Book 5 Star Hotels in Mediterranean Region
Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels
Save 10% or more on select hotels with Insider Prices
Book on the app to instantly earn 5% on 350,000+ hotels
Tomorrow night
Check prices in Mediterranean Region for tomorrow night, Dec 16 - Dec 17Featured Mediterranean Region 5 Stars Hotels
Barcelona Airport Hotel
Plaza de la Volateria, 3 El Prat de Llobregat
Free Cancellation
Reserve now, pay when you stay
425.57 mi from city center
$137 nightly
The price is $153 total per night
$153 total
Dec 24 - Dec 25
Total with taxes and fees
Barcelona Airport Hotel features a gym, free WiFi in public areas, and conference space. If you drive, self parking is EUR 15 per day, or you can take advantage of the free airport shuttle (available 24 hours). The front desk has multilingual staff on hand 24/7 to help with securing valuables, tours or tickets, and luggage storage. Additional amenities include a 24-hour business center, a seasonal outdoor pool, and a computer station.
Pool
Free airport shuttle
Hotel Riu Plaza España
C/ Gran Via, 84 Madrid
Free Cancellation
Reserve now, pay when you stay
636.37 mi from city center
$161 nightly
The price is $177 total per night
$177 total
Dec 18 - Dec 19
Total with taxes and fees
Guests of Hotel Riu Plaza España enjoy a gym, free WiFi in public areas, and conference space. Self parking is available for EUR 32.50 per night. Multilingual staff at the 24-hour front desk can assist with concierge services, luggage storage, and securing valuables. Additional amenities include a business center, a seasonal outdoor pool, and a computer station.
Pool
Free WiFi
Hotel Emperador
Gran Via 53 Madrid Madrid
Free Cancellation
Reserve now, pay when you stay
636.12 mi from city center
At Hotel Emperador, guests enjoy an outdoor pool, a gym, and a rooftop terrace. Transportation is made easy with limo/town car service. The front desk has multilingual staff on hand 24/7 to help with tours or tickets, luggage storage, and securing valuables. Additional amenities include free WiFi in public areas, a conference center, and a business center.
Pool
Free WiFi
Hotel Regina
Alcala 19 Madrid Madrid
Free Cancellation
Reserve now, pay when you stay
635.63 mi from city center
Guests of Hotel Regina enjoy features like a 24-hour gym, free WiFi in public areas, and laundry facilities. For transportation, you can make use of an airport shuttle (available 24 hours) for EUR 75 per vehicle roundtrip, as well as limo/town car service. The 24-hour front desk has staff standing by to help with tours or tickets, luggage storage, and dry cleaning/laundry. Additional amenities include a porter/bellhop, wedding services, and a banquet hall.
Free WiFi
Restaurant
Hotel Acta Moa- New Opening
Avenida Almirante Gago Coutinho 30 Lisbon
Free Cancellation
Reserve now, pay when you stay
890.55 mi from city center
$61 nightly
The price is $74 total per night
$74 total
Dec 16 - Dec 17
Total with taxes and fees
Hotel Acta Moa- New Opening features a gym, free WiFi in public areas, and a seasonal outdoor pool. The 24-hour front desk has staff standing by to help with luggage storage, and answer any questions about the accommodations.
Pool
Free WiFi
Hotel Dei Mellini
Via Muzio Clementi 81 Rome RM
481.25 mi from city center
$269 nightly
The price is $313 total per night
$313 total
Jan 7 - Jan 8, 2026
Total with taxes and fees
Guests of Hotel Dei Mellini enjoy a gym, free WiFi in public areas, and meeting rooms. For transportation, you can make use of an airport shuttle (available 24 hours) for EUR 60 per vehicle, as well as limo/town car service. The front desk has multilingual staff on hand 24/7 to help with tours or tickets, securing valuables, and luggage storage. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Other amenities at this family-friendly hotel include conference space, a 24-hour business center, and a free kid's club.
Pet friendly
Free WiFi
Hostal Madrid Atocha
Calle Mezquite 5B Madrid Madrid
Free Cancellation
Reserve now, pay when you stay
634.23 mi from city center
$66 nightly
The price is $73 total per night
$73 total
Jan 7 - Jan 8, 2026
Total with taxes and fees
Guests of Hostal Madrid Atocha enjoy a rooftop terrace, free WiFi in public areas, and microwave in a common area. Self parking is available for EUR 20 per day. The front desk is staffed 24/7 to help with locker space, and answer any questions about the accommodations. This smoke-free hostal also has a vending machine.
Pet friendly
Free WiFi
The Hive Hotel
Via Torino 6 Rome RM
Free Cancellation
Reserve now, pay when you stay
481.66 mi from city center
$106 nightly
The price is $135 total per night
$135 total
Dec 18 - Dec 19
Total with taxes and fees
Guests staying at The Hive Hotel enjoy access to a full-service spa, a gym, and free WiFi in public areas. Self parking is available for EUR 40.00 per night. The front desk is staffed 24/7 to help with tours or tickets, luggage storage, and securing valuables. Other amenities at this spa hotel include a terrace and an ATM.
Spa
Free WiFi
Arc la Rambla
La Rambla 19 Barcelona
Free Cancellation
Reserve now, pay when you stay
425.54 mi from city center
$82 nightly
The price is $103 total per night
$103 total
Jan 6 - Jan 7, 2026
Total with taxes and fees
Guests staying at Arc la Rambla enjoy a rooftop terrace, free WiFi in public areas, and a communal living room. The 24-hour front desk has multilingual staff ready to assist with access to locker space, tours or tickets, and securing valuables. This smoke-free hotel also has a vending machine.
Free WiFi
Air conditioning
Don't see what you're looking for?
See all available properties in Mediterranean Region
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Best 5 star hotels in Mediterranean Region
Guarantee yourself a relaxing time when you book the best of the best: 5 star hotels in Mediterranean Region. After all, treating yourself to the finer things is what vacations are about.
What are the criteria for a 5 star hotel?
5 star hotel requirements include distinctive services and amenities that surpass all others. These Mediterranean Region hotels bring an incomparable degree of quality and attention to detail, with guest satisfaction being top priority. Your 5 star hotel should be dressed to impress, with design details like marble surfaces and hi-tech fixtures.
What amenities can I expect at a 5 star hotel?
Mediterranean Region 5 star hotels and resorts typically offer luxury amenities such as:
- Gourmet restaurant
- Full-service fitness center with pool
- Luxury spa
- Welcome gifts upon arrival
- Top-of-the-line beds and linens
- Designer personal care products
- Premium cable, free Wi-Fi and device docking stations
How do I find an amazing 5 star hotel?
Finding 5 star hotel deals in Mediterranean Region with Orbitz is as easy as your stay will be. For the top-shelf vacation you deserve, we’ll help you choose the right hotel in the right place:
- Search hotels by price, ranging from $73 to $313
- Find the best-loved hotels through word-of-mouth advice when you check out over reviews by Orbitz travelers
- Choose from 777,853 5 star hotels in Mediterranean Region!
Mediterranean Region hotels essential information
Accommodation | 777,853 hotels |
|---|---|
Lowest Price | $73 |
Highest Price | $313 |
Popular hotels | Barcelona Airport Hotel, Hotel Riu Plaza España, Hotel Emperador, Hotel Regina, Hotel Acta Moa- New Opening, Hotel Dei Mellini, Hostal Madrid Atocha, The Hive Hotel, Arc la Rambla |
Recent Reviews
Hotel Riu Plaza España
5/5 Excellent
"Rooms are big enough for 4 adults with the sofa bed, everything was clean, the staff was kind and breakfast was more than expected!! The best thing is the location- will definitely go back! "
A verified traveler stayed at Hotel Riu Plaza España
Posted 18 hours ago
