Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5
Due to coronavirus (COVID-19) travel advisories, some destinations may be unavailable for certain dates. Find out more.

Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels

Save 10% or more on select hotels with Insider Prices

Book on the app to instantly earn 5% on 350,000+ hotels

Tonight
Next weekend
Jun 12 - Jun 14

Top Rated Southern Illinois Hotels

Extended Stay America - St. Louis - O' Fallon, IL
Extended Stay America - St. Louis - O' Fallon, IL
2.5 out of 5.0 154 Regency Park, O'Fallon, IL
Free Cancellation
$58
3.6/5 (16 reviews)

We wish they had blow dryer in the rooms.the room was clean and the staff was nice

Reviewed on Aug 6, 2019
Renovated in 2017, Extended Stay America - St. Louis - O' Fallon, IL offers free WiFi in public areas, coffee in a common area, and laundry facilities. If you ...
Hampton Inn St Louis/Fairview Heights
Hampton Inn St Louis/Fairview Heights
2.5 out of 5.0 150 Ludwig Dr, Fairview Heights, IL
Free Cancellation
$89
4.1/5 (21 reviews)

All clean, neat highways & multiple restaurants . Staff who checked me in were very friendly & helpful

Reviewed on Sep 20, 2019
Hampton Inn St Louis/Fairview Heights features a 24-hour fitness center, free WiFi in public areas, and a business center. If you drive, take advantage of free ...
Comfort Suites Mount Vernon
Comfort Suites Mount Vernon
2.5 out of 5.0 404 South 44th Street, Mount Vernon, IL
Free Cancellation
$80
4.7/5 (29 reviews)

Quiet, clean room and very comfortable furnishings.

Reviewed on Jun 3, 2020
Comfort Suites Mount Vernon offers an indoor pool, a spa tub, and free WiFi in public areas. There's free parking if you drive. Front-desk staff are standing ...
Hampton Inn Suites St LouisEdwardsville
Hampton Inn Suites St LouisEdwardsville
2.5 out of 5.0 5723 Heritage Crossing Dr, Glen Carbon, IL
Free Cancellation
$94
3.9/5 (11 reviews)

Great location! Helpful staff. Breakfast satisfying.

Reviewed on May 27, 2019
Guests of Hampton Inn Suites St LouisEdwardsville have access to an indoor pool, a fitness center, and a spa tub. You can put free parking to good use if you ...
Hampton Inn Carbondale
Hampton Inn Carbondale
2.5 out of 5.0 2175 Reed Station Pkwy, Carbondale, IL
Free Cancellation
$99
4.4/5 (17 reviews)

great place. Lovely decor. Very comfortable. Good breakfast.

Reviewed on Jul 27, 2019
At Hampton Inn Carbondale, guests enjoy features like an indoor pool, a fitness center, and a spa tub. There's free parking if you drive. Front-desk staff can ...
Hilton Garden Inn St. Louis Shiloh/O'Fallon IL
Hilton Garden Inn St. Louis Shiloh/O'Fallon IL
3.0 out of 5.0 360 Regency Park Drive, O'Fallon, IL
Free Cancellation
$101
3.9/5 (10 reviews)

It was well cleaned and comfortable. Thernostat was set to 77 and took us a while to figure out why it was so hot

Reviewed on Nov 25, 2018
At Hilton Garden Inn St. Louis Shiloh/O'Fallon IL, guests enjoy features like an indoor pool, a 24-hour fitness center, and a spa tub. If you decide to drive, ...
Hampton Inn Mt Vernon
Hampton Inn Mt Vernon
2.5 out of 5.0 221 Potomac Blvd, Mount Vernon, IL
Free Cancellation
$88
4.4/5 (16 reviews)

Great breakfast! Bathroom needs updating but it was clean. Overall, nice place to stay.

Reviewed on Dec 29, 2019
Guests of Hampton Inn Mt Vernon have access to an indoor pool, a 24-hour fitness center, and a spa tub. A stay here includes free parking. The front desk is ...
Cozy Waterfront Cabin at Lake of Egypt
Cozy Waterfront Cabin at Lake of Egypt
Goreville, IL
Get Rates
At this cabin, guests have access to barbecue grills.
Hampton Inn St Louis/Collinsville
Hampton Inn St Louis/Collinsville
2.5 out of 5.0 7 Commerce Drive, Collinsville, IL
Free Cancellation
$76
3.8/5 (15 reviews)

A clean, lovely hotel for a reasonable price! And they really took the pandemic seriously!

Reviewed on May 31, 2020
At Hampton Inn St Louis/Collinsville, guests enjoy features like an indoor pool, a 24-hour fitness center, and a spa tub. If you plan to drive, free parking ...

Luxury Hotels in Southern Illinois

See all 377 Properties in Southern Illinois

Pet Friendly Southern Illinois Hotels

See all 377 Properties in Southern Illinois
Southern Illinois Hotels

Orbitz makes it easy to find the best Southern Illinois hotel deals for your trip. With an outstanding selection, easy-to-use search tools and descriptive hotel profiles, you'll find Southern Illinois hotel deals in a wink..

Great selection of hotels in Southern Illinois

Whether you're searching for hotels in Southern Illinois on business, or hunting for a family getaway, Southern Illinois hotel options are only a click away. Find hotels in Southern Illinois with the location, star-rating and facilities you need. Narrow your search results even further by star rating, hotel chain and amenities, such as free parking, babysitting services, or fitness centers. And with area maps, you can view Southern Illinois hotels close you are to the airport and nearby attractions.

Southern Illinois hotel reviews, photos and virtual tours

Thanks to photos and virtual tours, you can look before you book your Southern Illinois hotel reservation. Check out Southern Illinois hotel properties using interactive tools which allow you view hotel rooms, common areas and key features. On Orbitz, you can also learn more about hotels in Southern Illinois with unbiased reviews from verified Southern Illinois hotel guests. We ask guests to offer candid feedback on services, comfort, location, value and amenities.

Grab Southern Illinois hotel deals and special offers

Orbitz works around the clock to find exclusive offers and Southern Illinois hotel deals, just for you. Sign up for deals by e-mail where you'll get first crack at money-saving extras like promo codes, resort credits, free nights and more. You can also "Like" Orbitz on Facebook and follow us on Twitter to receive up-to-the-minute news on hotel discounts, giveaways and more.

24/7 support with Southern Illinois hotel reservations

When it comes to finding hotels in Southern Illinois, an Orbitz specialist can help you find the property right for you. Chat live or call 1-800-454-3743 any time for help booking your hotels in Southern Illinois. Our team of experts can help you pinpoint Southern Illinois hotels options suited to your tastes and budget.

Forget Orbitz change or cancel fees on Southern Illinois hotels

On Orbitz, Southern Illinois hotel deals mean flexibility. If you need to change your Southern Illinois hotel reservations, or cancel your stay, Orbitz doesn't charge cancel or change fees. Orbitz also offers great selection on airline tickets, vacation packages, and car rental deals to so you can plan your trip to Southern Illinois all in one place.

 

Recent Reviews

*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.