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Luxury Hotels in Panama

Estimated price for 1 night/2 adults

American Trade Hotel
American Trade Hotel
4.5 out of 5.0 Plaza Herrera Casco Viejo, Panama City, Panama
Free Cancellation
4.5/5 (2 reviews)

gorgeous hotel, loved the interior design. great location.

Reviewed on Feb 4, 2019
Waldorf Astoria Panama
Waldorf Astoria Panama
5.0 out of 5.0 47th St. & Uruguay Street, Panama City, Panama
Free Cancellation
4.5/5 (30 reviews)

Loved everything!!!! We always stay there in panama

Reviewed on Apr 9, 2019
Bristol Panama
Bristol Panama
5.0 out of 5.0 Avenida Aquilino de La Guardia, Bella Vista, Panama City, Panama
Free Cancellation
4.5/5 (35 reviews)

Pool unfortunately under repair . Staff wonderful . Nice lock.

Reviewed on Mar 14, 2019
JW Marriott Panama
JW Marriott Panama
5.0 out of 5.0 Calle Punta Colon, Punta Pacifica, Panama City, Panama
Free Cancellation
4.4/5 (78 reviews)

View fabulous. Staff great. Checkin process too slow. Need more than one front desk person.

Reviewed on Mar 30, 2019
Sortis Hotel, Spa & Casino, Autograph Collection
Sortis Hotel, Spa & Casino, Autograph Collection
4.5 out of 5.0 56 y 57 East Street, Obarrio, Bella Vista, Panama City, Panama
Free Cancellation
4.2/5 (19 reviews)

Beautiful hotel. Excellent location. The first night our linen was dirty. After that everything else was great.

Reviewed on Mar 8, 2019
Hilton Panama
Hilton Panama
4.5 out of 5.0 Balboa Ave. and Aquilino De La Guardia, Panama City, Panama
Free Cancellation
4.1/5 (15 reviews)

I loved everything! There was not one thing about this hotel, staff and amenities that would change!!

Reviewed on Apr 24, 2019

Book Panama luxury vacations

You want the best of everything in life, and that includes when you travel. Get the full treatment on your next trip, with five-star service, delicious dining and tons of extra amenities to pamper you like royalty. With luxury Panama vacations, “living the dream” isn’t just a saying. You really can make your dreams a reality—and then dream even bigger. You’ll never look at vacations the same way again.

Experience the ultimate luxury
With silky soft sheets and plush pillows, you’ve never slept better than you will in your luxury hotel room. But when the sun peeks through the curtains, you’ll jump out of bed. That’s because in Panama, real life is even better than dreams. Grab yourself a gourmet coffee and get to the first task of the day—even if that just means a leisurely brunch, or getting to your spa appointment. On luxury vacations in Panama, the day is yours. We’re just here to help you have your perfect 5-star getaway.

  • Live a life of luxury: We have tons of highly rated hotels, where you’ll find all the upscale amenities you want. You could find splendid spas, ritzy restaurants, deluxe bath products and more.
  • Bundles for your budget: You don’t have to be a big spender to find luxury vacation packages—but you can be if you want to. When you bundle your flight and hotel with Orbitz, you know you’re getting a great deal. 

Your luxury vacation starts now. Booking on Orbitz is so easy, you’ll feel like you have a personal assistant…and once you’re in Panama, you just might. The only problem in your future: You won’t want to go home!

Recently Reviewed Luxury Hotels

Recently Booked Luxury Hotels

*Savings based on all package bookings with Flight + Hotel made on from January 1, 2018 to December 31, 2018 as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages.