See all properties

21C Museum Hotel St Louis

4.5 star property
Luxury hotel with a fitness center and a steam room

Choose dates to view prices

Photo gallery for 21C Museum Hotel St Louis

Interior
Dining
Billiards
Loft, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout drapes
Exterior

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Pet friendly
  • Free WiFi
  • Air conditioning

Explore the area

View in a map
1528 Locust street, St. Louis, MO, 63103
  • Place, St. Louis Union Station
    ‪6 min walk‬
  • Place, Enterprise Center
    ‪6 min walk‬
  • Place, City Museum
    ‪6 min walk‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪19 min drive‬

Room options

View all photos for Deluxe Room, 1 King Bed

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(80 reviews)
  • 309 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout drapes

Luxury Double Room, 2 Queen Beds

9.2 out of 10
Wonderful
(24 reviews)
  • 423 sq ft
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room (Bunk Bed)

In-room safe, desk, laptop workspace, blackout drapes

Room (Bunk Bed)

8.0 out of 10
Very good
(6 reviews)
  • 237 sq ft
  • 1 bedroom
  • Sleeps 2
  • 1 Twin Bunk Bed

View all photos for Loft, 2 Queen Beds

In-room safe, desk, laptop workspace, blackout drapes

Loft, 2 Queen Beds

8.0 out of 10
Very good
(1 review)
  • 431 sq ft
  • Sleeps 4
  • 2 Queen Beds

View all photos for Deluxe Room, Accessible (Accessible)

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, Accessible (Accessible)

  • 269 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed (21C)

  • 1119 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed (Library)

  • 732 sq ft
  • City view
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed | In-room safe, desk, laptop workspace, blackout drapes

Luxury Suite, 1 King Bed

10.0 out of 10
Exceptional
(1 review)
  • 549 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible | In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, 1 Double Bed, Accessible

  • 388 sq ft
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Suite, 1 Double Bed, Accessible

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Suite, 1 Double Bed, Accessible

  • 517 sq ft
  • Sleeps 2
  • 1 Double Bed

You may also like

Ad
Room, 2 Queen Beds | Hypo-allergenic bedding, free WiFi, bed sheets

Tru By Hilton St. Louis Downtown

Downtown West
  • Breakfast included
  • Pet friendly
  • Free WiFi
  • Gym
7.6 out of 10, Good, 599 reviews
$81 nightly
The price is $95
Jan 18 - Jan 19, 2026
Total with taxes and fees
Tru By Hilton St. Louis Downtown

About the neighborhood

St. Louis

Located in Downtown West, 21C Museum Hotel St Louis is within a 10-minute walk of popular sights such as City Museum and Enterprise Center. This 4.5-star hotel welcomes guests with 104 rooms and conveniences like an indoor pool, free in-room WiFi, and a gym.

What's nearby

  • Washington Avenue Historic District - 3 min walk - 0.2 miles
  • St. Louis Union Station - 6 min walk - 0.4 miles
  • Enterprise Center - 6 min walk - 0.4 miles
  • City Museum - 6 min walk - 0.4 miles
  • St. Louis Aquarium at Union Station - 9 min walk - 0.5 miles

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • St. Louis Lambert Intl. Airport (STL) - 26 min drive

Restaurants

  • ‪Medina Grill - ‬5 min walk
  • ‪White Knight Diner - ‬4 min walk
  • ‪City Museum Rooftop Cafe - ‬5 min walk
  • ‪Idol Wolf - ‬1 min walk
  • ‪Budweiser Kiel Club - ‬6 min walk

About this property

21C Museum Hotel St Louis

Luxury hotel with a fitness center and a steam room
Guests of 21C Museum Hotel St Louis have access to an indoor pool, a gym, and a steam room. Valet parking is offered for USD 50 per day. The front desk is staffed 24/7 to help with dry cleaning/laundry, concierge services, and luggage storage. Other amenities at this luxury hotel include free WiFi in public areas, meeting rooms, and a business center.
Guests can expect free WiFi and flat-screen TVs with cable channels. Bathrooms offer hair dryers, free toiletries, and bathrobes. Espresso makers, safes, and phones are also available. Change of towels is available on request.
Recreational amenities at the hotel include an indoor pool, a steam room, and a fitness center.
Guests can pamper themselves by indulging in the onsite spa services. Services include massages.

Similar properties

Bar (on property)
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
  • Pet friendly
  • Free WiFi
  • Restaurant
  • Air conditioning
8.8 out of 10, Excellent, 1,173 reviews
$97 nightly
The price is $115
Jan 25 - Jan 26, 2026
Total with taxes and fees
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 50 per day; includes in/out privileges)
  • Limited onsite valet parking

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business center
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • This property welcomes pets for USD 100 per accommodation, per stay
  • Dogs only
  • Service animals exempt from fees

Property payment types

Important information

Fees

  • Service fee: USD 5 per accommodation, per stay

These are all of the charges provided to us by the property.

Optional extras

These fees and deposits will be charged at check-in, check-out, or the time of service.

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

This list may not be comprehensive. Fees and deposits might not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a smoke detector and outdoor lighting
  • Check-in: 4:00 PM—-11:00 AM
  • Check-out: 11:00 AM
  • Minimum check-in age: 21
The front desk is open 24 hours a day. Driving? This property offers valet parking (fees apply).

We should mention

Details about charges, deposits, or other important information:

  • This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
  • Charges for extra guests may apply and vary depending on the property's policy.
  • A cash deposit, credit card, or debit card for incidental charges, as well as a government-issued photo ID, may be required at check-in.
  • Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
  • This property accepts credit cards. Cash is not accepted. 
  • Onsite safety features include a smoke detector and outdoor lighting.

Additional information about polices, regulations, and more:

  • Reservations need to be made in advance for massage services. Contact the hotel at the phone number listed on your booking confirmation.
  • No cribs or infant beds are available.
  • No rollaway or extra beds are available.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

Frequently asked questions

Is free cancellation available at 21C Museum Hotel St Louis ?

21C Museum Hotel St Louis offers free cancellation on select room rates. If you'd like to learn more, look at the cancellation policy on Orbitz.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of Dec 29, 2025, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on Jan 8, 2026 start from $251.1, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

What's there to do close to 21C Museum Hotel St Louis ?

This hotel is situated in Downtown West within a 10-minute walk of City Museum and Enterprise Center. You'll also find St. Louis Union Station and Busch Stadium less than a mile away.

Is parking available on site at 21C Museum Hotel St Louis ?

Yes, valet parking is offered for USD 50 per day with in/out privileges.

Is there a spa available at 21C Museum Hotel St Louis ?

Spa services at the hotel include massages.

Does 21C Museum Hotel St Louis include a casino at the property?

No, 21C Museum Hotel St Louis doesn't have a casino.

Will I find an indoor pool at 21C Museum Hotel St Louis ?

Yes, this hotel has an indoor pool.

Is 21C Museum Hotel St Louis a good place to stay for couples?

There are plenty of amenities for couples at this hotel, including an indoor pool, a bar, and a restaurant.

Are there hot tubs at 21C Museum Hotel St Louis ?

No, but this hotel does have a steam room.

Does 21C Museum Hotel St Louis have a restaurant with a breakfast menu?

Yes, 21C Museum Hotel St Louis serves a cooked-to-order breakfast each morning for a surcharge from its restaurant.

Will 21C Museum Hotel St Louis allow pets to stay for free?

Although they can't stay for free, dogs are welcome at 21C Museum Hotel St Louis for a fee of USD 100 per accommodation, per stay.

Does 21C Museum Hotel St Louis have connecting rooms?

No, this hotel doesn't feature connecting guestrooms.

What is the closest airport to 21C Museum Hotel St Louis ?

The closest major airport to 21C Museum Hotel St Louis is St. Louis Lambert Intl. Airport (STL), which is 18.4 mi away (26 minutes by car). Another top airport is St. Louis, MO (SUS-Spirit of St. Louis), which is located 25.8 mi away (32-minute drive).

Are there rooms with balconies that I can book at 21C Museum Hotel St Louis ?

No, there aren't any guestrooms with balconies at 21C Museum Hotel St Louis .

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 1089 out of 1514 reviews
Rating 8 - Good. 227 out of 1514 reviews
Rating 6 - Okay. 98 out of 1514 reviews
Rating 4 - Poor. 46 out of 1514 reviews
Rating 2 - Terrible. 54 out of 1514 reviews

9.2/10

Cleanliness

9.2/10

Staff & service

9.2/10

Amenities

9.4/10

Property conditions & facilities

9.2/10

Eco-friendliness

Reviews

10/10 Excellent

Katherine, Philadelphia

Liked: Staff & service
Exce
Stayed 4 nights in Sep 2025

10/10 Excellent

Travis

Stayed 1 night in Nov 2025

8/10 Good

Lisa

Liked: Cleanliness, staff & service, room comfort
Hotel itself was amazing. Had a little issues with the room. But the manger stepped up to assist to make everything better
Stayed 2 nights in Sep 2025

10/10 Excellent

Sarah

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Love the pool, spa area and the art work. We stay here often And love coming back. Great outdoor space to have a cocktail from the full bar , shuffle board , pool table and awesome mingling spaces for friends
Stayed 1 night in Sep 2025

10/10 Excellent

Angella

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

That tub though!

The hotel was beautiful. The room was so nice. That tub though, that was the highlight of my stay. The soaked tub was worth every penny.
Stayed 1 night in Sep 2025

8/10 Good

Rohat

Business traveler, Traveled with family
Liked: Staff & service, amenities, property conditions & facilities
Staff and hotel were great, area is kind of dangerous, lot's of homeless people hanging around, parking is either pay to valet for street parking or park yourself? Experience within hotel was great.
Stayed 2 nights in Jul 2025

10/10 Excellent

Jake

Stayed 1 night in Sep 2025

10/10 Excellent

ANDREA Nicole

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Top notch all the way. Absolutely love these hotels!
Stayed 2 nights in May 2025

10/10 Excellent

Latisha

Liked: Cleanliness
Stayed 1 night in Sep 2025

8/10 Good

Jane

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Sep 2025

2/10 Terrible

John

Disliked: Cleanliness, staff & service, property conditions & facilities, room comfort

Common Areas Are Nice; Hotel Not Worth Your Time

I wanted to like the 21c Museum Hotel St. Louis, but my stay was disappointing from start to finish. I was moved twice; the first room had a bathroom issue; the second (promised as the same type) was noticeably smaller. I was then placed in a suite that had a strong, unpleasant odor, which I tolerated only because I was exhausted from the room changes. Common areas didn’t help: elevators were not clean, and despite requesting service, housekeeping didn’t arrive until almost 7pm. While the bar staff and one front-desk attendant were friendly, several others were curt and unhelpful. Most concerning, a staff member, likely maintenance, tried to enter my room before checkout without knocking and offered only a half-hearted apology when he saw me. I was told the first night would be refunded, but Hotels.com had no record of a refund request from the property. I had planned to return for Thanksgiving and had already booked, but I’ve since canceled. Overall, this was a poor experience marked by inconsistent service, cleanliness issues, and a lack of accountability.
Stayed 3 nights in Sep 2025

6/10 Okay

Kelly

Liked: Staff & service

Beautiful design, lacking maintenance

You can tell that there was a lot of care that went into the design and creation of this hotel, but unfortunately, there has been a lack of maintenance that erodes the overall experience. The Good: - The Museum is well curated, thoughtfully presented, and inspired. We really enjoyed each exhibit. - Idol Wolf and Good Press are both high-quality restaurants, and we enjoyed the food and service at each. The portion sizes and ingredients were both above our expectations for a hotel restaurant. The Bad: - While the rooms are clean, there was a general lack of maintenance for the most basic needs for a hotel guest. For example, our shampoo and body wash were both ripped off the wall, and rather than being repaired, the broken bottles were just placed in the shower. We needed to call the front desk in order to receive functioning toiletries, which was disappointing given the price of our nightly stay. - While a small detail, we were only provided one coffee cup in our room. A great coffee maker can only be enjoyed if we have a cup to drink out of, and it underlined the lack of attention to detail we had seen in other parts of our stay. - The pool and locker rooms were very poorly maintained and frankly dirty. Towels were not consistently available (only in the women's locker room), the shower grout was visibly moldy, and there was a lack of general maintenance in what clearly was a previously beautiful pool and spa area. Overall, the experience was fine, but below expectations.
Stayed 1 night in Sep 2025

10/10 Excellent

JeTaun

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
My stay was nice and comfortable. The staff was very courteous
Stayed 3 nights in Sep 2025

10/10 Excellent

martin

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Sep 2025

10/10 Excellent

Connie

Traveled with group
Liked: Cleanliness, amenities, property conditions & facilities
Great place to stay. Will definitely stay here next time I’m in st. Luis
Stayed 1 night in Sep 2025

10/10 Excellent

Sabrina

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Sep 2025

10/10 Excellent

Renean

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Sep 2025

10/10 Excellent

Fred

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 3 nights in Sep 2025

10/10 Excellent

Connie

Traveled with group
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great experience!
Stayed 1 night in Sep 2025

10/10 Excellent

marie

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 1 night in Aug 2025

2/10 Terrible

Angie

Disliked: Cleanliness, property conditions & facilities, room comfort
Stayed 1 night in Sep 2025

10/10 Excellent

Alex

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 1 night in Sep 2025

10/10 Excellent

Whitney

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Wonderful stay!
Stayed 1 night in Sep 2025

8/10 Good

Jeffrey, Springfield

Traveled with partner
The restaurant and coffee shop servers and valets were great- others seemed to be quiet quitting and disinterested
Stayed 2 nights in Sep 2025

8/10 Good

Brittany

Liked: Cleanliness, staff & service, property conditions & facilities
Didn't have our room ready until after check in time advertised..
Stayed 1 night in Sep 2025