$194 Cheap flight deals from Des Moines (DSM) to Saint Helena Island (CHS)
Earn rewards on top of your airline miles with Orbitz Rewards
Many airlines offer flexible change policies
Sign up to receive text alerts about your trip
This Weekend's Flight Deals from Des Moines to Saint Helena Island
This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Airfares from $194 One Way, $275 Round Trip from Des Moines to Saint Helena Island
Prices starting at $275 for return flights and $194 for one-way flights to Saint Helena Island were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Saint Helena Island economy flight packages
The Ryder Hotel
Feb 12 - Feb 16
Des Moines (DSM) to Charleston (CHS)
Reviewed on May 11, 2025
Emeline
Feb 12 - Feb 16
Des Moines (DSM) to Charleston (CHS)
Reviewed on Sep 18, 2025
Andrew Pinckney Inn
Feb 12 - Feb 16
Des Moines (DSM) to Charleston (CHS)
Reviewed on Nov 27, 2025
More About Flying To Saint Helena Island from Des Moines
Route Information for Flights from Des Moines to Saint Helena Island
Origin Airport IATA Code | DSM |
|---|---|
Destination Airport IATA Code | CHS |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
Des Moines to Saint Helena Island
If you are looking to find the best deals on Des Moines to Saint Helena Island flights, look no further than Orbitz. Orbitz offers guaranteed low prices as well as cutting-edge mobile tools to help you book cheap flights from Des Moines to Saint Helena Island.
Mobile Apps Make Life Easier
Our mobile apps for Android and iPhone phones as well as tablets and iPads let you find the cheapest flights from Des Moines to Saint Helena Island—whether you are at home or running errands. Use the apps to also keep track of delays to your Des Moines to Saint Helena Island flights and baggage claim information.
Get Miles for Your Flights From Des Moines to Saint Helena Island
It’s easy to earn points or miles for your frequent flyer or airline loyalty program on qualifying Des Moines to Saint Helena Island flights with Orbitz. You can add your frequent flyer number to your online flight booking, and even store your numbers in your Orbitz account profile so they automatically get added the next time you book a flight.
Stay Informed While You Travel
Orbitz keeps you updated on information that’s relevant to your flights from Des Moines to Saint Helena Island. We can send you and six of your personal contacts free travel alerts via SMS text, voicemail, or email, so you instantly know about flight delays or changes.
Keep More Money in Your Pocket With Discount Flights
Orbitz looks for the best deals on Des Moines to Saint Helena Island flights for you. Mix and match airlines for your departing and return flights to fit your travel schedule and budget.
Flights from Des Moines
- Des Moines to Houston
- Des Moines to Dallas
- Des Moines to Atlanta
- Des Moines to Phoenix
- Des Moines to Orlando
- Des Moines to Seattle
- Des Moines to Chicago
- Des Moines to Los Angeles
- Des Moines to New York
- Des Moines to Charlotte
- Des Moines to Detroit
- Des Moines to Washington
- Des Moines to London
- Des Moines to New Orleans
- Des Moines to Sacramento
- Des Moines to Toronto
- Des Moines to San Francisco
- Des Moines to Rome
- Des Moines to Paris
- Des Moines to Hartford
Des Moines Airports
More Destinations
- Flights from Greensboro to Beaufort
- Flights from White Plains to Beaufort
- Flights from Islip to Hilton Head Island
- Flights from Austin to Hilton Head Island
- Flights from Kansas City to Hilton Head Island
- Flights from Los Angeles to Hilton Head Island
- Flights from Salt Lake City to Hilton Head Island
- Flights from Hartford to Hilton Head Island
- Flights from Omaha to Hilton Head Island
- Flights from Des Moines to Hilton Head Island
- Flights from Syracuse to Hilton Head Island
- Flights from Milwaukee to Hilton Head Island
- Flights from Harrisburg - Hershey to Hilton Head Island
- Flights from Rochester to Hilton Head Island
- Flights from Akron to Hilton Head Island
- Flights from Dayton to Hilton Head Island
- Flights from Birmingham to Hilton Head Island
- Flights from Lexington to Hilton Head Island
- Flights from Albany to Hilton Head Island
- Flights from Charlottesville to Hilton Head Island
- Flights from Boston to Edisto Island
- Flights from Charlotte to Edisto Island
- Flights from Chicago to Edisto Island
- Flights from Los Angeles to Edisto Island
- Flights from Minneapolis - St. Paul to Edisto Island
- Flights from Nashville to Edisto Island
- Flights from New York to Edisto Island
- Flights from San Francisco to Edisto Island
- Flights from Seattle to Edisto Island
- Flights from St. Louis to Edisto Island
- Flights from Fort Lauderdale to Edisto Island
- Flights from Burlington to Edisto Island
- Flights from Huntsville to Edisto Island
- Flights from Colorado Springs to Edisto Island
- Flights from Fort Wayne to Edisto Island
- Flights from Lexington to Edisto Island
- Flights from Greenville - Spartanburg to Edisto Island
- Flights from Charleston to Edisto Island
- Flights from Salisbury to Edisto Island
- Flights from Wichita to Edisto Island
- Flights from Beaumont to Edisto Island
- Flights from Bozeman to Edisto Island
- Flights from Atlanta to Harbor Island
- Flights from Boston to Harbor Island
- Flights from Cleveland to Harbor Island
- Flights from Houston to Harbor Island
- Flights from Memphis to Harbor Island
- Flights from Mexico City to Harbor Island
- Flights from Miami to Harbor Island
- Flights from Nashville to Harbor Island
- Flights from New York to Harbor Island
- Flights from San Antonio to Harbor Island
- Flights from San Francisco to Harbor Island
- Flights from Seattle to Harbor Island
- Flights from St. Louis to Harbor Island
- Flights from Omaha to Harbor Island
- Flights from Fort Lauderdale to Harbor Island
- Flights from Richmond to Harbor Island
- Flights from Syracuse to Harbor Island
- Flights from Knoxville to Harbor Island
- Flights from Albany to Harbor Island
- Flights from Bangor to Harbor Island
- Flights from Ithaca to Harbor Island
- Flights from Charlottesville to Harbor Island
- Flights from Fargo to Harbor Island
- Flights from Covington to Harbor Island
- Flights from Houston to Hunting Island
- Flights from Nashville to Hunting Island
- Flights from Pittsburgh to Hunting Island
- Flights from Evansville to Parris Island
- Flights from Flint to Parris Island
- Flights from Green Bay to Parris Island
- Flights from Jackson to Parris Island
- Flights from Boston to Parris Island
- Flights from Houston to Parris Island
- Flights from Indianapolis to Parris Island
- Flights from Minneapolis - St. Paul to Parris Island
- Flights from Orlando to Parris Island
- Flights from Phoenix to Parris Island
- Flights from Salt Lake City to Parris Island
- Flights from Lake Charles to Parris Island
- Flights from Fort Lauderdale to Parris Island
- Flights from Burlington to Parris Island
- Flights from La Crosse to Parris Island
- Flights from Scranton to Parris Island
- Flights from Fort Myers to Parris Island
- Flights from Little Rock to Parris Island
- Flights from Harrisburg - Hershey to Parris Island
- Flights from Greensboro to Parris Island
- Flights from Knoxville to Parris Island
- Flights from Cedar Rapids - Iowa City to Parris Island
- Flights from Huntsville to Parris Island
- Flights from Colorado Springs to Parris Island
- Flights from Lexington to Parris Island
- Flights from Grand Rapids to Parris Island
- Flights from Wichita to Parris Island
- Flights from Bismarck to Parris Island
- Flights from Boston to Hunting Island State Park
- Flights from Newark to Hunting Island State Park
- Flights from Charlotte to Fripp Island
Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.