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Featured Byron 2 Stars Hotels

Aspen Suites
1211 2nd Street Rochester MN
Free Cancellation
Reserve now, pay when you stay
8.16 mi from city center
$152 nightly
The price is $175 total per night
$175 total
Dec 28 - Dec 29
Total with taxes and fees
Guests of Aspen Suites have access to an indoor pool, a gym, and free WiFi in public areas. There's free parking and a free area shuttle. The front desk is staffed 24/7 to help with dry cleaning/laundry, securing valuables, and concierge services. Additional amenities include a hot tub, a 24-hour business center, and coffee/tea in a common area.
Pool
Hot Tub

EVEN Hotel Rochester - Mayo Clinic Area by IHG
101 11TH Avenue SW Rochester MN
Free Cancellation
8.29 mi from city center
$99 nightly
The price is $114 total per night
$114 total
Dec 28 - Dec 29
Total with taxes and fees
At EVEN Hotel Rochester - Mayo Clinic Area by IHG, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. Self parking is offered for USD 20 per night. The 24-hour front desk has multilingual staff ready to assist with dry cleaning/laundry and securing valuables. Additional amenities include a hot tub, conference space, and a 24-hour business center.
Pool
Hot Tub

Kahler Inn and Suites - Mayo Clinic Area
9 3rd Ave Nw Rochester MN
Free Cancellation
Reserve now, pay when you stay
8.84 mi from city center
$155 nightly
The price is $178 total per night
$178 total
Dec 28 - Dec 29
Total with taxes and fees
Guests staying at Kahler Inn and Suites - Mayo Clinic Area enjoy an indoor pool, a gym, and free WiFi in public areas. Self parking is offered for USD 15 per night. The 24-hour front desk has staff always at the ready. Additional amenities include laundry facilities, a TV in a common area, and a water dispenser.
Pool
Breakfast included

Hyatt House Rochester/Mayo Clinic Area
110 Civic Center Drive NW Rochester MN
Free Cancellation
Reserve now, pay when you stay
8.96 mi from city center
$129 nightly
The price is $149 total per night
$149 total
Dec 28 - Dec 29
Total with taxes and fees
Guests staying at Hyatt House Rochester/Mayo Clinic Area enjoy an indoor pool, a gym, and free WiFi in public areas. If you drive, self parking is USD 16 per day, and there's also a free area shuttle. The front desk is staffed 24/7 to help with luggage storage, dry cleaning/laundry, and securing valuables. Additional amenities include a hot tub, conference space, and a 24-hour business center.
Pool
Hot Tub

Kahler Grand Hotel
20 2nd Ave Sw Rochester MN
Free Cancellation
Reserve now, pay when you stay
8.95 mi from city center
$149 nightly
The price is $172 total per night
$172 total
Dec 28 - Dec 29
Total with taxes and fees
At Kahler Grand Hotel, guests enjoy features like an indoor pool, a 24-hour gym, and a sauna. Valet parking is offered for USD 30.00 per day. The front desk has multilingual staff on hand 24/7 to help with luggage storage, dry cleaning/laundry, and securing valuables. Additional amenities include free WiFi in public areas, a hot tub, and meeting rooms.
Pool
Hot Tub

Hampton Inn Rochester-South
1755 S Broadway Rochester MN
Free Cancellation
Reserve now, pay when you stay
9.35 mi from city center
$81 nightly
The price is $93 total per night
$93 total
Jan 24 - Jan 25, 2026
Total with taxes and fees
Guests of Hampton Inn Rochester-South have access to an indoor pool, a 24-hour gym, and free WiFi in public areas. You can take advantage of free parking, along with a free area shuttle. The front desk is staffed 24/7 to help with dry cleaning/laundry, concierge services, and luggage storage. Additional amenities include a hot tub, a 24-hour business center, and coffee/tea in a common area.
Pool
Hot Tub

Hotel Indigo Rochester – Mayo Clinic Area by IHG
220 S Broadway Rochester MN
Free Cancellation
9.11 mi from city center
$77 nightly
The price is $89 total per night
$89 total
Jan 24 - Jan 25, 2026
Total with taxes and fees
Hotel Indigo Rochester – Mayo Clinic Area by IHG offers a gym, a rooftop terrace, and free WiFi in public areas. Self parking is available for USD 16.00 per night. Front-desk staff can answer questions 24/7, and assist with luggage storage, securing valuables, and dry cleaning/laundry. Additional amenities include meeting rooms, conference space, and a 24-hour business center.
Pet friendly
Free WiFi

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
4353 Canal Pl SE Rochester MN
Free Cancellation
Reserve now, pay when you stay
10.43 mi from city center
$71 nightly
The price is $82 total per night
$82 total
Dec 28 - Dec 29
Total with taxes and fees
At La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S, guests have access to a gym, free WiFi in public areas, and meeting rooms. There's free parking if you drive. The front desk is staffed 24 hours a day to help with luggage storage and securing valuables. Additional amenities include conference space, a 24-hour business center, and coffee/tea in a common area.
Pool
Breakfast included

Spark by Hilton Rochester South
4165 Maine Ave SE Rochester MN
Free Cancellation
Reserve now, pay when you stay
10.65 mi from city center
$71 nightly
The price is $81 total per night
$81 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Guests staying at Spark by Hilton Rochester South enjoy an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking, along with a free area shuttle. The 24-hour front desk has staff standing by to help with luggage storage, securing valuables, and dry cleaning/laundry. Additional amenities include conference space, a 24-hour business center, and coffee/tea in a common area.
Pool
Breakfast included
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Byron hotels essential information
Accommodation | 391 hotels |
|---|---|
Lowest Price | $81 |
Highest Price | $178 |
Popular hotels | Kahler Grand Hotel, Kahler Inn and Suites - Mayo Clinic Area, Hampton Inn Rochester-South, Spark by Hilton Rochester South, Hotel Indigo Rochester – Mayo Clinic Area by IHG, Hyatt House Rochester/Mayo Clinic Area, La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S, EVEN Hotel Rochester - Mayo Clinic Area by IHG, Aspen Suites |
Recent Reviews

Hotel Indigo Rochester – Mayo Clinic Area by IHG
5/5 Excellent
"The room was perfect clean and absolutely perfect "
A verified traveler stayed at Hotel Indigo Rochester – Mayo Clinic Area by IHG
Posted 17 hours ago
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