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Selected fares from Knoxville to Myrtle Beach

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

From Knoxville to Myrtle Beach

When you’re ready to trade the Smoky Mountains of Tennessee for the sandy beaches of South Carolina, you can save money on your flights from Knoxville to Myrtle Beach by visiting You can save additional money by also making hotel and car rental arrangements, or you can choose one of the affordable vacation packages.

Leaving from McGhee Tyson Airport

McGhee Tyson Airport is located on Alcoa Highway, approximately twelve miles from downtown Knoxville. Car rental services, taxi services, and buses are available for convenient transportation to the airport, or you can drive yourself and park in one of the convenient short- or long-term parking areas, where parking fees range from $8 to $18 per day. Once inside the terminal, you can grab a cup of coffee at Starbucks or a quick snack from the food court while you wait to board your plane.

Enjoying Myrtle Beach

You’ll be arriving at the Myrtle Beach International Airport, located approximately six miles from the boardwalk. If you are planning to use shuttle services to reach your hotel, you will need to arrange the service ahead of time. Taxi services are available without prior arrangement but can be quite expensive, or you can rent a car from one of the nine car rental agencies located on the ground floor of the terminal. While visiting Myrtle Beach, be sure to visit the 1.2-mile oceanfront boardwalk and take a ride on the SkyWheel, one of the tallest Ferris wheels in the country. When you need a break from the beach, you can shop in one of the many outlet malls, visit Ripley’s Aquarium, or have some fun at the Myrtle Beach Pavillion Amusement Park. During the summer months, temperatures at Myrtle Beach average in the high 80s, dropping to the mid-50s during the winter months, and ranging between the 60s and 70s for the rest of the year. July and August are considered the busy season, so be prepared for crowds if visiting during those months.  

Flights from Knoxville to Myrtle Beach

Myrtle Beach is a great place to visit, so if you need an extended vacation or just a weekend getaway, be sure to visit for great deals on flights from Knoxville to Myrtle Beach. For additional savings, be sure to book your hotel and rental car, or select from one of the great deals on vacation packages.


*Savings based on all holiday package bookings with Flight + Hotel on from January through December 2017, as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages. For Free Flight or 100% Off Flight deals, package savings is greater than or equal to the current cost of one component, when both are priced separately.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.