COVID-19 alert: Travel requirements are changing rapidly, including need for pre-travel COVID-19 testing and quarantine on arrival.

Hotels in Southern Illinois

Search over 479 hotels from $59

Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels

Save 10% or more on select hotels with Insider Prices

Book on the app to instantly earn 5% on 350,000+ hotels

Top Rated Southern Illinois Hotels

Don't see what you're looking for?
See all available properties in Southern Illinois
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Luxury Hotels in Southern Illinois

    Super 8 by Wyndham Troy IL/St. Louis Area

    Super 8 by Wyndham Troy IL/St. Louis Area

    910 Edwardsville Rd, Troy, IL
    The price is $67 per night from May 17 to May 17
    3.7/5Good! (37 reviews)
    Super 8 by Wyndham Troy IL/St. Louis Area
    Super 8 by Wyndham Effingham

    Super 8 by Wyndham Effingham

    1400 Thelma Keller Ave, Effingham, IL
    The price is $62 per night from May 16 to May 16
    3.6/5Good! (32 reviews)
    Super 8 by Wyndham Effingham
    Suite Dreams Hotel

    Suite Dreams Hotel

    300 Broadway Avenue East, Mattoon, IL
    The price is $79 per night from May 12 to May 12
    4/5Very Good! (1 review)
    Suite Dreams Hotel

Pet Friendly Southern Illinois Hotels

Recent Reviews