Florida Keys Vacation Homes

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Featured Vacation Homes in Florida Keys

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotel Options in Florida Keys

    Cheeca Lodge & Spa

    Cheeca Lodge & Spa

    81801 Overseas Highway, Mile Marker 82 Islamorada FL
    $209 nightly
    The price is $236 total per night from Oct 4 to Oct 5
    $236 total
    Oct 4 - Oct 5
    Total with taxes and fees
    9.2/10 Wonderful! (1,444 reviews)
    Reefhouse Resort & Marina

    Reefhouse Resort & Marina

    103800 Overseas Hwy Key Largo FL
    $259 nightly
    The price is $286 total per night from Sep 9 to Sep 10
    $286 total
    Sep 9 - Sep 10
    Total with taxes and fees
    9.2/10 Wonderful! (1,531 reviews)
    Baker's Cay Resort Key Largo, Curio Collection by Hilton

    Baker's Cay Resort Key Largo, Curio Collection by Hilton

    97000 Overseas Hwy Key Largo FL
    $286 nightly
    The price is $322 total per night from Sep 28 to Sep 29
    $322 total
    Sep 28 - Sep 29
    Total with taxes and fees
    8.6/10 Excellent! (1,184 reviews)

Florida Keys Vacation Homes

Book vacation homes in Florida Keys
Next time you take a group getaway top Florida Keys, don’t confine your friends and family to one or two hotel rooms. Instead, snag a deal on a full-sized house and get the best of both worlds. Vacation home rentals are perfect for families and large groups that want to live like locals on vacation. Whether you are searching for a villa that pulls out all the stops or a four-bedroom house to host the best summer vacation ever, Orbitz has a variety of Florida Keys vacation homes for rent that are ideal for you. Your perfect pad is only a few clicks away.

Homes for every Florida Keys vacation
If you’re planning a vacation with a lot of people, you’ll want room to stretch out, and a rental home has plenty of space. Many vacation homes also come with everything you’ll need for a proper getaway, like kitchens with every gadget you can think of, along with updated furnishings, fancy spa tubs and balconies. You may even wind up in a rental home that has a sprawling backyard for barbecues, games and general relaxation. These rentals offer the added bonus of putting you right in the thick of things in Florida Keys; instead of going to a small hotel room at the end of a busy day, you’re going home.

Vacations are all about creating lasting memories, and a Florida Keys rental home makes it easy to create good ones. Whether you’re getting the college crowd back together or bringing along your folks and your kids, a trip to Florida Keys is sure to be a winner.

Florida Keys Vacation Homes essential information

Accommodation
1048 Vacation Homes
Lowest Price
$164
Highest Price
$823
Popular accommodation
Sugarloaf Key RV Resort & Cottages, Escape To Marathon in Large 4BR 3BA Canal Front Home Sleep 10 with Heated Pool, Charming 3-bedroom house featuring a heated private pool., Bluegreen Vacations Hammocks at Marathon, Ascend Collection Resort, Ocean Dream, Family friendly, Direct Ocean, Pool/spa, Kayaks, Giant chess, bocci, 7 Bedroom with Dockage, Pool, Firepit, Paddle Boards & Kayaks , Oceanside Paradise Free Kayaks Bikes Pool & Hot Tub Tennis & Pickle ball, Waterfront 2BR w/ Dock, Hot Tub & Easy Ocean Access – Boaters Welcome!, Luxurious 3-bedroom house perfect for relaxing in the heart of Key Largo.