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Car Rentals in Florida Keys

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Rent a car on the mainland and zoom down the staggering Overseas Highway to what is often called the American Caribbean, the Florida Keys. This tropical paradise offers perfect, balmy weather, bath-warm turquoise waters, a thriving coral reef, and plenty of fun in the sun.

Rent a car through Orbitz and you can choose whether to pick up your car at nearby Miami International Airport, or on one of the islands themselves. Being able to drive through the Gulf of Mexico is a unique experience, and you can zip between Key West, Key Largo, Big Pine Key or Islamorada at your leisure.


Florida Keys and beyond: Three destinations by car

Each of the islands in the Florida Keys exudes a different vibe. Here are three great destinations to discover by car.

Overseas Highway

Not a destination but a mind-blowingly beautiful drive, the Overseas Highway snakes seamlessly over turquoise ocean and sandy coast. Measuring 100 miles long, it stretches from the mainland all the way to Key West, at the far end of the island chain. It’s worth renting a car for this spectacular drive alone.

Distance: 100 miles

Key Largo and John Pennekamp Coral Reef State Park

The closest key to mainland Florida, Key Largo is also the largest, so having a car is a good idea. It’s a place to unwind and enjoy the great outdoors. The John Pennekamp Coral Reef State Park, the first undersea park in the US, encompasses 70 nautical square miles, creating a playground for divers and snorkelers.

Key West

The most famous of the Florida Keys is Key West, one-time home of Ernest Hemingway. This beautiful key juts enticingly into the Gulf of Mexico. Drive the Overseas Highway to the very end to discover a laid-back island where the cocktails flow freely, the pristine beaches are powder-white, and the sunsets are legendary.