Compare Hotels in New Madrid County
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Top Rated New Madrid County Hotels

Hampton Inn Sikeston
1240 Commerce Drive Sikeston MO
Free Cancellation
Reserve now, pay when you stay
$102 nightly
The price is $115 total per night
$115 total
Jul 12 - Jul 13
Total with taxes and fees
At Hampton Inn Sikeston, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The front desk is staffed 24 hours a day to help with securing valuables and luggage storage. If you like to take your furry friend along on your adventures, this pet-friendly property offers an off-leash area. Additional amenities include meeting rooms, conference space, and a 24-hour business center.
Pool
Breakfast included

Fairfield Inn & Suites by Marriott Sikeston
1239 Commerce Drive Sikeston MO
Free Cancellation
Reserve now, pay when you stay
$110 nightly
The price is $124 total per night
$124 total
Jul 12 - Jul 13
Total with taxes and fees
Built in 2025, the brand new Fairfield Inn & Suites by Marriott Sikeston offers an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The 24-hour front desk has staff standing by to help with luggage storage, dry cleaning/laundry, and securing valuables. Additional amenities include coffee/tea in a common area and laundry facilities.
Pool
Breakfast included

Holiday Inn Express & Suites Sikeston Southwest by IHG
115 Hospitality Dr Sikeston MO
Free Cancellation
$105 nightly
The price is $119 total per night
$119 total
Aug 2 - Aug 3
Total with taxes and fees
Guests staying at Holiday Inn Express & Suites Sikeston Southwest by IHG enjoy an indoor pool, a gym, and free WiFi in public areas. A stay here includes free parking. The 24-hour front desk has staff standing by to help with luggage storage and securing valuables. Additional amenities include a business center, coffee/tea in a common area, and a meeting room.
Pool
Breakfast included

New Orleans Inn Portageville
600 US-61 Portageville MO
Free Cancellation
Reserve now, pay when you stay
$52 nightly
The price is $56 total per night
$56 total
Jul 5 - Jul 6
Total with taxes and fees
At New Orleans Inn Portageville , guests have access to a garden. There's free parking if you drive. Front-desk staff are standing by 24/7 to assist with any requests.
Pet friendly
Parking included

TownePlace Suites by Marriott Sikeston
1239 Commerce Drive Sikeston MO
Free Cancellation
Reserve now, pay when you stay
$109 nightly
The price is $123 total per night
$123 total
Jul 12 - Jul 13
Total with taxes and fees
Built in 2025, the brand new TownePlace Suites by Marriott Sikeston offers an indoor pool, a gym, and free WiFi in public areas. Free parking is included with your stay. The 24-hour front desk has multilingual staff ready to assist with securing valuables and concierge services. Additional amenities include a business center, coffee/tea in a common area, and a computer station.
Pool
Breakfast included

Super 8 By Wyndham Marston
501 S Outer Road Marston MO
Free Cancellation
Reserve now, pay when you stay
$74 nightly
The price is $84 total per night
$84 total
Jul 5 - Jul 6
Total with taxes and fees
Super 8 By Wyndham Marston offers free WiFi in public areas and coffee in a common area. Free parking is available if you drive. Front-desk staff are standing by 24/7 to assist with any requests.
Breakfast included
Pet friendly

Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
Free Cancellation
Reserve now, pay when you stay
$111 nightly
The price is $128 total per night
$128 total
Jul 9 - Jul 10
Total with taxes and fees
Drury Inn & Suites Sikeston, MO features an indoor pool, an outdoor pool, and a gym. If you drive, put free parking to good use. The front desk is staffed 24/7 to help with dry cleaning/laundry, luggage storage, and securing valuables. Additional amenities include free WiFi in public areas, meeting rooms, and a business center.
Pool
Breakfast included

Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
Free Cancellation
Reserve now, pay when you stay
$69 nightly
The price is $78 total per night
$78 total
Jul 26 - Jul 27
Total with taxes and fees
Renovated in 2023, Days Inn and Suites by Wyndham Sikeston offers a gym, free WiFi in public areas, and meeting rooms. Free parking is included with your stay. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a library, laundry facilities, and a banquet hall.
Breakfast included
Pet friendly

Drury Inn & Suites Hayti Caruthersville
1317 E Highway 84 Hayti MO
Free Cancellation
Reserve now, pay when you stay
$98 nightly
The price is $112 total per night
$112 total
Jul 12 - Jul 13
Total with taxes and fees
At Drury Inn & Suites Hayti Caruthersville, guests enjoy an indoor pool, a gym, and free WiFi in public areas. If you drive, put free parking to good use. The front desk is staffed 24 hours a day to help with luggage storage and securing valuables. Additional amenities include a hot tub, meeting rooms, and a business center.
Pool
Hot Tub
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See all available properties in New Madrid County
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
New Madrid County hotels essential information
Accommodation | 102 hotels |
|---|---|
Lowest Price | $56 |
Highest Price | $128 |
Popular hotels | Hampton Inn Sikeston, Fairfield Inn & Suites by Marriott Sikeston, Holiday Inn Express & Suites Sikeston Southwest by IHG, New Orleans Inn Portageville , TownePlace Suites by Marriott Sikeston, Super 8 By Wyndham Marston, Drury Inn & Suites Sikeston, MO, Days Inn and Suites by Wyndham Sikeston, Drury Inn & Suites Hayti Caruthersville |
Recent Reviews

Hampton Inn Sikeston
5/5 Excellent
"Rooms were clean and comfortable. Breakfast was ok. Staff was friendly and helpful. Pool area was a bit steamy, but granddaughter enjoyed it very much. We will definitely recommend."
A verified traveler stayed at Hampton Inn Sikeston
Posted 1 day ago
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