Hotels in Santee

Search over 308 hotels from $66

Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels

Save 10% or more on select hotels with Insider Prices

Book on the app to instantly earn 5% on 350,000+ hotels

May 10 - May 11
Tonight
Check prices in Santee for tonight, May 10 - May 11
May 11 - May 12
Tomorrow night
Check prices in Santee for tomorrow night, May 11 - May 12

Top Rated Santee Hotels

Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
Free Cancellation
Reserve now, pay when you stay
0.26 mi from city center
$75 nightly
The price is $83 total per night
$83 total
May 12 - May 13
Total with taxes and fees
At Baymont by Wyndham Santee, guests have access to free WiFi in public areas, coffee in a common area, and express check-in. You can put free parking to good use if you drive. The 24-hour front desk has multilingual staff ready to help with concierge services, and answer any questions about the area. Additional amenities include express check-out and a vending machine.
Breakfast included
Pet friendly
Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St. Santee SC
Free Cancellation
Reserve now, pay when you stay
0.27 mi from city center
$106 nightly
The price is $118 total per night
$118 total
May 27 - May 28
Total with taxes and fees
At Tru By Hilton Santee, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. If you drive, put free parking to good use. The 24-hour front desk has staff always at the ready. This hotel also has a 24-hour business center.
Pool
Breakfast included
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 out of 5
221 Britain St Santee SC
Free Cancellation
0.17 mi from city center
$113 nightly
The price is $126 total per night
$126 total
May 31 - Jun 1
Total with taxes and fees
Renovated in 2023, Comfort Inn & Suites Santee offers a gym, free WiFi in public areas, and a business center. You can put free parking to good use if you drive. The 24-hour front desk has multilingual staff ready to help secure valuables, and answer any questions about the area. Additional amenities include a seasonal outdoor pool, coffee/tea in a common area, and a computer station.
Pool
Breakfast included
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

2.5 out of 5
9060 Old Number Six Hwy Santee SC
Free Cancellation
Reserve now, pay when you stay
0.59 mi from city center
$119 nightly
The price is $132 total per night
$132 total
May 25 - May 26
Total with taxes and fees
At Hampton Inn Santee-I-95, guests have access to a 24-hour gym, free WiFi in public areas, and conference space. If you drive, put free parking to good use. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include a 24-hour business center, a seasonal outdoor pool, and free newspapers.
Pool
Breakfast included
Best Western Plus Santee Inn

Best Western Plus Santee Inn

2.5 out of 5
I 95 Exit 98 Santee SC
Free Cancellation
Reserve now, pay when you stay
0.56 mi from city center
$118 nightly
The price is $131 total per night
$131 total
May 18 - May 19
Total with taxes and fees
Guests staying at Best Western Plus Santee Inn enjoy an outdoor pool, a gym, and free WiFi in public areas. If you drive, put free parking to good use. The 24-hour front desk has staff always at the ready. If you like to take your furry friend along on your adventures, this pet-friendly property offers an off-leash area. Additional amenities include conference space, a business center, and free newspapers.
Pool
Breakfast included
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

3 out of 5
9074 Old Number Six Hwy Santee SC
Free Cancellation
Reserve now, pay when you stay
0.62 mi from city center
$134 nightly
The price is $149 total per night
$149 total
Jun 1 - Jun 2
Total with taxes and fees
Guests staying at Fairfield Inn & Suites by Marriott Santee enjoy an outdoor pool, a gym, and free WiFi in public areas. You can put free parking to good use if you drive. Front-desk staff can answer questions 24/7, and assist with dry cleaning/laundry, luggage storage, and securing valuables. If you like to take your furry friend along on your adventures, this pet-friendly property offers an off-leash area. Additional amenities include conference space, a business center, and coffee/tea in a common area.
Pool
Breakfast included
Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95

2.5 out of 5
8929 Old Number Six Highway Santee SC
Free Cancellation
0.14 mi from city center
$59 nightly
The price is $66 total per night
$66 total
May 31 - Jun 1
Total with taxes and fees
Quality Inn & Suites Santee I-95 features free WiFi in public areas, a seasonal outdoor pool, and microwave in a common area. If you drive, put free parking to good use. The 24-hour front desk has multilingual staff ready to assist with sightseeing, directions, and local dining recommendations. Additional amenities include a refrigerator in a common area, a computer station, and laundry facilities.
Pool
Breakfast included
Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

2 out of 5
9117 Old Number Six Hwy Santee SC
Free Cancellation
Reserve now, pay when you stay
0.73 mi from city center
$63 nightly
The price is $70 total per night
$70 total
May 11 - May 12
Total with taxes and fees
Travelodge by Wyndham Santee features free WiFi in public areas, a business center, and coffee in a common area. Free parking is available if you drive. The 24-hour front desk has staff standing by to help with securing valuables and tours/tickets. Additional amenities include an ATM and a vending machine.
Breakfast included
Pet friendly
Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

3 out of 5
139 Bradford Blvd Santee SC
Free Cancellation
0.17 mi from city center
$122 nightly
The price is $135 total per night
$135 total
May 25 - May 26
Total with taxes and fees
At Holiday Inn Santee by IHG, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. Free parking is available if you drive. The 24-hour front desk has staff standing by to help with securing valuables and luggage storage. Other amenities at this golf hotel include meeting rooms, conference space, and a business center.
Pool
Pet friendly
Super 8 by Wyndham Santee

Super 8 by Wyndham Santee

2 out of 5
9125 Old Highway 6 Santee SC
Free Cancellation
Reserve now, pay when you stay
0.78 mi from city center
$64 nightly
The price is $71 total per night
$71 total
May 17 - May 18
Total with taxes and fees
Guests of Super 8 by Wyndham Santee enjoy access to free WiFi in public areas, meeting rooms, and a business center. You can take advantage of free parking if you drive. The 24-hour front desk has staff standing by to help with dry cleaning or laundry, and answer any questions about the accommodations. Other amenities at this golf motel include a seasonal outdoor pool, express check-in, and express check-out.
Pool
Breakfast included
Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95

2 out of 5
123 Mall Street Santee SC
Free Cancellation
Reserve now, pay when you stay
0.45 mi from city center
$75 nightly
The price is $83 total per night
$83 total
May 18 - May 19
Total with taxes and fees
Ramada by Wyndham Santee I-95 features a nightclub, karaoke, and an outdoor pool. There's free parking, and an airport shuttle (available 24 hours) for USD 80 per room roundtrip. The front desk is staffed 24/7 to help with dry cleaning or laundry, and answer any questions about the accommodations. Other amenities at this golf hotel include a 24-hour gym, free WiFi in public areas, and meeting rooms.
Pool
Pet friendly
Red Roof Inn Santee

Red Roof Inn Santee

2 out of 5
9091 Old Hwy 6 Santee SC
Free Cancellation
Reserve now, pay when you stay
0.17 mi from city center
$63 nightly
The price is $70 total per night
$70 total
May 13 - May 14
Total with taxes and fees
Red Roof Inn Santee features free WiFi in public areas, coffee in a common area, and express check-out. If you drive, put free parking to good use. The front desk is staffed 24/7 to help secure valuables, and answer any questions about the accommodations. This hotel also has a vending machine.
Breakfast included
Pet friendly
Don't see what you're looking for?
See all available properties in Santee
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap Santee hotels options

    Baymont by Wyndham Santee

    Baymont by Wyndham Santee

    249 Britain Street Santee SC
    $75 nightly
    The price is $83 total per night from May 12 to May 13
    $83 total
    May 12 - May 13
    Total with taxes and fees
    8/10 Very Good! (1,466 reviews)
    Red Roof Inn Santee

    Red Roof Inn Santee

    9091 Old Hwy 6 Santee SC
    $63 nightly
    The price is $70 total per night from May 13 to May 14
    $70 total
    May 13 - May 14
    Total with taxes and fees
    6.6/10 (654 reviews)
    Travelodge by Wyndham Santee

    Travelodge by Wyndham Santee

    9117 Old Number Six Hwy Santee SC
    $63 nightly
    The price is $70 total per night from May 11 to May 12
    $70 total
    May 11 - May 12
    Total with taxes and fees
    7.2/10 Good! (728 reviews)
    Super 8 by Wyndham Santee

    Super 8 by Wyndham Santee

    9125 Old Highway 6 Santee SC
    $64 nightly
    The price is $71 total per night from May 17 to May 18
    $71 total
    May 17 - May 18
    Total with taxes and fees
    6.8/10 (459 reviews)
    Econo Lodge Santee

    Econo Lodge Santee

    9112 Old 6 Highway Santee SC
    $76 nightly
    The price is $84 total per night from May 24 to May 25
    $84 total
    May 24 - May 25
    Total with taxes and fees
    6.4/10 (314 reviews)
    Comfort Inn & Suites Santee

    Comfort Inn & Suites Santee

    221 Britain St Santee SC
    $113 nightly
    The price is $126 total per night from May 31 to Jun 1
    $126 total
    May 31 - Jun 1
    Total with taxes and fees
    8/10 Very Good! (1,012 reviews)

Where is a good place to stay in Santee?

What are the best family-friendly hotels in Santee?

Check out these hotels for your family's stay in Santee. Comfort Inn & Suites Santee is a hotel offering free parking, free buffet breakfast, and laundry facilities. You and your family can also consider Fairfield Inn & Suites by Marriott Santee, a hotel offering an outdoor pool, free parking, and free breakfast.

What are the best hotels in central Santee?

Here are some of the most popular hotels in the center of Santee:

While you're enjoying local activities like golfing, take some time to check out the restaurants in family-friendly Santee. Close to central Santee, you'll find interesting places to visit like Santee Cooper Country Club.

What are some of the best hotels near Santee State Park?

Get some fresh air at this natural setting, which is 2.7 mi from the heart of Santee. You'll find 20 hotels within 5 miles of Santee State Park, giving you plenty of options to choose from including:

Santee hotels essential information

Accommodation
308 hotels
Lowest Price
$66
Highest Price
$149
Popular hotels
Baymont by Wyndham Santee, Tru By Hilton Santee, Comfort Inn & Suites Santee, Hampton Inn Santee-I-95, Best Western Plus Santee Inn, Fairfield Inn & Suites by Marriott Santee, Quality Inn & Suites Santee I-95, Travelodge by Wyndham Santee, Holiday Inn Santee by IHG, Super 8 by Wyndham Santee, Ramada by Wyndham Santee I-95, Red Roof Inn Santee

Recent Reviews

Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

1/5 Terrible
"The room was outdated and there was construction going on outside of our room first thing in the am. The windows were covered with plastic. And the pool was closed even though it was noted it was open and available to use. Thankfully the holiday Inn next door allowed the kids to swim there for a bit to blow off some pent up energy from the long travel. Beds were rock hard."
A verified traveler stayed at Comfort Inn & Suites Santee
Posted 4 hours ago
Comfort Inn & Suites Santee

More to Explore