 out of 1286 reviews
Rating 6 - Okay. 75 out of 1286 reviews
Rating 4 - Poor. 41 out of 1286 reviews
Rating 2 - Terrible. 50 out of 1286 reviews

9.2/10

Cleanliness

9.2/10

Staff & service

9.2/10

Amenities

9.4/10

Property conditions & facilities

9.2/10

Eco-friendliness

Reviews

10/10 Excellent

Carrie

Business traveler
Liked: Cleanliness, amenities, property conditions & facilities
What a cool place this is! Off the charts! Beautiful comfy corner room - friendly staff- gorgeous and provocative art gallery open 24/7 - pool sauna steam - food drink wine coffee- eclectic neighborhood- what else could one wish for? Xo
Stayed 1 night in Jul 2025

10/10 Excellent

Mary

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Loved this hotel!
Stayed 1 night in Jun 2025

10/10 Excellent

John

Business traveler
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Great gym and pool, fun atmosphere on main level
Stayed 1 night in Apr 2025

8/10 Good

Jerome

Traveled with group
Liked: Cleanliness, property conditions & facilities, room comfort
Stayed 1 night in May 2025

4/10 Poor

John

Traveled with family and small children
Disliked: Staff & service, amenities, property conditions & facilities
I've stayed at 21c in Nashville and fully enjoyed the experience. In St. Louis it's not in a great neighborhood, very run down. The room phone never worked thank got for cell phones and elevators. The temperature controls didn't work properly. Fire alarm went off in the middle of the day while my 3 year old grandson was sleeping my daughter in law had to carry him down ten flights of stairs only to be told it was a mistake alarm. Valet parking is $50 for an open fenced lot across the street??? We walked around one afternoon and never really found anything cool or fun to go do... I would avoid this hotel get something g. Lose to the. Cardinals ball park same pricing with a way better experience!
Stayed 3 nights in Apr 2025

6/10 Okay

Jessica

Traveled with partner
Liked: Cleanliness, amenities
Disliked: Staff & service
Looks good and the toiletries brand is amazing
Stayed 1 night in Apr 2025

10/10 Excellent

Richard, Hickory

Stayed 1 night in Apr 2025

10/10 Excellent

Moe

Stayed 3 nights in Apr 2025

10/10 Excellent

Joni

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Spectacular restaurant, comfortable room, good museum, and it feels safe. The elevator has keyed access to each floor.
Stayed 2 nights in Apr 2025

8/10 Good

Fran

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Repeat Customer

This was our 2nd stay which speaks volumes! We love this place. It is upscale but relaxed. Historic but modern. Great location in walking distance of many attractions, but quiet. Clean. So Clean. I feel very comfortable walking around the room without shoes. Just a couple issues I will note...no after hours room service or even vending to get a snack or drink. And, only 1 roll of toilet paper. I think 2 rolls would have made us less nervous.😉
Stayed 1 night in Apr 2025

6/10 Okay

Siegfried

Liked: Cleanliness, amenities, property conditions & facilities
Bar service was very slow. Staff didn’t tell us there was a coffee shop.
Stayed 2 nights in Apr 2025

8/10 Good

Heather

Liked: Cleanliness, property conditions & facilities
This hotel has a lot of potential. It’s in a good area of the city. The hotel itself is so fun bright colored wallpaper art all over the place pool hot tub saunas pool tables literally has something for everybody. The front desk staff was OK. The valet attendant were fantastic all in all enjoyed the trip
Stayed 2 nights in Apr 2025

10/10 Excellent

Elia

Liked: Cleanliness, staff & service, property conditions & facilities
Me gusto mucho la atencion al cliente y el progecionalizmo. Gracias
Stayed 2 nights in Apr 2025

10/10 Excellent

Sandra

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We enjoyed our two nights at this hotel. The property was nice and we were able to walk to Enterprise stadium easily.
Stayed 2 nights in Apr 2025

10/10 Excellent

Hilary

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Loved everything! Will be back!

We will be coming back! We absolutely loved the hotel. From the rooms (we had a Deluxe King Suite) to the restaurants to the huge art museum…it did not disappoint. It was also within walking distance to our event at Enterprise Center. Staff were very friendly. Although we didn’t get in, the pool and hot tub both were large and looked nice. They also have two huge weight/workout rooms, treatment rooms, steam rooms, etc.
Stayed 1 night in Apr 2025

8/10 Good

Kenda

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Apr 2025

10/10 Excellent

Andrea, Du Quoin Illinois

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
I stayed at this hotel for the stl go marathon and absolutely loved it! Super close to the start/finish so that was convenient. The hotel itself was beautiful and unique. From the art, to the amenities, and staff! Ugh it was all perfect. I will be staying here again next time I’m in town. 10/10!
One of the art galleries
View from the hotel window
Stayed 1 night in Apr 2025

10/10 Excellent

Samuel

Liked: Cleanliness, staff & service, property conditions & facilities
It’s easy to walk to most every venue I go to downtown. The hotel is amazingly beautiful.
Stayed 1 night in Apr 2025

2/10 Terrible

Steve

Disliked: Cleanliness, staff & service, property conditions & facilities, room comfort
We checked in the rain, not realizing they didn’t have a car port area or porters with umbrellas. Signage was very confusing outside and inside. The 1st room we were given had no electricity. The second room we were given had stains on the walls, carpet and bedding-which we suspected was mold. There was also someone’s medical patch on the shower floor. When my wife went to look at it closer, the shower floor had disgusting build up of something along the sides. My wife felt sick and we had already gotten ready for bed so when we called about the bed they said house cleaning was gone and we could move to another room by coming back downstairs and going through the same 30 minute process we had already done. Yes we should have checked the room before doing anything, but we’ve never had a boutique hotel that wasn’t more than acceptable. My wife slept in the chair, I slept in my clothes on top of other clothes on top of the bedding. The elevator appeared to have wine thrown all over it when we checked in, but was cleaned in the morning. They did refund the additional two nights we were scheduled to stay in, so I’m thankful for that. But we were told the one night “stay” would also be refunded which didn’t happen. This was one of the worst experiences I’ve had in my significant travel history.
Stayed 2 nights in Apr 2025

8/10 Good

Emma

Liked: Cleanliness, staff & service, property conditions & facilities
Great place in St. Louis.
Stayed 1 night in Apr 2025

10/10 Excellent

Kenneth

Liked: Cleanliness, staff & service, property conditions & facilities
No parking except valet
Stayed 1 night in Apr 2025

10/10 Excellent

Eric

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
It was a really nice place to stay. Me and my wife enjoyed the hotel, pool, dinning, and the staff. We are going to go back. hopfuly for my birthday. Thank you hotel 21c!
Stayed 2 nights in Apr 2025

10/10 Excellent

Michelle

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Amazing
Stayed 2 nights in Apr 2025

10/10 Excellent

Emily

Traveled with family
Liked: Staff & service, property conditions & facilities, room comfort
Stayed 2 nights in Apr 2025

10/10 Excellent

Jennifer

Traveled with group, Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
I always love staying at this hotel! The decor is beautiful and the drinks and food are top notch!
Stayed 1 night in Apr 2025