Compare Hotels in Orangeburg County
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Top Rated Orangeburg County Hotels

Baymont by Wyndham Santee
249 Britain Street Santee SC
Free Cancellation
Reserve now, pay when you stay
$80 nightly
The price is $89 total per night
$89 total
May 10 - May 11
Total with taxes and fees
At Baymont by Wyndham Santee, guests have access to free WiFi in public areas, coffee in a common area, and express check-in. You can put free parking to good use if you drive. The 24-hour front desk has multilingual staff ready to help with concierge services, and answer any questions about the area. Additional amenities include express check-out and a vending machine.
Breakfast included
Pet friendly

Tru By Hilton Santee
263 Britain St. and 273 Britain St. Santee SC
Free Cancellation
Reserve now, pay when you stay
$106 nightly
The price is $118 total per night
$118 total
May 27 - May 28
Total with taxes and fees
At Tru By Hilton Santee, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. If you drive, put free parking to good use. The 24-hour front desk has staff always at the ready. This hotel also has a 24-hour business center.
Pool
Breakfast included

Tru by Hilton Orangeburg
739 Citadel Road Orangeburg SC
Free Cancellation
Reserve now, pay when you stay
$114 nightly
The price is $127 total per night
$127 total
May 24 - May 25
Total with taxes and fees
At Tru by Hilton Orangeburg, guests have access to a gym, free WiFi in public areas, and a business center. Free parking is available if you drive. The 24-hour front desk has staff standing by to help with securing valuables and luggage storage. Additional amenities include coffee/tea in a common area, an arcade/game room, and express check-in.
Breakfast included
Pet friendly

Super 8 by Wyndham, Orangeburg
3608 Saint Matthews Rd Orangeburg SC
Free Cancellation
Reserve now, pay when you stay
$60 nightly
The price is $67 total per night
$67 total
Jun 1 - Jun 2
Total with taxes and fees
Super 8 by Wyndham, Orangeburg features free WiFi in public areas, a business center, and coffee in a common area. If you drive, put free parking to good use. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include laundry facilities, a vending machine, and a TV in a common area.
Breakfast included
Pet friendly

Travelodge by Wyndham Orangeburg
3620 Saint Matthews Rd Orangeburg SC
Free Cancellation
Reserve now, pay when you stay
$79 nightly
The price is $88 total per night
$88 total
May 10 - May 11
Total with taxes and fees
Travelodge by Wyndham Orangeburg features free WiFi in public areas, coffee in a common area, and express check-out. Free parking is available if you drive. Front-desk staff are standing by 24/7 to assist with any requests. This smoke-free motel also has a vending machine.
Parking included
Free WiFi

Comfort Inn & Suites Santee
221 Britain St Santee SC
Free Cancellation
$113 nightly
The price is $126 total per night
$126 total
May 31 - Jun 1
Total with taxes and fees
Renovated in 2023, Comfort Inn & Suites Santee offers a gym, free WiFi in public areas, and a business center. You can put free parking to good use if you drive. The 24-hour front desk has multilingual staff ready to help secure valuables, and answer any questions about the area. Additional amenities include a seasonal outdoor pool, coffee/tea in a common area, and a computer station.
Pool
Breakfast included

Spark by Hilton Orangeburg
731 Citadel Road Orangeburg SC
Free Cancellation
Reserve now, pay when you stay
$103 nightly
The price is $115 total per night
$115 total
May 11 - May 12
Total with taxes and fees
Renovated in 2025, Spark by Hilton Orangeburg offers a gym, free WiFi in public areas, and a seasonal outdoor pool. If you drive, take advantage of free parking. Front-desk staff are standing by 24/7 to assist with any requests. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include coffee/tea in a common area, express check-out, and a terrace.
Pool
Breakfast included

Hampton Inn Santee-I-95
9060 Old Number Six Hwy Santee SC
Free Cancellation
Reserve now, pay when you stay
$119 nightly
The price is $132 total per night
$132 total
May 25 - May 26
Total with taxes and fees
At Hampton Inn Santee-I-95, guests have access to a 24-hour gym, free WiFi in public areas, and conference space. If you drive, put free parking to good use. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include a 24-hour business center, a seasonal outdoor pool, and free newspapers.
Pool
Breakfast included

Best Western Plus Santee Inn
I 95 Exit 98 Santee SC
Free Cancellation
Reserve now, pay when you stay
$118 nightly
The price is $131 total per night
$131 total
May 18 - May 19
Total with taxes and fees
Guests staying at Best Western Plus Santee Inn enjoy an outdoor pool, a gym, and free WiFi in public areas. If you drive, put free parking to good use. The 24-hour front desk has staff always at the ready. If you like to take your furry friend along on your adventures, this pet-friendly property offers an off-leash area. Additional amenities include conference space, a business center, and free newspapers.
Pool
Breakfast included
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See all available properties in Orangeburg County
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Orangeburg County hotels essential information
Accommodation | 650 hotels |
|---|---|
Lowest Price | $67 |
Highest Price | $132 |
Popular hotels | Baymont by Wyndham Santee, Tru By Hilton Santee, Tru by Hilton Orangeburg, Super 8 by Wyndham, Orangeburg, Travelodge by Wyndham Orangeburg, Comfort Inn & Suites Santee, Spark by Hilton Orangeburg, Hampton Inn Santee-I-95, Best Western Plus Santee Inn |
Recent Reviews

Travelodge by Wyndham Orangeburg
4/5 Good
"Room was clean, spacious and comfortable. Great price for a quick one night stay. Check in staff was very nice. Only negative was continental breakfast was very minimal. Bed was comfy and bathroom was clean."
A verified traveler stayed at Travelodge by Wyndham Orangeburg
Posted 2 hours ago
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