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21C Museum Hotel St Louis

4.5 star property
Luxury hotel with a fitness center and a steam room

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Photo gallery for 21C Museum Hotel St Louis

Interior
Billiards
Dining
Loft, 2 Queen Beds | 1 bedroom, in-room safe, desk, laptop workspace
Exterior

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Bar

Explore the area

View in a map
1528 Locust street, St. Louis, MO, 63103
  • Place, St. Louis Union Station
    ‪6 min walk‬
  • Place, Enterprise Center
    ‪6 min walk‬
  • Place, Busch Stadium
    ‪14 min walk‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪18 min drive‬

Room options

View all photos for Deluxe Room, 1 King Bed

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(76 reviews)
  • 309 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds | 1 bedroom, in-room safe, desk, laptop workspace

Luxury Double Room, 2 Queen Beds

9.2 out of 10
Wonderful
(23 reviews)
  • 423 sq ft
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room (Bunk Bed)

1 bedroom, in-room safe, desk, laptop workspace

Room (Bunk Bed)

8.0 out of 10
Very good
(6 reviews)
  • 237 sq ft
  • 1 bedroom
  • Sleeps 2
  • 1 Twin Bunk Bed

View all photos for Loft, 2 Queen Beds

1 bedroom, in-room safe, desk, laptop workspace

Loft, 2 Queen Beds

  • 431 sq ft
  • Sleeps 4
  • 2 Queen Beds

View all photos for Deluxe Room, Accessible (Accessible)

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Room, Accessible (Accessible)

  • 269 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C) | 1 bedroom, in-room safe, desk, laptop workspace

Suite, 1 King Bed (21C)

  • 1119 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library) | 1 bedroom, in-room safe, desk, laptop workspace

Suite, 1 King Bed (Library)

  • 732 sq ft
  • City view
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed | 1 bedroom, in-room safe, desk, laptop workspace

Luxury Suite, 1 King Bed

10.0 out of 10
Exceptional
(1 review)
  • 549 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible | 1 bedroom, in-room safe, desk, laptop workspace

Deluxe Room, 1 Double Bed, Accessible

  • 388 sq ft
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Suite, 1 Double Bed, Accessible

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Suite, 1 Double Bed, Accessible

  • 517 sq ft
  • Sleeps 2
  • 1 Double Bed

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Exterior

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About the neighborhood

St. Louis

Located in Downtown West, 21C Museum Hotel St Louis is within a 10-minute walk of popular sights such as City Museum and Enterprise Center. This 4.5-star hotel welcomes guests with 104 rooms and conveniences like an indoor pool, free in-room WiFi, and a gym.

What's nearby

  • St. Louis Union Station - 6 min walk - 0.4 miles
  • Enterprise Center - 6 min walk - 0.4 miles
  • City Museum - 6 min walk - 0.4 miles
  • Busch Stadium - 14 min walk - 0.8 miles
  • Gateway Arch - 2 min drive - 1.1 miles

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • St. Louis Lambert Intl. Airport (STL) - 26 min drive

Restaurants

  • ‪Medina Grill - ‬5 min walk
  • ‪City Museum Rooftop Cafe - ‬5 min walk
  • ‪White Knight Diner - ‬4 min walk
  • ‪Idol Wolf - ‬1 min walk
  • ‪Budweiser Kiel Club - ‬6 min walk

About this property

21C Museum Hotel St Louis

Luxury hotel with a fitness center and a steam room
Guests of 21C Museum Hotel St Louis have access to an indoor pool, a gym, and a steam room. Valet parking is offered for USD 50 per day. The front desk is staffed 24/7 to help with luggage storage, dry cleaning/laundry, and concierge services. Other amenities at this luxury hotel include free WiFi in public areas, meeting rooms, and a business center.
Guests can expect free WiFi and flat-screen TVs with cable channels. Bathrooms offer hair dryers, free toiletries, and bathrobes. Espresso makers, safes, and phones are also available. Change of towels is available on request.
Recreational amenities at the hotel include an indoor pool, a steam room, and a fitness center.
Guests can pamper themselves by indulging in the onsite spa services. Services include massages.

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Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business center
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Access methods

Staffed front desk

Pets

  • This property welcomes pets for USD 100 per accommodation, per stay
  • Dogs only
  • Service animals exempt from fees

Property payment types

Important information

Optional extras

These fees and deposits will be charged at check-in, check-out, or the time of service.

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

This list may not be comprehensive. Fees and deposits might not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a smoke detector and outdoor lighting
  • Check-in: 4:00 PM—-11:00 AM
  • Check-out: 11:00 AM
  • Minimum check-in age: 21
The front desk is open 24 hours a day. Driving? This property offers valet parking (fees apply).

We should mention

Details about charges, deposits, or other important information:

  • This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
  • Charges for extra guests may apply and vary depending on the property's policy.
  • A cash deposit, credit card, or debit card for incidental charges, as well as a government-issued photo ID, may be required at check-in.
  • Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
  • This property accepts credit cards. Cash is not accepted. 
  • Onsite safety features include a smoke detector and outdoor lighting.

Additional information about polices, regulations, and more:

  • Reservations need to be made in advance for massage services. Contact the hotel at the phone number listed on your booking confirmation.
  • No cribs or infant beds are available.
  • No rollaway or extra beds are available.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

Frequently asked questions

Is free cancellation available at 21C Museum Hotel St Louis ?

21C Museum Hotel St Louis offers free cancellation on select room rates. If you'd like to learn more, look at the cancellation policy on Orbitz.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of Nov 9, 2025, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on Nov 21, 2025 start from $152.1, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

What's there to do close to 21C Museum Hotel St Louis ?

This hotel is situated in Downtown West within a 10-minute walk of City Museum and Enterprise Center. You'll also find St. Louis Union Station and Busch Stadium less than a mile away.

Is parking available on site at 21C Museum Hotel St Louis ?

Yes, valet parking is offered for USD 50 per day with in/out privileges.

Is there a spa available at 21C Museum Hotel St Louis ?

Spa services at the hotel include massages.

Does 21C Museum Hotel St Louis include a casino at the property?

No, 21C Museum Hotel St Louis doesn't have a casino.

Will I find an indoor pool at 21C Museum Hotel St Louis ?

Yes, this hotel has an indoor pool.

Is 21C Museum Hotel St Louis a good place to stay for couples?

There are plenty of amenities for couples at this hotel, including an indoor pool, a bar, and a restaurant.

Are there hot tubs at 21C Museum Hotel St Louis ?

No, but this hotel does have a steam room.

Does 21C Museum Hotel St Louis have a restaurant with a breakfast menu?

Yes, 21C Museum Hotel St Louis serves a cooked-to-order breakfast each morning for a surcharge from its restaurant.

Will 21C Museum Hotel St Louis allow pets to stay for free?

Although they can't stay for free, dogs are welcome at 21C Museum Hotel St Louis for a fee of USD 100 per accommodation, per stay.

Does 21C Museum Hotel St Louis have connecting rooms?

No, there aren't connecting guestrooms at this hotel.

What is the closest airport to 21C Museum Hotel St Louis ?

The closest major airport to 21C Museum Hotel St Louis is St. Louis Lambert Intl. Airport (STL), which is 18.4 mi away (26 minutes by car). Another top airport is St. Louis, MO (SUS-Spirit of St. Louis), which is located 25.8 mi away (32-minute drive).

Can I book a room with a balcony at 21C Museum Hotel St Louis ?

No, there aren't any guestrooms with balconies at 21C Museum Hotel St Louis .

Reviews

21C Museum Hotel St Louis Reviews

9.0

Wonderful

9.2/10

Cleanliness

9.2/10

Staff & service

9.2/10

Amenities

9.4/10

Property conditions & facilities

9.2/10

Eco-friendliness
Rating 10 - Excellent. 1043 out of 1445 reviews
Rating 8 - Good. 211 out of 1445 reviews
Rating 6 - Okay. 93 out of 1445 reviews
Rating 4 - Poor. 44 out of 1445 reviews
Rating 2 - Terrible. 54 out of 1445 reviews

Reviews

10/10 Excellent

Laila

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in May 2025

6/10 Okay

Veronica

Liked: Staff & service, property conditions & facilities
Nice hotel but the bathroom was dirty and the area was a little shady.
Stayed 1 night in Aug 2025

10/10 Excellent

Leslie

So different and classy
Stayed 1 night in Aug 2025

10/10 Excellent

Edward

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 3 nights in Aug 2025

10/10 Excellent

Matthew

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Always enjoy staying at this hotel. Staff is always willing to lend a hand. Love the pool, art, and other amenities.
Stayed 2 nights in Jun 2025

6/10 Okay

Anjelica

Traveled with family and small children, Traveled with family
Liked: Staff & service
Disliked: Cleanliness
I loved the hotel it was super pretty but it was so dirty. Our room was so dirty. They had the air off so it was super hot when we got there. Coffee machine was broken and they said they’d fix it and no one ever did. The location is not safe. There are tons of homeless in the area and we couldn’t even walk the town because of it. I like to but wouldn’t stay again.
Stayed 2 nights in Jul 2025

8/10 Good

Sylvia

Stayed 1 night in Jul 2025

10/10 Excellent

Denise

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 4 nights in Jul 2025

10/10 Excellent

Kim

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Jul 2025

8/10 Good

Darrell

Stayed 2 nights in Jul 2025

10/10 Excellent

Franny

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 1 night in Aug 2025

4/10 Poor

Cydney, Pilot Grove

Traveled with partner
Liked: Staff & service
Disliked: Cleanliness
One word captures the rooms. DRITY. Or maybe filthy. For the price of the hotel the rooms should at least be dusted. Not only was the room in need of a serious cleaning but I located a random pill on the floor and after checking it on drugs.com determined it was a 60 mg Adderall pill. Door entrances to the room were dusty and filthy again the space was just very unclean. The room was so dusty that both myself, and my significant other have been coughing and hacking and our allergies are in over drive. On the positive side, the hotel does have a very nice gallery space on the second floor and in the basement the fitness center and the pool were absolutely amazing.
Dust on window ledge.
Random pill just sitting on the floor.
Dust next to sofa.
Condition of the room doors.
Stayed 1 night in Aug 2025

10/10 Excellent

Jamie

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 3 nights in Jul 2025

10/10 Excellent

Frank

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great gym and pool.
Stayed 3 nights in Apr 2025

10/10 Excellent

Cynthia

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Jul 2025

4/10 Poor

Kyle

Traveled with family and small children
Liked: Property conditions & facilities
Disliked: Cleanliness, staff & service
The property was beautiful but we did not have a good experience. There were wrappers in the hallway on the 4th floor and it looked dirty. That evening an employee opened and came all the way into our room with his key card and it freaked us out, we never found out why that happened. He just ran out the door without saying anything. The next day, the fire alarms went off multiple times and we had to go down to street level and hang out in the lobby area for 45 minutes until the firefighters declared it a false alarm. We wanted to go to the bar and get some drinks, there was nobody at the hostess station so we sat down until the bartender very rudely told us we had to wait to be seated. I asked about going to the museum and I was told that it was closed due to a private event. I asked if I could go the next morning and the front desk employee told me I could go very early because they had another event the next day too. I asked if 6am would be alright and they said yes. I woke up specifically to go see the museum and the main gallery had already been closed for the event. We were also told the pool opened at 5am but my husband went down at 5:15am and it was closed. The hotel is nice but it just feels like it has some pretty big management issues. The room was nice though and the girl who did the valet parking (a young woman wearing knee braces both times we saw her) was very friendly and efficient! Coffee at the cafe spot was great as well.
Stayed 2 nights in Jul 2025

4/10 Poor

Celeste

Liked: Cleanliness, property conditions & facilities
Disliked: Staff & service
Check in was horrible. We arrived around midnight, with no reservation. Unbeknown to us, there were a few events happening that weekend and almost all hotels were booked full. We were grateful to have found this hotel. However, at check in, the
Stayed 1 night in Jul 2025

8/10 Good

Liz

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Jul 2025

10/10 Excellent

Joseph

Stayed 3 nights in Jul 2025

8/10 Good

Angela

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Wonderful hotel. I always enjoying seeking out and finding a 21C. The vibe was inviting and creative. Beautiful works of art. Loved the pool and gym/sauna/steam room area. We will stay again.
Stayed 1 night in Jul 2025

10/10 Excellent

Tedtra

Stayed 1 night in Jul 2025

10/10 Excellent

Bruce

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Art Deco at its Finest

This has been one of the best hotels I've been to in several years. Beautiful and clean with the the most beautiful art work around the whole hotel and the fact that it has its own Art Gallery is absolutely amazing.
Stayed 1 night in Jul 2025

10/10 Excellent

Trenicia

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Loved it! No complaints
Stayed 2 nights in Jul 2025

6/10 Okay

Bill

Traveled with family
Disliked: Amenities
The property was unique, breakfast at cafe was good. The bad, the first valet was not helpful at all , the front desk people were not helpful, when we got to our rooms my room still had food in the refrigerator and it was broke. The room was extremely hot because the a/c was off . Went to take a shower that night and the shower button was broke the drain was broke . Told front desk and they didn’t seem to concerned said that they’d heard there were some issues with some rooms. Overall for the money would not stay again
Stayed 4 nights in Jul 2025

10/10 Excellent

Sean

Traveled with group
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Jul 2025