
$235 Cheap flight deals from Roanoke (ROA) to Sanford (ORL)
Earn rewards on top of your airline miles with Orbitz Rewards
Many airlines offer flexible change policies
Sign up to receive text alerts about your trip
This Weekend's Flight Deals from Roanoke to Sanford
This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Airfares from $235 One Way, $249 Round Trip from Roanoke to Sanford
Prices starting at $249 for return flights and $235 for one-way flights to Sanford were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Sanford economy flight packages

Palazzo Lakeside Hotel
Nov 8 - Nov 15
Roanoke (ROA) to Orlando (MCO)
Reviewed on Jul 19, 2025

Westgate Palace Hotel / Universal / I-Drive
Nov 8 - Nov 15
Roanoke (ROA) to Orlando (MCO)
Reviewed on Aug 6, 2025

The Grove Resort & Water Park Orlando
Nov 8 - Nov 15
Roanoke (ROA) to Orlando (MCO)
Reviewed on Aug 22, 2025
More About Flying To Sanford from Roanoke
Route Information for Flights from Roanoke to Sanford
Origin Airport IATA Code | ROA |
---|---|
Destination Airport IATA Code | ORL |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
Roanoke to Sanford
Whether you want to book cheap flights from Roanoke to Sanford or are looking for the perfect package holiday, Orbitz is your one-stop source. Taking the stress and expense out of travel, Orbitz helps you find the best fares for Roanoke to Sanford flights.
Make the Most of Your Vacation
Not only does Orbitz have cheap deals for Roanoke to Sanford flights, we can also help you plan your vacation in advance. Why wait in lengthy lines for tickets to shows, amusement parks, and other attractions when you could be making the most of your holiday? Add activities to your flight booking for fewer hassles once you arrive in Sanford.
Planning on the Go
Book your flights from Roanoke to Sanford wherever you are with the Orbitz app for Android and iPhone. Or simply use m.orbitz.com on your mobile browser to search and book the Roanoke to Sanford flights that you want. And if you’re running late, you check your flight status and baggage claim information on your mobile device too too.
Craft Your Perfect Vacation
Orbitz takes the stress out of vacation planning with great deals on flights from Roanoke to Sanford, hotels, car rentals, cruises, and more. Mix and match results for your perfect trip, or book a complete vacation package.
Keep Informed With Orbitz
With Orbitz’s free alerts service, you will stay informed of flight or services disruptions to your Roanoke to Sanford flights. The alerts can be sent straight to your mobile phone or email.
Flights from Roanoke
- Roanoke to New York
- Roanoke to Orlando
- Roanoke to Chicago
- Roanoke to Dallas
- Roanoke to Houston
- Roanoke to Los Angeles
- Roanoke to Washington
- Roanoke to Newark
- Roanoke to Detroit
- Roanoke to San Francisco
- Roanoke to Chattanooga
- Roanoke to Key West
- Roanoke to Kansas City
- Roanoke to Hartford
- Roanoke to Abu Dhabi
- Roanoke to El Paso
Roanoke Airports
More Destinations
More Destinations
- Flights from Atlanta to Orlando
- Flights from Boston to Orlando
- Flights from Chicago to Orlando
- Flights from Dallas to Orlando
- Flights from Houston to Orlando
- Flights from New York to Orlando
- Flights from Philadelphia to Orlando
- Flights from Atlantic City (ACY) to Orlando (SFB)
- Flights from Alpena (APN) to Orlando (SFB)
- Flights from Appleton (ATW) to Orlando (SFB)
- Flights from Watertown (ATY) to Orlando (SFB)
- Flights from Asheville (AVL) to Orlando (SFB)
- Flights from Kalamazoo (AZO) to Orlando (SFB)
- Flights from Hartford (BDL) to Orlando (SFB)
- Flights from Bradford (BFD) to Orlando (SFB)
- Flights from Billings (BIL) to Orlando (SFB)
- Flights from Nashville (BNA) to Orlando (SFB)
- Flights from Boston (BOS) to Orlando (SFB)
- Flights from Brunswick (BQK) to Orlando (SFB)
- Flights from Brownsville (BRO) to Orlando (SFB)
- Flights from Burbank (BUR) to Orlando (SFB)
- Flights from Baltimore (BWI) to Orlando (SFB)
- Flights from Columbia (CAE) to Orlando (SFB)
- Flights from Akron (CAK) to Orlando (SFB)
- Flights from Sault Ste. Marie (CIU) to Orlando (SFB)
- Flights from Charlotte (CLT) to Orlando (SFB)
- Flights from Colorado Springs (COS) to Orlando (SFB)
- Flights from Dallas (DAL) to Orlando (SFB)
- Flights from Washington (DCA) to Orlando (SFB)
- Flights from Dallas (DFW) to Orlando (SFB)
- Flights from Panama City (ECP) to Orlando (SFB)
- Flights from Newark Liberty Intl. Airport (EWR) to Orlando (SFB)
- Flights from Key West (EYW) to Orlando (SFB)
- Flights from Fargo (FAR) to Orlando (SFB)
- Flights from Fresno (FAT) to Orlando (SFB)
- Flights from Flint (FNT) to Orlando (SFB)
- Flights from Isla Baltra (GPS) to Orlando (SFB)
- Flights from Gulfport (GPT) to Orlando (SFB)
- Flights from Greensboro (GSO) to Orlando (SFB)
- Flights from Hagerstown (HGR) to Orlando (SFB)
- Flights from White Plains (HPN) to Orlando (SFB)
- Flights from Huntington (HTS) to Orlando (SFB)
- Flights from Washington (IAD) to Orlando (SFB)
- Flights from Niagara Falls (IAG) to Orlando (SFB)
- Flights from Houston (IAH) to Orlando (SFB)
- Flights from Indianapolis (IND) to Orlando (SFB)
- Flights from New York (JFK) to Orlando (SFB)
- Flights from Latrobe (LBE) to Orlando (SFB)
- Flights from Orlando (MCO) to Orlando (SFB)
- Flights from Miami (MIA) to Orlando (SFB)
- Flights from Milwaukee (MKE) to Orlando (SFB)
- Flights from Melbourne (MLB) to Orlando (SFB)
- Flights from Muscle Shoals (MSL) to Orlando (SFB)
- Flights from Minneapolis (MSP) to Orlando (SFB)
- Flights from New Orleans (MSY) to Orlando (SFB)
- Flights from Marathon (MTH) to Orlando (SFB)
- Flights from Myrtle Beach (MYR) to Orlando (SFB)
- Flights from Miami (OPF) to Orlando (SFB)
- Flights from Plattsburgh (PBG) to Orlando (SFB)
- Flights from West Palm Beach (PBI) to Orlando (SFB)
- Flights from Atlanta (PDK) to Orlando (SFB)
- Flights from Greenville (PGV) to Orlando (SFB)
- Flights from Philadelphia (PHL) to Orlando (SFB)
- Flights from Peoria (PIA) to Orlando (SFB)
- Flights from Laurel (PIB) to Orlando (SFB)
- Flights from Pellston (PLN) to Orlando (SFB)
- Flights from Pensacola (PNS) to Orlando (SFB)
- Flights from Providence (PVD) to Orlando (SFB)
- Flights from Portland (PWM) to Orlando (SFB)
- Flights from Raleigh (RDU) to Orlando (SFB)
- Flights from Rockford (RFD) to Orlando (SFB)
- Flights from Richmond (RIC) to Orlando (SFB)
- Flights from Reno (RNO) to Orlando (SFB)
- Flights from Fort Myers (RSW) to Orlando (SFB)
- Flights from San Antonio (SAT) to Orlando (SFB)
- Flights from State College (SCE) to Orlando (SFB)
- Flights from Seattle (SEA) to Orlando (SFB)
- Flights from San Francisco (SFO) to Orlando (SFB)
- Flights from Springfield (SGF) to Orlando (SFB)
- Flights from Weyers Cave (SHD) to Orlando (SFB)
- Flights from San Angelo (SJT) to Orlando (SFB)
- Flights from San Juan (SJU) to Orlando (SFB)
- Flights from Salt Lake City (SLC) to Orlando (SFB)
- Flights from Orange County (SNA) to Orlando (SFB)
- Flights from Sarasota (SRQ) to Orlando (SFB)
- Flights from St. Louis (SUS) to Orlando (SFB)
- Flights from Tallahassee (TLH) to Orlando (SFB)
- Flights from Tri-Cities (TRI) to Orlando (SFB)
- Flights from Knoxville (TYS) to Orlando (SFB)
- Flights from Fayetteville (XNA) to Orlando (SFB)
- Flights from Hamilton (YHM) to Orlando (SFB)
- Flights from Kitchener (YKF) to Orlando (SFB)
- Flights from Youngstown (YNG) to Orlando (SFB)
- Flights from Ottawa (YOW) to Orlando (SFB)
- Flights from Toronto (YTZ) to Orlando (SFB)
- Flights from Montreal (YUL) to Orlando (SFB)
- Flights from Winnipeg (YWG) to Orlando (SFB)
- Flights from London (YXU) to Orlando (SFB)
- Flights from Calgary (YYC) to Orlando (SFB)
- Flights from Toronto (YYZ) to Orlando (SFB)
Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.