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21C Museum Hotel St Louis

4.5 star property
Luxury hotel with a fitness center and a steam room

Choose dates to view prices

Photo gallery for 21C Museum Hotel St Louis

Interior
Billiards
Exterior
Loft, 2 Queen Beds | 1 bedroom, in-room safe, desk, laptop workspace
Dining

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Bar

Explore the area

View in a map
1528 Locust street, St. Louis, MO, 63103
  • Place, St. Louis Union Station
    ‪6 min walk‬
  • Place, Enterprise Center
    ‪6 min walk‬
  • Place, City Museum
    ‪6 min walk‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪19 min drive‬

Room options

View all photos for Deluxe Room, 1 King Bed

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(77 reviews)
  • 309 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds | 1 bedroom, in-room safe, desk, laptop workspace

Luxury Double Room, 2 Queen Beds

9.2 out of 10
Wonderful
(23 reviews)
  • 423 sq ft
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room (Bunk Bed)

1 bedroom, in-room safe, desk, laptop workspace

Room (Bunk Bed)

8.0 out of 10
Very good
(6 reviews)
  • 237 sq ft
  • 1 bedroom
  • Sleeps 2
  • 1 Twin Bunk Bed

View all photos for Loft, 2 Queen Beds

1 bedroom, in-room safe, desk, laptop workspace

Loft, 2 Queen Beds

  • 431 sq ft
  • Sleeps 4
  • 2 Queen Beds

View all photos for Deluxe Room, Accessible (Accessible)

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Room, Accessible (Accessible)

  • 269 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C) | 1 bedroom, in-room safe, desk, laptop workspace

Suite, 1 King Bed (21C)

  • 1119 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library) | 1 bedroom, in-room safe, desk, laptop workspace

Suite, 1 King Bed (Library)

  • 732 sq ft
  • City view
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed | 1 bedroom, in-room safe, desk, laptop workspace

Luxury Suite, 1 King Bed

10.0 out of 10
Exceptional
(1 review)
  • 549 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible | 1 bedroom, in-room safe, desk, laptop workspace

Deluxe Room, 1 Double Bed, Accessible

  • 388 sq ft
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Suite, 1 Double Bed, Accessible

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Suite, 1 Double Bed, Accessible

  • 517 sq ft
  • Sleeps 2
  • 1 Double Bed

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About the neighborhood

St. Louis

Located in Downtown West, 21C Museum Hotel St Louis is within a 10-minute walk of popular sights such as City Museum and Enterprise Center. This 4.5-star hotel welcomes guests with 104 rooms and conveniences like an indoor pool, free in-room WiFi, and a gym.

What's nearby

  • St. Louis Union Station - 6 min walk - 0.4 miles
  • Enterprise Center - 6 min walk - 0.4 miles
  • City Museum - 6 min walk - 0.4 miles
  • America's Center Convention Complex - 12 min walk - 0.7 miles
  • Busch Stadium - 14 min walk - 0.8 miles

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • St. Louis Lambert Intl. Airport (STL) - 26 min drive

Restaurants

  • ‪Medina Grill - ‬5 min walk
  • ‪City Museum Rooftop Cafe - ‬5 min walk
  • ‪White Knight Diner - ‬4 min walk
  • ‪Idol Wolf - ‬1 min walk
  • ‪Budweiser Kiel Club - ‬6 min walk

About this property

21C Museum Hotel St Louis

Luxury hotel with a fitness center and a steam room
Guests of 21C Museum Hotel St Louis have access to an indoor pool, a gym, and a steam room. Valet parking is offered for USD 50 per day. The front desk is staffed 24/7 to help with luggage storage, dry cleaning/laundry, and concierge services. Other amenities at this luxury hotel include free WiFi in public areas, meeting rooms, and a business center.
Guests can expect free WiFi and flat-screen TVs with cable channels. Bathrooms offer hair dryers, free toiletries, and bathrobes. Espresso makers, safes, and phones are also available. Change of towels is available on request.
Recreational amenities at the hotel include an indoor pool, a steam room, and a fitness center.
Guests can pamper themselves by indulging in the onsite spa services. Services include massages.

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8.8 out of 10, Excellent, 1,119 reviews
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Total with taxes and fees
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Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business center
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Access methods

Staffed front desk

Pets

  • This property welcomes pets for USD 100 per accommodation, per stay
  • Dogs only
  • Service animals exempt from fees

Property payment types

Important information

Fees

  • Service fee: USD 5 per accommodation, per stay

These are all of the charges provided to us by the property.

Optional extras

These fees and deposits will be charged at check-in, check-out, or the time of service.

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

This list may not be comprehensive. Fees and deposits might not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a smoke detector and outdoor lighting
  • Check-in: 4:00 PM—-11:00 AM
  • Check-out: 11:00 AM
  • Minimum check-in age: 21
The front desk is open 24 hours a day. Driving? This property offers valet parking (fees apply).

We should mention

Details about charges, deposits, or other important information:

  • This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
  • Charges for extra guests may apply and vary depending on the property's policy.
  • A cash deposit, credit card, or debit card for incidental charges, as well as a government-issued photo ID, may be required at check-in.
  • Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
  • This property accepts credit cards. Cash is not accepted. 
  • Onsite safety features include a smoke detector and outdoor lighting.

Additional information about polices, regulations, and more:

  • Reservations need to be made in advance for massage services. Contact the hotel at the phone number listed on your booking confirmation.
  • No cribs or infant beds are available.
  • No rollaway or extra beds are available.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

Frequently asked questions

Is free cancellation available at 21C Museum Hotel St Louis ?

21C Museum Hotel St Louis offers free cancellation on select room rates. If you'd like to learn more, look at the cancellation policy on Orbitz.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of Nov 22, 2025, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on Dec 2, 2025 start from $161.1, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

What's there to do close to 21C Museum Hotel St Louis ?

This hotel is situated in Downtown West within a 10-minute walk of City Museum and Enterprise Center. You'll also find St. Louis Union Station and Dome at America’s Center less than a mile away.

Will I be able to park at 21C Museum Hotel St Louis ?

Yes, valet parking is offered for USD 50 per day with in/out privileges.

Is there a spa available at 21C Museum Hotel St Louis ?

Spa services at the hotel include massages.

Does 21C Museum Hotel St Louis include a casino at the property?

No, 21C Museum Hotel St Louis doesn't have a casino.

Will I find an indoor pool at 21C Museum Hotel St Louis ?

Yes, this hotel has an indoor pool.

Is 21C Museum Hotel St Louis good for couples?

There are plenty of amenities for couples at this hotel, including an indoor pool, a bar, and a restaurant.

Does 21C Museum Hotel St Louis have a hot tub?

No, but this hotel does have a steam room.

Does 21C Museum Hotel St Louis have a restaurant with a breakfast menu?

Yes, 21C Museum Hotel St Louis serves a cooked-to-order breakfast each morning for a surcharge from its restaurant.

Will 21C Museum Hotel St Louis allow pets to stay for free?

Although they can't stay for free, dogs are welcome at 21C Museum Hotel St Louis for a fee of USD 100 per accommodation, per stay.

Does 21C Museum Hotel St Louis have connecting rooms?

No, this hotel doesn't feature connecting guestrooms.

What is the closest airport to 21C Museum Hotel St Louis ?

The closest major airport to 21C Museum Hotel St Louis is St. Louis Lambert Intl. Airport (STL), which is 18.4 mi away (26 minutes by car). Another top airport is St. Louis, MO (SUS-Spirit of St. Louis), which is located 25.8 mi away (32-minute drive).

Are there rooms with balconies at 21C Museum Hotel St Louis ?

No, there aren't any guestrooms with balconies at 21C Museum Hotel St Louis .

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 1060 out of 1470 reviews
Rating 8 - Good. 216 out of 1470 reviews
Rating 6 - Okay. 96 out of 1470 reviews
Rating 4 - Poor. 44 out of 1470 reviews
Rating 2 - Terrible. 54 out of 1470 reviews

9.2/10

Cleanliness

9.2/10

Staff & service

9.2/10

Amenities

9.4/10

Property conditions & facilities

9.2/10

Eco-friendliness

Reviews

10/10 Excellent

Katherine, Philadelphia

Liked: Staff & service
Exce
Stayed 4 nights in Sep 2025

10/10 Excellent

Kenneth

Stayed 1 night in Aug 2025

10/10 Excellent

James

Stayed 2 nights in Jul 2025

10/10 Excellent

Jonathan

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Very nice and clean property. The elevators performed better this trip. You can’t beat the nice bathrooms and comfortable beds. Plus the swim club, hot tub, sauna, steam room and other amenities make it the best place to stay in St Louis. Only complaint is ice and water for bottles. The fountains don’t work and haven’t in over a year, plus getting ice is like pulling teeth. But the food and everything else was great service at the hotel. Will stay again on future trips to St Louis.
Stayed 4 nights in Aug 2025

10/10 Excellent

George

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 1 night in Aug 2025

10/10 Excellent

Deni

Stayed 1 night in Aug 2025

10/10 Excellent

Sarah

Stayed 2 nights in Aug 2025

6/10 Okay

Patricia

Liked: Staff & service, property conditions & facilities, room comfort

Just ok

Well to start this hotel has no ice machines, you have to go to the front desk for a bucket of ice. Valet parking, the gentleman that checked us in on 8-14 was as friendly as could be, not so much friendliness getting car on 8/16, different employee. Front counter checking on on 8/14 not very friendly early shift, lady that worked night shift was great. Water station didn't work on 10th floor. Cleaning lady was in my room at 9,10 and 11 on my 1st morning, I was staying for 2 nights. Was trying to sleep but that went out the window. No Do Not Disturb signs.. and check out isn't till 11, so why knocking on my door and just come on on my room at 9 & 10.... room needs good cleaning cobwebs hanging from lights and dust on lamps and headboard of bed, throw pillows had feathers coming out of them. No microwave in rooms and fridge wasn't very cold. Last curtain broke.Not sure I would stay here again
Stayed 1 night in Aug 2025

6/10 Okay

Catherine

Traveled with family and small children
Liked: Amenities
The ambience of the room was good. I didn’t like that they don’t have a microwave inside the room.
Stayed 1 night in Aug 2025

10/10 Excellent

Amber

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 1 night in Jun 2025

10/10 Excellent

Michael

Business traveler
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Just stayed one night for a quick business trip but was impressed. Staff was excellent and room was really nice. Looks like they have a nice bar and restaurant in the lobby but didn't have a chance to check it out. I did hit the coffeeshop in the morning and it was really nice. I'll certainly be back next time I need to come to town.
Stayed 1 night in Aug 2025

10/10 Excellent

Joe

Stayed 1 night in Aug 2025

10/10 Excellent

Angela

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities
Amazing hotel!
Stayed 1 night in Aug 2025

8/10 Good

Verified traveler

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stay was fine and the room was comfortable. We did have an issue at checkout with someone trying to charge drinks to our room. The parking situation is also less than ideal. 50 dollar valet parking and it was just a lot on the street that didnt seem very safe for your vehicle. There was only street parking or another unfenced lot behind the hotel that was paid parking for 30 dollars.
Stayed 1 night in Aug 2025

10/10 Excellent

Tuan

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Valet too expensive ($50/day)
Stayed 3 nights in Aug 2025

6/10 Okay

Verified traveler

Liked: Staff & service, property conditions & facilities, room comfort
Stayed 2 nights in Aug 2025

10/10 Excellent

Amanda

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beautiful hotel and great food options. Gym and pool were great also.
Stayed 1 night in Aug 2025

10/10 Excellent

Keri

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Aug 2025

10/10 Excellent

Patricia, Saint Charles

Liked: Cleanliness, staff & service, property conditions & facilities
Fun place to stay. Museum on the 2nd floor was so much fun.
Stayed 1 night in Aug 2025

10/10 Excellent

Jannie

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Aug 2025

10/10 Excellent

Jennifer L

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
We enjoyed our stay! Close to Busch Stadium which was our destination. Staff was friendly and extremely helpful. Valet parking was worth it.
Stayed 2 nights in Aug 2025

10/10 Excellent

Amy

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Aug 2025

10/10 Excellent

Amy

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Nice stay at 21c St. Louis

The valet and front desk staff were great! Everyone was friendly and helpful, really created a welcoming environment. The overnight parking is a little pricey, but they took good care of our car and offered a speedy retrieval when needed. Parking in the area is limited, and while there is some street parking, wasn’t sure it was secure enough for an overnight. The hotel amenities were wonderful. The indoor pool and hot tub were great, along with a really nice gym. All facilities were really clean. Be sure to check out the art galleries on the second floor. The gallery space was some of the best we’ve seen at a 21c Hotel. Free bottled water with easy refill stations was a plus. Our one critique was that our room carpet and bathroom floor could’ve used a better cleaning, and the rooms are showing some wear and tear. Not horrible, but we stayed here about two years ago for the first time, and the room was extremely clean and well cared for. Hopefully, they’ll pay better attention to this because it’s a nice hotel in a cool building and it would be a shame to let it fall into disrepair.
Stayed 1 night in Aug 2025

10/10 Excellent

Cicely

Liked: Property conditions & facilities
Stayed 1 night in Aug 2025

10/10 Excellent

Brian

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Jul 2025