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21C Museum Hotel St Louis

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Photo gallery for 21C Museum Hotel St Louis

A multi-story building with a symmetrical facade, large windows, and a central entrance with a canopy.
A spacious lobby with a large spherical sculpture, a seating area, and a view of the outside through a large window.
A reception area with a curved wooden desk, a laptop, and a chair. The wall has a sign reading "Locust Street Athletic and Swim Club."
A reception desk with a wooden finish and the name "IDOL WOLF" on it.
A spacious lobby with multiple seating areas, a pool table, and artwork on the walls.

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Pet friendly
  • Free WiFi
  • Air conditioning

Explore the area

View in a map
1528 Locust street, St. Louis, MO, 63103
  • Place, City Museum
    ‪5 min walk‬
  • Place, St. Louis Union Station
    ‪8 min walk‬
  • Place, Enterprise Center
    ‪8 min walk‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪20 min drive‬

Room options

View all photos for Deluxe Room, 1 King Bed

A hotel room with a large bed, a desk with a chair, a small table, and a lamp.

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(128 reviews)
  • 309 sq ft
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

A hotel room with two beds, a large window, a modern ceiling light, and a view of a staircase.

Luxury Double Room, 2 Queen Beds

9.6 out of 10
Exceptional
(41 reviews)
  • 423 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room (Bunk Bed)

A hotel room with a bunk bed, a round table with a chair, a potted plant, and a colorful abstract painting on the wall.

Room (Bunk Bed)

8.6 out of 10
Excellent
(9 reviews)
  • 237 sq ft
  • Sleeps 2
  • 1 Twin Bunk Bed

View all photos for Loft, 2 Queen Beds

A hotel room with two beds, a large padded headboard, a flat-screen TV, a window with a city view, and a small side table with a plant.

Loft, 2 Queen Beds

8.8 out of 10
Excellent
(3 reviews)
  • 431 sq ft
  • Sleeps 4
  • 2 Queen Beds

View all photos for Deluxe Room, Accessible (Accessible)

A hotel room with a large bed, a desk with a chair, a small table, and a lamp.

Deluxe Room, Accessible (Accessible)

10.0 out of 10
Exceptional
(1 review)
  • 269 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (21C)

A hotel room with a large bed, a desk, a chair, a nightstand, and a mirror.

Suite, 1 King Bed (21C)

  • 1119 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Library)

A hotel room with a large bed, a wooden headboard, a nightstand with a lamp, a green armchair, and a large painting on the wall.

Suite, 1 King Bed (Library)

  • City view
  • 732 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed | In-room safe, desk, laptop workspace, blackout drapes

Luxury Suite, 1 King Bed

9.4 out of 10
Exceptional
(3 reviews)
  • 549 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 Double Bed, Accessible

A hotel room with two beds, a sofa, a TV, and a large abstract painting.

Deluxe Room, 1 Double Bed, Accessible

  • 388 sq ft
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Suite, 1 Double Bed, Accessible

A hotel room with a large bed, a desk with a chair, a small table, and a lamp.

Deluxe Suite, 1 Double Bed, Accessible

  • 517 sq ft
  • Sleeps 2
  • 1 Double Bed

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$143 nightly
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Total with taxes and fees
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About the neighborhood

St. Louis

Located in Downtown West, 21C Museum Hotel St Louis is within a 10-minute walk of popular sights such as St. Louis Union Station and City Museum. This 4.5-star hotel welcomes guests with 104 rooms and conveniences like an indoor pool, free in-room WiFi, and a gym.

What's nearby

  • Washington Avenue Historic District - 2 min walk - 0.1 miles
  • City Museum - 5 min walk - 0.3 miles
  • St. Louis Union Station - 8 min walk - 0.4 miles
  • Enterprise Center - 8 min walk - 0.5 miles
  • St. Louis Aquarium at Union Station - 11 min walk - 0.6 miles

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • St. Louis Lambert Intl. Airport (STL) - 24 min drive

Restaurants

  • ‪Rosalita's Cantina - ‬6 min walk
  • ‪Hair of the Dog - ‬7 min walk
  • ‪Imo's Pizza Headquarters & Retail Store - ‬7 min walk
  • ‪Good Press - ‬1 min walk
  • ‪Medina Grill - ‬5 min walk

About this property

21C Museum Hotel St Louis

Guests of 21C Museum Hotel St Louis have access to an indoor pool, a gym, and a steam room. Valet parking is offered for USD 55 per day. The front desk is staffed 24/7 to help with dry cleaning/laundry, luggage storage, and concierge services. Other amenities at this luxury hotel include free WiFi in public areas, meeting rooms, and a business center.
Guests can expect free WiFi and flat-screen TVs with cable channels. Bathrooms offer hair dryers, free toiletries, and bathrobes. Espresso makers, safes, and phones are also available. Change of towels is available on request.
Recreational amenities at the hotel include an indoor pool, a steam room, and a fitness center.
Guests can pamper themselves by indulging in the onsite spa services. Services include massages.

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Oct 4 - Oct 5
Total with taxes and fees
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Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 55 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business center
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Non-plastic coffee stirrers available
  • Non-plastic drinking straws available
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM

Late check-in subject to availability

Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • This property welcomes pets for USD 100 per accommodation, per stay
  • Dogs only
  • Service animals exempt from fees

Property payment types

Important information

Fees

  • Service fee: USD 5 per accommodation, per stay

These are all of the charges provided to us by the property.

Optional extras

These fees and deposits will be charged at check-in, check-out, or the time of service.

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 55 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

This list may not be comprehensive. Fees and deposits might not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a fire extinguisher, a smoke detector, and outdoor lighting
  • Check-in: 4:00 PM—-11:00 AM
  • Check-out: 11:00 AM
  • Minimum check-in age: 21
The front desk is open 24 hours a day. Driving? This property offers valet parking (fees apply).

We should mention

Details about charges, deposits, or other important information:

  • This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
  • Charges for extra guests may apply and vary depending on the property's policy.
  • A cash deposit, credit card, or debit card for incidental charges, as well as a government-issued photo ID, may be required at check-in.
  • Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
  • This property accepts credit cards. Cash is not accepted. 
  • Onsite safety features include a fire extinguisher, a smoke detector, and outdoor lighting.

Additional information about polices, regulations, and more:

  • Reservations need to be made in advance for massage services. Contact the hotel at the phone number listed on your booking confirmation.
  • No cribs or infant beds are available.
  • No rollaway or extra beds are available.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21C Museum Hotel St Louis

21c Museum St Louis St Louis

21C Museum Hotel St Louis Hotel

21C Museum Hotel St Louis St. Louis

21C Museum Hotel St Louis Hotel St. Louis

21C Museum Hotel St Louis (Opening Spring 2023)

Frequently asked questions

Is free cancellation available at 21C Museum Hotel St Louis ?

21C Museum Hotel St Louis offers free cancellation on select room rates. If you'd like to learn more, look at the cancellation policy on Orbitz.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of Sep 14, 2026, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on Oct 11, 2026 start from $173, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

What's there to do close to 21C Museum Hotel St Louis ?

This hotel is situated in Downtown West, just steps from City Museum, and within a 10-minute walk of St. Louis Union Station and Enterprise Center. You'll also find Dome at America’s Center and Busch Stadium less than a mile away.

Will I be able to park at 21C Museum Hotel St Louis ?

Yes, valet parking is offered for USD 50 per day with in/out privileges.

Is there a spa available at 21C Museum Hotel St Louis ?

Spa services at the hotel include massages.

Does 21C Museum Hotel St Louis have luxury amenities?

Yes, guests can indulge in luxuries such as an indoor pool, a restaurant, and massages at this hotel.

Does 21C Museum Hotel St Louis include a casino at the property?

No, 21C Museum Hotel St Louis doesn't have a casino.

Will I find an indoor pool at 21C Museum Hotel St Louis ?

Yes, this hotel has an indoor pool.

What amenities will couples enjoy at 21C Museum Hotel St Louis ?

There are plenty of amenities for couples at this hotel, including a restaurant, an indoor pool, and a bar/lounge.

Are there hot tubs at 21C Museum Hotel St Louis ?

No, but guests can enjoy a steam room at this hotel.

Does 21C Museum Hotel St Louis have a restaurant with a breakfast menu?

Yes, 21C Museum Hotel St Louis serves a cooked-to-order breakfast each morning for a surcharge from its restaurant.

Will 21C Museum Hotel St Louis allow pets to stay for free?

Although they can't stay for free, dogs are welcome at 21C Museum Hotel St Louis for a fee of USD 100 per accommodation, per stay.

Are there connecting rooms at 21C Museum Hotel St Louis ?

No, there aren't connecting guestrooms at this hotel.

What is the closest airport to 21C Museum Hotel St Louis ?

The closest major airport to 21C Museum Hotel St Louis is St. Louis Lambert Intl. Airport (STL), which is 18.4 mi away (24 minutes by car). Another top airport is Belleville, IL (BLV-MidAmerica-St. Louis), which is located 25.9 mi away (32-minute drive).

Can I book a room with a balcony at 21C Museum Hotel St Louis ?

No, you won't find guestrooms with balconies at 21C Museum Hotel St Louis .

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 1485 out of 2106 reviews
Rating 8 - Good. 324 out of 2106 reviews
Rating 6 - Okay. 150 out of 2106 reviews
Rating 4 - Poor. 68 out of 2106 reviews
Rating 2 - Terrible. 79 out of 2106 reviews

9.2/10

Cleanliness

9.0/10

Staff & service

9.0/10

Amenities

9.2/10

Property conditions & facilities

Reviews

Verified review

10/10 Excellent

Quentin

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great stay!
Stayed 3 nights in May 2026
Verified review

10/10 Excellent

Heidi

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Everything was amazing beautiful hotel and excellent staff
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Alexander

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great stay
Stayed 2 nights in Apr 2026
Verified review

10/10 Excellent

Katrina

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Nice place great location
Stayed 2 nights in Mar 2026
Verified review

10/10 Excellent

Myerisa

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The stay was amazing!! Will be staying again!
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Michele

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
the hotel was well appointed and staff very attentive.
Stayed 1 night in Jun 2026
Verified review

10/10 Excellent

Molly

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great place and I would stay here again next time in St Louis
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Matthew

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Very nice classic clean hotel
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Juan

Liked: Cleanliness, staff & service, property conditions & facilities
Great place to stay.
Stayed 1 night in Apr 2026
Verified review

8/10 Good

John

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Nice place
Stayed 1 night in Jun 2026
Verified review

10/10 Excellent

Michael

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
All the restaurants and bar were excellent.
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Carl

Liked: Cleanliness
Great stay
Stayed 1 night in Apr 2026
Verified review

10/10 Excellent

Evan

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beautiful property, great food, great drinks, great staff. I love a 21C
Stayed 1 night in Jun 2026
Verified review

10/10 Excellent

Emina

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We will definitely come back and always stay in this hotel since everything was very high level. We love it and I recommend if you go to St. Louis book room in this hotel.
Stayed 1 night in Jun 2026
Verified review

10/10 Excellent

Chris

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Highly recommended!!
Stayed 1 night in Jun 2026
Verified review

10/10 Excellent

Kenneth

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great location, clean rooms, wonderful pool and hot tub
Stayed 2 nights in Apr 2026
Verified review

10/10 Excellent

Jeff

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Stayed there with my 12 year old daughter and we loved it. Stayed in the bunk bed room, which was really fun. One of the coolest hotels we have stayed at. Definately visiting again next year.
Stayed 2 nights in Feb 2026
Verified review

10/10 Excellent

Meeta

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great place to stay. Pool/spa area is great and well maintained. Restaurant /bar were great and bartenders and front desk staff was great. Parking is way too expensive but valet drivers/staff were very friendly and efficient.
Stayed 3 nights in May 2026
Verified review

10/10 Excellent

Chris

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
A great time!! Everyone was so friendly!!
Stayed 1 night in Mar 2026
Verified review

10/10 Excellent

David

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great location, staff, and bar/restaurant. The art gallery is an incredible bonus, along with the workout facilities!
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Lauren

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The room was clean and the bathroom was great! The shower was the absolute best!! The property was very nice, there was plenty to do in the hotel itself and was close by to other activities in St. Louis.
Stayed 3 nights in May 2026
Verified review

10/10 Excellent

Jenlyn

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
I loved the art museum, the bar and cafe. The staff were so friendly and helpful
Stayed 2 nights in May 2026
Verified review

10/10 Excellent

Joseph

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Really cool hotel with great onsite bar/restaurant, gym, pool and art gallery.
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Elizabeth

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The rooms were clean and common areas well maintained. Breakfast was the best and the staff were all helpful and very kind to all guests. It was the best stay I've had in a hotel.
Stayed 1 night in May 2026
Verified review

10/10 Excellent

ADIS

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Nice room size and clean
Stayed 1 night in Jun 2026

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