$115 Cheap flight deals from Santo Domingo (SDQ) to Mayagüez (SJU)
Earn rewards on top of your airline miles with Orbitz Rewards
Many airlines offer flexible change policies
Sign up to receive text alerts about your trip
This Weekend's Flight Deals from Santo Domingo to Mayagüez
This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Airfares from $115 One Way, $186 Round Trip from Santo Domingo to Mayagüez
Prices starting at $186 for return flights and $115 for one-way flights to Mayagüez were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Mayagüez economy flight packages
THE BUOY
Aug 12 - Aug 15
Santo Domingo (SDQ) to San Juan (SJU)
Reviewed on Jun 30, 2026
Signature Collection at Rio Mar
Sep 4 - Sep 6
Santo Domingo (SDQ) to San Juan (SJU)
San Juan (SJU) to Santo Domingo (SDQ)
Fortaleza Suites
Aug 13 - Aug 17
Santo Domingo (SDQ) to San Juan (SJU)
San Juan (SJU) to Santo Domingo (SDQ)
Reviewed on Jul 8, 2026
Mayagüez packages with premium economy flights
Flor De India
Aug 10 - Aug 16
Santo Domingo (SDQ) to San Juan (SJU)
Reviewed on Jul 8, 2026
THE BUOY
Aug 10 - Aug 16
Santo Domingo (SDQ) to San Juan (SJU)
Reviewed on Jun 30, 2026
Fairmont El San Juan Villa Experience
Aug 10 - Aug 16
Santo Domingo (SDQ) to San Juan (SJU)
Reviewed on Jun 16, 2026
More About Flying To Mayagüez from Santo Domingo
Route Information for Flights from Santo Domingo to Mayagüez
Origin Airport IATA Code | SDQ |
|---|---|
Destination Airport IATA Code | SJU |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
Santo Domingo to Mayagüez
Searching for deals for cheap flights from Santo Domingo to Mayagüez? Orbitz has your guaranteed low prices and offers cutting-edge mobile tools to make it easy to find bargain air tickets.
Use Orbitz Apps to Find Santo Domingo to Mayagüez Flights
Smartphone users can download the Orbitz app for Android and iPhone devices to get information on low fare deals for flights from Santo Domingo to Mayagüez anytime. These apps allow users to not only book tickets but check on their flight status and get the details they need to find the right departure gate—right on their mobile device.
Earn Miles on Your Cheap Flight
Orbitz makes it simple to earn points for your frequent flyer program when you book certain flights from Santo Domingo to Mayagüez. Just enter the account number associated with your frequent flyer program during the booking process, and your points or miles will be added after you complete your flight.
Orbitz Flight Alerts Keep You Updated
Along with offering bargain prices for Santo Domingo to Mayagüez flights, Orbitz also features free flight alerts that inform you of any abrupt changes to your travel itinerary. You can opt to have your alerts sent by email, voice, or text message. Orbitz will even forward the alerts to your contacts, who may need to adjust their plans for picking you up at the terminal.
Get Bargain Fares for Santo Domingo to Mayagüez Flights
Orbitz makes it quick and easy to find airfare sales and low fare tickets. Decide which airline and flight times you want or, if your schedule is flexible, choose a range of dates to see the best prices.
- Flights to Mayagüez
- Flights from Santo Domingo
- Santo Domingo Airports
- Mayagüez Airports
- Airlines Operating
Flights from Santo Domingo
- Santo Domingo to New York
- Santo Domingo to Toronto
- Santo Domingo to Orlando
- Santo Domingo to Montreal
- Santo Domingo to Dallas
- Santo Domingo to Madrid
- Santo Domingo to Washington
- Santo Domingo to Chicago
- Santo Domingo to Columbus
- Santo Domingo to San Francisco
- Santo Domingo to Paris
- Santo Domingo to London
- Santo Domingo to Rome
- Santo Domingo to Milan
- Santo Domingo to São Paulo
- Santo Domingo to Atlantic City
- Santo Domingo to Málaga
Santo Domingo Airports
More Destinations
- Hotels near Surf 'N Fun Water Park
- Hotels near Mayagüez Mall
- Hotels near Buye Beach
- Guest Houses in San German
- Historic Hotels in San German
- Pet Friendly Hotels in San German
- San German Hotels
- Las Marias Hotels
- Villas in Las Marias
- Hormigueros Hotels
- Apartments in Cabo Rojo
- Cabin Rentals in Cabo Rojo
- Hotels with Bar in Cabo Rojo
- Pet Friendly Hotels in Cabo Rojo
- Hotels with a Wedding Venue in Cabo Rojo
- Cabo Rojo Hotels
- Vacation Homes in Cabo Rojo
- Rv Parks in Cabo Rojo
- Villas in Cabo Rojo
- Cotuí Hotels
- Aguada Hotels
- Vacation Homes in Aguada
- Villas in Aguada
- Hotels near University of Puerto Rico Mayagüez Campus
- La Mela Hotels
- Mayag üez Pueblo Hotels
- Hotels near Club Deportivo Del Oeste
- Hotels near Eugenio María de Hostos
- Santurce Hotels
- Hotels near La Torre de Piedra
- Stella Hotels
- Vacation Homes in Stella
- Añasco Hotels
- Flights from Barrero
- Flights from San German
- Flights to Cabo Rojo
- Flights from Cabo Rojo
- Flights from Boston to Rincon
- Flights from Charlotte to Rincon
- Flights from Newark to Rincon
- Flights from Tampa to Rincon
- Flights from Nashville to Desecheo Island
- Flights from St. Louis to Desecheo Island
- Flights from Buffalo to Desecheo Island
- Flights from Jacksonville to Desecheo Island
- Flights from Charleston to Desecheo Island
- Flights from Eugenio María de Hostos
- Flights from Kolkata (CCU) to Mayagüez (MAZ)
- Flights from Charlotte (CLT) to Mayagüez (MAZ)
- Flights from Bangkok (DMK) to Mayagüez (MAZ)
- Flights from Panama City (ECP) to Mayagüez (MAZ)
- Flights from Newark Liberty Intl. Airport (EWR) to Mayagüez (MAZ)
- Flights from Yopal (EYP) to Mayagüez (MAZ)
- Flights from Fairbanks (FAI) to Mayagüez (MAZ)
- Flights from Puerto del Rosario (FUE) to Mayagüez (MAZ)
- Flights from La Gomera (GMZ) to Mayagüez (MAZ)
- Flights from Green Bay (GRB) to Mayagüez (MAZ)
- Flights from Klawock (KLW) to Mayagüez (MAZ)
- Flights from Ciudad de Catamayo (LOH) to Mayagüez (MAZ)
- Flights from Lynchburg (LYH) to Mayagüez (MAZ)
- Flights from Harrisburg (MDT) to Mayagüez (MAZ)
- Flights from Manchester (MHT) to Mayagüez (MAZ)
- Flights from Merida (MID) to Mayagüez (MAZ)
- Flights from Montes Claros (MOC) to Mayagüez (MAZ)
- Flights from Madison (MSN) to Mayagüez (MAZ)
- Flights from Sao Paulo de Olivenca (OLC) to Mayagüez (MAZ)
- Flights from Philadelphia (PHL) to Mayagüez (MAZ)
- Flights from Pensacola (PNS) to Mayagüez (MAZ)
- Flights from Reggio di Calabria (REG) to Mayagüez (MAZ)
- Flights from San Angelo (SJT) to Mayagüez (MAZ)
- Flights from Orange County (SNA) to Mayagüez (MAZ)
- Flights from Whangarei (WRE) to Mayagüez (MAZ)
- Flights from Winnipeg (YWG) to Mayagüez (MAZ)
- Flights to Santurce
- Flights from Killeen to Aguadilla
- Flights from Portland to Aguadilla
- Flights from Seattle to Aguadilla
- Flights from Omaha to Aguadilla
- Flights from Pittsburgh to Aguadilla
- Flights from Scranton to Aguadilla
- Flights from Allentown to Aguadilla
- Flights from White Plains to Aguadilla
- Flights from Palm Beach to Aguadilla
- Flights to Añasco
- Flights from Añasco
Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.