Florida Keys Vacation Homes

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Featured Vacation Homes in Florida Keys

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotel Options in Florida Keys

    Reefhouse Resort & Marina

    Reefhouse Resort & Marina

    103800 Overseas Hwy Key Largo FL
    $419 nightly
    The price is $466 total per night from Apr 12 to Apr 13
    $466 total
    Apr 12 - Apr 13
    Total with taxes and fees
    9.2/10 Wonderful! (1,386 reviews)
    Waterside Suites & Marina

    Waterside Suites & Marina

    201 Ocean Drive Key Largo FL
    $182 nightly
    The price is $205 total per night from Apr 13 to Apr 14
    $205 total
    Apr 13 - Apr 14
    Total with taxes and fees
    9/10 Wonderful! (1,245 reviews)
    Cheeca Lodge & Spa

    Cheeca Lodge & Spa

    81801 Overseas Highway, Mile Marker 82 Islamorada FL
    $371 nightly
    The price is $418 total per night from Apr 13 to Apr 14
    $418 total
    Apr 13 - Apr 14
    Total with taxes and fees
    9.2/10 Wonderful! (1,298 reviews)

Florida Keys Vacation Homes

Book vacation homes in Florida Keys
Next time you take a group getaway top Florida Keys, don’t confine your friends and family to one or two hotel rooms. Instead, snag a deal on a full-sized house and get the best of both worlds. Vacation home rentals are perfect for families and large groups that want to live like locals on vacation. Whether you are searching for a villa that pulls out all the stops or a four-bedroom house to host the best summer vacation ever, Orbitz has a variety of Florida Keys vacation homes for rent that are ideal for you. Your perfect pad is only a few clicks away.

Homes for every Florida Keys vacation
If you’re planning a vacation with a lot of people, you’ll want room to stretch out, and a rental home has plenty of space. Many vacation homes also come with everything you’ll need for a proper getaway, like kitchens with every gadget you can think of, along with updated furnishings, fancy spa tubs and balconies. You may even wind up in a rental home that has a sprawling backyard for barbecues, games and general relaxation. These rentals offer the added bonus of putting you right in the thick of things in Florida Keys; instead of going to a small hotel room at the end of a busy day, you’re going home.

Vacations are all about creating lasting memories, and a Florida Keys rental home makes it easy to create good ones. Whether you’re getting the college crowd back together or bringing along your folks and your kids, a trip to Florida Keys is sure to be a winner.

Florida Keys Vacation Homes essential information

Accommodation
972 Vacation Homes
Lowest Price
$205
Highest Price
$977
Popular accommodation
The Hammocks at Marathon, Oceanview 3BR/3BA Cottage 5009: Village at Hawks Cay Villas, Waterfront, saltwater lagoon, 2 pools, ocean access, marina, tennis, pickleball, Charming 3-bedroom house featuring a heated private pool., Refined. Safe. Clean. Waterfront. Golf cart , courtesy to our guests, ★Remodeled tropical delight townhome★private plunge pool close to fun activities, Oceanfront home-shared swimming pool, dockage-just 20 miles from Key West, Oceanfront, Pool, Tiki, Amazing Views, Near Vaca, Great Dockage, Kayaks, Bikes, NEW ! Lagoon-front townhouse with Marina! Day Dreams Key Largo.