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21C Museum Hotel St Louis

4.5 star property
Luxury hotel with a fitness center and a steam room

Choose dates to view prices

Photo gallery for 21C Museum Hotel St Louis

Restaurant
Exterior
Bar (on property)
Massages
Exterior

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Pet friendly
  • Free WiFi
  • Air conditioning

Explore the area

View in a map
1528 Locust street, St. Louis, MO, 63103
  • Place, St. Louis Union Station
    ‪6 min walk‬
  • Place, Enterprise Center
    ‪6 min walk‬
  • Place, City Museum
    ‪6 min walk‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪19 min drive‬

Room options

View all photos for Deluxe Room, 1 King Bed

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(82 reviews)
  • 309 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout drapes

Luxury Double Room, 2 Queen Beds

9.2 out of 10
Wonderful
(24 reviews)
  • 423 sq ft
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room (Bunk Bed)

In-room safe, desk, laptop workspace, blackout drapes

Room (Bunk Bed)

8.0 out of 10
Very good
(6 reviews)
  • 237 sq ft
  • 1 bedroom
  • Sleeps 2
  • 1 Twin Bunk Bed

View all photos for Loft, 2 Queen Beds

In-room safe, desk, laptop workspace, blackout drapes

Loft, 2 Queen Beds

8.0 out of 10
Very good
(1 review)
  • 431 sq ft
  • Sleeps 4
  • 2 Queen Beds

View all photos for Deluxe Room, Accessible (Accessible)

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, Accessible (Accessible)

  • 269 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed (21C)

  • 1119 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed (Library)

  • 732 sq ft
  • City view
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed | In-room safe, desk, laptop workspace, blackout drapes

Luxury Suite, 1 King Bed

10.0 out of 10
Exceptional
(1 review)
  • 549 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible | In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, 1 Double Bed, Accessible

  • 388 sq ft
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Suite, 1 Double Bed, Accessible

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Suite, 1 Double Bed, Accessible

  • 517 sq ft
  • Sleeps 2
  • 1 Double Bed

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Bar (on property)

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Downtown St. Louis
  • Pet friendly
  • Free WiFi
  • Restaurant
  • Air conditioning
8.8 out of 10, Excellent, 1,186 reviews
$97 nightly
The price is $115
Jan 25 - Jan 26
Total with taxes and fees
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

About the neighborhood

St. Louis

Located in Downtown West, 21C Museum Hotel St Louis is within a 10-minute walk of popular sights such as St. Louis Union Station and City Museum. This 4.5-star hotel welcomes guests with 104 rooms and conveniences like an indoor pool, free in-room WiFi, and a gym.

What's nearby

  • Washington Avenue Historic District - 3 min walk - 0.2 miles
  • St. Louis Union Station - 6 min walk - 0.4 miles
  • Enterprise Center - 6 min walk - 0.4 miles
  • City Museum - 6 min walk - 0.4 miles
  • St. Louis Aquarium at Union Station - 9 min walk - 0.5 miles

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • St. Louis Lambert Intl. Airport (STL) - 24 min drive

Restaurants

  • ‪White Knight Diner - ‬4 min walk
  • ‪City Museum Rooftop Cafe - ‬5 min walk
  • ‪Medina Grill - ‬5 min walk
  • ‪Budweiser Kiel Club - ‬6 min walk
  • ‪Idol Wolf - ‬1 min walk

About this property

21C Museum Hotel St Louis

Luxury hotel with a fitness center and a steam room
Guests of 21C Museum Hotel St Louis have access to an indoor pool, a gym, and a steam room. Valet parking is offered for USD 50 per day. The front desk is staffed 24/7 to help with concierge services, dry cleaning/laundry, and luggage storage. Other amenities at this luxury hotel include free WiFi in public areas, meeting rooms, and a business center.
Guests can expect free WiFi and flat-screen TVs with cable channels. Bathrooms offer hair dryers, free toiletries, and bathrobes. Espresso makers, safes, and phones are also available. Change of towels is available on request.
Recreational amenities at the hotel include an indoor pool, a steam room, and a fitness center.
Guests can pamper themselves by indulging in the onsite spa services. Services include massages.

Similar properties

Bar (on property)
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
  • Pet friendly
  • Free WiFi
  • Restaurant
  • Air conditioning
8.8 out of 10, Excellent, 1,186 reviews
$97 nightly
The price is $115
Jan 25 - Jan 26
Total with taxes and fees
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business center
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • This property welcomes pets for USD 100 per accommodation, per stay
  • Dogs only
  • Service animals exempt from fees

Property payment types

Important information

Fees

  • Service fee: USD 5 per accommodation, per stay

These are all of the charges provided to us by the property.

Optional extras

These fees and deposits will be charged at check-in, check-out, or the time of service.

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

This list may not be comprehensive. Fees and deposits might not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a smoke detector and outdoor lighting
  • Check-in: 4:00 PM—-11:00 AM
  • Check-out: 11:00 AM
  • Minimum check-in age: 21
The front desk is open 24 hours a day. Driving? This property offers valet parking (fees apply).

We should mention

Details about charges, deposits, or other important information:

  • This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
  • Charges for extra guests may apply and vary depending on the property's policy.
  • A cash deposit, credit card, or debit card for incidental charges, as well as a government-issued photo ID, may be required at check-in.
  • Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
  • This property accepts credit cards. Cash is not accepted. 
  • Onsite safety features include a smoke detector and outdoor lighting.

Additional information about polices, regulations, and more:

  • Reservations need to be made in advance for massage services. Contact the hotel at the phone number listed on your booking confirmation.
  • No cribs or infant beds are available.
  • No rollaway or extra beds are available.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

Frequently asked questions

Is free cancellation available at 21C Museum Hotel St Louis ?

21C Museum Hotel St Louis offers free cancellation on select room rates. If you'd like to learn more, look at the cancellation policy on Orbitz.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of Jan 11, 2026, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on Feb 1, 2026 start from $143.65, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

What's there to do close to 21C Museum Hotel St Louis ?

This hotel is situated in Downtown West, just steps from City Museum, and within a 10-minute walk of St. Louis Union Station and Enterprise Center. You'll also find Busch Stadium and Dome at America’s Center less than a mile away.

Is there parking available at 21C Museum Hotel St Louis ?

Yes, valet parking is offered for USD 50 per day with in/out privileges.

Is there a spa available at 21C Museum Hotel St Louis ?

Spa services at the hotel include massages.

Does 21C Museum Hotel St Louis include a casino at the property?

No, 21C Museum Hotel St Louis doesn't have a casino.

Will I find an indoor pool at 21C Museum Hotel St Louis ?

Yes, this hotel has an indoor pool.

Is 21C Museum Hotel St Louis a good place to stay for couples?

There are plenty of amenities for couples at this hotel, including an indoor pool, a bar, and a restaurant.

Does 21C Museum Hotel St Louis have a hot tub?

No, but this hotel does have a steam room.

Does 21C Museum Hotel St Louis have a restaurant with a breakfast menu?

Yes, 21C Museum Hotel St Louis serves a cooked-to-order breakfast each morning for a surcharge from its restaurant.

Will 21C Museum Hotel St Louis allow pets to stay for free?

Although they can't stay for free, dogs are welcome at 21C Museum Hotel St Louis for a fee of USD 100 per accommodation, per stay.

Are there connecting rooms at 21C Museum Hotel St Louis ?

No, there aren't connecting guestrooms at this hotel.

What is the closest airport to 21C Museum Hotel St Louis ?

The closest major airport to 21C Museum Hotel St Louis is St. Louis Lambert Intl. Airport (STL), which is 18.4 mi away (24 minutes by car). Another top airport is St. Louis, MO (SUS-Spirit of St. Louis), which is located 25.8 mi away (32-minute drive).

Can I book a room with a balcony at 21C Museum Hotel St Louis ?

No, you won't find guestrooms with balconies at 21C Museum Hotel St Louis .

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 1104 out of 1541 reviews
Rating 8 - Good. 231 out of 1541 reviews
Rating 6 - Okay. 105 out of 1541 reviews
Rating 4 - Poor. 47 out of 1541 reviews
Rating 2 - Terrible. 54 out of 1541 reviews

9.2/10

Cleanliness

9.2/10

Staff & service

9.2/10

Amenities

9.4/10

Property conditions & facilities

9.2/10

Eco-friendliness

Reviews

10/10 Excellent

Katherine, Philadelphia

Liked: Staff & service
Exce
Stayed 4 nights in Sep 2025

10/10 Excellent

Travis

Stayed 1 night in Nov 2025

10/10 Excellent

Jemma

Business traveler
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
My stay there was great. The staff were so friendly and accommodating.
Stayed 1 night in Oct 2025

10/10 Excellent

anthony

Business traveler
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Love the 21C. I try staying here every time I’m in St. Louis. There’s a great restaurant, a full art gallery and a steam room / gym as well. The staff is always super accommodating.
Stayed 1 night in Oct 2025

8/10 Good

Alex

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
The room was clean and spacious. However, the information is not accurate—you need to pay additional $50 for parking.
Stayed 1 night in Sep 2025

10/10 Excellent

Rachel

Stayed 1 night in Sep 2025

10/10 Excellent

Rhonda

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Great location downtown and the best valet service.
Stayed 1 night in Oct 2025

2/10 Terrible

William

Disliked: Staff & service, room comfort

Unethical Hotel - avoid

We booked and paid for a suite through Hotels.com, but when we arrived, the air conditioning wasn’t working. It was a warm day, and after three separate requests for help, nothing was done. Hours later, just before we left for the concert we came to see, I went to the front desk when they finally admitted they couldn’t fix it. Their “solution” was to move us — not to another suite(one wasn’t available), but to the a small basic room. We didn’t have time to switch before the concert, so after a long night out we came back tired, only to have to pack up all our things and move rooms ourselves. The room we were moved to was dramatically smaller, and their idea of compensation was offering us free breakfast. The difference in cost between the suite we paid for and the basic room we were given was significant — not to mention the complete disruption to our stay. When I went to the desk to discuss a refund, the employee couldn’t have been less interested in helping. Hotels.com tried to assist but explained that the hotel refused to authorize a refund, so their hands were tied. At the end of the day, this hotel charged us for a suite they couldn’t provide, wasted our time, and made no real effort to make things right. The lack of accountability and basic customer service was astonishing. There are plenty of places to stay that actually value their guests — this isn’t one of them. Avoid it.
Stayed 1 night in Oct 2025

10/10 Excellent

Rodney

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Museum and a hotel, very clean, incredible pool and amenities area.
Stayed 1 night in Oct 2025

10/10 Excellent

april

Liked: Cleanliness, staff & service, property conditions & facilities
Beautiful Hotel.
Stayed 3 nights in Sep 2025

6/10 Okay

alphonzia

Liked: Cleanliness, property conditions & facilities, room comfort
No hot tub
Stayed 2 nights in Oct 2025

10/10 Excellent

Scott

Stayed 2 nights in Sep 2025

10/10 Excellent

Keri

Business traveler
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Sep 2025

10/10 Excellent

Sara

Stayed 1 night in Oct 2025

10/10 Excellent

Anne

Traveled with family
Liked: Cleanliness, staff & service, amenities
Excellent staff
Stayed 3 nights in Oct 2025

10/10 Excellent

Kathleen

Stayed 1 night in Sep 2025

2/10 Terrible

Paul

Stayed 2 nights in Oct 2025

10/10 Excellent

Ana

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great customer service !
Stayed 1 night in Oct 2025

6/10 Okay

Kayla

Stayed 2 nights in Sep 2025

8/10 Good

Lisa

Liked: Cleanliness, staff & service, room comfort
Hotel itself was amazing. Had a little issues with the room. But the manger stepped up to assist to make everything better
Stayed 2 nights in Sep 2025

10/10 Excellent

Sarah

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Love the pool, spa area and the art work. We stay here often And love coming back. Great outdoor space to have a cocktail from the full bar , shuffle board , pool table and awesome mingling spaces for friends
Stayed 1 night in Sep 2025

10/10 Excellent

Angella

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

That tub though!

The hotel was beautiful. The room was so nice. That tub though, that was the highlight of my stay. The soaked tub was worth every penny.
Stayed 1 night in Sep 2025

8/10 Good

Rohat

Business traveler, Traveled with family
Liked: Staff & service, amenities, property conditions & facilities
Staff and hotel were great, area is kind of dangerous, lot's of homeless people hanging around, parking is either pay to valet for street parking or park yourself? Experience within hotel was great.
Stayed 2 nights in Jul 2025

10/10 Excellent

Jake

Stayed 1 night in Sep 2025

10/10 Excellent

ANDREA Nicole

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Top notch all the way. Absolutely love these hotels!
Stayed 2 nights in May 2025