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21C Museum Hotel St Louis

4.5 star property
Luxury hotel with a fitness center and a steam room

Choose dates to view prices

Photo gallery for 21C Museum Hotel St Louis

Interior
Billiards
Loft, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout drapes
Dining
Exterior

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Bar

Explore the area

View in a map
1528 Locust street, St. Louis, MO, 63103
  • Place, St. Louis Union Station
    ‪6 min walk‬
  • Place, Enterprise Center
    ‪6 min walk‬
  • Place, City Museum
    ‪6 min walk‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪19 min drive‬

Room options

View all photos for Deluxe Room, 1 King Bed

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(77 reviews)
  • 309 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout drapes

Luxury Double Room, 2 Queen Beds

9.2 out of 10
Wonderful
(23 reviews)
  • 423 sq ft
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room (Bunk Bed)

In-room safe, desk, laptop workspace, blackout drapes

Room (Bunk Bed)

8.0 out of 10
Very good
(6 reviews)
  • 237 sq ft
  • 1 bedroom
  • Sleeps 2
  • 1 Twin Bunk Bed

View all photos for Loft, 2 Queen Beds

In-room safe, desk, laptop workspace, blackout drapes

Loft, 2 Queen Beds

8.0 out of 10
Very good
(1 review)
  • 431 sq ft
  • Sleeps 4
  • 2 Queen Beds

View all photos for Deluxe Room, Accessible (Accessible)

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, Accessible (Accessible)

  • 269 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed (21C)

  • 1119 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed (Library)

  • 732 sq ft
  • City view
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed | In-room safe, desk, laptop workspace, blackout drapes

Luxury Suite, 1 King Bed

10.0 out of 10
Exceptional
(1 review)
  • 549 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible | In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, 1 Double Bed, Accessible

  • 388 sq ft
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Suite, 1 Double Bed, Accessible

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Suite, 1 Double Bed, Accessible

  • 517 sq ft
  • Sleeps 2
  • 1 Double Bed

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About the neighborhood

St. Louis

Located in Downtown West, 21C Museum Hotel St Louis is within a 10-minute walk of popular sights such as City Museum and Enterprise Center. This 4.5-star hotel welcomes guests with 104 rooms and conveniences like an indoor pool, free in-room WiFi, and a gym.

What's nearby

  • Washington Avenue Historic District - 3 min walk - 0.2 miles
  • St. Louis Union Station - 6 min walk - 0.4 miles
  • Enterprise Center - 6 min walk - 0.4 miles
  • City Museum - 6 min walk - 0.4 miles
  • St. Louis Aquarium at Union Station - 9 min walk - 0.5 miles

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • St. Louis Lambert Intl. Airport (STL) - 26 min drive

Restaurants

  • ‪White Knight Diner - ‬4 min walk
  • ‪Medina Grill - ‬5 min walk
  • ‪City Museum Rooftop Cafe - ‬5 min walk
  • ‪Idol Wolf - ‬1 min walk
  • ‪Budweiser Kiel Club - ‬6 min walk

About this property

21C Museum Hotel St Louis

Luxury hotel with a fitness center and a steam room
Guests of 21C Museum Hotel St Louis have access to an indoor pool, a gym, and a steam room. Valet parking is offered for USD 50 per day. The front desk is staffed 24/7 to help with dry cleaning/laundry, concierge services, and luggage storage. Other amenities at this luxury hotel include free WiFi in public areas, meeting rooms, and a business center.
Guests can expect free WiFi and flat-screen TVs with cable channels. Bathrooms offer hair dryers, free toiletries, and bathrobes. Espresso makers, safes, and phones are also available. Change of towels is available on request.
Recreational amenities at the hotel include an indoor pool, a steam room, and a fitness center.
Guests can pamper themselves by indulging in the onsite spa services. Services include massages.

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Total with taxes and fees
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Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business center
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • This property welcomes pets for USD 100 per accommodation, per stay
  • Dogs only
  • Service animals exempt from fees

Property payment types

Important information

Fees

  • Service fee: USD 5 per accommodation, per stay

These are all of the charges provided to us by the property.

Optional extras

These fees and deposits will be charged at check-in, check-out, or the time of service.

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

This list may not be comprehensive. Fees and deposits might not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a smoke detector and outdoor lighting
  • Check-in: 4:00 PM—-11:00 AM
  • Check-out: 11:00 AM
  • Minimum check-in age: 21
The front desk is open 24 hours a day. Driving? This property offers valet parking (fees apply).

We should mention

Details about charges, deposits, or other important information:

  • This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
  • Charges for extra guests may apply and vary depending on the property's policy.
  • A cash deposit, credit card, or debit card for incidental charges, as well as a government-issued photo ID, may be required at check-in.
  • Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
  • This property accepts credit cards. Cash is not accepted. 
  • Onsite safety features include a smoke detector and outdoor lighting.

Additional information about polices, regulations, and more:

  • Reservations need to be made in advance for massage services. Contact the hotel at the phone number listed on your booking confirmation.
  • No cribs or infant beds are available.
  • No rollaway or extra beds are available.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

Frequently asked questions

Is free cancellation available at 21C Museum Hotel St Louis ?

21C Museum Hotel St Louis offers free cancellation on select room rates. If you'd like to learn more, look at the cancellation policy on Orbitz.

What's there to do close to 21C Museum Hotel St Louis ?

This hotel is situated in Downtown West within a 10-minute walk of City Museum and Enterprise Center. You'll also find St. Louis Union Station and Dome at America’s Center less than a mile away.

Is there parking available at 21C Museum Hotel St Louis ?

Yes, valet parking is offered for USD 50 per day with in/out privileges.

Is there a spa available at 21C Museum Hotel St Louis ?

Spa services at the hotel include massages.

Does 21C Museum Hotel St Louis include a casino at the property?

No, 21C Museum Hotel St Louis doesn't have a casino.

Will I find an indoor pool at 21C Museum Hotel St Louis ?

Yes, this hotel has an indoor pool.

Is 21C Museum Hotel St Louis a good place to stay for couples?

There are plenty of amenities for couples at this hotel, including an indoor pool, a bar, and a restaurant.

Does 21C Museum Hotel St Louis have a hot tub?

No, but this hotel does have a steam room.

Does 21C Museum Hotel St Louis have a restaurant with a breakfast menu?

Yes, 21C Museum Hotel St Louis serves a cooked-to-order breakfast each morning for a surcharge from its restaurant.

Will 21C Museum Hotel St Louis allow pets to stay for free?

Although they can't stay for free, dogs are welcome at 21C Museum Hotel St Louis for a fee of USD 100 per accommodation, per stay.

Does 21C Museum Hotel St Louis have connecting rooms?

No, this hotel doesn't feature connecting guestrooms.

What is the closest airport to 21C Museum Hotel St Louis ?

The closest major airport to 21C Museum Hotel St Louis is St. Louis Lambert Intl. Airport (STL), which is 18.4 mi away (26 minutes by car). Another top airport is St. Louis, MO (SUS-Spirit of St. Louis), which is located 25.8 mi away (32-minute drive).

Are there rooms with balconies that I can book at 21C Museum Hotel St Louis ?

No, at 21C Museum Hotel St Louis , there aren't any guestrooms that list a balcony.

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 1069 out of 1482 reviews
Rating 8 - Good. 219 out of 1482 reviews
Rating 6 - Okay. 96 out of 1482 reviews
Rating 4 - Poor. 44 out of 1482 reviews
Rating 2 - Terrible. 54 out of 1482 reviews

9.2/10

Cleanliness

9.2/10

Staff & service

9.2/10

Amenities

9.4/10

Property conditions & facilities

9.2/10

Eco-friendliness

Reviews

10/10 Excellent

Katherine, Philadelphia

Liked: Staff & service
Exce
Stayed 4 nights in Sep 2025

10/10 Excellent

Travis

Stayed 1 night in Nov 2025

8/10 Good

Steven

Business traveler
Liked: Cleanliness, staff & service, room comfort
Stayed 3 nights in Jul 2025

10/10 Excellent

Larry

Business traveler
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

A literal museum

A terrific hotel created from what once was the YMCA. (Be sure to take a look at the exquisite tile work in the downstairs swimming pool.) There’s fascinating modern art, including a large gallery on the second floor. But beware that the hotel is on a desolate street of abandoned buildings so be prepared to pay high valet fees for parking or take Uber everywhere.
Stayed 3 nights in Sep 2025

10/10 Excellent

Matthew

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 2 nights in Aug 2025

10/10 Excellent

Sarah

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Loved the art and the building itself. Bed sheets weren’t as clean and the pillows weren’t comfortable. The towels in the bathroom were frayed.
Stayed 1 night in Sep 2025

10/10 Excellent

Kevin

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Sep 2025

10/10 Excellent

Kerry

Liked: Cleanliness, amenities
Great idea with the museum, fantastic older building with so much chsracter.
Stayed 1 night in Aug 2025

10/10 Excellent

Robyn J

Stayed 1 night in Aug 2025

10/10 Excellent

monica

Traveled with group
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in May 2025

10/10 Excellent

Thomas

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Excellent hotel. Very unique, good vibes.
Stayed 3 nights in Aug 2025

10/10 Excellent

Irma

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
We had a great time at the hotel. Pool, spa, gym are outstanding, the plus of having a museum in the 2nd floor and great service in the restaurants and hotel made our stay very enjoyable!
Stayed 2 nights in Aug 2025

6/10 Okay

Kristina

Liked: Cleanliness, staff & service, property conditions & facilities
The room was clean, however very small. You can only park valet for $50 a night. Hefty!!! A small coffee that was at best luke warm will cost you $4.67. Go to Starbucks!!! Close to many sightings, however lots of better choices are available with parking included. I will not return to this hotel.
Stayed 2 nights in Aug 2025

6/10 Okay

lennoria

Liked: Staff & service, property conditions & facilities
Disliked: Cleanliness
My room was not clean
Stayed 2 nights in Aug 2025

10/10 Excellent

Lisa

Liked: Cleanliness, staff & service, property conditions & facilities
Stay here often!
Stayed 1 night in Aug 2025

10/10 Excellent

Benjamin, Chicago

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Amazing pool, great food and drink options, terrific staff.
Stayed 1 night in Aug 2025

10/10 Excellent

Susan

Traveled with group
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Everybody's great, but especially the valets!

The whole staff is always wonderful here. The bartenders are spectacular. But who really stands out is the valet staff. A++, above and beyond every single time. Thanks!
Stayed 1 night in Aug 2025

8/10 Good

Shuwanda

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Jun 2025

10/10 Excellent

Rachel

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Love the art at the hotel.
Stayed 1 night in Aug 2025

10/10 Excellent

james

Stayed 1 night in Aug 2025

8/10 Good

Beth

Traveled with group
Liked: Cleanliness, property conditions & facilities, room comfort

Clean but pay to park

It was a nice hotel. It was a little discouraging that we had to pay to park after paying the price of the room. From the parking area (around back), you had to go to the front, then go up steps to enter the hotel. I just didn't love the setup. There are no ice machines, no vending, but they do have a bar and coffee shop. All and all it was a nice stay, but I don't know that I would want to stay again.
Stayed 2 nights in Aug 2025

10/10 Excellent

Amy

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Aug 2025

10/10 Excellent

Alina

Business traveler
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Amazing experience-best hotel stay Ive had to date

This place is amazing. I booked here on a whim because of the giant crystal ball in the lobby and i was working an event less than 20 minutes away. Im so glad i did. The valet parking was lovely and made me feel my car with my whole business inside was secure. Check in was smooth and our room was beautiful. We ate at the restaurant Idol Wolf, and the burgers were very well done. I loved the cotton candy the brought out complimentary at the end. We had outdoor seating and it was very comfortable and easy to have a conversation, while the indoor seating was full and quite loud for me... but i know others like a lively atmosphere. After food, we wandered up the colorful beautiful staircase and found ourselves in a gorgeous museum full of moving art, lovely little sitting areas, and moving meaningful pieces around every turn. The museum was curated very well and it was so wonderful to get to explore it without having to leave the building. The pool was gorgeous and very well maintained. My companion enjoyed hpurs down there while i luxuriated in the amazing bath tub for some solo relaxation. We had an absolute blast. This was the best hotel I've ever yet stayed in in over 20 years of travel. I highly recommend it. You wont be disappointed.
Stayed 1 night in Aug 2025

10/10 Excellent

Steven

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Aug 2025

8/10 Good

Lee

Liked: Cleanliness, staff & service, property conditions & facilities
Nice hotel but the area wasn’t the best
Stayed 3 nights in Aug 2025