$101 Cheap flight deals from Madison (MSN) to Upstate South Carolina (GSP)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

This Weekend's Flight Deals from Madison to Upstate South Carolina

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Oct 4 - Tue, Oct 7
MSN
Dane County Regional
AVL
Asheville Regional
$319 Roundtrip, found 4 days ago
$319
Roundtrip
found 4 days ago
Select Delta flight, departing Sat, Oct 4 from Dane County Regional to Asheville Regional, returning Tue, Oct 7, priced at $319 found 4 days ago

Airfares from $101 One Way, $249 Round Trip from Madison to Upstate South Carolina

Prices starting at $249 for return flights and $101 for one-way flights to Upstate South Carolina were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Jan 4 - Sat, Jan 10
MSN
Madison
GSP
Greenville
$249 Roundtrip, found 2 days ago
$249
Roundtrip
found 2 days ago
Select Delta flight, departing Sun, Jan 4 from Madison to Greenville, returning Sat, Jan 10, priced at $249 found 2 days ago
Tue, Jan 6 - Wed, Jan 7
MSN
Madison
GSP
Greenville
$251 Roundtrip, found 2 days ago
$251
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Jan 6 from Madison to Greenville, returning Wed, Jan 7, priced at $251 found 2 days ago
Wed, Dec 24 - Thu, Dec 25
MSN
Madison
AVL
Asheville
$259 Roundtrip, found 6 days ago
$259
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Dec 24 from Madison to Asheville, returning Thu, Dec 25, priced at $259 found 6 days ago
Fri, Jan 2 - Tue, Jan 6
MSN
Madison
GSP
Greenville
$279 Roundtrip, found 2 days ago
$279
Roundtrip
found 2 days ago
Select Delta flight, departing Fri, Jan 2 from Madison to Greenville, returning Tue, Jan 6, priced at $279 found 2 days ago
Sun, Jan 4 - Tue, Jan 20
MSN
Madison
GSP
Greenville
$308 Roundtrip, found 2 days ago
$308
Roundtrip
found 2 days ago
Select Delta flight, departing Sun, Jan 4 from Madison to Greenville, returning Tue, Jan 20, priced at $308 found 2 days ago

Upstate South Carolina economy flight packages

Price found within the past 48 hours. Click for updated prices.
Baymont by Wyndham Greenwood
2.5-star property

Baymont by Wyndham Greenwood

7.6/10 Good! (736 reviews)

Nov 26 - Nov 28

2 night stay

Madison (MSN) to Greenville (GSP)

American Airlines • Non-stop roundtrip • Coach
Price was $670, price is now $639 per person
$639
per person
found 1 day ago
From check-in to check-out, the service was great. Room was clean, everything worked as advertised. The breakfast was good, with a good variety of items. I microwaved two boiled eggs and exploded them in the microwave. It was loud enough to be heard in West Virginia! Instead of calling me the idiot that I was, the nice lady working the breakfast bar just laughed and told me not to worry, that she would clean it up after I offered to do it. She was AWESOME!!!

Reviewed on Mar 14, 2024

Inn on the Square, an Ascend Collection Hotel
3.0-star property

Inn on the Square, an Ascend Collection Hotel

9.2/10 Wonderful! (692 reviews)

Nov 26 - Nov 28

2 night stay

Madison (MSN) to Greenville (GSP)

American Airlines • Non-stop roundtrip • Coach
Price was $714, price is now $680 per person
$680
per person
found 1 day ago
Clean and comfortable. Cozy

Reviewed on Nov 18, 2024

Holiday Inn Express & Suites Greenwood Mall by IHG
2.5-star property

Holiday Inn Express & Suites Greenwood Mall by IHG

9/10 Wonderful! (468 reviews)

Nov 26 - Nov 28

2 night stay

Madison (MSN) to Greenville (GSP)

American Airlines • Non-stop roundtrip • Coach
Price was $716, price is now $682 per person
$682
per person
found 1 day ago
Place is great. Clean and the beds are comfortable.

Reviewed on Mar 16, 2025

Don't see what you're looking for?
See all available trips from Madison to Upstate South Carolina
View all trips

More About Flying To Upstate South Carolina from Madison

Route Information for Flights from Madison to Upstate South Carolina

Origin Airport IATA Code
MSN
Destination Airport IATA Code
GSP
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Madison to Upstate South Carolina

The best fares for Madison to Upstate South Carolina flights are always found on Orbitz. With superior discounts and the latest innovations in mobile access, your ideal trip starts with Orbitz.

The Easy Way to Plan Travel Cheaply

We provide access to many low-cost vacation packages and travelers can mix and match airlines when scheduling their flights for the best prices and flight times. Finding cheap tickets on flights from Madison to Upstate South Carolina is easy when you make Orbitz your #1 travel planner.

Book Madison to Upstate South Carolina Flights With Mobile Apps

Our iPhone and Android mobile apps can be used to compare and book flights from Madison to Upstate South Carolina. These apps are perfect for checking the status of flights, gate and baggage claims details, car rental rates, and for receiving alerts on special savings that are exclusive to mobile users. Mobile app users can even score great rates when booking hotel rooms. You can compare hotels, virtually view photo galleries, and check out user reviews using the app, as well as find out which ones are closest to you.

Orbitz also offers free travel updates that are sent to your email or mobile phone that notifies you of booking changes, disruptions in service, or delayed flights.

Increase Your Rewards While Enjoying Super Low Rates

Boost your points or miles for your frequent flyer program on certain Madison to Upstate South Carolina flights. Simply provide your frequent flyer information when booking flights from Madison to Upstate South Carolina with Orbitz and get both a low fare and travel rewards. You can enter this information in your Orbitz account profile for easy remembering in future bookings.

More Destinations

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.