Hotels near Santee National Wildlife Refuge
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Tonight
Check prices close to Santee National Wildlife Refuge for tonight, Mar 21 - Mar 22Tomorrow night
Check prices close to Santee National Wildlife Refuge for tomorrow night, Mar 22 - Mar 23Featured Hotels near Santee National Wildlife Refuge

Lake Marion in South Carolina.
Summerton SC
1.28 mi from Santee National Wildlife Refuge
At this vacation home, guests have access to a gym and barbecue grills.

Lakefront tiny cabin amazing view on Lake Marion! Pet friendly & sleeps 6
Summerton SC
2.27 mi from Santee National Wildlife Refuge
$158 nightly
The price is $176 total per night
$176 total
Mar 26 - Mar 27
Total with taxes and fees
At this cabin, guests have access to features like laundry facilities.

Quality Inn & Suites Santee I-95
8929 Old Number Six Highway Santee SC
Free Cancellation
Reserve now, pay when you stay
4.26 mi from Santee National Wildlife Refuge
$59 nightly
The price is $66 total per night
$66 total
Mar 29 - Mar 30
Total with taxes and fees
Quality Inn & Suites Santee I-95 features free WiFi in public areas, a seasonal outdoor pool, and microwave in a common area. If you drive, put free parking to good use. The 24-hour front desk has multilingual staff ready to assist with sightseeing, directions, and local dining recommendations. Additional amenities include a refrigerator in a common area, a computer station, and laundry facilities.
Pool
Breakfast included

Hampton Inn Santee-I-95
9060 Old Number Six Hwy Santee SC
Free Cancellation
Reserve now, pay when you stay
4.36 mi from Santee National Wildlife Refuge
$130 nightly
The price is $145 total per night
$145 total
Apr 20 - Apr 21
Total with taxes and fees
At Hampton Inn Santee-I-95, guests have access to a 24-hour gym, free WiFi in public areas, and conference space. If you drive, put free parking to good use. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include a 24-hour business center, a seasonal outdoor pool, and free newspapers.
Pool
Breakfast included

Best Western Plus Santee Inn
I 95 Exit 98 Santee SC
Free Cancellation
Reserve now, pay when you stay
4.36 mi from Santee National Wildlife Refuge
$119 nightly
The price is $132 total per night
$132 total
Mar 29 - Mar 30
Total with taxes and fees
Guests staying at Best Western Plus Santee Inn enjoy an outdoor pool, a gym, and free WiFi in public areas. If you drive, put free parking to good use. The 24-hour front desk has staff always at the ready. If you like to take your furry friend along on your adventures, this pet-friendly property offers an off-leash area. Additional amenities include conference space, a business center, and free newspapers.
Pool
Breakfast included

Fairfield Inn & Suites by Marriott Santee
9074 Old Number Six Hwy Santee SC
4.36 mi from Santee National Wildlife Refuge
$143 nightly
The price is $159 total per night
$159 total
Apr 5 - Apr 6
Total with taxes and fees
Guests staying at Fairfield Inn & Suites by Marriott Santee enjoy an outdoor pool, a gym, and free WiFi in public areas. You can put free parking to good use if you drive. Front-desk staff can answer questions 24/7, and assist with luggage storage, dry cleaning/laundry, and securing valuables. If you like to take your furry friend along on your adventures, this pet-friendly property offers an off-leash area. Additional amenities include conference space, a business center, and coffee/tea in a common area.
Pool
Breakfast included

Holiday Inn Santee by IHG
139 Bradford Blvd Santee SC
Free Cancellation
4.45 mi from Santee National Wildlife Refuge
$134 nightly
The price is $149 total per night
$149 total
Apr 20 - Apr 21
Total with taxes and fees
At Holiday Inn Santee by IHG, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. Free parking is available if you drive. The 24-hour front desk has staff standing by to help with luggage storage and securing valuables. Other amenities at this golf hotel include meeting rooms, conference space, and a business center.

Tru By Hilton Santee
263 Britain St. and 273 Britain St. Santee SC
Free Cancellation
Reserve now, pay when you stay
4.46 mi from Santee National Wildlife Refuge
$119 nightly
The price is $132 total per night
$132 total
Apr 13 - Apr 14
Total with taxes and fees
At Tru By Hilton Santee, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. If you drive, put free parking to good use. The 24-hour front desk has staff always at the ready. This hotel also has a 24-hour business center.
Pool
Breakfast included

Baymont by Wyndham Santee
249 Britain Street Santee SC
Free Cancellation
Reserve now, pay when you stay
4.48 mi from Santee National Wildlife Refuge
$80 nightly
The price is $89 total per night
$89 total
Mar 22 - Mar 23
Total with taxes and fees
At Baymont by Wyndham Santee, guests have access to free WiFi in public areas, coffee in a common area, and express check-in. You can put free parking to good use if you drive. The 24-hour front desk has multilingual staff ready to help with concierge services, and answer any questions about the area. Additional amenities include express check-out and a vending machine.
Breakfast included
Pet friendly
Don't see what you're looking for?
See all available properties in Santee National Wildlife Refuge
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Santee National Wildlife Refuge hotels essential information
Accommodation | 381 hotels |
|---|---|
Lowest Price | $66 |
Highest Price | $176 |
Popular hotels | Baymont by Wyndham Santee, Tru By Hilton Santee, Best Western Plus Santee Inn, Hampton Inn Santee-I-95, Fairfield Inn & Suites by Marriott Santee, Lakefront tiny cabin amazing view on Lake Marion! Pet friendly & sleeps 6 , Lake Marion in South Carolina., Holiday Inn Santee by IHG, Quality Inn & Suites Santee I-95 |
Recent Reviews

Tru By Hilton Santee
5/5 Excellent
"Great place to stay! Bed was comfortable room was very clean. We were able to bring our dog with us and we slept like babies. I would recommend this hotel."
A verified traveler stayed at Tru By Hilton Santee
Posted 16 hours ago
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