Located in Downtown West, 21C Museum Hotel St Louis is within a 10-minute walk of popular sights such as City Museum and Enterprise Center. This 4.5-star hotel welcomes guests with 104 rooms and conveniences like an indoor pool, free in-room WiFi, and a gym.
What's nearby
St. Louis Union Station - 6 min walk - 0.4 miles
Enterprise Center - 6 min walk - 0.4 miles
City Museum - 6 min walk - 0.4 miles
Busch Stadium - 14 min walk - 0.8 miles
Gateway Arch - 2 min drive - 1.1 miles
Getting around
8th and Pine Station - 13 min walk
St. Louis Gateway Station - 14 min walk
St. Louis Lambert Intl. Airport (STL) - 26 min drive
Restaurants
Medina Grill - 5 min walk
City Museum Rooftop Cafe - 5 min walk
White Knight Diner - 4 min walk
Budweiser Kiel Club - 6 min walk
Idol Wolf - 1 min walk
About this property
21C Museum Hotel St Louis
Luxury hotel with a fitness center and a steam room
Guests of 21C Museum Hotel St Louis have access to an indoor pool, a gym, and a steam room. Valet parking is offered for USD 50 per day. The front desk is staffed 24/7 to help with dry cleaning/laundry, luggage storage, and concierge services. Other amenities at this luxury hotel include free WiFi in public areas, meeting rooms, and a business center.
Guests can expect free WiFi and flat-screen TVs with cable channels. Bathrooms offer hair dryers, free toiletries, and bathrobes. Espresso makers, safes, and phones are also available. Change of towels is available on request.
Recreational amenities at the hotel include an indoor pool, a steam room, and a fitness center.
Guests can pamper themselves by indulging in the onsite spa services. Services include massages.
Similar properties
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Valet parking on site (USD 50 per day; includes in/out privileges)
Food and drink
Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
A bar/lounge
A coffee shop/cafe
A restaurant
Things to do
Billiards/pool table
Gym
Indoor pool
Steam room
Family friendly
Indoor pool
Soundproofed rooms
Conveniences
24-hour front desk
ATM
Luggage storage
Vending machine
Guest services
Change of bedsheets (on request)
Change of towels on request
Concierge services
Dry cleaning/laundry service
Housekeeping (daily)
Business services
Business center
Meeting rooms
Spa
Massage
Spa services
Accessibility
If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21
Check-out
Check-out before 11:00 AM
Special check-in instructions
Front desk staff will greet guests on arrival at the property
Access methods
Staffed front desk
Pets
This property welcomes pets for USD 100 per accommodation, per stay
Dogs only
Service animals exempt from fees
Property payment types
Important information
Optional extras
These fees and deposits will be charged at check-in, check-out, or the time of service.
Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
Valet parking fee: USD 50 per day (in/out privileges)
Pet fee: USD 100 per accommodation, per stay
Service animals are exempt from fees
This list may not be comprehensive. Fees and deposits might not include tax and are subject to change.
You need to know
Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a smoke detector and outdoor lighting
Check-in: 4:00 PM—-11:00 AM
Check-out: 11:00 AM
Minimum check-in age: 21
The front desk is open 24 hours a day. Driving? This property offers valet parking (fees apply).
We should mention
Details about charges, deposits, or other important information:
This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
Charges for extra guests may apply and vary depending on the property's policy.
A cash deposit, credit card, or debit card for incidental charges, as well as a government-issued photo ID, may be required at check-in.
Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
This property accepts credit cards. Cash is not accepted.
Onsite safety features include a smoke detector and outdoor lighting.
Additional information about polices, regulations, and more:
Reservations need to be made in advance for massage services. Contact the hotel at the phone number listed on your booking confirmation.
No cribs or infant beds are available.
No rollaway or extra beds are available.
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).
Property is also known as
21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)
Frequently asked questions
Is free cancellation available at 21C Museum Hotel St Louis ?
21C Museum Hotel St Louis offers free cancellation on select room rates. If you'd like to learn more, look at the cancellation policy on Orbitz.
How much does it cost to stay at 21C Museum Hotel St Louis ?
As of Oct 23, 2025, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on Nov 2, 2025 start from $143.1, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.
What's there to do close to 21C Museum Hotel St Louis ?
This hotel is situated in Downtown West within a 10-minute walk of City Museum and Enterprise Center. You'll also find St. Louis Union Station and Busch Stadium less than a mile away.
Is there parking available at 21C Museum Hotel St Louis ?
Yes, valet parking is offered for USD 50 per day with in/out privileges.
Is there a spa available at 21C Museum Hotel St Louis ?
Spa services at the hotel include massages.
Does 21C Museum Hotel St Louis include a casino at the property?
No, 21C Museum Hotel St Louis doesn't have a casino.
Will I find an indoor pool at 21C Museum Hotel St Louis ?
Yes, this hotel has an indoor pool.
What amenities will couples enjoy at 21C Museum Hotel St Louis ?
There are plenty of amenities for couples at this hotel, including an indoor pool, a bar, and a restaurant.
Does 21C Museum Hotel St Louis have a hot tub?
No, but this hotel does have a steam room.
Does 21C Museum Hotel St Louis have a restaurant with a breakfast menu?
Yes, 21C Museum Hotel St Louis serves a cooked-to-order breakfast each morning for a surcharge from its restaurant.
Will 21C Museum Hotel St Louis allow pets to stay for free?
Although they can't stay for free, dogs are welcome at 21C Museum Hotel St Louis for a fee of USD 100 per accommodation, per stay.
Are there connecting rooms at 21C Museum Hotel St Louis ?
No, this hotel doesn't feature connecting guestrooms.
What is the closest airport to 21C Museum Hotel St Louis ?
The closest major airport to 21C Museum Hotel St Louis is St. Louis Lambert Intl. Airport (STL), which is 18.4 mi away (26 minutes by car). Another top airport is St. Louis, MO (SUS-Spirit of St. Louis), which is located 25.8 mi away (32-minute drive).
Are there rooms with balconies at 21C Museum Hotel St Louis ?
No, you won't find guestrooms with balconies at 21C Museum Hotel St Louis .