Hotels in O Brien
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Top Rated O Brien Hotels

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!
obrien FL
9.11 mi from city center
Guests staying at this vacation home enjoy a gym, an arcade/game room, and laundry facilities. Other amenities at this beach vacation home include barbecue grills and a garden.
Kitchen
Washer

La Quinta Inn & Suite by Wyndham Lake City
165NW CALI DRIVE Lake City FL
Free Cancellation
Reserve now, pay when you stay
18.21 mi from city center
$94 nightly
The price is $105 total per night
$105 total
Dec 28 - Dec 29
Total with taxes and fees
Guests of La Quinta Inn & Suite by Wyndham Lake City have access to an indoor pool, a 24-hour gym, and free WiFi in public areas. A stay here includes free parking. The 24-hour front desk has staff always at the ready. Additional amenities include a business center, laundry facilities, and a gift shop.
Pool
Breakfast included

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
16367 NW 167TH BLVD Alachua FL
Free Cancellation
29.91 mi from city center
$113 nightly
The price is $127 total per night
$127 total
Dec 28 - Dec 29
Total with taxes and fees
Guests of Holiday Inn Express & Suites Alachua - Gainesville Area by IHG have access to an outdoor pool, a 24-hour gym, and free WiFi in public areas. A stay here includes free parking. The front desk has multilingual staff on hand 24/7 to help with securing valuables, dry cleaning/laundry, and luggage storage. Additional amenities include a hot tub, a business center, and coffee/tea in a common area.
Pool
Hot Tub

Tru by Hilton Lake City
284 NW Centurion Court Lake City FL
Free Cancellation
Reserve now, pay when you stay
17.91 mi from city center
$100 nightly
The price is $113 total per night
$113 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Guests of Tru by Hilton Lake City have access to an outdoor pool, a gym, and free WiFi in public areas. If you plan to drive, free parking is available. The 24-hour front desk has staff standing by to help with securing valuables, luggage storage, and dry cleaning/laundry. Additional amenities include a 24-hour business center, coffee/tea in a common area, and express check-in.
Pool
Breakfast included

Best Western Plus Lake City
350 SW Florida Gateway Dr Lake City FL
Free Cancellation
Reserve now, pay when you stay
17.89 mi from city center
$87 nightly
The price is $98 total per night
$98 total
Dec 28 - Dec 29
Total with taxes and fees
At Best Western Plus Lake City, guests enjoy an indoor pool, a gym, and free WiFi in public areas. If you drive, take advantage of free parking. The front desk is staffed 24 hours a day to help with securing valuables and dry cleaning/laundry. Additional amenities include a 24-hour business center, coffee/tea in a common area, and express check-out.
Pool
Breakfast included

Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy
1699 NE Co Rd 337 High Springs FL
24.65 mi from city center
$179 nightly
The price is $197 total per night
$197 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
If you drive, take advantage of free parking. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls.
Kitchen
Pet friendly

Motel 6 – Lake City, Fl – Medical Center
3340 W US Highway 90 Lake City FL
Free Cancellation
18 mi from city center
$61 nightly
The price is $69 total per night
$69 total
Dec 28 - Dec 29
Total with taxes and fees
At Motel 6 – Lake City, Fl – Medical Center, guests have access to a vending machine. Free parking is included with your stay. The 24-hour front desk has staff always at the ready.
Pet friendly
Parking included

Hampton Inn & Suites Lake City
450 SW Florida Gateway Drive Lake City FL
Free Cancellation
Reserve now, pay when you stay
17.84 mi from city center
$116 nightly
The price is $131 total per night
$131 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
At Hampton Inn & Suites Lake City, guests enjoy features like an outdoor pool, a gym, and free WiFi in public areas. A stay here includes free parking. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. Additional amenities include conference space, a 24-hour business center, and coffee/tea in a common area.
Pool
Breakfast included

Holiday Inn & Suites Lake City by IHG
213 Sw Commerce Dr Lake City FL
Free Cancellation
18.1 mi from city center
$95 nightly
The price is $107 total per night
$107 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
Guests staying at Holiday Inn & Suites Lake City by IHG enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. There's free parking if you drive. The 24-hour front desk has staff standing by to help with luggage storage, securing valuables, and dry cleaning/laundry. Additional amenities include conference space, a 24-hour business center, and coffee/tea in a common area.
Pool
Pet friendly

Comfort Suites Lake City
3690 W Us Highway 90 Lake City FL
Free Cancellation
Reserve now, pay when you stay
17.73 mi from city center
$107 nightly
The price is $120 total per night
$120 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
Guests staying at Comfort Suites Lake City enjoy an outdoor pool, a gym, and free WiFi in public areas. There's free parking if you drive. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include a 24-hour business center, a meeting room, and a computer station.
Pool
Breakfast included

Baymont by Wyndham Lake City I-75
3598 W Us Highway 90 Lake City FL
Free Cancellation
Reserve now, pay when you stay
17.8 mi from city center
$58 nightly
The price is $65 total per night
$65 total
Dec 28 - Dec 29
Total with taxes and fees
Guests of Baymont by Wyndham Lake City I-75 have access to an outdoor pool, a gym, and free WiFi in public areas. If you drive, put free parking to good use. The front desk is staffed 24/7 to help secure valuables, and answer any questions about the accommodations. Additional amenities include a hot tub, meeting rooms, and conference space.
Pool
Hot Tub

Holiday Inn Express & Suites Live Oak by IHG
6694 Us Highway 129 Live Oak FL
Free Cancellation
20.02 mi from city center
$121 nightly
The price is $133 total per night
$133 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
Guests staying at Holiday Inn Express & Suites Live Oak by IHG enjoy an outdoor pool, a gym, and free WiFi in public areas. If you drive, put free parking to good use. The 24-hour front desk has multilingual staff ready to help secure valuables, and answer any questions about the area. Additional amenities include a business center, coffee/tea in a common area, and a meeting room.
Pool
Breakfast included
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where is a good place to stay in O Brien?
What are the best hotels in O Brien?
Here are some top hotels in O Brien:
- La Quinta Inn & Suite by Wyndham Lake City is located 18.2 mi away, and this hotel has free breakfast, free WiFi, and free parking.
- Holiday Inn Express & Suites Alachua - Gainesville Area by IHG is located 29.9 mi away, and this hotel has free breakfast, free WiFi, and free parking.
- Tru by Hilton Lake City is located 17.9 mi away, and this hotel has free breakfast, free WiFi, and free parking.
O Brien hotels essential information
Accommodation | 345 hotels |
|---|---|
Lowest Price | $65 |
Highest Price | $197 |
Popular hotels | Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!, La Quinta Inn & Suite by Wyndham Lake City, Holiday Inn Express & Suites Alachua - Gainesville Area by IHG, Tru by Hilton Lake City, Best Western Plus Lake City, Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy, Motel 6 – Lake City, Fl – Medical Center, Hampton Inn & Suites Lake City, Holiday Inn & Suites Lake City by IHG, Comfort Suites Lake City, Baymont by Wyndham Lake City I-75, Holiday Inn Express & Suites Live Oak by IHG |
Recent Reviews

Tru by Hilton Lake City
5/5 Excellent
"Dese'rae (sp) was lovely. Very helpful, informative and friendly. "
A verified traveler stayed at Tru by Hilton Lake City
Posted 3 days ago
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