Florida Keys Vacation Homes

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Featured Vacation Homes in Florida Keys

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotel Options in Florida Keys

    Reefhouse Resort & Marina

    Reefhouse Resort & Marina

    103800 Overseas Hwy Key Largo FL
    $439 nightly
    The price is $489 total per night from Mar 10 to Mar 11
    $489 total
    Mar 10 - Mar 11
    Total with taxes and fees
    9.4/10 Exceptional! (1,405 reviews)
    Waterside Suites & Marina

    Waterside Suites & Marina

    201 Ocean Drive Key Largo FL
    $209 nightly
    The price is $236 total per night from Mar 10 to Mar 11
    $236 total
    Mar 10 - Mar 11
    Total with taxes and fees
    9/10 Wonderful! (1,243 reviews)
    Cheeca Lodge & Spa

    Cheeca Lodge & Spa

    81801 Overseas Highway, Mile Marker 82 Islamorada FL
    $388 nightly
    The price is $437 total per night from Mar 22 to Mar 23
    $437 total
    Mar 22 - Mar 23
    Total with taxes and fees
    9.2/10 Wonderful! (1,306 reviews)

Florida Keys Vacation Homes

Book vacation homes in Florida Keys
Next time you take a group getaway top Florida Keys, don’t confine your friends and family to one or two hotel rooms. Instead, snag a deal on a full-sized house and get the best of both worlds. Vacation home rentals are perfect for families and large groups that want to live like locals on vacation. Whether you are searching for a villa that pulls out all the stops or a four-bedroom house to host the best summer vacation ever, Orbitz has a variety of Florida Keys vacation homes for rent that are ideal for you. Your perfect pad is only a few clicks away.

Homes for every Florida Keys vacation
If you’re planning a vacation with a lot of people, you’ll want room to stretch out, and a rental home has plenty of space. Many vacation homes also come with everything you’ll need for a proper getaway, like kitchens with every gadget you can think of, along with updated furnishings, fancy spa tubs and balconies. You may even wind up in a rental home that has a sprawling backyard for barbecues, games and general relaxation. These rentals offer the added bonus of putting you right in the thick of things in Florida Keys; instead of going to a small hotel room at the end of a busy day, you’re going home.

Vacations are all about creating lasting memories, and a Florida Keys rental home makes it easy to create good ones. Whether you’re getting the college crowd back together or bringing along your folks and your kids, a trip to Florida Keys is sure to be a winner.

Florida Keys Vacation Homes essential information

Accommodation
972 Vacation Homes
Lowest Price
$236
Highest Price
$780
Popular accommodation
The Hammocks at Marathon, Charming 3-bedroom house featuring a heated private pool., Direct Oceanfront-Atlantic Side-Dockage-Pool and 20 miles from Key West, ★Remodeled tropical delight townhome★private plunge pool close to fun activities, Refined. Safe. Clean. Waterfront. Golf cart , courtesy to our guests, NEW ! Lagoon-front townhouse with Marina! Day Dreams Key Largo., Waterfront, saltwater lagoon, 2 pools, ocean access, marina, tennis, pickleball, the fountain, BRAND NEW! KEYS BEACH RETREAT! CAPTIVATING WATERVIEW VILLA! WIFI! FREE GOLF CART