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21C Museum Hotel St Louis

4.5 star property
Luxury hotel with a fitness center and a steam room

Choose dates to view prices

Photo gallery for 21C Museum Hotel St Louis

Restaurant
Exterior
Exterior
Bar (on property)
Massages

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Pet friendly
  • Free WiFi
  • Air conditioning

Explore the area

View in a map
1528 Locust street, St. Louis, MO, 63103
  • Place, City Museum
    ‪5 min walk‬
  • Place, St. Louis Union Station
    ‪8 min walk‬
  • Place, Enterprise Center
    ‪8 min walk‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪19 min drive‬

Room options

View all photos for Deluxe Room, 1 King Bed

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(82 reviews)
  • 309 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout drapes

Luxury Double Room, 2 Queen Beds

9.2 out of 10
Wonderful
(24 reviews)
  • 423 sq ft
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room (Bunk Bed)

In-room safe, desk, laptop workspace, blackout drapes

Room (Bunk Bed)

8.0 out of 10
Very good
(6 reviews)
  • 237 sq ft
  • 1 bedroom
  • Sleeps 2
  • 1 Twin Bunk Bed

View all photos for Loft, 2 Queen Beds

In-room safe, desk, laptop workspace, blackout drapes

Loft, 2 Queen Beds

8.0 out of 10
Very good
(1 review)
  • 431 sq ft
  • Sleeps 4
  • 2 Queen Beds

View all photos for Deluxe Room, Accessible (Accessible)

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, Accessible (Accessible)

  • 269 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed (21C)

  • 1119 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed (Library)

  • 732 sq ft
  • City view
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed | In-room safe, desk, laptop workspace, blackout drapes

Luxury Suite, 1 King Bed

10.0 out of 10
Exceptional
(1 review)
  • 549 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible | In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, 1 Double Bed, Accessible

  • 388 sq ft
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Suite, 1 Double Bed, Accessible

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Suite, 1 Double Bed, Accessible

  • 517 sq ft
  • Sleeps 2
  • 1 Double Bed

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Exterior

MainStay Suites St. Louis - Galleria

Richmond Heights
  • Pool
  • Pet friendly
  • Parking included
  • Free WiFi
6.8 out of 10, 84 reviews
$88 nightly
The price is $103
Feb 19 - Feb 20
Total with taxes and fees
MainStay Suites St. Louis - Galleria

About the neighborhood

St. Louis

Located in Downtown West, 21C Museum Hotel St Louis is within a 10-minute walk of popular sights such as St. Louis Union Station and City Museum. This 4.5-star hotel welcomes guests with 104 rooms and conveniences like an indoor pool, free in-room WiFi, and a gym.

What's nearby

  • Washington Avenue Historic District - 2 min walk - 0.1 miles
  • City Museum - 5 min walk - 0.3 miles
  • St. Louis Union Station - 8 min walk - 0.4 miles
  • Enterprise Center - 8 min walk - 0.5 miles
  • St. Louis Aquarium at Union Station - 11 min walk - 0.6 miles

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • St. Louis Lambert Intl. Airport (STL) - 24 min drive

Restaurants

  • ‪White Knight Diner - ‬4 min walk
  • ‪City Museum Rooftop Cafe - ‬5 min walk
  • ‪Medina Grill - ‬5 min walk
  • ‪Budweiser Kiel Club - ‬6 min walk
  • ‪Idol Wolf - ‬1 min walk

About this property

21C Museum Hotel St Louis

Luxury hotel with a fitness center and a steam room
Guests of 21C Museum Hotel St Louis have access to an indoor pool, a gym, and a steam room. Valet parking is offered for USD 50 per day. The front desk is staffed 24/7 to help with concierge services, dry cleaning/laundry, and luggage storage. Other amenities at this luxury hotel include free WiFi in public areas, meeting rooms, and a business center.
Guests can expect free WiFi and flat-screen TVs with cable channels. Bathrooms offer hair dryers, free toiletries, and bathrobes. Espresso makers, safes, and phones are also available. Change of towels is available on request.
Recreational amenities at the hotel include an indoor pool, a steam room, and a fitness center.
Guests can pamper themselves by indulging in the onsite spa services. Services include massages.

Similar properties

Bar (on property)
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
  • Pet friendly
  • Free WiFi
  • Restaurant
  • Air conditioning
8.8 out of 10, Excellent, 1,206 reviews
$87 nightly
The price is $104
Jan 25 - Jan 26
Total with taxes and fees
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business center
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • This property welcomes pets for USD 100 per accommodation, per stay
  • Dogs only
  • Service animals exempt from fees

Property payment types

Important information

Fees

  • Service fee: USD 5 per accommodation, per stay

These are all of the charges provided to us by the property.

Optional extras

These fees and deposits will be charged at check-in, check-out, or the time of service.

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

This list may not be comprehensive. Fees and deposits might not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a smoke detector and outdoor lighting
  • Check-in: 4:00 PM—-11:00 AM
  • Check-out: 11:00 AM
  • Minimum check-in age: 21
The front desk is open 24 hours a day. Driving? This property offers valet parking (fees apply).

We should mention

Details about charges, deposits, or other important information:

  • This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
  • Charges for extra guests may apply and vary depending on the property's policy.
  • A cash deposit, credit card, or debit card for incidental charges, as well as a government-issued photo ID, may be required at check-in.
  • Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
  • This property accepts credit cards. Cash is not accepted. 
  • Onsite safety features include a smoke detector and outdoor lighting.

Additional information about polices, regulations, and more:

  • Reservations need to be made in advance for massage services. Contact the hotel at the phone number listed on your booking confirmation.
  • No cribs or infant beds are available.
  • No rollaway or extra beds are available.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

Frequently asked questions

Is free cancellation available at 21C Museum Hotel St Louis ?

21C Museum Hotel St Louis offers free cancellation on select room rates. If you'd like to learn more, look at the cancellation policy on Orbitz.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of Jan 21, 2026, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on Feb 10, 2026 start from $143.66, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

What's there to do close to 21C Museum Hotel St Louis ?

This hotel is situated in Downtown West, just steps from City Museum, and within a 10-minute walk of St. Louis Union Station and Enterprise Center. You'll also find Busch Stadium and Dome at America’s Center less than a mile away.

Is there parking available at 21C Museum Hotel St Louis ?

Yes, valet parking is offered for USD 50 per day with in/out privileges.

Is there a spa available at 21C Museum Hotel St Louis ?

Spa services at the hotel include massages.

Does 21C Museum Hotel St Louis include a casino at the property?

No, 21C Museum Hotel St Louis doesn't have a casino.

Will I find an indoor pool at 21C Museum Hotel St Louis ?

Yes, this hotel has an indoor pool.

Is 21C Museum Hotel St Louis good for couples?

There are plenty of amenities for couples at this hotel, including an indoor pool, a bar, and a restaurant.

Does 21C Museum Hotel St Louis have a hot tub?

No, but this hotel does have a steam room.

Does 21C Museum Hotel St Louis have a restaurant with a breakfast menu?

Yes, 21C Museum Hotel St Louis serves a cooked-to-order breakfast each morning for a surcharge from its restaurant.

Will 21C Museum Hotel St Louis allow pets to stay for free?

Although they can't stay for free, dogs are welcome at 21C Museum Hotel St Louis for a fee of USD 100 per accommodation, per stay.

Does 21C Museum Hotel St Louis have connecting rooms?

No, there aren't connecting guestrooms at this hotel.

What is the closest airport to 21C Museum Hotel St Louis ?

The closest major airport to 21C Museum Hotel St Louis is St. Louis Lambert Intl. Airport (STL), which is 18.4 mi away (24 minutes by car). Another top airport is St. Louis, MO (SUS-Spirit of St. Louis), which is located 25.8 mi away (32-minute drive).

Can I book a room with a balcony at 21C Museum Hotel St Louis ?

No, there aren't any guestrooms with balconies at 21C Museum Hotel St Louis .

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 1119 out of 1565 reviews
Rating 8 - Good. 237 out of 1565 reviews
Rating 6 - Okay. 107 out of 1565 reviews
Rating 4 - Poor. 47 out of 1565 reviews
Rating 2 - Terrible. 55 out of 1565 reviews

9.2/10

Cleanliness

9.2/10

Staff & service

9.2/10

Amenities

9.4/10

Property conditions & facilities

Reviews

10/10 Excellent

LR

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The cafe that sold breakfast ran out of healthy options each morning (yogurt parfait cup/ overnight oats & quinoa $8 each) They had other plates, egg with meat, etc that looked nice fwiw. Cute gift shop in the cafe. Fashionable hotel with no real 'front desk' just a checkin counter, but volunteers were staffing a St. Louis info table in the lobby while we were there- very friendly. The bar/tapas restaurant across the lobby was fun, $$, and kitchen closed at 10 or so when our events got out so I didn't get to try it. LOVED the historic building, originally a YMCA, the handsome billiards room and the terrific tiled pool with vaulted ceiling- they don't make them like that anymore. Steam room, sauna, showers were great- bring a room towel in case the spa runs short! Open til 10:30p or 11p fyi. Art Museum on the 2nd floor is free to visitors, and had some challenging, gorgeous, funny, and thought-provoking art. Historic Campbell Mansion next door was a neat contrast and a quick peek into the high Victorian era. Glad I went, would stay again
Stayed 3 nights in Jan 2026

10/10 Excellent

Hazley

Stayed 2 nights in Dec 2025

10/10 Excellent

Katherine, Philadelphia

Liked: Staff & service
Exce
Stayed 4 nights in Sep 2025

10/10 Excellent

Travis

Stayed 1 night in Nov 2025

10/10 Excellent

CASEY

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 1 night in Oct 2025

6/10 Okay

Gregg

Stayed 1 night in Oct 2025

10/10 Excellent

Brandi

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

This place was absolutely incredible. 10/10.

I have been to my fair share of hotels. Mostly higher end properties and this is now one of my favorite hotels of all time. The beauty, the art, the service, the intentionality...this place was absolutely incredible. 10/10.
Stayed 2 nights in Oct 2025

10/10 Excellent

Helen

Stayed 2 nights in Oct 2025

10/10 Excellent

Jonathan

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Neat place that is a different than you average hotel. Fun experience.
Stayed 1 night in Oct 2025

10/10 Excellent

Peter

Stayed 2 nights in Sep 2025

8/10 Good

Catricia

Stayed 1 night in Oct 2025

10/10 Excellent

Vincent

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The staff was very kind and eager to help. Valet were quick, friendly, but very expensive considering it is not covered parking where they park the cars. The breakfast place was a joke on service, took an hour for an order and blamed a single cook in the back but thats poor management and should keep to yourself. The hotel itself was clean and had a great atmosphere. The art was great. Room AC worked well and the cleaning crew were efficient and tidy. Good distance from some major attractions although the time for walking distance to some are greatly underestimated, unless you are running to the Arch or Union Station.
Stayed 2 nights in Oct 2025

10/10 Excellent

michael

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Unique hotel and very convenient to City Museum.
Stayed 2 nights in Oct 2025

10/10 Excellent

Mianfeng

Liked: Cleanliness
Stayed 1 night in Aug 2025

6/10 Okay

Pamela, Leawood

Traveled with partner
Hotel could be deserving 4 star iF.. entry was vacuumed during our multiple day stay more than 1 coffee cup and only2 towels in bathroom , replaced burnt out lightbulbs in room, fresh pastries ( they were a day old according to staff) , etc. Just not managed well.
Stayed 2 nights in Oct 2025

10/10 Excellent

KEVIN

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Oct 2025

10/10 Excellent

Lora

Stayed 1 night in Oct 2025

10/10 Excellent

Lyndsey

Stayed 1 night in Oct 2025

8/10 Good

Melissa

Traveled with family
Liked: Cleanliness
Some things missing from room and we called the front desk but they never showed up. The air conditioner was very loud and kept us up. The pool area was great but out of towels.
Stayed 1 night in Oct 2025

10/10 Excellent

Tiffany

Liked: Cleanliness, staff & service, property conditions & facilities
Beautiful space, unique atmosphere and very clean.
Stayed 1 night in Oct 2025

6/10 Okay

Royal

Traveled with partner
Liked: Staff & service, amenities, property conditions & facilities
Disliked: Cleanliness
We had doubts our room had been cleaned. The shower had large globs of hair on the walls. The rest of the bathroom also left question marks, I flushed toilet, hair on counter and in sink. We were in a rush and didn’t have time to address concerns with staff before our event. We just avoided the bathroom when we returned.
Stayed 1 night in Oct 2025

10/10 Excellent

Sonali

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities
Lovely place
Stayed 2 nights in Oct 2025

10/10 Excellent

Timothy

Stayed 1 night in Oct 2025

10/10 Excellent

Michelle

Stayed 1 night in Oct 2025

10/10 Excellent

Kevin

Stayed 1 night in Oct 2025