Florida Keys Vacation Homes

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Featured Vacation Homes in Florida Keys

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotel Options in Florida Keys

    Cheeca Lodge & Spa

    Cheeca Lodge & Spa

    81801 Overseas Highway, Mile Marker 82, Marker 82, Islamorada, FL
    $179 nightly
    The price is $201 total per night from Oct 26 to Oct 27
    $201 total
    Oct 26 - Oct 27
    Total with taxes and fees
    9/10 Wonderful! (1,232 reviews)
    Reefhouse Resort & Marina

    Reefhouse Resort & Marina

    103800 Overseas Hwy, Key Largo, FL
    $259 nightly
    The price is $286 total per night from Oct 26 to Oct 27
    $286 total
    Oct 26 - Oct 27
    Total with taxes and fees
    9.2/10 Wonderful! (1,300 reviews)
    Baker's Cay Resort Key Largo, Curio Collection by Hilton

    Baker's Cay Resort Key Largo, Curio Collection by Hilton

    97000 Overseas Hwy, Key Largo, FL
    $339 nightly
    The price is $381 total per night from Nov 2 to Nov 3
    $381 total
    Nov 2 - Nov 3
    Total with taxes and fees
    8.6/10 Excellent! (1,017 reviews)

Florida Keys Vacation Homes

Book vacation homes in Florida Keys
Next time you take a group getaway top Florida Keys, don’t confine your friends and family to one or two hotel rooms. Instead, snag a deal on a full-sized house and get the best of both worlds. Vacation home rentals are perfect for families and large groups that want to live like locals on vacation. Whether you are searching for a villa that pulls out all the stops or a four-bedroom house to host the best summer vacation ever, Orbitz has a variety of Florida Keys vacation homes for rent that are ideal for you. Your perfect pad is only a few clicks away.

Homes for every Florida Keys vacation
If you’re planning a vacation with a lot of people, you’ll want room to stretch out, and a rental home has plenty of space. Many vacation homes also come with everything you’ll need for a proper getaway, like kitchens with every gadget you can think of, along with updated furnishings, fancy spa tubs and balconies. You may even wind up in a rental home that has a sprawling backyard for barbecues, games and general relaxation. These rentals offer the added bonus of putting you right in the thick of things in Florida Keys; instead of going to a small hotel room at the end of a busy day, you’re going home.

Vacations are all about creating lasting memories, and a Florida Keys rental home makes it easy to create good ones. Whether you’re getting the college crowd back together or bringing along your folks and your kids, a trip to Florida Keys is sure to be a winner.

Florida Keys Vacation Homes essential information

Accommodation
1039 Vacation Homes
Lowest Price
$201
Highest Price
$698
Popular accommodation
The Hammocks at Marathon, Perla Blanca 4 Bed 5 Bath kayaks pool boat dock, Mariners Club Townhouse, Unit 603, Epic Amenities, Tennis & Indoor Pickleball, Restful waterfront townhome with deck, great water views & washer/dryer, Charming townhome with ocean views, an open porch & steps from the water, Oceanside Paradise in the FL Keys Free Kayaks Bikes Wifi Outdoor BBQ Grill, Old Florida Style, wrap around porch, boat basin for dockage, open water, Beachside Retreat w/ Pool, Boat Ramp Dock for Rent, Waterfront, dog-friendly home with beautiful canal view & 2 shaded porches