Book Panama Luxury Vacations

Best Luxury vacations in Panama

Courtyard by Marriott Panama Multiplaza Mall
Hotel Posada Los Delfines
Hotel Central Boquete

Luxury vacation packages for 3 nights

Summit Rainforest & Golf Resort
Wyndham Panama Albrook Mall Hotel & Convention Center
Hilton Panama

Luxury vacation packages for 4 nights

Summit Rainforest & Golf Resort
Las Clementinas
Best Western El Dorado Panama Hotel

Luxury vacation packages for 5 nights

Sortis Hotel, Spa & Casino, Autograph Collection
Courtyard by Marriott Panama Multiplaza Mall
JW Marriott Panama

Luxury vacation packages for 6-7 nights

Wyndham Panama Albrook Mall Hotel & Convention Center
The Westin Playa Bonita Panama
Toscana Inn

Luxury hotels in Panama

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Book Panama luxury vacations

You want the best of everything in life, and that includes when you travel. Get the full treatment on your next trip, with five-star service, delicious dining and tons of extra amenities to pamper you like royalty. With luxury Panama vacations, “living the dream” isn’t just a saying. You really can make your dreams a reality—and then dream even bigger. You’ll never look at vacations the same way again.

Experience the ultimate luxury
With silky soft sheets and plush pillows, you’ve never slept better than you will in your luxury hotel room. But when the sun peeks through the curtains, you’ll jump out of bed. That’s because in Panama, real life is even better than dreams. Grab yourself a gourmet coffee and get to the first task of the day—even if that just means a leisurely brunch, or getting to your spa appointment. On luxury vacations in Panama, the day is yours. We’re just here to help you have your perfect 5-star getaway.

  • Live a life of luxury: We have tons of highly rated hotels, where you’ll find all the upscale amenities you want. You could find splendid spas, ritzy restaurants, deluxe bath products and more.
  • Bundles for your budget: You don’t have to be a big spender to find luxury vacation packages—but you can be if you want to. When you bundle your flight and hotel with Orbitz, you know you’re getting a great deal. 

Your luxury vacation starts now. Booking on Orbitz is so easy, you’ll feel like you have a personal assistant…and once you’re in Panama, you just might. The only problem in your future: You won’t want to go home!

How much does it cost to fly to Panama?

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Tue, Aug 10 - Wed, Aug 11
PTY
Tocumen Intl.
DAV
Enrique Malek Intl.
$142
Copa
Tue, Jul 13 - Thu, Jul 15
SJO
Juan Santamaria Intl.
PTY
Tocumen Intl.
$173
Copa
Sun, Jul 4 - Sat, Jul 10
PAC
Marcos A. Gelabert Intl.
BOC
Bocas del Toro Intl.
$310
Hahn Air Technologies
Thu, Jun 24 - Sat, Jun 26
PAC
Marcos A. Gelabert Intl.
DAV
Enrique Malek Intl.
$312
Hahn Air Technologies
Wed, Jul 21 - Wed, Jul 28
SJO
Juan Santamaria Intl.
DAV
Enrique Malek Intl.
$344
Copa
Mon, Nov 1 - Sat, Nov 13
MIA
Miami Intl.
PTY
Tocumen Intl.
$344
Avianca
Tue, Aug 3 - Tue, Aug 17
MIA
Miami Intl.
DAV
Enrique Malek Intl.
$358
Copa
Wed, Oct 13 - Tue, Oct 19
MIA
Miami Intl.
PTY
Tocumen Intl.
$359
United
Wed, Aug 4 - Wed, Aug 18
MIA
Miami Intl.
PTY
Tocumen Intl.
$359
Delta
Mon, Nov 1 - Sat, Nov 13
MIA
Miami Intl.
PTY
Tocumen Intl.
$364
Copa
Wed, Sep 15 - Tue, Sep 21
LAX
Los Angeles Intl.
PTY
Tocumen Intl.
$475
Spirit Airlines
Sun, Sep 5 - Sat, Sep 18
JFK
John F. Kennedy Intl.
PTY
Tocumen Intl.
$495
Delta
Mon, Sep 27 - Mon, Oct 4
JFK
John F. Kennedy Intl.
DAV
Enrique Malek Intl.
$614
Copa
Wed, Sep 1 - Mon, Sep 6
LAX
Los Angeles Intl.
DAV
Enrique Malek Intl.
$750
Avianca