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21C Museum Hotel St Louis

4.5 star property

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Photo gallery for 21C Museum Hotel St Louis

Restaurant
Massages
Exterior
Bar (on property)
Exterior

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Pet friendly
  • Free WiFi
  • Air conditioning

Explore the area

View in a map
1528 Locust street, St. Louis, MO, 63103
  • Place, City Museum
    ‪5 min walk‬
  • Place, St. Louis Union Station
    ‪8 min walk‬
  • Place, Enterprise Center
    ‪8 min walk‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪20 min drive‬

Room options

View all photos for Deluxe Room, 1 King Bed

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(108 reviews)
  • 309 sq ft
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout drapes

Luxury Double Room, 2 Queen Beds

9.4 out of 10
Exceptional
(34 reviews)
  • 423 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room (Bunk Bed)

Room (Bunk Bed) | In-room safe, desk, laptop workspace, blackout drapes

Room (Bunk Bed)

8.4 out of 10
Very good
(7 reviews)
  • 237 sq ft
  • Sleeps 2
  • 1 Twin Bunk Bed

View all photos for Loft, 2 Queen Beds

Loft, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout drapes

Loft, 2 Queen Beds

8.0 out of 10
Very good
(1 review)
  • 431 sq ft
  • Sleeps 4
  • 2 Queen Beds

View all photos for Deluxe Room, Accessible (Accessible)

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, Accessible (Accessible)

10.0 out of 10
Exceptional
(1 review)
  • 269 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed (21C)

  • 1119 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed (Library)

  • City view
  • 732 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Suite, 1 King Bed

A hotel room with a large bed, a green sofa, a small round table, and a large abstract painting on the wall.

Luxury Suite, 1 King Bed

10.0 out of 10
Exceptional
(2 reviews)
  • 549 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible | In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, 1 Double Bed, Accessible

  • 388 sq ft
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Suite, 1 Double Bed, Accessible

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Suite, 1 Double Bed, Accessible

  • 517 sq ft
  • Sleeps 2
  • 1 Double Bed

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About the neighborhood

St. Louis

Located in Downtown West, 21C Museum Hotel St Louis is within a 10-minute walk of popular sights such as St. Louis Union Station and City Museum. This 4.5-star hotel welcomes guests with 104 rooms and conveniences like an indoor pool, free in-room WiFi, and a gym.

What's nearby

  • Washington Avenue Historic District - 2 min walk - 0.1 miles
  • City Museum - 5 min walk - 0.3 miles
  • St. Louis Union Station - 8 min walk - 0.4 miles
  • Enterprise Center - 8 min walk - 0.5 miles
  • St. Louis Aquarium at Union Station - 11 min walk - 0.6 miles

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • St. Louis Lambert Intl. Airport (STL) - 24 min drive

Restaurants

  • ‪Budweiser Kiel Club - ‬6 min walk
  • ‪Imo's Pizza Headquarters & Retail Store - ‬7 min walk
  • ‪City Museum Rooftop Cafe - ‬5 min walk
  • ‪Rosalita's Cantina - ‬6 min walk
  • ‪Blood & Sand - ‬2 min walk

About this property

21C Museum Hotel St Louis

Guests of 21C Museum Hotel St Louis have access to an indoor pool, a gym, and a steam room. Valet parking is offered for USD 50 per day. The front desk is staffed 24/7 to help with dry cleaning/laundry, luggage storage, and concierge services. Other amenities at this luxury hotel include free WiFi in public areas, meeting rooms, and a business center.
Guests can expect free WiFi and flat-screen TVs with cable channels. Bathrooms offer hair dryers, free toiletries, and bathrobes. Espresso makers, safes, and phones are also available. Change of towels is available on request.
Recreational amenities at the hotel include an indoor pool, a steam room, and a fitness center.
Guests can pamper themselves by indulging in the onsite spa services. Services include massages.

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May 25 - May 26
Total with taxes and fees
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Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business center
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM

Late check-in subject to availability

Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • This property welcomes pets for USD 100 per accommodation, per stay
  • Dogs only
  • Service animals exempt from fees

Property payment types

Important information

Fees

  • Service fee: USD 5 per accommodation, per stay

These are all of the charges provided to us by the property.

Optional extras

These fees and deposits will be charged at check-in, check-out, or the time of service.

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

This list may not be comprehensive. Fees and deposits might not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a fire extinguisher, a smoke detector, and outdoor lighting
  • Check-in: 4:00 PM—-11:00 AM
  • Check-out: 11:00 AM
  • Minimum check-in age: 21
The front desk is open 24 hours a day. Driving? This property offers valet parking (fees apply).

We should mention

Details about charges, deposits, or other important information:

  • This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
  • Charges for extra guests may apply and vary depending on the property's policy.
  • A cash deposit, credit card, or debit card for incidental charges, as well as a government-issued photo ID, may be required at check-in.
  • Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
  • This property accepts credit cards. Cash is not accepted. 
  • Onsite safety features include a fire extinguisher, a smoke detector, and outdoor lighting.

Additional information about polices, regulations, and more:

  • Reservations need to be made in advance for massage services. Contact the hotel at the phone number listed on your booking confirmation.
  • No cribs or infant beds are available.
  • No rollaway or extra beds are available.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21C Museum Hotel St Louis

21c Museum St Louis St Louis

21C Museum Hotel St Louis Hotel

21C Museum Hotel St Louis St. Louis

21C Museum Hotel St Louis Hotel St. Louis

21C Museum Hotel St Louis (Opening Spring 2023)

Frequently asked questions

Is free cancellation available at 21C Museum Hotel St Louis ?

21C Museum Hotel St Louis offers free cancellation on select room rates. If you'd like to learn more, look at the cancellation policy on Orbitz.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of May 12, 2026, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on May 24, 2026 start from $165, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

What's there to do close to 21C Museum Hotel St Louis ?

This hotel is situated in Downtown West, just steps from City Museum, and within a 10-minute walk of St. Louis Union Station and Enterprise Center. You'll also find Busch Stadium and Dome at America’s Center less than a mile away.

Will I be able to park at 21C Museum Hotel St Louis ?

Yes, valet parking is offered for USD 50 per day with in/out privileges.

Is there a spa available at 21C Museum Hotel St Louis ?

Spa services at the hotel include massages.

Does 21C Museum Hotel St Louis have luxury amenities?

Yes, guests can indulge in luxuries such as an indoor pool, a restaurant, and massages at this hotel.

Does 21C Museum Hotel St Louis include a casino at the property?

No, 21C Museum Hotel St Louis doesn't have a casino.

Will I find an indoor pool at 21C Museum Hotel St Louis ?

Yes, this hotel has an indoor pool.

What amenities will couples enjoy at 21C Museum Hotel St Louis ?

There are plenty of amenities for couples at this hotel, including a restaurant, an indoor pool, and a bar/lounge.

Are there hot tubs at 21C Museum Hotel St Louis ?

No, but guests can enjoy a steam room at this hotel.

Does 21C Museum Hotel St Louis have a restaurant with a breakfast menu?

Yes, 21C Museum Hotel St Louis serves a cooked-to-order breakfast each morning for a surcharge from its restaurant.

Will 21C Museum Hotel St Louis allow pets to stay for free?

Although they can't stay for free, dogs are welcome at 21C Museum Hotel St Louis for a fee of USD 100 per accommodation, per stay.

Are there connecting rooms at 21C Museum Hotel St Louis ?

No, there aren't connecting guestrooms at this hotel.

What is the closest airport to 21C Museum Hotel St Louis ?

The closest major airport to 21C Museum Hotel St Louis is St. Louis Lambert Intl. Airport (STL), which is 18.4 mi away (24 minutes by car). Another top airport is St. Louis, MO (SUS-Spirit of St. Louis), which is located 25.8 mi away (32-minute drive).

Can I book a room with a balcony at 21C Museum Hotel St Louis ?

No, you won't find guestrooms with balconies at 21C Museum Hotel St Louis .

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 1288 out of 1828 reviews
Rating 8 - Good. 280 out of 1828 reviews
Rating 6 - Okay. 131 out of 1828 reviews
Rating 4 - Poor. 59 out of 1828 reviews
Rating 2 - Terrible. 70 out of 1828 reviews

9.2/10

Cleanliness

9.0/10

Staff & service

9.0/10

Amenities

9.2/10

Property conditions & facilities

Reviews

10/10 Excellent

Richard

Stayed 1 night in Feb 2026

10/10 Excellent

David

Stayed 1 night in Jan 2026

10/10 Excellent

Keely

Stayed 1 night in Feb 2026

10/10 Excellent

Michael

Traveled with partner
Liked: Cleanliness, amenities, property conditions & facilities
We loved this hotel. It is something you expect in much more sophisticated cities but not St. Louis. Our king bed suite was tastefully furnished and very large. Lots of great touches and very clean. The lobby and museum were stylish and exciting. We ate at both Idolwolf and the cafe. Again great ambiance and delicious food. Our visit was a one night staycation to celebrate our anniversary and it couldn’t have turned out better.
View of the bar on a Sunday morning
Stayed 1 night in Feb 2026

10/10 Excellent

Roger

Stayed 1 night in Feb 2026

10/10 Excellent

Diana

Liked: Cleanliness, property conditions & facilities
Room was clean stuff was friendly and everyone was super nice
Stayed 2 nights in Feb 2026

10/10 Excellent

Linda

Liked: Cleanliness, amenities, property conditions & facilities
Beautiful, unique hotel. Loved the esthetics and vibe of the entire building.
Stayed 1 night in Feb 2026

10/10 Excellent

Lauren

Stayed 1 night in Feb 2026

10/10 Excellent

Kimbriel

Traveled with partner
Liked: Cleanliness, amenities, property conditions & facilities
Everything was great i can’t wait to stay again
Stayed 2 nights in Jan 2026

8/10 Good

Kurt

Stayed 1 night in Jan 2026

2/10 Terrible

Lauren

Disliked: Cleanliness, staff & service, amenities
Dirty room and I’ll mannered management. Not worth the money I’d rather stay at motel 6.
Stayed 1 night in Jan 2026

10/10 Excellent

Luz

Stayed 1 night in Jan 2026

8/10 Good

Lindsey

Stayed 3 nights in Jan 2026

10/10 Excellent

Meredith

Business traveler
Liked: Cleanliness, amenities, property conditions & facilities
Hotel was very quiet and staff helpful and courteous. The coffee shop was great for coffee and breakfast and the rooms were clean with hot water and great water pressure. The only thing I would change was the mattress - bed was very firm, kind of felt like lying on a table. Gallery was a fun feature and next time I'm in STL I will be back!
Stayed 1 night in Jan 2026

10/10 Excellent

Brad

Stayed 1 night in Jan 2026

10/10 Excellent

Michelle

Liked: Cleanliness, staff & service, amenities
Everything was perfect!
Stayed 2 nights in Jan 2026

10/10 Excellent

Brad

Traveled with family
Liked: Cleanliness, staff & service, amenities
We did have a great stay but one thing bothered us. While at the bar Friday night, a customer approximately 25-30 years old allowed her dog to run loose through the hotel while she sat at the bar drinking. When a customer brought the dog to the young lady, she sat the dog on the bar. When bar staff explained the dog was not allowed, the female became belligerent, threatening to assault at least one bartender, calling bar staff profane names. Bar staff cut her drinks off and asked her to leave. The female began recording staff from her cell phone and creating a disturbance with other patrons. After about 30 minutes, management called police. Police showed up and between hotel management and police, they allowed her to go back to her room. I felt like management did not support staff and the female should have been told to leave.
Stayed 2 nights in Jan 2026

10/10 Excellent

anthony

Liked: Cleanliness, amenities, property conditions & facilities
Clean room and the hotel itself is just gorgeous.
Stayed 1 night in Jan 2026

2/10 Terrible

Lauren

Disliked: Cleanliness, staff & service, amenities
Room was dirty and not properly stocked. Staff were extremely rude aside from the nice guys working in the breakfast spot. Manager is classless will never stay here again.
Stayed 1 night in Jan 2026

10/10 Excellent

John, Cincinnati

Stayed 1 night in Jan 2026

10/10 Excellent

Andrew

Liked: Cleanliness, staff & service, amenities
Very nice and clean
Stayed 1 night in Jan 2026

10/10 Excellent

Jessica

Business traveler
Liked: Cleanliness, amenities, property conditions & facilities
Room was great.
Stayed 1 night in Nov 2025

4/10 Poor

ANGELA

Business traveler, Traveled with family
Liked: Cleanliness
Disliked: Staff & service, amenities
Front desk staff was rude No parking so had to use valet, then had to wait forever to get our car
Stayed 2 nights in Jan 2026

10/10 Excellent

Joel

Stayed 2 nights in Jan 2026

10/10 Excellent

angela

Stayed 3 nights in Jan 2026