Business Hotels in Orangeburg, SC
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Featured Orangeburg Business Hotels

Baymont by Wyndham Orangeburg North
3583 Saint Matthews Rd, Orangeburg, SC
Free Cancellation
Reserve now, pay when you stay
$65 nightly
The price is $72 total per night
$72 total
Jul 14 - Jul 15
Total includes taxes and fees
Guests of Baymont by Wyndham Orangeburg North enjoy access to free WiFi in public areas, a business center, and a seasonal outdoor pool. A stay here includes free parking. The front desk is staffed 24/7 to help secure valuables, and answer any questions about the accommodations. Other amenities at this adults-only hotel include coffee/tea in a common area, express check-out, and laundry facilities.
Pool
Breakfast included

Hampton Inn Santee-I-95
9060 Old Number Six Hwy, Santee, SC
Free Cancellation
Reserve now, pay when you stay
$132 nightly
The price is $147 total per night
$147 total
Jul 20 - Jul 21
Total includes taxes and fees
At Hampton Inn Santee-I-95, guests have access to a 24-hour gym, free WiFi in public areas, and conference space. If you drive, put free parking to good use. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include a 24-hour business center, a seasonal outdoor pool, and free newspapers.
Pool
Breakfast included

Spark by Hilton Orangeburg
731 Citadel Road, Orangeburg, SC
Free Cancellation
Reserve now, pay when you stay
$93 nightly
The price is $103 total per night
$103 total
Jul 20 - Jul 21
Total includes taxes and fees
Renovated in 2025, Spark by Hilton Orangeburg offers a gym, free WiFi in public areas, and a seasonal outdoor pool. If you drive, take advantage of free parking. Front-desk staff are standing by 24/7 to assist with any requests. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include coffee/tea in a common area, a meeting room, and express check-out.
Pool
Breakfast included

Hampton Inn & Suites Orangeburg
749 Citadel Road, Orangeburg, SC
Free Cancellation
Reserve now, pay when you stay
$135 nightly
The price is $150 total per night
$150 total
Aug 3 - Aug 4
Total includes taxes and fees
Guests of Hampton Inn & Suites Orangeburg have access to an outdoor pool, a gym, and free WiFi in public areas. If you decide to drive, there's free parking. The 24-hour front desk has staff standing by to help with dry cleaning/laundry, securing valuables, and luggage storage. Additional amenities include a business center, coffee/tea in a common area, and express check-in.

Econo Lodge
9112 Old 6 Highway, Santee, SC
Free Cancellation
Reserve now, pay when you stay
$60 nightly
The price is $67 total per night
$67 total
Aug 10 - Aug 11
Total includes taxes and fees
Econo Lodge features free WiFi in public areas and a garden. There's free parking if you drive. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. This hotel also has barbecue grills.
Pet friendly
Parking included

Southern Lodge
3616 Saint Matthews Rd, Orangeburg, SC
Southern Lodge features free WiFi in public areas, a business center, and coffee in a common area. You can take advantage of free parking if you drive. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include laundry facilities and a TV in a common area.
Breakfast included
Parking included

Super 8 by Wyndham, Orangeburg
3608 Saint Matthews Rd, Orangeburg, SC
Free Cancellation
Reserve now, pay when you stay
$58 nightly
The price is $64 total per night
$64 total
Jul 14 - Jul 15
Total includes taxes and fees
Super 8 by Wyndham, Orangeburg features free WiFi in public areas, a business center, and coffee in a common area. If you drive, put free parking to good use. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include laundry facilities, a TV in a common area, and a vending machine.

Best Western Plus Santee Inn
I 95 Exit 98, Santee, SC
Free Cancellation
Reserve now, pay when you stay
$115 nightly
The price is $127 total per night
$127 total
Jul 20 - Jul 21
Total includes taxes and fees
Guests staying at Best Western Plus Santee Inn enjoy an outdoor pool, a gym, and free WiFi in public areas. If you drive, put free parking to good use. The 24-hour front desk has staff always at the ready. If you like to take your furry friend along on your adventures, this pet-friendly property offers an off-leash area. Additional amenities include conference space, a business center, and free newspapers.
Pool
Breakfast included

Comfort Inn & Suites
746 Citadel Rd, Orangeburg, SC
Free Cancellation
Reserve now, pay when you stay
$110 nightly
The price is $122 total per night
$122 total
Aug 3 - Aug 4
Total includes taxes and fees
At Comfort Inn & Suites, guests enjoy an indoor pool, a gym, and free WiFi in public areas. If you decide to drive, there's free parking. The front desk is staffed 24/7 to help with tours or tickets, securing valuables, and dry cleaning/laundry. Additional amenities include a business center, a meeting room, and express check-out.
Pool
Breakfast included

Comfort Inn & Suites Santee
221 Britain St, Santee, SC
Free Cancellation
Reserve now, pay when you stay
$110 nightly
The price is $122 total per night
$122 total
Jul 20 - Jul 21
Total includes taxes and fees
Renovated in 2023, Comfort Inn & Suites Santee offers a gym, free WiFi in public areas, and a business center. You can put free parking to good use if you drive. The 24-hour front desk has multilingual staff ready to help secure valuables, and answer any questions about the area. Additional amenities include a seasonal outdoor pool, coffee/tea in a common area, and a computer station.
Pool
Breakfast included

Days Inn by Wyndham Orangeburg
3691 Saint Matthews Rd, Orangeburg, SC
Free Cancellation
Reserve now, pay when you stay
$46 nightly
The price is $52 total per night
$52 total
Aug 8 - Aug 9
Total includes taxes and fees
Guests of Days Inn by Wyndham Orangeburg enjoy free WiFi in public areas, a business center, and express check-out. You can put free parking to good use if you drive. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include laundry facilities and a vending machine.
Breakfast included
Pet friendly

Fairfield Inn by Marriott Orangeburg
663 Citadel Road, Orangeburg, SC
Free Cancellation
Reserve now, pay when you stay
$93 nightly
The price is $103 total per night
$103 total
Aug 7 - Aug 8
Total includes taxes and fees
At Fairfield Inn by Marriott Orangeburg, guests have access to a gym, free WiFi in public areas, and a 24-hour business center. A stay here includes free parking. The 24-hour front desk has staff standing by to help with securing valuables and dry cleaning/laundry. Additional amenities include a seasonal outdoor pool, coffee/tea in a common area, and express check-in.

Holiday Inn Express & Suites Orangeburg by IHG
118 Sleep Inn Road, Orangeburg, SC
Free Cancellation
$111 nightly
The price is $123 total per night
$123 total
Aug 10 - Aug 11
Total includes taxes and fees
At Holiday Inn Express & Suites Orangeburg by IHG, guests have access to a 24-hour gym, free WiFi in public areas, and a 24-hour business center. If you drive, take advantage of free parking. The front desk is staffed 24/7 to help with securing valuables, dry cleaning/laundry, and luggage storage. Additional amenities include a seasonal outdoor pool, coffee/tea in a common area, and express check-out.
Pool
Breakfast included

Holiday Inn Santee by IHG
139 Bradford Blvd, Santee, SC
Free Cancellation
$111 nightly
The price is $123 total per night
$123 total
Aug 3 - Aug 4
Total includes taxes and fees
At Holiday Inn Santee by IHG, guests enjoy an indoor pool, a gym, and free WiFi in public areas. Free parking is available if you drive. The 24-hour front desk has staff standing by to help with luggage storage and securing valuables. Other amenities at this golf hotel include meeting rooms, conference space, and a business center.
Pool
Pet friendly

Baymont by Wyndham Santee
249 Britain Street, Santee, SC
Free Cancellation
Reserve now, pay when you stay
$75 nightly
The price is $83 total per night
$83 total
Jul 14 - Jul 15
Total includes taxes and fees
At Baymont by Wyndham Santee, guests have access to free WiFi in public areas, coffee in a common area, and express check-in. You can put free parking to good use if you drive. The 24-hour front desk has multilingual staff ready to help with concierge services, and answer any questions about the area. Additional amenities include express check-out and a vending machine.
Breakfast included
Pet friendly
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Orangeburg hotels essential information
Accommodation | 234 hotels |
---|---|
Lowest Price | $52 |
Highest Price | $150 |
Popular hotels | Baymont by Wyndham Orangeburg North, Hampton Inn Santee-I-95, Spark by Hilton Orangeburg, Hampton Inn & Suites Orangeburg, Econo Lodge, Southern Lodge, Super 8 by Wyndham, Orangeburg, Best Western Plus Santee Inn, Comfort Inn & Suites, Comfort Inn & Suites Santee, Days Inn by Wyndham Orangeburg, Fairfield Inn by Marriott Orangeburg, Holiday Inn Express & Suites Orangeburg by IHG, Holiday Inn Santee by IHG, Baymont by Wyndham Santee |
Recent Business Hotels Reviews

Travelodge by Wyndham Orangeburg
5/5 Excellent
"This place is very clean and very affordable "
A verified traveler stayed at Travelodge by Wyndham Orangeburg
Posted 3 days ago
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