Hotels in South Central Houston
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Featured Hotels in South Central Houston

Hotel Zaza Houston Museum District
5701 Main Street Houston TX
Free Cancellation
Reserve now, pay when you stay
1.66 mi from South Central Houston
$253 nightly
The price is $296 total per night
$296 total
Apr 19 - Apr 20
Total with taxes and fees
Hotel Zaza Houston Museum District features a full-service spa, an outdoor pool, and a 24-hour gym. Valet parking is available for USD 59 per night, and there's also a free area shuttle. Front-desk staff can answer questions 24/7, and assist with luggage storage, dry cleaning/laundry, and concierge services. Other amenities at this luxury hotel include a sauna, free WiFi in public areas, and conference space.
Pool
Pet friendly

Hilton Houston Plaza/Medical Center
6633 Travis St Houston TX
Free Cancellation
Reserve now, pay when you stay
2.74 mi from South Central Houston
$100 nightly
The price is $117 total per night
$117 total
Apr 19 - Apr 20
Total with taxes and fees
Guests staying at Hilton Houston Plaza/Medical Center enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. Self parking is available for USD 20 per day. Multilingual staff at the front desk are standing by 24/7 to help with dry cleaning/laundry, luggage storage, and concierge services. Other amenities at this luxury hotel include meeting rooms, conference space, and coffee/tea in a common area.
Pool
Free WiFi

InterContinental Houston by IHG
6750 Main St Houston TX
Free Cancellation
2.89 mi from South Central Houston
$180 nightly
The price is $211 total per night
$211 total
Apr 12 - Apr 13
Total with taxes and fees
Guests of InterContinental Houston by IHG have access to an outdoor pool, a 24-hour gym, and free WiFi in public areas. Parking is available for USD 40 per day (USD 53 per day for valet parking), and there's also a free area shuttle. Front-desk staff can answer questions 24/7, and assist with luggage storage, dry cleaning/laundry, and concierge services. Additional amenities include conference space, a 24-hour business center, and express check-out.

The Westin Houston Medical Center/Museum District
1709 DRYDEN ROAD Houston TX
Free Cancellation
Reserve now, pay when you stay
2.65 mi from South Central Houston
$183 nightly
The price is $212 total per night
$212 total
Apr 11 - Apr 12
Total with taxes and fees
At The Westin Houston Medical Center/Museum District, guests enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. Valet parking is available for USD 54 per night. Multilingual staff at the front desk are standing by 24/7 to help with luggage storage, dry cleaning/laundry, and concierge services. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include conference space, a business center, and coffee/tea in a common area.
Pool
Pet friendly

DoubleTree by Hilton Houston Medical Center Hotel & Suites
6800 Main Street Houston TX
Free Cancellation
Reserve now, pay when you stay
2.91 mi from South Central Houston
$102 nightly
The price is $119 total per night
$119 total
Apr 26 - Apr 27
Total with taxes and fees
At DoubleTree by Hilton Houston Medical Center Hotel & Suites, guests enjoy features like an outdoor pool, a 24-hour gym, and free WiFi in public areas. If you drive, self parking is USD 25.00 per night, and there's also a free area shuttle. The 24-hour front desk has multilingual staff ready to assist with luggage storage and securing valuables. Additional amenities include conference space, a 24-hour business center, and a computer station.
Pool
Pet friendly

Americas Best Value Inn Medical Center Downtown
2419 Riverside Dr Houston TX
Free Cancellation
Reserve now, pay when you stay
1.16 mi from South Central Houston
$83 nightly
The price is $97 total per night
$97 total
Apr 8 - Apr 9
Total with taxes and fees
At Americas Best Value Inn Medical Center Downtown, guests have access to free WiFi in public areas, coffee in a common area, and express check-out. Free parking is included with your stay. The front desk is staffed 24/7 to help with tours or tickets, and answer any questions about the accommodations. This motel also has a vending machine.
Parking included
Free WiFi

Extended Stay America Suites Houston Med Ctr Braeswood Bl
1301 Braeswood Blvd Houston TX
Free Cancellation
Reserve now, pay when you stay
2.89 mi from South Central Houston
$71 nightly
The price is $83 total per night
$83 total
Apr 13 - Apr 14
Total with taxes and fees
Guests of Extended Stay America Suites Houston Med Ctr Braeswood Bl have access to an outdoor pool, a gym, and free WiFi in public areas. Free parking is available if you drive. The front desk is staffed 24 hours a day to help with luggage storage and securing valuables. Additional amenities include conference space, coffee/tea in a common area, and laundry facilities.

Houston Marriott Medical Center/Museum District
6580 Fannin Street Houston TX
Free Cancellation
Reserve now, pay when you stay
2.61 mi from South Central Houston
$207 nightly
The price is $242 total per night
$242 total
Apr 25 - Apr 26
Total with taxes and fees
Guests of Houston Marriott Medical Center/Museum District enjoy a 24-hour gym, free WiFi in public areas, and a conference center. Valet parking is available for USD 49 per day, and there's also a free area shuttle. The front desk is staffed 24/7 to help with dry cleaning/laundry, securing valuables, and luggage storage. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include a business center, express check-in, and express check-out.
Pet friendly
Free WiFi

Downtowner Inns - Houston Downtown
2510 Hamilton St Houston TX
0.95 mi from South Central Houston
$87 nightly
The price is $102 total per night
$102 total
Apr 13 - Apr 14
Total with taxes and fees
Downtowner Inns - Houston Downtown features free WiFi in public areas and a vending machine. You can put free parking to good use if you drive. The 24-hour front desk has staff standing by to help with luggage storage, and answer any questions about the accommodations.
Breakfast included
Parking included
Don't see what you're looking for?
See all available properties in South Central Houston
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
South Central Houston hotels essential information
Accommodation | 1,075 hotels |
|---|---|
Lowest Price | $83 |
Highest Price | $296 |
Popular hotels | Hotel Zaza Houston Museum District, Hilton Houston Plaza/Medical Center, InterContinental Houston by IHG, The Westin Houston Medical Center/Museum District, DoubleTree by Hilton Houston Medical Center Hotel & Suites, Americas Best Value Inn Medical Center Downtown, Extended Stay America Suites Houston Med Ctr Braeswood Bl, Houston Marriott Medical Center/Museum District, Downtowner Inns - Houston Downtown |
Popular places to visit

MD Anderson Cancer Center
4.5/5(802 reviews)
Though MD Anderson Cancer Center might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.

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4.5/5(361 reviews)
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Houston Zoo
4.5/5(1,018 reviews)
Why not visit the native and exotic animals who call Houston Zoo home during your trip to Houston? Experience the area's fascinating museums and lively festivals.
Recent Reviews

DoubleTree by Hilton Houston Medical Center Hotel & Suites
5/5 Excellent
"The lady at the breakfast buffet is wonderful. She's so friendly and helpful, perfect for the job!"
A verified traveler stayed at DoubleTree by Hilton Houston Medical Center Hotel & Suites
Posted 3 hours ago
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