Business Hotels in Santee, SC
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Featured Santee Business Hotels

Hampton Inn Santee-I-95
9060 Old Number Six Hwy Santee SC
Free Cancellation
Reserve now, pay when you stay
$112 nightly
The price is $124 total per night
$124 total
Dec 23 - Dec 24
Total with taxes and fees
At Hampton Inn Santee-I-95, guests have access to a 24-hour gym, free WiFi in public areas, and conference space. If you drive, put free parking to good use. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include a 24-hour business center, a seasonal outdoor pool, and free newspapers.

Econo Lodge
9112 Old 6 Highway Santee SC
Free Cancellation
Reserve now, pay when you stay
$63 nightly
The price is $70 total per night
$70 total
Jan 7 - Jan 8, 2026
Total with taxes and fees
Econo Lodge Santee features free WiFi in public areas and barbecue grills. There's free parking if you drive. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. This hotel also has a garden.
Pet friendly
Parking included

Best Western Plus Santee Inn
I 95 Exit 98 Santee SC
Free Cancellation
Reserve now, pay when you stay
$118 nightly
The price is $131 total per night
$131 total
Dec 22 - Dec 23
Total with taxes and fees
Guests staying at Best Western Plus Santee Inn enjoy an outdoor pool, a gym, and free WiFi in public areas. If you drive, put free parking to good use. The 24-hour front desk has staff always at the ready. If you like to take your furry friend along on your adventures, this pet-friendly property offers an off-leash area. Additional amenities include conference space, a business center, and free newspapers.

Comfort Inn & Suites Santee
221 Britain St Santee SC
Free Cancellation
Reserve now, pay when you stay
$104 nightly
The price is $116 total per night
$116 total
Dec 16 - Dec 17
Total with taxes and fees
Renovated in 2023, Comfort Inn & Suites Santee offers a gym, free WiFi in public areas, and a business center. You can put free parking to good use if you drive. The 24-hour front desk has multilingual staff ready to help secure valuables, and answer any questions about the area. Additional amenities include a seasonal outdoor pool, coffee/tea in a common area, and a computer station.

Holiday Inn Santee by IHG
139 Bradford Blvd Santee SC
Free Cancellation
$104 nightly
The price is $115 total per night
$115 total
Dec 21 - Dec 22
Total with taxes and fees
At Holiday Inn Santee by IHG, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. Free parking is available if you drive. The 24-hour front desk has staff standing by to help with luggage storage and securing valuables. Other amenities at this golf hotel include meeting rooms, conference space, and a business center.

Baymont by Wyndham Santee
249 Britain Street Santee SC
Free Cancellation
Reserve now, pay when you stay
$80 nightly
The price is $89 total per night
$89 total
Dec 16 - Dec 17
Total with taxes and fees
At Baymont by Wyndham Santee, guests have access to free WiFi in public areas, coffee in a common area, and express check-in. You can put free parking to good use if you drive. The 24-hour front desk has multilingual staff ready to help with concierge services, and answer any questions about the area. Additional amenities include express check-out and a vending machine.

Travelodge by Wyndham Santee
9117 Old Number Six Hwy Santee SC
Free Cancellation
Reserve now, pay when you stay
$61 nightly
The price is $68 total per night
$68 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
Travelodge by Wyndham Santee features free WiFi in public areas, a business center, and coffee in a common area. Free parking is available if you drive. The 24-hour front desk has staff standing by to help with securing valuables and tours/tickets. Additional amenities include an ATM and a vending machine.

Super 8 by Wyndham Santee
9125 Old Highway 6 Santee SC
Free Cancellation
Reserve now, pay when you stay
$70 nightly
The price is $78 total per night
$78 total
Dec 16 - Dec 17
Total with taxes and fees
Guests of Super 8 by Wyndham Santee enjoy access to free WiFi in public areas, meeting rooms, and a business center. You can take advantage of free parking if you drive. The 24-hour front desk has staff standing by to help with dry cleaning or laundry, and answer any questions about the accommodations. Other amenities at this golf motel include a seasonal outdoor pool, express check-in, and express check-out.

Ramada by Wyndham Santee I-95
123 Mall Street Santee SC
Free Cancellation
Reserve now, pay when you stay
$73 nightly
The price is $81 total per night
$81 total
Jan 10 - Jan 11, 2026
Total with taxes and fees
Guests of Ramada by Wyndham Santee I-95 have access to an outdoor pool, a 24-hour gym, and free WiFi in public areas. There's free parking, and an airport shuttle (available 24 hours) for USD 80 per room roundtrip. The 24-hour front desk has staff always at the ready. Other amenities at this golf hotel include meeting rooms, a conference center, and a 24-hour business center.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Santee hotels essential information
Accommodation | 306 hotels |
|---|---|
Lowest Price | $68 |
Highest Price | $131 |
Popular hotels | Hampton Inn Santee-I-95, Econo Lodge, Best Western Plus Santee Inn, Comfort Inn & Suites Santee, Holiday Inn Santee by IHG, Baymont by Wyndham Santee, Travelodge by Wyndham Santee, Super 8 by Wyndham Santee, Ramada by Wyndham Santee I-95 |
Recent Business Hotels Reviews

Fairfield Inn & Suites by Marriott Santee
5/5 Excellent
"Everything was great"
A verified traveler stayed at Fairfield Inn & Suites by Marriott Santee
Posted 3 days ago
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