See all properties

21C Museum Hotel St Louis

4.5 star property
Luxury hotel with a fitness center and a steam room

Choose dates to view prices

Photo gallery for 21C Museum Hotel St Louis

Exterior
Room, 1 King Bed, Corner | 1 bedroom, in-room safe, desk, laptop workspace
Indoor pool
Lobby
1 bedroom, in-room safe, desk, laptop workspace

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Bar

Explore the area

Map
1528 Locust street, St. Louis, MO, 63103
  • St. Louis Union Station
    ‪6 min walk‬
  • City Museum
    ‪6 min walk‬
  • Busch Stadium
    ‪14 min walk‬
  • St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪21 min drive‬

Book today, save on your next hotel stay

It's that easy when you're a member of Orbitz Rewards. It's free to join!

Room options

Loft, 2 Queen Beds

  • Sleeps 4
  • 2 Queen Beds

Luxury Suite, 1 King Bed

  • Sleeps 2
  • 1 King Bed

View all photos for Room (Bunk Bed)

Room (Bunk Bed) | 1 bedroom, in-room safe, desk, laptop workspace

Room (Bunk Bed)

8.0 out of 10
Very good
(6 reviews)
  • Sleeps 2
  • 1 Twin Bunk Bed

Deluxe Room, Accessible (Accessible)

  • Sleeps 2
  • 1 King Bed

Suite, 1 King Bed (Library)

  • Sleeps 2
  • 1 King Bed

Suite, 1 King Bed (21C)

  • Sleeps 2
  • 1 King Bed

Deluxe Room, 1 Double Bed, Accessible

  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Room, 1 King Bed

Deluxe Room, 1 King Bed | 1 bedroom, in-room safe, desk, laptop workspace

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(59 reviews)
  • 309 sq ft
  • Sleeps 2
  • 1 King Bed

Deluxe Suite, 1 Double Bed, Accessible

  • Sleeps 2
  • 1 Double Bed

View all photos for Deluxe Double Room, 2 Queen Beds

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Double Room, 2 Queen Beds

8.4 out of 10
Very good
(17 reviews)
  • 369 sq ft
  • Sleeps 4
  • 2 Queen Beds

Deluxe Room, 1 Double Bed, Accessible

  • Sleeps 4
  • 1 Double Bed

View all photos for Room, 1 King Bed, Corner

Room, 1 King Bed, Corner | 1 bedroom, in-room safe, desk, laptop workspace

Room, 1 King Bed, Corner

8.8 out of 10
Excellent
(22 reviews)
  • 326 sq ft
  • City view
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed

1 bedroom, in-room safe, desk, laptop workspace

Suite, 1 King Bed

  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Suite, 1 King Bed

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Suite, 1 King Bed

9.2 out of 10
Wonderful
(5 reviews)
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

1 bedroom, in-room safe, desk, laptop workspace

Luxury Double Room, 2 Queen Beds

9.0 out of 10
Wonderful
(16 reviews)
  • 423 sq ft
  • Sleeps 4
  • 2 Queen Beds

You may also like

Ad
Front of property

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Downtown St. Louis
  • Pet friendly
  • Free WiFi
  • Restaurant
  • Air conditioning
8.6 out of 10, Excellent, 1,036 reviews
$111 nightly
The price is $132
Jul 13 - Jul 14
Total includes taxes and fees
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

About the neighborhood

St. Louis

Located in Downtown West, 21C Museum Hotel St Louis is within a 10-minute walk of popular sights such as Enterprise Center and City Museum. This 4.5-star hotel welcomes guests with 104 rooms and conveniences like an indoor pool, free in-room WiFi, and a gym.

What's nearby

  • St. Louis Union Station - 6 min walk - 0.4 miles
  • Enterprise Center - 6 min walk - 0.4 miles
  • City Museum - 6 min walk - 0.4 miles
  • Busch Stadium - 14 min walk - 0.8 miles
  • Gateway Arch - 2 min drive - 1.1 miles

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • St. Louis Lambert Intl. Airport (STL) - 26 min drive

Restaurants

  • ‪Rosalita's Cantina - ‬6 min walk
  • ‪Grand Hall Lounge Union Station - ‬11 min walk
  • ‪Hair of the Dog - ‬7 min walk
  • ‪Peabody Lounge - ‬6 min walk
  • ‪Medina Mediterranean Grill - ‬5 min walk

About this property

21C Museum Hotel St Louis

Luxury hotel with a fitness center and a steam room
Guests of 21C Museum Hotel St Louis have access to an indoor pool, a gym, and a steam room. Valet parking is offered for USD 50 per day. The front desk is staffed 24/7 to help with dry cleaning/laundry, luggage storage, and concierge services. Other amenities at this luxury hotel include free WiFi in public areas, meeting rooms, and a business center.
Guests can expect free WiFi and flat-screen TVs with cable channels. Bathrooms offer hair dryers, free toiletries, and bathrobes. Espresso makers, safes, and phones are also available. Change of towels is available on request.
Recreational amenities at the hotel include an indoor pool, a steam room, and a fitness center.
Guests can pamper themselves by indulging in the onsite spa services. Services include massages.

Languages

English

Similar properties

Miscellaneous

Hyatt Regency St. Louis at The Arch

  • Pet friendly
  • Free WiFi
  • Restaurant
  • Air conditioning
8.4 out of 10, Very Good, 3,834 reviews
$138 nightly
The price is $163
Jul 31 - Aug 1
Total includes taxes and fees
Hyatt Regency St. Louis at The Arch

Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business center
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Access methods

Staffed front desk

Pets

  • This property welcomes pets for USD 100 per accommodation, per stay
  • Dogs only
  • Service animals exempt from fees

Property payment types

Important information

Fees

  • Service fee: USD 5 per accommodation, per stay

These are all of the charges provided to us by the property.

Optional extras

These fees and deposits will be charged at check-in, check-out, or the time of service.

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

This list may not be comprehensive. Fees and deposits might not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a smoke detector and outdoor lighting
  • Check-in: 4:00 PM—-11:00 AM
  • Check-out: 11:00 AM
  • Minimum check-in age: 21
The front desk is open 24 hours a day. Driving? This property offers valet parking (fees apply).

We should mention

Details about charges, deposits, or other important information:

  • This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
  • Charges for extra guests may apply and vary depending on the property's policy.
  • A cash deposit, credit card, or debit card for incidental charges, as well as a government-issued photo ID, may be required at check-in.
  • Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
  • This property accepts credit cards. Cash is not accepted. 
  • Onsite safety features include a smoke detector and outdoor lighting.

Additional information about polices, regulations, and more:

  • Reservations need to be made in advance for massage services. Contact the hotel at the phone number listed on your booking confirmation.
  • No cribs or infant beds are available.
  • No rollaway or extra beds are available.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

Frequently asked questions

Is free cancellation available at 21C Museum Hotel St Louis ?

21C Museum Hotel St Louis offers free cancellation on select room rates. If you'd like to learn more, look at the cancellation policy on Orbitz.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of Jul 1, 2025, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on Jul 31, 2025 start from $161.1, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

What's there to do close to 21C Museum Hotel St Louis ?

This hotel is situated in Downtown West within a 10-minute walk of Enterprise Center and City Museum. You'll also find St. Louis Union Station and Busch Stadium less than a mile away.

Is there parking available at 21C Museum Hotel St Louis ?

Yes, valet parking is offered for USD 50 per day with in/out privileges.

Is there a spa available at 21C Museum Hotel St Louis ?

Spa services at the hotel include massages.

Does 21C Museum Hotel St Louis include a casino at the property?

No, 21C Museum Hotel St Louis doesn't have a casino.

Will I find an indoor pool at 21C Museum Hotel St Louis ?

Yes, this hotel has an indoor pool.

What will couples enjoy most about a stay at 21C Museum Hotel St Louis ?

There are plenty of amenities for couples at this hotel, including an indoor pool, a bar, and a restaurant.

Does 21C Museum Hotel St Louis have a hot tub?

No, but guests can enjoy a steam room at this hotel.

Does 21C Museum Hotel St Louis have a restaurant with a breakfast menu?

Yes, 21C Museum Hotel St Louis serves a cooked-to-order breakfast each morning for a surcharge from its restaurant.

Will 21C Museum Hotel St Louis allow pets to stay for free?

Although they can't stay for free, dogs are welcome at 21C Museum Hotel St Louis for a fee of USD 100 per accommodation, per stay.

Does 21C Museum Hotel St Louis have connecting rooms?

No, there aren't connecting guestrooms at this hotel.

What is the closest airport to 21C Museum Hotel St Louis ?

The closest major airport to 21C Museum Hotel St Louis is St. Louis Lambert Intl. Airport (STL), which is 18.4 mi away (26 minutes by car). Another top airport is St. Louis, MO (SUS-Spirit of St. Louis), which is located 25.8 mi away (32-minute drive).

Are there rooms with balconies at 21C Museum Hotel St Louis ?

No, at 21C Museum Hotel St Louis , there aren't any guestrooms that list a balcony.

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 876 out of 1211 reviews
Rating 8 - Good. 183 out of 1211 reviews
Rating 6 - Okay. 68 out of 1211 reviews
Rating 4 - Poor. 37 out of 1211 reviews
Rating 2 - Terrible. 47 out of 1211 reviews

9.2/10

Cleanliness

9.2/10

Staff & service

9.2/10

Amenities

9.4/10

Property conditions & facilities

9.2/10

Eco-friendliness

Reviews

10/10 Excellent

Mary

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Loved this hotel!
Stayed 1 night in Jun 2025

10/10 Excellent

Michelle

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Amazing
Stayed 2 nights in Apr 2025

10/10 Excellent

Bradley

Stayed 3 nights in Mar 2025

8/10 Good

Cynthia

Traveled with partner
Liked: Staff & service, property conditions & facilities
Rooms are nice, museum is a good bonus. Restaurant inside of the restaurant was pretty good but the service lacked
Stayed 2 nights in Mar 2025

10/10 Excellent

Christine

Traveled with family and small children
Liked: Cleanliness, staff & service, property conditions & facilities
i wish there were more breakfast options at the hotel. we are breakfasty oeople Standing in line at a lunch counter for a pre packaged turkey roll up and an orange fanta doesn't hit the spot for my Howard Johnson childhood memories. iby the same token My 13 year old doesnt love a filthy martini extra olives which is more likely your demographic. WE LOVE 21C. we have stayed twice and will ABSOLUTELY stay again.
Stayed 3 nights in Mar 2025

10/10 Excellent

Holly

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Mar 2025

8/10 Good

mell

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
love the museum and how long it was open for access
Stayed 1 night in Mar 2025

10/10 Excellent

Alison

Stayed 1 night in Feb 2025

10/10 Excellent

Samuel

Traveled with family
Liked: Cleanliness, amenities
It’s eclectic and a calming atmosphere to be in. I brought my friend and she was very impressed with the experience. It’s one of my fav places to stay.
Stayed 1 night in Mar 2025

10/10 Excellent

Verified traveler

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 2 nights in Mar 2025

10/10 Excellent

Mark, Bloomington

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
I have stayed at 21C hitels before, but never this one in St. Louis. The facility is beautiful! Our room was very clean, and the bathroom was huge! The amenities here are wonderful. The pool is beautiful, and the hot tub is huge. The check in process was smooth and quick, and we got a very early check in. The gentleman at the front desk was very accommodating and especially cordial. The only downfall was the neighborhood. That, however, is not a hotel problem, but a St. Louis issue. I always forget how dead the St. Louis downtown is unless there's a Cardinal baseball game scheduled. Walking through a pretty dark and desolate downtown to get back to the hotel late at night is concerning. I walk all over downtown Chicago at all hours and never feel unsafe, but I dont have the same confidence in downtown St. Louis.
Stayed 1 night in Mar 2025

6/10 Okay

Ashley

Traveled with family
Liked: Room comfort

Cool, but quite a few misses in my opinion

The hotel is in a good spot close to union station activities and everything else is 10min away which isn’t a bad drive. Loved that it was artsy and cute decor. Cute bar inside. Did not have enough time to experience restaurant but the menu sounded good. The fitness spa area is a nice accommodation and visiting the art free museum associated with hotel was nice to bum around. My stars were due to walking in not feeling like the staff was very accommodating and acted annoyed with me and eachother so that was different. Just weird attitudes kind of cool kids not really great concierges. But, Finding street parking was easy on a weekend so appreciated that. But, they are limited in carts and The elevators were all broken except one so that took forever. Room appeared semi clean. They left only a 1/4 used toilet paper roll and a few tissues back in tissue box. Just odd. So the staff didn’t even restock and there was food and drinks left in the fridge from previous people. So I felt like it was “fake” cleaned. There was a wad of hair on our bed and in the bathtub it had another wad of a dust bunny. The coffee machine would have been great but they didn’t stock any cups. Maybe they were trying to encourage you to go to their coffee shop. Which I did and it was good and the staff there were probably the most with the program. It was fine. I’d come back to try their Spanish restaurant but would probably stay elsewhere with my family next time. We did all like the decor in hotel
Stayed 2 nights in Mar 2025

10/10 Excellent

Jeremy

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
To start off the valet was amazing and the staff was great. The bartenders were on point and our waiter was very helpful too. The little coffee shop was great for a quick breakfast and the robes were like a hug from your loved one. Room were really cool with an older feel yet modern. The gallery was very unique and loved all the amenities. Only thing I would say I didn’t like was the pillows on the bed. But all in all would definitely stay again if ever in St Louis.
Stayed 2 nights in Mar 2025

8/10 Good

James

Stayed 1 night in Jan 2025

10/10 Excellent

Colleen

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Welcoming, kind staff. So enjoyed our stay.
Stayed 2 nights in Mar 2025

10/10 Excellent

Nyna

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
This hotel is fantastic. All in one entertainment with the museum combined. Very clean and nice staff.
Stayed 1 night in Mar 2025

8/10 Good

Nathalie

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Mar 2025

10/10 Excellent

Toni

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Mar 2025

6/10 Okay

Arron

Business traveler
Liked: Staff & service, amenities
Disliked: Cleanliness, property conditions & facilities
I’ve been visiting St. Louis for over 12 years and used to try different hotels — until I stayed at 21c. Since that first visit, I haven’t stayed anywhere else. It had a fresh energy, a unique atmosphere, and the kind of people that made it feel exciting. The real standout has always been the staff, especially the bar and restaurant team — people like Carson, Cam, and JoJo. Their effort, warmth, and attention to detail make every stay feel like more than just a hotel visit. Over time, they’ve become familiar faces and genuine friends. But on my most recent stay, I was let down — not by them, but by housekeeping and management. My room simply wasn’t clean: mould in the shower, someone else’s hair, stains left untouched, and amenities not replaced. Once you see it, you start noticing more — and unfortunately, I did. I raised it with the team (not even their job to fix) and they went out of their way to make things right — offering a credit and even leaving a bottle of their own gin in my room. Lovely gestures, truly appreciated — but the mould was still there the next day. The issue wasn’t fixed. For a short stay, I’d still recommend it. But for anything longer, if you value cleanliness and comfort, I’d think twice. The team out front are brilliant — but they’re being let down by what’s happening behind the scenes.
Stayed 9 nights in Mar 2025

10/10 Excellent

Steve

Stayed 1 night in Mar 2025

8/10 Good

JANA

Traveled with group
Liked: Staff & service, amenities, property conditions & facilities
The property is very special, with a historic and totally renovated pool and spa, and a large art exhibit. The bar and lobby are loaded with art and beautifully designed surroundings. Only one of three elevators were working this week, so a lot of waiting and frankly feeling unsafe. The breakfast restaurant is good. There is no lunch option and the front desk has zero intel regarding outside options. The dinner menu is ridiculously expensive and not very enticing. Drinks are crazy expensive ($14 for 3 oz of sav blanc) The valet is $45/night in kind of a rundown, crummy neighborhood.
Stayed 2 nights in Mar 2025

10/10 Excellent

Veronica

Liked: Cleanliness, staff & service, property conditions & facilities
Beautiful hotel. Amazing indoor pool. My kids Loved the bunk beds.
Stayed 2 nights in Mar 2025

10/10 Excellent

Rebecca

Traveled with partner
Liked: Amenities
We stayed here for a night while we were in town to watch the Blues. It's close enough to walk to the stadium or take a quick uber. It was close to union station too. Wonderful hotel! We will be back.
Stayed 1 night in Mar 2025

10/10 Excellent

Jocelynne

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 2 nights in Mar 2025

10/10 Excellent

Verified traveler

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Great
Stayed 1 night in Feb 2025