Book Panama Luxury Vacations

Choose two or more items and save on your trip:

Best Luxury vacations in Panama

Waldorf Astoria Panama
Hotel Ojos del Rio
Gamboa Rainforest Reserve

Luxury vacation packages for 3 nights

American Trade Hotel
Gamboa Rainforest Reserve
The Westin Playa Bonita Panama

Luxury vacation packages for 4 nights

Wyndham Panama Albrook Mall Hotel & Convention Center
Waldorf Astoria Panama
Hotel Ojos del Rio

Luxury vacation packages for 5 nights

Gamboa Rainforest Reserve
Summit Rainforest & Golf Resort
Courtyard by Marriott Panama Multiplaza Mall

Luxury vacation packages for 6-7 nights

Gamboa Rainforest Reserve
Summit Rainforest & Golf Resort
The Westin Playa Bonita Panama

Luxury hotels in Panama

Don't see what you're looking for?
See all available properties in Panama
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Book Panama luxury vacations

You want the best of everything in life, and that includes when you travel. Get the full treatment on your next trip, with five-star service, delicious dining and tons of extra amenities to pamper you like royalty. With luxury Panama vacations, “living the dream” isn’t just a saying. You really can make your dreams a reality—and then dream even bigger. You’ll never look at vacations the same way again.

Experience the ultimate luxury
With silky soft sheets and plush pillows, you’ve never slept better than you will in your luxury hotel room. But when the sun peeks through the curtains, you’ll jump out of bed. That’s because in Panama, real life is even better than dreams. Grab yourself a gourmet coffee and get to the first task of the day—even if that just means a leisurely brunch, or getting to your spa appointment. On luxury vacations in Panama, the day is yours. We’re just here to help you have your perfect 5-star getaway.

  • Live a life of luxury: We have tons of highly rated hotels, where you’ll find all the upscale amenities you want. You could find splendid spas, ritzy restaurants, deluxe bath products and more.
  • Bundles for your budget: You don’t have to be a big spender to find luxury vacation packages—but you can be if you want to. When you bundle your flight and hotel with Orbitz, you know you’re getting a great deal. 

Your luxury vacation starts now. Booking on Orbitz is so easy, you’ll feel like you have a personal assistant…and once you’re in Panama, you just might. The only problem in your future: You won’t want to go home!

How much does it cost to fly to Panama?

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.